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The map label for this gene is cysK [H]

Identifier: 158422333

GI number: 158422333

Start: 787502

End: 788485

Strand: Direct

Name: cysK [H]

Synonym: AZC_0709

Alternate gene names: 158422333

Gene position: 787502-788485 (Clockwise)

Preceding gene: 158422332

Following gene: 158422334

Centisome position: 14.67

GC content: 69.0

Gene sequence:

>984_bases
ATGGCGACGTCCGCTGCCAAAGCCGCCTCTGCCGCCCCGCGTCCGGGCCGGGGCCGTGTCTATGATTCCATCACCGAGAC
CGTCGGCAACACGCCGCTGGTGCGCCTGCACCGGCTGCCCGAGCTGCGCGGCGTGAAGGCCAACATCCTGGCCAAGCTCG
AGTTCTTCAATCCCATCGCCAGCGTGAAGGACCGCATCGGCGTCGCCATGGTCGACGCCATCGCGGAAGCCGGCCAGCTC
GATCCCGATACCGTGCTGGTTGAGCCCACCTCCGGCAACACCGGCATCGCGCTCGCCTTCGTCGCCGCCGCCCGTGGCCT
GCGCCTCATCCTCGTCATGCCCGAGAGCATGTCGGTGGAGCGCCGCAAGATGCTGGCCCTGCTGGGCGCCGAGCTGGTGC
TGACGCCCGCCAACCTCGGCATGCGCGGCGCCGTCACCCGCGCCGAGGAACTGCTCAAGGAAATCCCCAAGTCGGTGATG
CCGCAGCAGTTCAAGAACAAGGCGAATCCCGCCGTCCACCGCGCCACCACGGCGGAGGAGATCTGGAACGATACGGACGG
CGCGGTCGATCTCGTCGTCTCTGGCGTCGGCACTGGCGGCACCATCACCGGCATCGGCCAGGTGCTGAAGCCCCGCAAGG
CCTCCCTGCGCATGGTGGCGGTGGAGCCCGAGGACAGCCCGGTGCTCTCCGGCGGCCAGCCCGGCCCGCACAAGATCCAG
GGCATCGGCGCCGGCTTCGTGCCGGACGTGCTCGACCGTTCGATCATCGACGAGGTGGTAACGGTGGGCAATCAGACCGC
CTTCGACACCGCCCGCGCGCTTGCCCGCTATGAGGGTATCCCCGGCGGCATCTCCTCGGGTGCGGCGGTGGCCGCGGCGC
TGGAGATCGGCGCCCGCAAGGAGAATGAAGGCAAGAACATCGTGGTGATCGTGCCCTCCTTCGCCGAGCGCTACCTCTCG
ACGGCGCTGTTCGAGGGTCTCTGA

Upstream 100 bases:

>100_bases
CATGGCATCGAGAACGACCGCATCGATTTCATCATCTGATCGTTCAACCCATACGTCCGACGGGCGCCGCGCGCCGTCCA
ATCCCTGAGGAGACCGTCCA

Downstream 100 bases:

>100_bases
TCCTCGTCTTCGTCCCGCGTTCTGCCGCGCCTCTCCCGCCCACCGGCGGGGGAGGCGTTTTGCATTGGGGGCCTCCGTCC
CGAATCGGGACGTTAGGGAA

Product: cysteine synthase K/M

Products: NA

Alternate protein names: OAS sulfhydrylase; OASS; Cysteine synthase A; CSase A; O-acetylserine (thiol)-lyase A; OAS-TL A; O-acetylserine-specific cysteine synthase; Sulfide-dependent cysteine synthase [H]

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MATSAAKAASAAPRPGRGRVYDSITETVGNTPLVRLHRLPELRGVKANILAKLEFFNPIASVKDRIGVAMVDAIAEAGQL
DPDTVLVEPTSGNTGIALAFVAAARGLRLILVMPESMSVERRKMLALLGAELVLTPANLGMRGAVTRAEELLKEIPKSVM
PQQFKNKANPAVHRATTAEEIWNDTDGAVDLVVSGVGTGGTITGIGQVLKPRKASLRMVAVEPEDSPVLSGGQPGPHKIQ
GIGAGFVPDVLDRSIIDEVVTVGNQTAFDTARALARYEGIPGGISSGAAVAAALEIGARKENEGKNIVVIVPSFAERYLS
TALFEGL

Sequences:

>Translated_327_residues
MATSAAKAASAAPRPGRGRVYDSITETVGNTPLVRLHRLPELRGVKANILAKLEFFNPIASVKDRIGVAMVDAIAEAGQL
DPDTVLVEPTSGNTGIALAFVAAARGLRLILVMPESMSVERRKMLALLGAELVLTPANLGMRGAVTRAEELLKEIPKSVM
PQQFKNKANPAVHRATTAEEIWNDTDGAVDLVVSGVGTGGTITGIGQVLKPRKASLRMVAVEPEDSPVLSGGQPGPHKIQ
GIGAGFVPDVLDRSIIDEVVTVGNQTAFDTARALARYEGIPGGISSGAAVAAALEIGARKENEGKNIVVIVPSFAERYLS
TALFEGL
>Mature_326_residues
ATSAAKAASAAPRPGRGRVYDSITETVGNTPLVRLHRLPELRGVKANILAKLEFFNPIASVKDRIGVAMVDAIAEAGQLD
PDTVLVEPTSGNTGIALAFVAAARGLRLILVMPESMSVERRKMLALLGAELVLTPANLGMRGAVTRAEELLKEIPKSVMP
QQFKNKANPAVHRATTAEEIWNDTDGAVDLVVSGVGTGGTITGIGQVLKPRKASLRMVAVEPEDSPVLSGGQPGPHKIQG
IGAGFVPDVLDRSIIDEVVTVGNQTAFDTARALARYEGIPGGISSGAAVAAALEIGARKENEGKNIVVIVPSFAERYLST
ALFEGL

Specific function: Catalyzes the conversion of O-acetylserine (OAS) to cysteine through the elimination of acetate and addition of hydrogen sulfide [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=313, Percent_Identity=41.2140575079872, Blast_Score=235, Evalue=5e-62,
Organism=Homo sapiens, GI295821200, Length=313, Percent_Identity=41.2140575079872, Blast_Score=235, Evalue=5e-62,
Organism=Homo sapiens, GI4557415, Length=313, Percent_Identity=41.2140575079872, Blast_Score=235, Evalue=5e-62,
Organism=Escherichia coli, GI1788754, Length=318, Percent_Identity=54.0880503144654, Blast_Score=288, Evalue=3e-79,
Organism=Escherichia coli, GI2367138, Length=302, Percent_Identity=39.0728476821192, Blast_Score=203, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17535051, Length=303, Percent_Identity=49.8349834983498, Blast_Score=288, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17562970, Length=300, Percent_Identity=50.3333333333333, Blast_Score=282, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI32566674, Length=295, Percent_Identity=50.8474576271186, Blast_Score=277, Evalue=6e-75,
Organism=Caenorhabditis elegans, GI115535073, Length=309, Percent_Identity=50.8090614886731, Blast_Score=268, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI17561720, Length=309, Percent_Identity=50.8090614886731, Blast_Score=254, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=49.5283018867925, Blast_Score=204, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI17534315, Length=330, Percent_Identity=41.8181818181818, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI25147552, Length=323, Percent_Identity=39.3188854489164, Blast_Score=177, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI17561716, Length=121, Percent_Identity=51.2396694214876, Blast_Score=112, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6321594, Length=314, Percent_Identity=37.8980891719745, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6321449, Length=339, Percent_Identity=33.6283185840708, Blast_Score=121, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24643623, Length=312, Percent_Identity=39.4230769230769, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI20129101, Length=312, Percent_Identity=39.4230769230769, Blast_Score=206, Evalue=2e-53,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 34179; Mature: 34048

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATSAAKAASAAPRPGRGRVYDSITETVGNTPLVRLHRLPELRGVKANILAKLEFFNPIA
CCCCHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEHHCCCCCCCCHHHHHHHHHHHCHHH
SVKDRIGVAMVDAIAEAGQLDPDTVLVEPTSGNTGIALAFVAAARGLRLILVMPESMSVE
HHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCHH
RRKMLALLGAELVLTPANLGMRGAVTRAEELLKEIPKSVMPQQFKNKANPAVHRATTAEE
HHHHHHHHCCHHEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHH
IWNDTDGAVDLVVSGVGTGGTITGIGQVLKPRKASLRMVAVEPEDSPVLSGGQPGPHKIQ
HHCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCEEE
GIGAGFVPDVLDRSIIDEVVTVGNQTAFDTARALARYEGIPGGISSGAAVAAALEIGARK
ECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCC
ENEGKNIVVIVPSFAERYLSTALFEGL
CCCCCEEEEECCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ATSAAKAASAAPRPGRGRVYDSITETVGNTPLVRLHRLPELRGVKANILAKLEFFNPIA
CCCHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEHHCCCCCCCCHHHHHHHHHHHCHHH
SVKDRIGVAMVDAIAEAGQLDPDTVLVEPTSGNTGIALAFVAAARGLRLILVMPESMSVE
HHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCHH
RRKMLALLGAELVLTPANLGMRGAVTRAEELLKEIPKSVMPQQFKNKANPAVHRATTAEE
HHHHHHHHCCHHEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHH
IWNDTDGAVDLVVSGVGTGGTITGIGQVLKPRKASLRMVAVEPEDSPVLSGGQPGPHKIQ
HHCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCEEE
GIGAGFVPDVLDRSIIDEVVTVGNQTAFDTARALARYEGIPGGISSGAAVAAALEIGARK
ECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCC
ENEGKNIVVIVPSFAERYLSTALFEGL
CCCCCEEEEECCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]