Click here to switch to the map view.

The map label for this gene is oxc [H]

Identifier: 158422092

GI number: 158422092

Start: 523826

End: 525565

Strand: Direct

Name: oxc [H]

Synonym: AZC_0468

Alternate gene names: 158422092

Gene position: 523826-525565 (Clockwise)

Preceding gene: 158422091

Following gene: 158422093

Centisome position: 9.76

GC content: 67.01

Gene sequence:

>1740_bases
ATGTCCGCAGTTGCACAGAGGGTCGAAACCGAAGCCGATGCCCAGCAGGAGCTGACCGACGGCTTCCATCTTGTCATCGA
TGCGCTGAAACTCAACGGCATCGAGACCATCTACGGCGTGCCGGGCATCCCGATCACGGATCTCGGGCGCATGGCGCAGG
CCGAAGGCATCCGCGTCGTCTCCTTCCGCCACGAGCAGAATGCGGGCAACGCCGCCGCCATCGCCGGCTTCCTCACCAAG
AAGCCGGGCGTCTGCCTCACGGTGTCCGCGCCGGGCTTCCTCAACGGCCTGACCGCGCTCGCCAACGCGACCACCAACTG
CTTCCCGATGATCCTCATCTCGGGCTCCTCCGAGCGCGAGATCGTCGACCTGCAGCAGGGCGACTATGAGGAGATGGACC
AGCTCGCCATCGCCAAGCCGCTCTGCAAGGCCGCCTTCCGCGTGCTGCATGCGGCCGACATCGGCATCGGCGTCGCCCGC
GCCATCCGCGCGGCCGTTTCCGGCCGTCCCGGTGGCGTCTATCTCGACCTGCCCGCGAAGCTCTTCTCGCAGGTGATGGA
TGCCGCCGCCGGCGAGAAATCGCTGGTGAAGGTCATCGATCCGGCCCCGGCCCAGATCCCCGGCCCGGCGGCTGTGGATC
GCGCCATCAACCTGCTGAAGGGTGCCAAGCGCCCGCTCATCATCCTCGGCAAGGGCGCCGCTTATGCCCAGGCCGACGAG
GAAATCCGCGCCTTCGTCGAGAAGAGCGGCATTCCCTTCCTGCCCATGAGCATGGCCAAGGGCCTGCTGCCCGACACCCA
CCCGCAGTCCGCCGGCGCCGCGCGTTCGACCGCGCTGAAGGACTCCGACGTGGTGATCCTGCTCGGCGCCCGGCTGAACT
GGCTGCTTTCGCACGGCAAGGGCAAGACCTGGGGCGAGCCCGGTTCCAAGCAGTTCATCCAGGTGGACATCGAGCCGAAG
GAGATGGACTCCAACGTCGAGATCGCCGCCCCGCTCGTGGGTGACATCGGCTCGGTGGTCTCCGCCCTGCTCGACCGGAT
CGACGGCTCCTGGCAGGCGCCGCCCGCGGACTGGATCGAGTCGATCCGCTCCAAGAAGGAAGCCAACATCGCCAAGATGG
CGCCGAAGCTTCTCAAGAACTCCTCCCCGATGGACTTCCACGGCGCGCTCGGCTCGCTGAAGAAGGTCATCGCCGAGCGT
CCCGACGCGATCCTCGTCAACGAGGGCGCCAACACCCTCGACCTCGCCCGCGGCATCATCGACATGTACCAGCCGCGCAA
GCGCCTGGACGTGGGCACCTGGGGCGTGATGGGCATCGGCATGGGCTTCGCCATCGCGGCGGCCGTCGAGACCGGAAAGC
CGGTGCTGGCGGTGGAAGGCGACAGCGCCTTCGGCTTCTCCGGCATGGAGGTAGAGACCATCTGCCGCTACGACCTGCCG
GTCACCATCGTCATCTTCAACAACAACGGCATCTACCGCGGCACGGACACCGATCCGACCGGCCGCGATCCGGGCACCAC
GGTGTTCGTGAAGGACAGCCGCTACGACAAGATGATGGAAGCCTTCGGCGGCGTGGGCGTGAACGTCACCACCCCCGACG
AGCTCTATCGCGCGGTCAGCGCCGCCATGGACAGTGGCAAGCCGACGCTCATCAACGCCGTCATCGATCCGGCGGCGGGC
AGCGAGAGCGGCAACATCGGCAGCCTCAACCCGCAGAGCGTGGTGGTGCGCAAGAAGTGA

Upstream 100 bases:

>100_bases
AGAGGCCGTTGCGGCCTTTGACGGTCCGCCGGTCCGCCGGCGCCCGACGCTTTGAGATCGCTTTTAGCCGGTATCCGAAG
AACATCCGGGAGGACGCGGA

Downstream 100 bases:

>100_bases
GCGCACACTCGGTCTGAAACGACTTCAAGTCACCCCGGGCGGGACCTTCGGGCCCCGCCTTCCTCTCCCCCGCGTTGACC
AACGAACACCCAAGCGTTGC

Product: oxalyl-CoA decarboxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 579; Mature: 578

Protein sequence:

>579_residues
MSAVAQRVETEADAQQELTDGFHLVIDALKLNGIETIYGVPGIPITDLGRMAQAEGIRVVSFRHEQNAGNAAAIAGFLTK
KPGVCLTVSAPGFLNGLTALANATTNCFPMILISGSSEREIVDLQQGDYEEMDQLAIAKPLCKAAFRVLHAADIGIGVAR
AIRAAVSGRPGGVYLDLPAKLFSQVMDAAAGEKSLVKVIDPAPAQIPGPAAVDRAINLLKGAKRPLIILGKGAAYAQADE
EIRAFVEKSGIPFLPMSMAKGLLPDTHPQSAGAARSTALKDSDVVILLGARLNWLLSHGKGKTWGEPGSKQFIQVDIEPK
EMDSNVEIAAPLVGDIGSVVSALLDRIDGSWQAPPADWIESIRSKKEANIAKMAPKLLKNSSPMDFHGALGSLKKVIAER
PDAILVNEGANTLDLARGIIDMYQPRKRLDVGTWGVMGIGMGFAIAAAVETGKPVLAVEGDSAFGFSGMEVETICRYDLP
VTIVIFNNNGIYRGTDTDPTGRDPGTTVFVKDSRYDKMMEAFGGVGVNVTTPDELYRAVSAAMDSGKPTLINAVIDPAAG
SESGNIGSLNPQSVVVRKK

Sequences:

>Translated_579_residues
MSAVAQRVETEADAQQELTDGFHLVIDALKLNGIETIYGVPGIPITDLGRMAQAEGIRVVSFRHEQNAGNAAAIAGFLTK
KPGVCLTVSAPGFLNGLTALANATTNCFPMILISGSSEREIVDLQQGDYEEMDQLAIAKPLCKAAFRVLHAADIGIGVAR
AIRAAVSGRPGGVYLDLPAKLFSQVMDAAAGEKSLVKVIDPAPAQIPGPAAVDRAINLLKGAKRPLIILGKGAAYAQADE
EIRAFVEKSGIPFLPMSMAKGLLPDTHPQSAGAARSTALKDSDVVILLGARLNWLLSHGKGKTWGEPGSKQFIQVDIEPK
EMDSNVEIAAPLVGDIGSVVSALLDRIDGSWQAPPADWIESIRSKKEANIAKMAPKLLKNSSPMDFHGALGSLKKVIAER
PDAILVNEGANTLDLARGIIDMYQPRKRLDVGTWGVMGIGMGFAIAAAVETGKPVLAVEGDSAFGFSGMEVETICRYDLP
VTIVIFNNNGIYRGTDTDPTGRDPGTTVFVKDSRYDKMMEAFGGVGVNVTTPDELYRAVSAAMDSGKPTLINAVIDPAAG
SESGNIGSLNPQSVVVRKK
>Mature_578_residues
SAVAQRVETEADAQQELTDGFHLVIDALKLNGIETIYGVPGIPITDLGRMAQAEGIRVVSFRHEQNAGNAAAIAGFLTKK
PGVCLTVSAPGFLNGLTALANATTNCFPMILISGSSEREIVDLQQGDYEEMDQLAIAKPLCKAAFRVLHAADIGIGVARA
IRAAVSGRPGGVYLDLPAKLFSQVMDAAAGEKSLVKVIDPAPAQIPGPAAVDRAINLLKGAKRPLIILGKGAAYAQADEE
IRAFVEKSGIPFLPMSMAKGLLPDTHPQSAGAARSTALKDSDVVILLGARLNWLLSHGKGKTWGEPGSKQFIQVDIEPKE
MDSNVEIAAPLVGDIGSVVSALLDRIDGSWQAPPADWIESIRSKKEANIAKMAPKLLKNSSPMDFHGALGSLKKVIAERP
DAILVNEGANTLDLARGIIDMYQPRKRLDVGTWGVMGIGMGFAIAAAVETGKPVLAVEGDSAFGFSGMEVETICRYDLPV
TIVIFNNNGIYRGTDTDPTGRDPGTTVFVKDSRYDKMMEAFGGVGVNVTTPDELYRAVSAAMDSGKPTLINAVIDPAAGS
ESGNIGSLNPQSVVVRKK

Specific function: Oxalic acid catabolism; second step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=576, Percent_Identity=40.9722222222222, Blast_Score=440, Evalue=1e-123,
Organism=Homo sapiens, GI21361361, Length=571, Percent_Identity=29.7723292469352, Blast_Score=192, Evalue=1e-48,
Organism=Escherichia coli, GI1788716, Length=561, Percent_Identity=61.8538324420677, Blast_Score=680, Evalue=0.0,
Organism=Escherichia coli, GI87081685, Length=562, Percent_Identity=25.2669039145907, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1790104, Length=484, Percent_Identity=28.099173553719, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1786717, Length=485, Percent_Identity=25.5670103092783, Blast_Score=129, Evalue=7e-31,
Organism=Escherichia coli, GI1787096, Length=548, Percent_Identity=23.5401459854015, Blast_Score=76, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17531301, Length=554, Percent_Identity=39.7111913357401, Blast_Score=372, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17531299, Length=554, Percent_Identity=39.7111913357401, Blast_Score=372, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17542570, Length=593, Percent_Identity=29.0050590219224, Blast_Score=183, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6320816, Length=545, Percent_Identity=35.5963302752294, Blast_Score=300, Evalue=4e-82,
Organism=Saccharomyces cerevisiae, GI6323755, Length=591, Percent_Identity=22.673434856176, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6321524, Length=503, Percent_Identity=21.0735586481113, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI19922626, Length=564, Percent_Identity=40.7801418439716, Blast_Score=406, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017660
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.8 [H]

Molecular weight: Translated: 61058; Mature: 60927

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVAQRVETEADAQQELTDGFHLVIDALKLNGIETIYGVPGIPITDLGRMAQAEGIRVV
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHCCEEEE
SFRHEQNAGNAAAIAGFLTKKPGVCLTVSAPGFLNGLTALANATTNCFPMILISGSSERE
EEECCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCCE
IVDLQQGDYEEMDQLAIAKPLCKAAFRVLHAADIGIGVARAIRAAVSGRPGGVYLDLPAK
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHH
LFSQVMDAAAGEKSLVKVIDPAPAQIPGPAAVDRAINLLKGAKRPLIILGKGAAYAQADE
HHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHH
EIRAFVEKSGIPFLPMSMAKGLLPDTHPQSAGAARSTALKDSDVVILLGARLNWLLSHGK
HHHHHHHHCCCCEECHHHHCCCCCCCCCCCCCCHHHHCCCCCCEEEEECCCHHHHHCCCC
GKTWGEPGSKQFIQVDIEPKEMDSNVEIAAPLVGDIGSVVSALLDRIDGSWQAPPADWIE
CCCCCCCCCCCEEEEECCHHHCCCCCEEECHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
SIRSKKEANIAKMAPKLLKNSSPMDFHGALGSLKKVIAERPDAILVNEGANTLDLARGII
HHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHH
DMYQPRKRLDVGTWGVMGIGMGFAIAAAVETGKPVLAVEGDSAFGFSGMEVETICRYDLP
HHHCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEHHEEECCCC
VTIVIFNNNGIYRGTDTDPTGRDPGTTVFVKDSRYDKMMEAFGGVGVNVTTPDELYRAVS
EEEEEECCCCEEECCCCCCCCCCCCCEEEEECCHHHHHHHHHCCCCEEECCHHHHHHHHH
AAMDSGKPTLINAVIDPAAGSESGNIGSLNPQSVVVRKK
HHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEECC
>Mature Secondary Structure 
SAVAQRVETEADAQQELTDGFHLVIDALKLNGIETIYGVPGIPITDLGRMAQAEGIRVV
CHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHCCEEEE
SFRHEQNAGNAAAIAGFLTKKPGVCLTVSAPGFLNGLTALANATTNCFPMILISGSSERE
EEECCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCCE
IVDLQQGDYEEMDQLAIAKPLCKAAFRVLHAADIGIGVARAIRAAVSGRPGGVYLDLPAK
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHH
LFSQVMDAAAGEKSLVKVIDPAPAQIPGPAAVDRAINLLKGAKRPLIILGKGAAYAQADE
HHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHH
EIRAFVEKSGIPFLPMSMAKGLLPDTHPQSAGAARSTALKDSDVVILLGARLNWLLSHGK
HHHHHHHHCCCCEECHHHHCCCCCCCCCCCCCCHHHHCCCCCCEEEEECCCHHHHHCCCC
GKTWGEPGSKQFIQVDIEPKEMDSNVEIAAPLVGDIGSVVSALLDRIDGSWQAPPADWIE
CCCCCCCCCCCEEEEECCHHHCCCCCEEECHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
SIRSKKEANIAKMAPKLLKNSSPMDFHGALGSLKKVIAERPDAILVNEGANTLDLARGII
HHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHH
DMYQPRKRLDVGTWGVMGIGMGFAIAAAVETGKPVLAVEGDSAFGFSGMEVETICRYDLP
HHHCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEHHEEECCCC
VTIVIFNNNGIYRGTDTDPTGRDPGTTVFVKDSRYDKMMEAFGGVGVNVTTPDELYRAVS
EEEEEECCCCEEECCCCCCCCCCCCCEEEEECCHHHHHHHHHCCCCEEECCHHHHHHHHH
AAMDSGKPTLINAVIDPAAGSESGNIGSLNPQSVVVRKK
HHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8157618 [H]