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The map label for this gene is pepA [H]

Identifier: 158422161

GI number: 158422161

Start: 595380

End: 596897

Strand: Direct

Name: pepA [H]

Synonym: AZC_0537

Alternate gene names: 158422161

Gene position: 595380-596897 (Clockwise)

Preceding gene: 158422160

Following gene: 158422162

Centisome position: 11.09

GC content: 69.1

Gene sequence:

>1518_bases
TTGACCTGTCTGGAGTGCTTCATGTCCGAGCCCGTGACCATTGCCTTCGCCAAGCACGGTGCGGCGCCGAGCGGCGTCCT
CCTCGTCCTCGTCGATGACGCGCTGAATTTCGGCCGCGAGGCGCAGAAGCTGCTGAAGCCCGCCCTCGGCCAGATCAAGC
GCGCCTTCGAGGCGGACCGCTTCAAGGGCAAGCTGGGCGGTGCGCTGGAGCTGATCGCCCCCGAGGGGCTCGATGTGGCC
CGCCTCATCGTGCTCGGCACCGGCAAGGCCGGCGAACTGAAGCCCACCGATTTCCTGCGCCTCGGTGGCATCGCGGCGGG
CAAGATCCCCGGCGGCAGCACGGCGGCGACCCTCCTCGCCGATCTGCCCGGCGCCAAGTTCGCGCCCGAGGCGGCGGCCG
AGATCGCGCTCGGCGCGCGTCTGCGCTCCTATGTCTTCGACCGCTACAAGACCCGGAAGAAGGAAGGCGACACCGATCCG
GTGACGCTGACCCTCACCCTGCTGGTGCCGGACGCTGCCGCGGCCGTGCGTGCCTGGACGCCCCGCGAGGCGGTGGGCGA
CGGCGTGCTGCTGGCCCGCGATCTCGTGAACGAGCCCGCCAACGTGCTCGATCCGCCGGAATTCGCCCGCCGCGCCACCG
AGCTCTCCGCCGTGGGCGTGGATGTGGAAGTGCTCGACGATGCCGCGCTCTCGCGCATCGGCATGCGGGCGCTGCTGGGC
GTCGGGCAGGGCTCCATCAAGGAGAGCCGCGTTGTCGTCATGCGCTGGAACGGCGGCAAGCCGGGCGAGGCGCCGGTCGC
CTTCATCGGCAAGGGCGTGACCTTCGACACCGGCGGCATCTCCATCAAGCCGGCCGCCGGCATGGAGGACATGAAGGGCG
ACATGGGCGGGGCCGCCTGCGTCACCGGCCTCATGCATGCGCTCGCCGCCCGCAAGGCGAAGGTGAATGCGGTGGGCGTC
ATCGGCATCGTGGAAAACATGCCCGACGGCGCCGCCCAGCGCCCCGGCGACATCGTGACCTCGCTCTCCGGCCAGACCAT
CGAGATCATCAATACCGACGCCGAGGGCCGCCTCGTGCTGGCCGATGTGCTCTGGTACACGAAGGACCGCTTCAAGCCGA
AGTTCATGGTGGACCTCGCCACCCTGACCGGCGCCATCATGGTGGCGCTCGGCACCGAGAATGCCGGCCTCTTCTCCAAT
GACGACACGCTGAGCACGCAGCTTGCCGCCGCAGGCGCCGCCACCGGCGAGAAGGTGTGGCGCATGCCGCTCTCGCCGGA
ATACGACAAGCTGATCGACTCGAAGTTCGCGGACATGAAGAACACCGGCGGGCGCAACGGCGGCTCCATCACCGCCGCCC
AGTTCCTCCAGCGCTTCGTGGACAAGACCCCTTGGGCGCATCTCGATATCGCCGGCACGGCCATGGCCTCGCCCGCCAGC
GACATCAACAAGAGCTGGGGTGCCGGCTGGGGCGTGCGCCTGCTCGACCAACTGGTGCGCGACAATTACGAGAAGTGA

Upstream 100 bases:

>100_bases
CCGGCGTGACAGGAAGCGGCTTTTGCGCCGCCCCGGCCTCGGGCGGCTTCCCTCCTGCGGGTGGGGGCTTTAGACAGGGT
TGAGCGACTATTGAATTTCG

Downstream 100 bases:

>100_bases
GCGCGTGTCCCCGGCCGCTCCGGCGGCCGGGGTTGGTCTTGAGTTGTACGGATTTTCGTACATATAATCGCATATGATCC
GACCCCGTGCCATGGACGTG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 505; Mature: 504

Protein sequence:

>505_residues
MTCLECFMSEPVTIAFAKHGAAPSGVLLVLVDDALNFGREAQKLLKPALGQIKRAFEADRFKGKLGGALELIAPEGLDVA
RLIVLGTGKAGELKPTDFLRLGGIAAGKIPGGSTAATLLADLPGAKFAPEAAAEIALGARLRSYVFDRYKTRKKEGDTDP
VTLTLTLLVPDAAAAVRAWTPREAVGDGVLLARDLVNEPANVLDPPEFARRATELSAVGVDVEVLDDAALSRIGMRALLG
VGQGSIKESRVVVMRWNGGKPGEAPVAFIGKGVTFDTGGISIKPAAGMEDMKGDMGGAACVTGLMHALAARKAKVNAVGV
IGIVENMPDGAAQRPGDIVTSLSGQTIEIINTDAEGRLVLADVLWYTKDRFKPKFMVDLATLTGAIMVALGTENAGLFSN
DDTLSTQLAAAGAATGEKVWRMPLSPEYDKLIDSKFADMKNTGGRNGGSITAAQFLQRFVDKTPWAHLDIAGTAMASPAS
DINKSWGAGWGVRLLDQLVRDNYEK

Sequences:

>Translated_505_residues
MTCLECFMSEPVTIAFAKHGAAPSGVLLVLVDDALNFGREAQKLLKPALGQIKRAFEADRFKGKLGGALELIAPEGLDVA
RLIVLGTGKAGELKPTDFLRLGGIAAGKIPGGSTAATLLADLPGAKFAPEAAAEIALGARLRSYVFDRYKTRKKEGDTDP
VTLTLTLLVPDAAAAVRAWTPREAVGDGVLLARDLVNEPANVLDPPEFARRATELSAVGVDVEVLDDAALSRIGMRALLG
VGQGSIKESRVVVMRWNGGKPGEAPVAFIGKGVTFDTGGISIKPAAGMEDMKGDMGGAACVTGLMHALAARKAKVNAVGV
IGIVENMPDGAAQRPGDIVTSLSGQTIEIINTDAEGRLVLADVLWYTKDRFKPKFMVDLATLTGAIMVALGTENAGLFSN
DDTLSTQLAAAGAATGEKVWRMPLSPEYDKLIDSKFADMKNTGGRNGGSITAAQFLQRFVDKTPWAHLDIAGTAMASPAS
DINKSWGAGWGVRLLDQLVRDNYEK
>Mature_504_residues
TCLECFMSEPVTIAFAKHGAAPSGVLLVLVDDALNFGREAQKLLKPALGQIKRAFEADRFKGKLGGALELIAPEGLDVAR
LIVLGTGKAGELKPTDFLRLGGIAAGKIPGGSTAATLLADLPGAKFAPEAAAEIALGARLRSYVFDRYKTRKKEGDTDPV
TLTLTLLVPDAAAAVRAWTPREAVGDGVLLARDLVNEPANVLDPPEFARRATELSAVGVDVEVLDDAALSRIGMRALLGV
GQGSIKESRVVVMRWNGGKPGEAPVAFIGKGVTFDTGGISIKPAAGMEDMKGDMGGAACVTGLMHALAARKAKVNAVGVI
GIVENMPDGAAQRPGDIVTSLSGQTIEIINTDAEGRLVLADVLWYTKDRFKPKFMVDLATLTGAIMVALGTENAGLFSND
DTLSTQLAAAGAATGEKVWRMPLSPEYDKLIDSKFADMKNTGGRNGGSITAAQFLQRFVDKTPWAHLDIAGTAMASPASD
INKSWGAGWGVRLLDQLVRDNYEK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=349, Percent_Identity=38.9684813753582, Blast_Score=226, Evalue=6e-59,
Organism=Homo sapiens, GI47155554, Length=316, Percent_Identity=33.5443037974684, Blast_Score=137, Evalue=2e-32,
Organism=Escherichia coli, GI1790710, Length=454, Percent_Identity=39.647577092511, Blast_Score=285, Evalue=5e-78,
Organism=Escherichia coli, GI87082123, Length=320, Percent_Identity=39.0625, Blast_Score=187, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17556903, Length=314, Percent_Identity=35.3503184713376, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17565172, Length=405, Percent_Identity=29.6296296296296, Blast_Score=95, Evalue=9e-20,
Organism=Drosophila melanogaster, GI20129969, Length=447, Percent_Identity=30.4250559284116, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24662227, Length=287, Percent_Identity=34.4947735191638, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24661038, Length=361, Percent_Identity=33.7950138504155, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI21355725, Length=282, Percent_Identity=37.2340425531915, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI161077148, Length=351, Percent_Identity=33.3333333333333, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI20130057, Length=351, Percent_Identity=33.3333333333333, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI19922386, Length=349, Percent_Identity=34.0974212034384, Blast_Score=181, Evalue=9e-46,
Organism=Drosophila melanogaster, GI21355645, Length=304, Percent_Identity=32.2368421052632, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24662223, Length=304, Percent_Identity=32.2368421052632, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI20129963, Length=349, Percent_Identity=34.0974212034384, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI21357381, Length=308, Percent_Identity=33.4415584415584, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI221379063, Length=308, Percent_Identity=33.4415584415584, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI221379062, Length=308, Percent_Identity=33.4415584415584, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24646701, Length=395, Percent_Identity=26.3291139240506, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24646703, Length=395, Percent_Identity=26.3291139240506, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21358201, Length=395, Percent_Identity=26.3291139240506, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 53021; Mature: 52889

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTCLECFMSEPVTIAFAKHGAAPSGVLLVLVDDALNFGREAQKLLKPALGQIKRAFEADR
CCHHHHHHCCCEEEEEECCCCCCCCEEEEEECCHHCCCHHHHHHHHHHHHHHHHHHHHHH
FKGKLGGALELIAPEGLDVARLIVLGTGKAGELKPTDFLRLGGIAAGKIPGGSTAATLLA
HCCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCHHHHCCCEEECCCCCCCHHHHHHH
DLPGAKFAPEAAAEIALGARLRSYVFDRYKTRKKEGDTDPVTLTLTLLVPDAAAAVRAWT
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCHHHHHHCCC
PREAVGDGVLLARDLVNEPANVLDPPEFARRATELSAVGVDVEVLDDAALSRIGMRALLG
CHHHHCCCCEEHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
VGQGSIKESRVVVMRWNGGKPGEAPVAFIGKGVTFDTGGISIKPAAGMEDMKGDMGGAAC
CCCCCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHCCCCCHHHH
VTGLMHALAARKAKVNAVGVIGIVENMPDGAAQRPGDIVTSLSGQTIEIINTDAEGRLVL
HHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHCCCCCEEEEEECCCCCCEEE
ADVLWYTKDRFKPKFMVDLATLTGAIMVALGTENAGLFSNDDTLSTQLAAAGAATGEKVW
EHHHHHHHHCCCCHHEEHHHHHHCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCEE
RMPLSPEYDKLIDSKFADMKNTGGRNGGSITAAQFLQRFVDKTPWAHLDIAGTAMASPAS
ECCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCHH
DINKSWGAGWGVRLLDQLVRDNYEK
HHHHHCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TCLECFMSEPVTIAFAKHGAAPSGVLLVLVDDALNFGREAQKLLKPALGQIKRAFEADR
CHHHHHHCCCEEEEEECCCCCCCCEEEEEECCHHCCCHHHHHHHHHHHHHHHHHHHHHH
FKGKLGGALELIAPEGLDVARLIVLGTGKAGELKPTDFLRLGGIAAGKIPGGSTAATLLA
HCCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCHHHHCCCEEECCCCCCCHHHHHHH
DLPGAKFAPEAAAEIALGARLRSYVFDRYKTRKKEGDTDPVTLTLTLLVPDAAAAVRAWT
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCHHHHHHCCC
PREAVGDGVLLARDLVNEPANVLDPPEFARRATELSAVGVDVEVLDDAALSRIGMRALLG
CHHHHCCCCEEHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
VGQGSIKESRVVVMRWNGGKPGEAPVAFIGKGVTFDTGGISIKPAAGMEDMKGDMGGAAC
CCCCCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHCCCCCHHHH
VTGLMHALAARKAKVNAVGVIGIVENMPDGAAQRPGDIVTSLSGQTIEIINTDAEGRLVL
HHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHCCCCCEEEEEECCCCCCEEE
ADVLWYTKDRFKPKFMVDLATLTGAIMVALGTENAGLFSNDDTLSTQLAAAGAATGEKVW
EHHHHHHHHCCCCHHEEHHHHHHCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCEE
RMPLSPEYDKLIDSKFADMKNTGGRNGGSITAAQFLQRFVDKTPWAHLDIAGTAMASPAS
ECCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCHH
DINKSWGAGWGVRLLDQLVRDNYEK
HHHHHCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA