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The map label for this gene is gyaR [H]

Identifier: 158422156

GI number: 158422156

Start: 589426

End: 590484

Strand: Reverse

Name: gyaR [H]

Synonym: AZC_0532

Alternate gene names: 158422156

Gene position: 590484-589426 (Counterclockwise)

Preceding gene: 158422165

Following gene: 158422141

Centisome position: 11.0

GC content: 68.65

Gene sequence:

>1059_bases
ATGGCGGCCATGAGCAAAGGGCCATTCTCATTTGTGCACCAACGCTATAGCTTGCCATCCTTCCCCTCTCCCTTCCTGAA
GGACTGCGCCATGGCGCCGGGTTCCGTCGAGCTGCTCGTTCTCATTCCGTTTCCGCCCCATGAACTGGCGCGGCTCGAGG
CCGTCTTCAAGGTGACCTATGCGCCGACGCCCGAGCAGCGCGCGGCGGCCATCGCCGCCAAGGGGCCGGACTTCCGCGCC
GTCCTGACCCACGGCACCGCCGGCATGACCGCCGCCGAGATGGACGCCATGCCCAAGCTCGAGATGATCTCCTGCTTTGG
CGTCGGCTATGACCGCATCGACGTGCAGGCGGCCATCGCCCGCCGCATCATCGTGACCCATGGTCCCGGCACCAACACCA
TTTCGGTCGCCGATCACACGCTGGCGCTGATGCTCGCCGCCATCCGTCGTATCGCCTCGCAGGACCACGCCGTGCGGCAG
GGCCAGTGGCACGAGGCCCGTCATTCGACGCCCGAACTCACCGGCATGCGCCTCGGCCTCATCGGCTACGGCTCCATCGC
GCGGGAAGTCGCCCGCCGCTGCGAGGCCGGATTCTCCATGACGGTCGGCTACCACAGCCGCCGCAAGGCCACCGACACGG
CCCACACCTATTATGAGACGCCCCTCGCCTTGGCCGAGGCATCCGACGTGCTGGTGGTGGCGGCGCCCGCCAATCCCCAG
ACGCGGCACATGGTCAACGAGGCGGTGCTCACCGCGCTCGGCCCCAATGGCTACCTCATCAACATCGCCCGCGGCTCGCT
GGTGGACACCGACGCGCTGATCGCCGCCCTCAATGCGGGCCGCATCGCCGGCGCGGGTCTCGACGTGGTGGATGGCGAGC
CGGTGGTTCCCGCCGCCTTGCTGCAGGCGCCCAACCTCGTCATCACGCCCCACAGCGCGGGCCGCTCGCCCAATGCCGAG
GACAACATGACCACCTTGGCGCTGCGCAACCTCAATGCGCATTTCGCCGGCCGGCCGGTCGAAACCCCGGTTCCGGAGTG
CGCCAAGGCGGCCGCCTGA

Upstream 100 bases:

>100_bases
GGATCGGCCTCTGACCTAAAGAAAGAGCACGCGCCCGTGAGCCGGCGGCAGTTCCCCGTGCGCCACATAGCATTCCCCAT
GCGCTGGGTGTAATGCCCGC

Downstream 100 bases:

>100_bases
GCGCCGAACCTTTCGAAAAGGACTCCGCCCGGCGCCGCCGGGCGGGTCAACCGGCCTTGCGGAAGGCCATCGGCGCGCCG
GCGCTCAGCAGCAGCTCGAT

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MAAMSKGPFSFVHQRYSLPSFPSPFLKDCAMAPGSVELLVLIPFPPHELARLEAVFKVTYAPTPEQRAAAIAAKGPDFRA
VLTHGTAGMTAAEMDAMPKLEMISCFGVGYDRIDVQAAIARRIIVTHGPGTNTISVADHTLALMLAAIRRIASQDHAVRQ
GQWHEARHSTPELTGMRLGLIGYGSIAREVARRCEAGFSMTVGYHSRRKATDTAHTYYETPLALAEASDVLVVAAPANPQ
TRHMVNEAVLTALGPNGYLINIARGSLVDTDALIAALNAGRIAGAGLDVVDGEPVVPAALLQAPNLVITPHSAGRSPNAE
DNMTTLALRNLNAHFAGRPVETPVPECAKAAA

Sequences:

>Translated_352_residues
MAAMSKGPFSFVHQRYSLPSFPSPFLKDCAMAPGSVELLVLIPFPPHELARLEAVFKVTYAPTPEQRAAAIAAKGPDFRA
VLTHGTAGMTAAEMDAMPKLEMISCFGVGYDRIDVQAAIARRIIVTHGPGTNTISVADHTLALMLAAIRRIASQDHAVRQ
GQWHEARHSTPELTGMRLGLIGYGSIAREVARRCEAGFSMTVGYHSRRKATDTAHTYYETPLALAEASDVLVVAAPANPQ
TRHMVNEAVLTALGPNGYLINIARGSLVDTDALIAALNAGRIAGAGLDVVDGEPVVPAALLQAPNLVITPHSAGRSPNAE
DNMTTLALRNLNAHFAGRPVETPVPECAKAAA
>Mature_351_residues
AAMSKGPFSFVHQRYSLPSFPSPFLKDCAMAPGSVELLVLIPFPPHELARLEAVFKVTYAPTPEQRAAAIAAKGPDFRAV
LTHGTAGMTAAEMDAMPKLEMISCFGVGYDRIDVQAAIARRIIVTHGPGTNTISVADHTLALMLAAIRRIASQDHAVRQG
QWHEARHSTPELTGMRLGLIGYGSIAREVARRCEAGFSMTVGYHSRRKATDTAHTYYETPLALAEASDVLVVAAPANPQT
RHMVNEAVLTALGPNGYLINIARGSLVDTDALIAALNAGRIAGAGLDVVDGEPVVPAALLQAPNLVITPHSAGRSPNAED
NMTTLALRNLNAHFAGRPVETPVPECAKAAA

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=247, Percent_Identity=29.5546558704453, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI61743967, Length=269, Percent_Identity=31.5985130111524, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4557497, Length=269, Percent_Identity=31.5985130111524, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI145580578, Length=278, Percent_Identity=30.5755395683453, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI4557499, Length=278, Percent_Identity=30.5755395683453, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI145580575, Length=276, Percent_Identity=31.1594202898551, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI6912396, Length=250, Percent_Identity=31.6, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI87082289, Length=308, Percent_Identity=32.1428571428571, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1789279, Length=240, Percent_Identity=30.4166666666667, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI87081824, Length=189, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787645, Length=246, Percent_Identity=26.4227642276423, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=249, Percent_Identity=30.5220883534137, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI25147481, Length=273, Percent_Identity=26.3736263736264, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320925, Length=275, Percent_Identity=28.7272727272727, Blast_Score=112, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6322116, Length=265, Percent_Identity=28.3018867924528, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324055, Length=250, Percent_Identity=30, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321253, Length=310, Percent_Identity=26.1290322580645, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6325144, Length=168, Percent_Identity=24.4047619047619, Blast_Score=73, Evalue=8e-14,
Organism=Drosophila melanogaster, GI28574284, Length=351, Percent_Identity=31.0541310541311, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI45552429, Length=329, Percent_Identity=31.0030395136778, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24585514, Length=329, Percent_Identity=31.0030395136778, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI28574282, Length=329, Percent_Identity=31.0030395136778, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI45551003, Length=324, Percent_Identity=31.1728395061728, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24585516, Length=312, Percent_Identity=30.1282051282051, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646446, Length=249, Percent_Identity=35.3413654618474, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646448, Length=249, Percent_Identity=35.3413654618474, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646452, Length=249, Percent_Identity=35.3413654618474, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646450, Length=249, Percent_Identity=35.3413654618474, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI62472511, Length=249, Percent_Identity=35.3413654618474, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI28574286, Length=278, Percent_Identity=31.294964028777, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI19921140, Length=277, Percent_Identity=29.6028880866426, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28571528, Length=252, Percent_Identity=34.1269841269841, Blast_Score=112, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 37287; Mature: 37156

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAMSKGPFSFVHQRYSLPSFPSPFLKDCAMAPGSVELLVLIPFPPHELARLEAVFKVTY
CCCCCCCCHHHHHHHCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHEEEEE
APTPEQRAAAIAAKGPDFRAVLTHGTAGMTAAEMDAMPKLEMISCFGVGYDRIDVQAAIA
CCCCHHHHEEEEECCCCCEEEEECCCCCCCHHHHHCCCCHHHHHHHCCCCCHHHHHHHHH
RRIIVTHGPGTNTISVADHTLALMLAAIRRIASQDHAVRQGQWHEARHSTPELTGMRLGL
CEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHCCCCCCCCEEEEE
IGYGSIAREVARRCEAGFSMTVGYHSRRKATDTAHTYYETPLALAEASDVLVVAAPANPQ
EECHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHCCCCHHEECCCCEEEEEECCCCH
TRHMVNEAVLTALGPNGYLINIARGSLVDTDALIAALNAGRIAGAGLDVVDGEPVVPAAL
HHHHHHHHHHEEECCCCEEEEECCCCCCCHHHHHHHHCCCCEECCCCEECCCCCCCCHHH
LQAPNLVITPHSAGRSPNAEDNMTTLALRNLNAHFAGRPVETPVPECAKAAA
HCCCCEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHCCC
>Mature Secondary Structure 
AAMSKGPFSFVHQRYSLPSFPSPFLKDCAMAPGSVELLVLIPFPPHELARLEAVFKVTY
CCCCCCCHHHHHHHCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHEEEEE
APTPEQRAAAIAAKGPDFRAVLTHGTAGMTAAEMDAMPKLEMISCFGVGYDRIDVQAAIA
CCCCHHHHEEEEECCCCCEEEEECCCCCCCHHHHHCCCCHHHHHHHCCCCCHHHHHHHHH
RRIIVTHGPGTNTISVADHTLALMLAAIRRIASQDHAVRQGQWHEARHSTPELTGMRLGL
CEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHCCCCCCCCEEEEE
IGYGSIAREVARRCEAGFSMTVGYHSRRKATDTAHTYYETPLALAEASDVLVVAAPANPQ
EECHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHCCCCHHEECCCCEEEEEECCCCH
TRHMVNEAVLTALGPNGYLINIARGSLVDTDALIAALNAGRIAGAGLDVVDGEPVVPAAL
HHHHHHHHHHEEECCCCEEEEECCCCCCCHHHHHHHHCCCCEECCCCEECCCCCCCCHHH
LQAPNLVITPHSAGRSPNAEDNMTTLALRNLNAHFAGRPVETPVPECAKAAA
HCCCCEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA