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The map label for this gene is hisI [H]

Identifier: 158422565

GI number: 158422565

Start: 1051952

End: 1052425

Strand: Reverse

Name: hisI [H]

Synonym: AZC_0941

Alternate gene names: 158422565

Gene position: 1052425-1051952 (Counterclockwise)

Preceding gene: 158422566

Following gene: 158422564

Centisome position: 19.6

GC content: 67.09

Gene sequence:

>474_bases
ATGACCGAACCGACGCCGGCCTTCGCCAGGGCCACAGACGCGCATGAGCTGGAAGAGGGCACGGTGCTGGCGCCGCGCTT
TGACGCCAACGGCCTCATCACCTGCGTGGCCGTGGACGCGGCCACGAACGAAATCCTCATGCTCGCGCACATGAATGCGG
AAGCCCTCTCGCTCACCATGGCGACGGGGGAGGCGCATTATTACAGCCGCTCGCGCAAGGCGCTGTGGAAGAAGGGCGAG
ACCTCCGGCCACACCCAGAAGGTCTCGGAAATCCGCATCGACTGCGATCAGGACGCCGTCATCATCAAGGTGACCATGGG
CGGCACGGGCGCCGCCTGCCACACCGGCCGGCGTTCCTGCTTCTACCGCACCATCCCCCTCGGCGCTCCCGCCTCGGCGG
ACACGAAGCTCGCCTTCACCGGCGACGAGCCGCGCTTCGATCCCAAGGCCGTCTACGGCAAGCACGAGCACTGA

Upstream 100 bases:

>100_bases
GCCAGTTCACCGGCGCCTTCCGCGACGACCCGGCCGAGCAGGTGCGATTCATCACCATGCTGCGCGGCCTGCGCTGACCC
CCCATCCTGACGAGCGTGCC

Downstream 100 bases:

>100_bases
GGGGCGGCCGCCACTCACGCGGGCTTGTCTGCGCCCATTAATACACAAAATCTATAGACGTTATTTTTATTCTTCCTGTA
AGGTCTCCCGGTTCGCAACC

Product: phosphoribosyl C-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 157; Mature: 156

Protein sequence:

>157_residues
MTEPTPAFARATDAHELEEGTVLAPRFDANGLITCVAVDAATNEILMLAHMNAEALSLTMATGEAHYYSRSRKALWKKGE
TSGHTQKVSEIRIDCDQDAVIIKVTMGGTGAACHTGRRSCFYRTIPLGAPASADTKLAFTGDEPRFDPKAVYGKHEH

Sequences:

>Translated_157_residues
MTEPTPAFARATDAHELEEGTVLAPRFDANGLITCVAVDAATNEILMLAHMNAEALSLTMATGEAHYYSRSRKALWKKGE
TSGHTQKVSEIRIDCDQDAVIIKVTMGGTGAACHTGRRSCFYRTIPLGAPASADTKLAFTGDEPRFDPKAVYGKHEH
>Mature_156_residues
TEPTPAFARATDAHELEEGTVLAPRFDANGLITCVAVDAATNEILMLAHMNAEALSLTMATGEAHYYSRSRKALWKKGET
SGHTQKVSEIRIDCDQDAVIIKVTMGGTGAACHTGRRSCFYRTIPLGAPASADTKLAFTGDEPRFDPKAVYGKHEH

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=92, Percent_Identity=41.304347826087, Blast_Score=81, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319819, Length=92, Percent_Identity=39.1304347826087, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 16951; Mature: 16820

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPTPAFARATDAHELEEGTVLAPRFDANGLITCVAVDAATNEILMLAHMNAEALSLTM
CCCCCCCHHCCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCCEEEEEEECCCCCEEEEE
ATGEAHYYSRSRKALWKKGETSGHTQKVSEIRIDCDQDAVIIKVTMGGTGAACHTGRRSC
ECCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCEEEEEEEECCCCCCCCCCCCCE
FYRTIPLGAPASADTKLAFTGDEPRFDPKAVYGKHEH
EEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TEPTPAFARATDAHELEEGTVLAPRFDANGLITCVAVDAATNEILMLAHMNAEALSLTM
CCCCCCHHCCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCCEEEEEEECCCCCEEEEE
ATGEAHYYSRSRKALWKKGETSGHTQKVSEIRIDCDQDAVIIKVTMGGTGAACHTGRRSC
ECCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCEEEEEEEECCCCCCCCCCCCCE
FYRTIPLGAPASADTKLAFTGDEPRFDPKAVYGKHEH
EEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]