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The map label for this gene is norG [H]

Identifier: 158421916

GI number: 158421916

Start: 340303

End: 341730

Strand: Reverse

Name: norG [H]

Synonym: AZC_0292

Alternate gene names: 158421916

Gene position: 341730-340303 (Counterclockwise)

Preceding gene: 158421918

Following gene: 158421914

Centisome position: 6.36

GC content: 70.59

Gene sequence:

>1428_bases
TTGAGCCGAACAGTATGGACATCAGGAACCACACAGTTGGCGGAAGCCGAAACCAGCAGTGCGCCCCGCACCGAGGCGGT
GATGGTCGAGATCCGTCGGCGCATCACCGGCCGCGCCCTCACCGGCGGCGAGAAGCTGCCGTCCATCCGGCGCCTCGCCG
GCGACCTCAAGGTGTCGCCGTCCACGGTGGTGGAAGCCTATGAGCGGCTGGTGGCGGAAGGGCTGGTGCGCGCCCGTCCC
GGCTCTGGCTTCTATGTGGCGGGCAGCCTGCCGGTGGTGGCCCTGCGCGAAGTGGCCCCCAAGCTCGACCGGGCCATCGA
TCCGCTCTGGGTCTCCCGCCAGTCTCTGGATGCGGGCGCGGACATGCTGCGGCCCGGCTGCGGCTGGCTGCCGGCCGACT
GGATGCCCAATGCCGCCATCCGGCGCAGCCTGCGGGCGCTGGCGCGGGCGGAGGACGGCATCCTGTCCGATTATGGCGGC
ACGCGCGGTTCGCTGGCGCTGCGGGGTCATCTCGCGCGCCAGTTCGCGGCGGAAGGCATCGAGGCTGGCGCCGACCAGAT
CCTGCTCACGCCCTCCGGCTCGCGGGCCATGGATCTGCTCTGCCGCTTCCTGCTGAAGCCGGGCGATACGGTGCTGGTGG
ACGATCCCTGCTATTTCAATTTCCAGGCGCTGCTGCGCGCCCACCAGATCCGGATCGTCAGCGTGCCCTACACGCCCACC
GGGCCAGACATCGAGCGCTTCGGGCAGGTGCTCGCCGCCGAGCGGCCGCGCCTCTACATCACCAATGCCGCGCTCCATAA
TCCCACGGGCGCCACCCTCTCGCCCCGCACCGCCCATCAGGTGCTGACGCTGGCCGCCGCTCACGACCTCACCATCGTGG
AGGACGAAATCTTCGCGGAATTCGAGCCCGAGCCCTCTCCCCGCCTCGCGGCGCTGGATGGCCTTGCCCGCGTCATCCGC
GTGGGCAGCTTCTCCAAGACCCTCTCGGCCTCCGCCCGCTGCGGCTATATCGTCGCCCGGCCGGAGTGGATCGAGGGGCT
GGTGGACCTGCAGGTGGCCACCAATTTCGGCGGCCCGAGCCCCATCGCCGCGGAGCTCGTCTTCGGCACGCTGAGCGACG
GCAGCTATCGCAAGCATCTGGCCGATCTGCGCACACGCCTCGCCCGCCGTCGGCGGGAGATGCTGGCGGAGCTGGGCAAG
CTCGGCATCACGCCTTGGACCCTGCCGCGCGGTGGCTTCTGTCTTTGGTGCCGCCTGCCGGACGGGCGCGACGCGGCAGC
CGTCGCGCAGGCGGCCCTGCGCGAGCGGGTGGTGCTGGCGCCGGGCAATGTCTTCAGCGTCACCCAGTCGGCTGGCGACC
TGATGCGCTTCAACGTGGCGCAGATGGATGGCGAGGTGCTGCGCGTGCTGGGGAACGCGCTGCGCTGA

Upstream 100 bases:

>100_bases
TGCCCCACCCTTCCGTTCCGCGATCCATGATGTGCGCTCCGTCCCCCGGTCTTCGAGATAGCGTGGACCGGGTTGCGCGC
ACAGGAACGGAGCCATACGG

Downstream 100 bases:

>100_bases
AATCAGCCCGCGCCCGCGAGCATGTCGAAGGCCTGACGGGCAAATTCCGGCAGCGCCTCGCGATTGCGCACGGCCACCAC
CACCTTGCGGCGCGCCCAGG

Product: transcriptional regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MSRTVWTSGTTQLAEAETSSAPRTEAVMVEIRRRITGRALTGGEKLPSIRRLAGDLKVSPSTVVEAYERLVAEGLVRARP
GSGFYVAGSLPVVALREVAPKLDRAIDPLWVSRQSLDAGADMLRPGCGWLPADWMPNAAIRRSLRALARAEDGILSDYGG
TRGSLALRGHLARQFAAEGIEAGADQILLTPSGSRAMDLLCRFLLKPGDTVLVDDPCYFNFQALLRAHQIRIVSVPYTPT
GPDIERFGQVLAAERPRLYITNAALHNPTGATLSPRTAHQVLTLAAAHDLTIVEDEIFAEFEPEPSPRLAALDGLARVIR
VGSFSKTLSASARCGYIVARPEWIEGLVDLQVATNFGGPSPIAAELVFGTLSDGSYRKHLADLRTRLARRRREMLAELGK
LGITPWTLPRGGFCLWCRLPDGRDAAAVAQAALRERVVLAPGNVFSVTQSAGDLMRFNVAQMDGEVLRVLGNALR

Sequences:

>Translated_475_residues
MSRTVWTSGTTQLAEAETSSAPRTEAVMVEIRRRITGRALTGGEKLPSIRRLAGDLKVSPSTVVEAYERLVAEGLVRARP
GSGFYVAGSLPVVALREVAPKLDRAIDPLWVSRQSLDAGADMLRPGCGWLPADWMPNAAIRRSLRALARAEDGILSDYGG
TRGSLALRGHLARQFAAEGIEAGADQILLTPSGSRAMDLLCRFLLKPGDTVLVDDPCYFNFQALLRAHQIRIVSVPYTPT
GPDIERFGQVLAAERPRLYITNAALHNPTGATLSPRTAHQVLTLAAAHDLTIVEDEIFAEFEPEPSPRLAALDGLARVIR
VGSFSKTLSASARCGYIVARPEWIEGLVDLQVATNFGGPSPIAAELVFGTLSDGSYRKHLADLRTRLARRRREMLAELGK
LGITPWTLPRGGFCLWCRLPDGRDAAAVAQAALRERVVLAPGNVFSVTQSAGDLMRFNVAQMDGEVLRVLGNALR
>Mature_474_residues
SRTVWTSGTTQLAEAETSSAPRTEAVMVEIRRRITGRALTGGEKLPSIRRLAGDLKVSPSTVVEAYERLVAEGLVRARPG
SGFYVAGSLPVVALREVAPKLDRAIDPLWVSRQSLDAGADMLRPGCGWLPADWMPNAAIRRSLRALARAEDGILSDYGGT
RGSLALRGHLARQFAAEGIEAGADQILLTPSGSRAMDLLCRFLLKPGDTVLVDDPCYFNFQALLRAHQIRIVSVPYTPTG
PDIERFGQVLAAERPRLYITNAALHNPTGATLSPRTAHQVLTLAAAHDLTIVEDEIFAEFEPEPSPRLAALDGLARVIRV
GSFSKTLSASARCGYIVARPEWIEGLVDLQVATNFGGPSPIAAELVFGTLSDGSYRKHLADLRTRLARRRREMLAELGKL
GITPWTLPRGGFCLWCRLPDGRDAAAVAQAALRERVVLAPGNVFSVTQSAGDLMRFNVAQMDGEVLRVLGNALR

Specific function: Positively regulates the expression of the NorB efflux pump and negatively regulates the expression of the AbcA efflux pump. Binds specifically to the promoters of norA, norB and norC and abcA genes. Could also have an aminotransferase activity [H]

COG id: COG1167

COG function: function code KE; Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI7705897, Length=274, Percent_Identity=25.1824817518248, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI33469970, Length=274, Percent_Identity=25.1824817518248, Blast_Score=89, Evalue=8e-18,
Organism=Escherichia coli, GI1790797, Length=476, Percent_Identity=28.1512605042017, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1787710, Length=457, Percent_Identity=28.4463894967177, Blast_Score=150, Evalue=2e-37,
Organism=Drosophila melanogaster, GI21356535, Length=390, Percent_Identity=22.8205128205128, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000524
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00155 Aminotran_1_2; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 51383; Mature: 51252

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRTVWTSGTTQLAEAETSSAPRTEAVMVEIRRRITGRALTGGEKLPSIRRLAGDLKVSP
CCCEEECCCCCHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCH
STVVEAYERLVAEGLVRARPGSGFYVAGSLPVVALREVAPKLDRAIDPLWVSRQSLDAGA
HHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCH
DMLRPGCGWLPADWMPNAAIRRSLRALARAEDGILSDYGGTRGSLALRGHLARQFAAEGI
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHCCCCCCCCCHHHHHHHHHHHHHHH
EAGADQILLTPSGSRAMDLLCRFLLKPGDTVLVDDPCYFNFQALLRAHQIRIVSVPYTPT
HCCCCEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHCEEEEEECCCCC
GPDIERFGQVLAAERPRLYITNAALHNPTGATLSPRTAHQVLTLAAAHDLTIVEDEIFAE
CCCHHHHHHHHHCCCCEEEEEECCEECCCCCCCCCHHHHHHHHHHHHCCCEEEEHHHHHC
FEPEPSPRLAALDGLARVIRVGSFSKTLSASARCGYIVARPEWIEGLVDLQVATNFGGPS
CCCCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEECHHHHHHHHEEEEEECCCCCC
PIAAELVFGTLSDGSYRKHLADLRTRLARRRREMLAELGKLGITPWTLPRGGFCLWCRLP
CHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECC
DGRDAAAVAQAALRERVVLAPGNVFSVTQSAGDLMRFNVAQMDGEVLRVLGNALR
CCCCHHHHHHHHHHCCEEECCCCEEEEHHCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SRTVWTSGTTQLAEAETSSAPRTEAVMVEIRRRITGRALTGGEKLPSIRRLAGDLKVSP
CCEEECCCCCHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCH
STVVEAYERLVAEGLVRARPGSGFYVAGSLPVVALREVAPKLDRAIDPLWVSRQSLDAGA
HHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCH
DMLRPGCGWLPADWMPNAAIRRSLRALARAEDGILSDYGGTRGSLALRGHLARQFAAEGI
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHCCCCCCCCCHHHHHHHHHHHHHHH
EAGADQILLTPSGSRAMDLLCRFLLKPGDTVLVDDPCYFNFQALLRAHQIRIVSVPYTPT
HCCCCEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHCEEEEEECCCCC
GPDIERFGQVLAAERPRLYITNAALHNPTGATLSPRTAHQVLTLAAAHDLTIVEDEIFAE
CCCHHHHHHHHHCCCCEEEEEECCEECCCCCCCCCHHHHHHHHHHHHCCCEEEEHHHHHC
FEPEPSPRLAALDGLARVIRVGSFSKTLSASARCGYIVARPEWIEGLVDLQVATNFGGPS
CCCCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEECHHHHHHHHEEEEEECCCCCC
PIAAELVFGTLSDGSYRKHLADLRTRLARRRREMLAELGKLGITPWTLPRGGFCLWCRLP
CHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECC
DGRDAAAVAQAALRERVVLAPGNVFSVTQSAGDLMRFNVAQMDGEVLRVLGNALR
CCCCHHHHHHHHHHCCEEECCCCEEEEHHCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA