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The map label for this gene is fdh [H]

Identifier: 158422450

GI number: 158422450

Start: 932710

End: 933879

Strand: Direct

Name: fdh [H]

Synonym: AZC_0826

Alternate gene names: 158422450

Gene position: 932710-933879 (Clockwise)

Preceding gene: 158422445

Following gene: 158422451

Centisome position: 17.37

GC content: 64.87

Gene sequence:

>1170_bases
ATGAAGGCACTGACTTTCCACGGCAAAGGCGACATCCGATGCGAACAGGTGCCCGACCCGACCATCCAGGAGCCGACGGA
CGCCATCATCAAGGTAACGGCCTGCGCCATCTGCGGCTCCGACGTGCACATCTATGACGGCGTGATCCCCTCCATGGAAA
GCGGCGACGTGCTCGGCCATGAAACCATGGGCGAGGTGGTGGAGGTGGGCAGCGGCACCACCACACTGAAGGTGGGCGAT
CGTGTGGTGGTGCCCTTCACCATCGCCTGCGGTCAGTGCTTCTTCTGCCAGCGCGGCTATTTCTCCGGTTGCGAGCGCTC
GAACCCCAACCACCAGATGGCGGAGAAAATGTGGGGTTTCTCGCCGGCCGGCCTCTATGGCTATTCGCACATGCTGGGCG
GCTATTCCGGCGGACAGGCGGAATATCTGCGCGTGCCTTTCGCCGACAGCGGCCCCATCAAGGTGCCGAACGGCCTTTCC
GACGAGCAGGTGCTGTTCCTCTCCGACATCTTCCCCACCGGCTACATGGCGGCGGAGTTCTGCGAGATCCGCGGCGGCGA
GACCATCGCCATCTGGGGCTGCGGACCCGTGGGCCAGATGGCCATCCGCAGCGCCTTCATGCTGGGCGCCGAACGGGTCA
TCGCTATCGATACGGTGCCCGAGCGTCTGGCGCTGGCCCAGGCGGGCGGCGCCGAGACCATCGATTTCCTCGCCGAGGAC
GTCTATGAGCGCATCCGCGAGATGACCGGCGGTCGGGGCGCGGATGCCTGCATCGATGCGGTGGGCACGGAGGCCGATGC
CTCGTCCTCCTTCGATGCGCGCATCGACCGCATCAAGGTCGCAACCTTCATGGGCACGGACCGGCCCCATGTGCTGCGCC
AAGCCATCCAGTGCTGCCGCAACTTCGGCATCGTCTCCATCGTCGGTGTTTACGGCGGGTTTCTCGACAAGATCCCCATG
GGTTCGGCCATCAATCGCGGCCTCACCTTCCGTATGGCCCAGACGCCGGTCCAGCGCTATCTGCCGACGCTCCTGAAGCG
GATCGAGGACGGCGACTTCGACCCGTCCTTCGTCATCACCCACCGGGCGAGCCTGGAAGAGGGGCCGGATCTCTACGCCA
AGTTCCGCGACAAGCAGGACGGCTGCATCAAGGTGGTGCTGAAGCCCTGA

Upstream 100 bases:

>100_bases
AGGGGGAGCCGGAGCTGTTTGCCAACAGGGCACGCATAGGAGCCGGCCGACAGCGCCGGAGGTGTCATGCGCAGGCCCGA
CCCTTCCATGAGGCGGCTCG

Downstream 100 bases:

>100_bases
CGGCCGTGCGGGTTCGCCCGCGCGGCCGATGCGCCCGAACCTCGAAGGGGCGCCTTCGCCCCTCTCCAGCCGCGACCAGG
AGCCAGCCATGCCCGAGAAG

Product: IMP dehydrogenase

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MKALTFHGKGDIRCEQVPDPTIQEPTDAIIKVTACAICGSDVHIYDGVIPSMESGDVLGHETMGEVVEVGSGTTTLKVGD
RVVVPFTIACGQCFFCQRGYFSGCERSNPNHQMAEKMWGFSPAGLYGYSHMLGGYSGGQAEYLRVPFADSGPIKVPNGLS
DEQVLFLSDIFPTGYMAAEFCEIRGGETIAIWGCGPVGQMAIRSAFMLGAERVIAIDTVPERLALAQAGGAETIDFLAED
VYERIREMTGGRGADACIDAVGTEADASSSFDARIDRIKVATFMGTDRPHVLRQAIQCCRNFGIVSIVGVYGGFLDKIPM
GSAINRGLTFRMAQTPVQRYLPTLLKRIEDGDFDPSFVITHRASLEEGPDLYAKFRDKQDGCIKVVLKP

Sequences:

>Translated_389_residues
MKALTFHGKGDIRCEQVPDPTIQEPTDAIIKVTACAICGSDVHIYDGVIPSMESGDVLGHETMGEVVEVGSGTTTLKVGD
RVVVPFTIACGQCFFCQRGYFSGCERSNPNHQMAEKMWGFSPAGLYGYSHMLGGYSGGQAEYLRVPFADSGPIKVPNGLS
DEQVLFLSDIFPTGYMAAEFCEIRGGETIAIWGCGPVGQMAIRSAFMLGAERVIAIDTVPERLALAQAGGAETIDFLAED
VYERIREMTGGRGADACIDAVGTEADASSSFDARIDRIKVATFMGTDRPHVLRQAIQCCRNFGIVSIVGVYGGFLDKIPM
GSAINRGLTFRMAQTPVQRYLPTLLKRIEDGDFDPSFVITHRASLEEGPDLYAKFRDKQDGCIKVVLKP
>Mature_389_residues
MKALTFHGKGDIRCEQVPDPTIQEPTDAIIKVTACAICGSDVHIYDGVIPSMESGDVLGHETMGEVVEVGSGTTTLKVGD
RVVVPFTIACGQCFFCQRGYFSGCERSNPNHQMAEKMWGFSPAGLYGYSHMLGGYSGGQAEYLRVPFADSGPIKVPNGLS
DEQVLFLSDIFPTGYMAAEFCEIRGGETIAIWGCGPVGQMAIRSAFMLGAERVIAIDTVPERLALAQAGGAETIDFLAED
VYERIREMTGGRGADACIDAVGTEADASSSFDARIDRIKVATFMGTDRPHVLRQAIQCCRNFGIVSIVGVYGGFLDKIPM
GSAINRGLTFRMAQTPVQRYLPTLLKRIEDGDFDPSFVITHRASLEEGPDLYAKFRDKQDGCIKVVLKP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=240, Percent_Identity=30.8333333333333, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI4501933, Length=240, Percent_Identity=30.4166666666667, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI71565152, Length=267, Percent_Identity=28.4644194756554, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI4501929, Length=241, Percent_Identity=31.5352697095436, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI156523966, Length=370, Percent_Identity=25.1351351351351, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI4501939, Length=350, Percent_Identity=25.7142857142857, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI71565154, Length=261, Percent_Identity=29.8850574712644, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI71743840, Length=229, Percent_Identity=30.5676855895196, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI262073058, Length=229, Percent_Identity=30.5676855895196, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786825, Length=393, Percent_Identity=45.5470737913486, Blast_Score=331, Evalue=5e-92,
Organism=Escherichia coli, GI87082125, Length=390, Percent_Identity=30.5128205128205, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1788073, Length=392, Percent_Identity=26.530612244898, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI226510992, Length=291, Percent_Identity=28.8659793814433, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI87081918, Length=227, Percent_Identity=36.1233480176211, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790045, Length=400, Percent_Identity=26.5, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1787863, Length=380, Percent_Identity=23.9473684210526, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788075, Length=400, Percent_Identity=25.5, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1788407, Length=239, Percent_Identity=27.6150627615063, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786552, Length=357, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790718, Length=306, Percent_Identity=23.202614379085, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=396, Percent_Identity=26.010101010101, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17562878, Length=267, Percent_Identity=28.8389513108614, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI25146526, Length=326, Percent_Identity=27.9141104294479, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17565904, Length=306, Percent_Identity=27.7777777777778, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71997431, Length=326, Percent_Identity=27.6073619631902, Blast_Score=85, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6319257, Length=422, Percent_Identity=28.6729857819905, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6322619, Length=277, Percent_Identity=29.6028880866426, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319955, Length=277, Percent_Identity=29.6028880866426, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=308, Percent_Identity=29.2207792207792, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320033, Length=409, Percent_Identity=26.4058679706601, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6323099, Length=395, Percent_Identity=23.7974683544304, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323729, Length=270, Percent_Identity=27.4074074074074, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323961, Length=369, Percent_Identity=25.7452574525745, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17137530, Length=390, Percent_Identity=26.1538461538462, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17737897, Length=390, Percent_Identity=25.3846153846154, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI17737895, Length=204, Percent_Identity=31.8627450980392, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 42087; Mature: 42087

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALTFHGKGDIRCEQVPDPTIQEPTDAIIKVTACAICGSDVHIYDGVIPSMESGDVLGH
CCEEEECCCCCEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCH
ETMGEVVEVGSGTTTLKVGDRVVVPFTIACGQCFFCQRGYFSGCERSNPNHQMAEKMWGF
HHHHHHHHCCCCCEEEEECCEEEEEEEEECCCEEEECCCCCCCCCCCCCCHHHHHHHCCC
SPAGLYGYSHMLGGYSGGQAEYLRVPFADSGPIKVPNGLSDEQVLFLSDIFPTGYMAAEF
CCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCEECCCCCCCCEEEEEECCCCCCHHHHHH
CEIRGGETIAIWGCGPVGQMAIRSAFMLGAERVIAIDTVPERLALAQAGGAETIDFLAED
HHCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCHHHHHHHHH
VYERIREMTGGRGADACIDAVGTEADASSSFDARIDRIKVATFMGTDRPHVLRQAIQCCR
HHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHEEEEEEEECCCCHHHHHHHHHHHH
NFGIVSIVGVYGGFLDKIPMGSAINRGLTFRMAQTPVQRYLPTLLKRIEDGDFDPSFVIT
CCCCEEHHHHHHHHHHHCCCCHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCEEEE
HRASLEEGPDLYAKFRDKQDGCIKVVLKP
EECCCCCCCHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure
MKALTFHGKGDIRCEQVPDPTIQEPTDAIIKVTACAICGSDVHIYDGVIPSMESGDVLGH
CCEEEECCCCCEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCH
ETMGEVVEVGSGTTTLKVGDRVVVPFTIACGQCFFCQRGYFSGCERSNPNHQMAEKMWGF
HHHHHHHHCCCCCEEEEECCEEEEEEEEECCCEEEECCCCCCCCCCCCCCHHHHHHHCCC
SPAGLYGYSHMLGGYSGGQAEYLRVPFADSGPIKVPNGLSDEQVLFLSDIFPTGYMAAEF
CCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCEECCCCCCCCEEEEEECCCCCCHHHHHH
CEIRGGETIAIWGCGPVGQMAIRSAFMLGAERVIAIDTVPERLALAQAGGAETIDFLAED
HHCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCHHHHHHHHH
VYERIREMTGGRGADACIDAVGTEADASSSFDARIDRIKVATFMGTDRPHVLRQAIQCCR
HHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHEEEEEEEECCCCHHHHHHHHHHHH
NFGIVSIVGVYGGFLDKIPMGSAINRGLTFRMAQTPVQRYLPTLLKRIEDGDFDPSFVIT
CCCCEEHHHHHHHHHHHCCCCHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCEEEE
HRASLEEGPDLYAKFRDKQDGCIKVVLKP
EECCCCCCCHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]