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The map label for this gene is matE [H]

Identifier: 158422010

GI number: 158422010

Start: 440035

End: 441369

Strand: Direct

Name: matE [H]

Synonym: AZC_0386

Alternate gene names: 158422010

Gene position: 440035-441369 (Clockwise)

Preceding gene: 158422009

Following gene: 158422012

Centisome position: 8.19

GC content: 71.39

Gene sequence:

>1335_bases
ATGAGCGGGTCCGCCTCCCTTCCGGCCGGGCCGGTCACCCATCGCAGCGTGCTGGCCATCGCCGCGCCCATGACGCTCGC
CCATCTCACGACGCCTCTGCTTGGGCTCGTCGCCACCACGGTGGTGGGGCGGCTCGGGGATGCGGCGGCGCTGGGCGGCG
TCGCGCTCGGTGCGGTGGTGTTCGATTTCCTGTTCTGGGGCTTCGGCTTCCTGCGCATGGGCACGGTGGGCCTCGCCGCG
CAGGCGCTGGGGCGCGGCGATAGCTTGGAACAGCGGGCGGTGCTCGCCCGCGCCCTGCTGCTCGCCTTTGCCTGCGGCGG
GGCCATGGTGCTCTTGCAATGGCCCATCGGGCGCCTCGCCCGCCATCTCGCCGGTGCCAGCCCCGCAGCGGATGCGGCGC
TTGCCACCTATTACGGCGTGCGCATCTGGGCGGCGCCGGTCAGCCTTGCCAATTACGCCTTGCTCGGCTGGTTCACCGGG
CTCGGGCGCACGGGACACGCGCTGGCGCTCCAGGCCGGCATCAACGGCATCAATATCGCGCTCTGCGTGTTGTTCGTCCT
CGGACTCGATCGCGGTGTCGAAGGGGCGGCTGAAGCGGCGCTCTGGGCCGAGGCGGCGGGCACGCTCGCCGGCCTGCTGC
TCTGCGCCCGCCTGCTCGGCTTCCGGCTGGAGGTGCCCCGCGCCGTGGTGACGGACCGCGCCCGGCTGATGGAGATGTTC
GCGCTCAATCGCGACATCATGATCCGCACGGCCGCGCTCCTCGCCGCCTTCGCCTTCTTCGCCGCGCAGGGCGCGCGGGC
GGGCGACGTGACGCTCGCAGCCAATGCGCTCCTCAACACCATGGTGCTGCTGTCGGTCTATTTCCTCGACGGATTTGCCA
CCGCCGCGGAGCAGCTCTGCGGCGCCGCCTCGGGGGCGCGGGACCGCACCGCCTTCTCGACCGCGCTGCGGCTGGTGCTC
GGCTGGGGTTATGGCTTTGCCGTGCCGGCGGTCGCCTTCTTCCTGCTGGCGGGCCCCACCATCCTCGGGCTCATGAGCAC
CAATGGGGAGGTGGTGGCCGAGGCGGTGCGCTATCTGCCCTTTGCCGCTCTGCTGCCGCTCTTCGGCGTCGCGGCCTATG
CCTATGACGGCGTCTATGTGGGCGCGCTCTGGTCGCGCGACATGCGCAACCTGATGCTGGCGGCGCTGGCTTTCTATCTC
GCCACGTGGTGGGCGCTCAGGCCCTTCGGCAATGCCGGGCTCTGGAGCGCACTGCTCCTTTTCCTCGCGGCGCGGGGCGT
GCTTCAGGCATGGCGCCTGCCGGCGCTGGTGCGGCGGACCTTTGCCGAAGGCTGA

Upstream 100 bases:

>100_bases
ATCTGGCGCTATTTCCTGCTCGGGGCGGTGGTGGTCATCCCGCTGTGGCTGATCTCCCGACTTTTCCGGAGCGGGCGGTG
AACGGTCGCCTGTCCCGGTC

Downstream 100 bases:

>100_bases
CCGCCTTCAGAGCTGCGGGAAGATGTGCGAGCCGTCGGCCCCCATGGGCAGGGGCTTCACCCACAGGGCGGAAGTCACCG
GCAGCGGTGCATAAAGGTGG

Product: multi anti extrusion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MSGSASLPAGPVTHRSVLAIAAPMTLAHLTTPLLGLVATTVVGRLGDAAALGGVALGAVVFDFLFWGFGFLRMGTVGLAA
QALGRGDSLEQRAVLARALLLAFACGGAMVLLQWPIGRLARHLAGASPAADAALATYYGVRIWAAPVSLANYALLGWFTG
LGRTGHALALQAGINGINIALCVLFVLGLDRGVEGAAEAALWAEAAGTLAGLLLCARLLGFRLEVPRAVVTDRARLMEMF
ALNRDIMIRTAALLAAFAFFAAQGARAGDVTLAANALLNTMVLLSVYFLDGFATAAEQLCGAASGARDRTAFSTALRLVL
GWGYGFAVPAVAFFLLAGPTILGLMSTNGEVVAEAVRYLPFAALLPLFGVAAYAYDGVYVGALWSRDMRNLMLAALAFYL
ATWWALRPFGNAGLWSALLLFLAARGVLQAWRLPALVRRTFAEG

Sequences:

>Translated_444_residues
MSGSASLPAGPVTHRSVLAIAAPMTLAHLTTPLLGLVATTVVGRLGDAAALGGVALGAVVFDFLFWGFGFLRMGTVGLAA
QALGRGDSLEQRAVLARALLLAFACGGAMVLLQWPIGRLARHLAGASPAADAALATYYGVRIWAAPVSLANYALLGWFTG
LGRTGHALALQAGINGINIALCVLFVLGLDRGVEGAAEAALWAEAAGTLAGLLLCARLLGFRLEVPRAVVTDRARLMEMF
ALNRDIMIRTAALLAAFAFFAAQGARAGDVTLAANALLNTMVLLSVYFLDGFATAAEQLCGAASGARDRTAFSTALRLVL
GWGYGFAVPAVAFFLLAGPTILGLMSTNGEVVAEAVRYLPFAALLPLFGVAAYAYDGVYVGALWSRDMRNLMLAALAFYL
ATWWALRPFGNAGLWSALLLFLAARGVLQAWRLPALVRRTFAEG
>Mature_443_residues
SGSASLPAGPVTHRSVLAIAAPMTLAHLTTPLLGLVATTVVGRLGDAAALGGVALGAVVFDFLFWGFGFLRMGTVGLAAQ
ALGRGDSLEQRAVLARALLLAFACGGAMVLLQWPIGRLARHLAGASPAADAALATYYGVRIWAAPVSLANYALLGWFTGL
GRTGHALALQAGINGINIALCVLFVLGLDRGVEGAAEAALWAEAAGTLAGLLLCARLLGFRLEVPRAVVTDRARLMEMFA
LNRDIMIRTAALLAAFAFFAAQGARAGDVTLAANALLNTMVLLSVYFLDGFATAAEQLCGAASGARDRTAFSTALRLVLG
WGYGFAVPAVAFFLLAGPTILGLMSTNGEVVAEAVRYLPFAALLPLFGVAAYAYDGVYVGALWSRDMRNLMLAALAFYLA
TWWALRPFGNAGLWSALLLFLAARGVLQAWRLPALVRRTFAEG

Specific function: Unknown

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI1790477, Length=433, Percent_Identity=38.3371824480369, Blast_Score=184, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 46302; Mature: 46171

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGSASLPAGPVTHRSVLAIAAPMTLAHLTTPLLGLVATTVVGRLGDAAALGGVALGAVV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
FDFLFWGFGFLRMGTVGLAAQALGRGDSLEQRAVLARALLLAFACGGAMVLLQWPIGRLA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHEEEECCHHHHH
RHLAGASPAADAALATYYGVRIWAAPVSLANYALLGWFTGLGRTGHALALQAGINGINIA
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHCCCCCHHHHH
LCVLFVLGLDRGVEGAAEAALWAEAAGTLAGLLLCARLLGFRLEVPRAVVTDRARLMEMF
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
ALNRDIMIRTAALLAAFAFFAAQGARAGDVTLAANALLNTMVLLSVYFLDGFATAAEQLC
HCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAASGARDRTAFSTALRLVLGWGYGFAVPAVAFFLLAGPTILGLMSTNGEVVAEAVRYLP
CCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHEEEECCCHHHHHHHHHHHH
FAALLPLFGVAAYAYDGVYVGALWSRDMRNLMLAALAFYLATWWALRPFGNAGLWSALLL
HHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
FLAARGVLQAWRLPALVRRTFAEG
HHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SGSASLPAGPVTHRSVLAIAAPMTLAHLTTPLLGLVATTVVGRLGDAAALGGVALGAVV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
FDFLFWGFGFLRMGTVGLAAQALGRGDSLEQRAVLARALLLAFACGGAMVLLQWPIGRLA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHEEEECCHHHHH
RHLAGASPAADAALATYYGVRIWAAPVSLANYALLGWFTGLGRTGHALALQAGINGINIA
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHCCCCCHHHHH
LCVLFVLGLDRGVEGAAEAALWAEAAGTLAGLLLCARLLGFRLEVPRAVVTDRARLMEMF
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
ALNRDIMIRTAALLAAFAFFAAQGARAGDVTLAANALLNTMVLLSVYFLDGFATAAEQLC
HCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAASGARDRTAFSTALRLVLGWGYGFAVPAVAFFLLAGPTILGLMSTNGEVVAEAVRYLP
CCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHEEEECCCHHHHHHHHHHHH
FAALLPLFGVAAYAYDGVYVGALWSRDMRNLMLAALAFYLATWWALRPFGNAGLWSALLL
HHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
FLAARGVLQAWRLPALVRRTFAEG
HHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]