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The map label for this gene is gyaR [H]

Identifier: 158421860

GI number: 158421860

Start: 280301

End: 281308

Strand: Reverse

Name: gyaR [H]

Synonym: AZC_0236

Alternate gene names: 158421860

Gene position: 281308-280301 (Counterclockwise)

Preceding gene: 158421862

Following gene: 158421857

Centisome position: 5.24

GC content: 68.15

Gene sequence:

>1008_bases
ATGGAAATGGCGCGTCGCAAGCCGCTCGTCGTCGTCACAAGGAAGCTGCCGGATGTCGTCGAGACCCGGATGCGCGAACT
TTTTGACGCCGAATTGAACGTGGATGACGTGCCGATGGACCAGGCTGCCCTTGTGGAAGCCGTCAAGCGCGCCGACGTCC
TCGTCCCGACCCTGACCGACCGCATCGACACGGCCGTGCTCTCGCAGGCCGGCGAGAACCTGCGCCTCATCGCCAGCTTC
TCGAACGGCGTCGACCACATCGACGTGGCGACCGCGCTCGCCCGCGGCATCACCGTTACCAACACGCCCGGCGTCCTCAC
CGAGGACACCGCCGACTTCACCATGGCGCTGATCCTCGCCTTGCCCCGCCGCGTCACCGAAGGCGCGCAGGTGCTGACCG
GCGATCAGGACGACTGGGCGGGCTGGTCGCCCACCTGGATGCTCGGCCGACGCATCTGGGGCAAGCGCCTAGGCATCATC
GGCATGGGCCGCATCGGCCAGGCGGTGGCGCGCCGCGCCAAGGCGTTCGGCCTCCAGATCCACTATCACAACCGCCGCCG
CCTGCCCGGCGCCATCGAGGATGCGCTGGAGGCGACCTACTGGGACAGCCTCGACCAGATGCTGGCCCGCATGGACATCG
TGTCGGTCAACTGCCCGCACACGCCGGCCACCTTCCACCTGCTCTCCGCCCGCCGCCTCAAGCTGCTGAAGCGCGAGGCC
TATGTGGTGAACACGGCGCGCGGCGAGATCATCGACGAGAATGCGCTCGCCCGCATGCTGGAAGCCGATGAGCTGGGCGG
CGCGGGCCTCGACGTGTTCGAGCAGGAGCCGGCGGTGAACCCGAAGCTCGTGCGCCTCGCCCGTCAGGGCAAGGTGGTCC
TGATGCCGCACATGGGCTCGGCGACGCTCGAAGGCCGCATCGACATGGGCGAGAAGGTGATCGTGAACATCCGCACCTTC
ATGGACGGGCACCGTCCACCGGACCGCGTCCTGCCCTCCATGCTCTGA

Upstream 100 bases:

>100_bases
CCGGACGGCGCCGCCCGTCAAGGCCGCGATGCGCACGGCGCCTTGTCTTTCCGCGCCTGTCTGCTAGACCGAACGAAAGC
TGGGGAAACGCAGAACGGGG

Downstream 100 bases:

>100_bases
TCCAGATATTCCGAAAGGCCGCCGTTCAGGCGGCCTTTTCATGTGCGGAGAGGTCGGTGATCCGGGCGCCCGTGCCGGTG
AGCGGATTGTCTTCGTCCCA

Product: dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MEMARRKPLVVVTRKLPDVVETRMRELFDAELNVDDVPMDQAALVEAVKRADVLVPTLTDRIDTAVLSQAGENLRLIASF
SNGVDHIDVATALARGITVTNTPGVLTEDTADFTMALILALPRRVTEGAQVLTGDQDDWAGWSPTWMLGRRIWGKRLGII
GMGRIGQAVARRAKAFGLQIHYHNRRRLPGAIEDALEATYWDSLDQMLARMDIVSVNCPHTPATFHLLSARRLKLLKREA
YVVNTARGEIIDENALARMLEADELGGAGLDVFEQEPAVNPKLVRLARQGKVVLMPHMGSATLEGRIDMGEKVIVNIRTF
MDGHRPPDRVLPSML

Sequences:

>Translated_335_residues
MEMARRKPLVVVTRKLPDVVETRMRELFDAELNVDDVPMDQAALVEAVKRADVLVPTLTDRIDTAVLSQAGENLRLIASF
SNGVDHIDVATALARGITVTNTPGVLTEDTADFTMALILALPRRVTEGAQVLTGDQDDWAGWSPTWMLGRRIWGKRLGII
GMGRIGQAVARRAKAFGLQIHYHNRRRLPGAIEDALEATYWDSLDQMLARMDIVSVNCPHTPATFHLLSARRLKLLKREA
YVVNTARGEIIDENALARMLEADELGGAGLDVFEQEPAVNPKLVRLARQGKVVLMPHMGSATLEGRIDMGEKVIVNIRTF
MDGHRPPDRVLPSML
>Mature_335_residues
MEMARRKPLVVVTRKLPDVVETRMRELFDAELNVDDVPMDQAALVEAVKRADVLVPTLTDRIDTAVLSQAGENLRLIASF
SNGVDHIDVATALARGITVTNTPGVLTEDTADFTMALILALPRRVTEGAQVLTGDQDDWAGWSPTWMLGRRIWGKRLGII
GMGRIGQAVARRAKAFGLQIHYHNRRRLPGAIEDALEATYWDSLDQMLARMDIVSVNCPHTPATFHLLSARRLKLLKREA
YVVNTARGEIIDENALARMLEADELGGAGLDVFEQEPAVNPKLVRLARQGKVVLMPHMGSATLEGRIDMGEKVIVNIRTF
MDGHRPPDRVLPSML

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=324, Percent_Identity=33.0246913580247, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI61743967, Length=264, Percent_Identity=35.6060606060606, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI4557497, Length=264, Percent_Identity=35.6060606060606, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI23308577, Length=263, Percent_Identity=31.9391634980989, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI145580578, Length=263, Percent_Identity=34.6007604562738, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI4557499, Length=263, Percent_Identity=34.6007604562738, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI145580575, Length=265, Percent_Identity=34.7169811320755, Blast_Score=127, Evalue=1e-29,
Organism=Escherichia coli, GI87082289, Length=333, Percent_Identity=37.2372372372372, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1789279, Length=260, Percent_Identity=31.5384615384615, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1787645, Length=269, Percent_Identity=26.7657992565056, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI87081824, Length=241, Percent_Identity=25.7261410788382, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1788660, Length=318, Percent_Identity=24.8427672955975, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=274, Percent_Identity=30.2919708029197, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI25147481, Length=268, Percent_Identity=31.3432835820896, Blast_Score=110, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6324055, Length=314, Percent_Identity=33.7579617834395, Blast_Score=149, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6320925, Length=313, Percent_Identity=29.3929712460064, Blast_Score=129, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6322116, Length=313, Percent_Identity=28.7539936102236, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6324964, Length=283, Percent_Identity=29.6819787985866, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6321253, Length=154, Percent_Identity=31.8181818181818, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6325144, Length=154, Percent_Identity=30.5194805194805, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324980, Length=153, Percent_Identity=30.718954248366, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28571528, Length=323, Percent_Identity=37.4613003095975, Blast_Score=164, Evalue=9e-41,
Organism=Drosophila melanogaster, GI24585514, Length=279, Percent_Identity=34.7670250896057, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI28574282, Length=279, Percent_Identity=34.7670250896057, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI45552429, Length=280, Percent_Identity=34.6428571428571, Blast_Score=158, Evalue=4e-39,
Organism=Drosophila melanogaster, GI28574284, Length=279, Percent_Identity=34.7670250896057, Blast_Score=158, Evalue=4e-39,
Organism=Drosophila melanogaster, GI45551003, Length=279, Percent_Identity=34.7670250896057, Blast_Score=158, Evalue=4e-39,
Organism=Drosophila melanogaster, GI28574286, Length=311, Percent_Identity=31.8327974276527, Blast_Score=147, Evalue=9e-36,
Organism=Drosophila melanogaster, GI19921140, Length=266, Percent_Identity=32.7067669172932, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24585516, Length=291, Percent_Identity=28.8659793814433, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24646446, Length=260, Percent_Identity=35, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24646448, Length=260, Percent_Identity=35, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24646452, Length=260, Percent_Identity=35, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24646450, Length=260, Percent_Identity=35, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI62472511, Length=260, Percent_Identity=35, Blast_Score=128, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 37091; Mature: 37091

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMARRKPLVVVTRKLPDVVETRMRELFDAELNVDDVPMDQAALVEAVKRADVLVPTLTD
CCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCEECHHHHH
RIDTAVLSQAGENLRLIASFSNGVDHIDVATALARGITVTNTPGVLTEDTADFTMALILA
HHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHH
LPRRVTEGAQVLTGDQDDWAGWSPTWMLGRRIWGKRLGIIGMGRIGQAVARRAKAFGLQI
HHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHEEEE
HYHNRRRLPGAIEDALEATYWDSLDQMLARMDIVSVNCPHTPATFHLLSARRLKLLKREA
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHH
YVVNTARGEIIDENALARMLEADELGGAGLDVFEQEPAVNPKLVRLARQGKVVLMPHMGS
HEEECCCCCEECHHHHHHHHHHHHCCCCCCCHHCCCCCCCHHHHHHHHCCCEEEEECCCC
ATLEGRIDMGEKVIVNIRTFMDGHRPPDRVLPSML
CEECCCCCCCCEEEEEEHHHHCCCCCHHHHCCCCC
>Mature Secondary Structure
MEMARRKPLVVVTRKLPDVVETRMRELFDAELNVDDVPMDQAALVEAVKRADVLVPTLTD
CCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCEECHHHHH
RIDTAVLSQAGENLRLIASFSNGVDHIDVATALARGITVTNTPGVLTEDTADFTMALILA
HHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHH
LPRRVTEGAQVLTGDQDDWAGWSPTWMLGRRIWGKRLGIIGMGRIGQAVARRAKAFGLQI
HHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHEEEE
HYHNRRRLPGAIEDALEATYWDSLDQMLARMDIVSVNCPHTPATFHLLSARRLKLLKREA
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHH
YVVNTARGEIIDENALARMLEADELGGAGLDVFEQEPAVNPKLVRLARQGKVVLMPHMGS
HEEECCCCCEECHHHHHHHHHHHHCCCCCCCHHCCCCCCCHHHHHHHHCCCEEEEECCCC
ATLEGRIDMGEKVIVNIRTFMDGHRPPDRVLPSML
CEECCCCCCCCEEEEEEHHHHCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA