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The map label for this gene is msrA

Identifier: 158422298

GI number: 158422298

Start: 745013

End: 745669

Strand: Reverse

Name: msrA

Synonym: AZC_0674

Alternate gene names: 158422298

Gene position: 745669-745013 (Counterclockwise)

Preceding gene: 158422299

Following gene: 158422297

Centisome position: 13.89

GC content: 66.82

Gene sequence:

>657_bases
ATGTTCTGGTCGAAGAAGCCCCTGGACCTTCCGACGCCCGAGACCGCCCTCAAGGGCCGCCCCGACGCCATTCCCACCGC
CCGCCTGCACCATGTGAACCAGAATCCGCTGAAGGGCCCCTATCCGGACGGCTTCCGGACGGCGATCTTCGCCCTCGGCT
GCTTCTGGGGCGCGGAGCGCGCCTTCTGGCGCACGCCGGGCGTCTGGGTCACGGCGGTGGGCTATCTCGCCGGCCTCACG
CCCAATCCCACCTATGAGGAAGTGTGCTCCGGCCGCACCGGGCACACGGAAGGCGTGCTGGTGGTCTATGACCCGGCCGT
CATCTCCTATGCCGATCTCGTGAAGCTCTTCTTCGAGAGCCACGACCCCACGCAGGGCATGCGGCAGGGCAATGACGTGG
GCACGCAGTATCGCTCCGGCATCTATACGAGCGACCCGCAGGAGAAGGCTGTCGCCGAGGCGGTGAAGGCAAGCTATGAG
GCCGCGCTGAAGGCCAAGGGCTTCGGACCCATCACCACCGAGATCATCGACGGCGGGCCGTTCTATTTCGCCGAGGACTA
TCACCAGCAGTATCTGTCGAAGAATCCCGGCGGCTACTGCGGGCTTGGCGGCACCGGCGTCTCCTGCCCCATCGGGGTGG
GCGTCGCGGCCCAGTGA

Upstream 100 bases:

>100_bases
CGTGTGCGGGAGCGCTCGCCCTTCGAGGCTGCCTGAGACGCCCCTCGCGGAACGGTGGGCGGCACCCCATATCTGCGCTC
GAACACAAAAGGAGCGCGCC

Downstream 100 bases:

>100_bases
GCATCGGGCGCCCGGCCAAGCCGGGCGCCTTCTTACGCTACGGCCGTGTGATTTCAGGCATTTGAAGCGGCGGATACGGC
TTAATCGGCTTCAACTCGAC

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MFWSKKPLDLPTPETALKGRPDAIPTARLHHVNQNPLKGPYPDGFRTAIFALGCFWGAERAFWRTPGVWVTAVGYLAGLT
PNPTYEEVCSGRTGHTEGVLVVYDPAVISYADLVKLFFESHDPTQGMRQGNDVGTQYRSGIYTSDPQEKAVAEAVKASYE
AALKAKGFGPITTEIIDGGPFYFAEDYHQQYLSKNPGGYCGLGGTGVSCPIGVGVAAQ

Sequences:

>Translated_218_residues
MFWSKKPLDLPTPETALKGRPDAIPTARLHHVNQNPLKGPYPDGFRTAIFALGCFWGAERAFWRTPGVWVTAVGYLAGLT
PNPTYEEVCSGRTGHTEGVLVVYDPAVISYADLVKLFFESHDPTQGMRQGNDVGTQYRSGIYTSDPQEKAVAEAVKASYE
AALKAKGFGPITTEIIDGGPFYFAEDYHQQYLSKNPGGYCGLGGTGVSCPIGVGVAAQ
>Mature_218_residues
MFWSKKPLDLPTPETALKGRPDAIPTARLHHVNQNPLKGPYPDGFRTAIFALGCFWGAERAFWRTPGVWVTAVGYLAGLT
PNPTYEEVCSGRTGHTEGVLVVYDPAVISYADLVKLFFESHDPTQGMRQGNDVGTQYRSGIYTSDPQEKAVAEAVKASYE
AALKAKGFGPITTEIIDGGPFYFAEDYHQQYLSKNPGGYCGLGGTGVSCPIGVGVAAQ

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=205, Percent_Identity=57.5609756097561, Blast_Score=260, Evalue=8e-70,
Organism=Homo sapiens, GI208609995, Length=184, Percent_Identity=60.3260869565217, Blast_Score=245, Evalue=3e-65,
Organism=Homo sapiens, GI208609993, Length=205, Percent_Identity=45.3658536585366, Blast_Score=185, Evalue=3e-47,
Organism=Escherichia coli, GI1790665, Length=188, Percent_Identity=57.9787234042553, Blast_Score=218, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17533973, Length=145, Percent_Identity=39.3103448275862, Blast_Score=94, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6320881, Length=167, Percent_Identity=37.7245508982036, Blast_Score=95, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24664627, Length=145, Percent_Identity=41.3793103448276, Blast_Score=90, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24664631, Length=145, Percent_Identity=40.6896551724138, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45553131, Length=140, Percent_Identity=40.7142857142857, Blast_Score=84, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA_AZOC5 (A8IPQ8)

Other databases:

- EMBL:   AP009384
- RefSeq:   YP_001523590.1
- ProteinModelPortal:   A8IPQ8
- SMR:   A8IPQ8
- GeneID:   5691749
- GenomeReviews:   AP009384_GR
- KEGG:   azc:AZC_0674
- HOGENOM:   HBG748152
- OMA:   SAIYCTT
- ProtClustDB:   CLSK979784
- BioCyc:   ACAU438753:AZC_0674-MONOMER
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 23510; Mature: 23510

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: ACT_SITE 54-54

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFWSKKPLDLPTPETALKGRPDAIPTARLHHVNQNPLKGPYPDGFRTAIFALGCFWGAER
CCCCCCCCCCCCCCHHHCCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
AFWRTPGVWVTAVGYLAGLTPNPTYEEVCSGRTGHTEGVLVVYDPAVISYADLVKLFFES
CEECCCCHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHC
HDPTQGMRQGNDVGTQYRSGIYTSDPQEKAVAEAVKASYEAALKAKGFGPITTEIIDGGP
CCCHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCC
FYFAEDYHQQYLSKNPGGYCGLGGTGVSCPIGVGVAAQ
CEEHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFWSKKPLDLPTPETALKGRPDAIPTARLHHVNQNPLKGPYPDGFRTAIFALGCFWGAER
CCCCCCCCCCCCCCHHHCCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
AFWRTPGVWVTAVGYLAGLTPNPTYEEVCSGRTGHTEGVLVVYDPAVISYADLVKLFFES
CEECCCCHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHC
HDPTQGMRQGNDVGTQYRSGIYTSDPQEKAVAEAVKASYEAALKAKGFGPITTEIIDGGP
CCCHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCC
FYFAEDYHQQYLSKNPGGYCGLGGTGVSCPIGVGVAAQ
CEEHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA