Click here to switch to the map view.

The map label for this gene is moeZ [H]

Identifier: 158421859

GI number: 158421859

Start: 279463

End: 280275

Strand: Direct

Name: moeZ [H]

Synonym: AZC_0235

Alternate gene names: 158421859

Gene position: 279463-280275 (Clockwise)

Preceding gene: 158421858

Following gene: 158421861

Centisome position: 5.2

GC content: 69.0

Gene sequence:

>813_bases
ATGGCTTTTTCCGCCGACGAGATCGAACGCTACGCCCGCCACATCGTGCTGCATGACGTGGGCGGGCCGGGACAGCAGAA
GCTGAAGGCCGCGAAAGTGCTGGTGGTCGGCGCCGGCGGGCTCGGCGCCCCGGCGCTGCTCTATCTGGCGGCGGCGGGCG
TCGGCCGGCTGATCATCGTCGATGACGACGCCGTGTCGCTCTCCAATCTCCAGCGGCAGGTCATCCACCGCACCGCCGAC
ATCGGCCGCCCCAAGACCGATAGCGCCAAAGAGGCCGTCGAGGCCCTCAATCCGCATGTGGAGGTGGAGACGCACGCCGT
GCGCCTGACGCCCGCCAATGCGCTCGATCTCATCTCCCGCGCCGATGTGGTGCTGGACGGCTCCGACAATTTCGCCACCC
GCTATCTGGTGTCGGATGCCTGCGTGCTGGCGAAGAAGACGCTGGTGACGGCGGCGCTCGGCACCTTCGATGCGACGCTC
ACCACCATAAGCGCCCATGAGACGGGGCCGGATGGCACGCCGAACCCCACCTATCGCTGCCTGTTCCCCGAACCGCCCCC
GCCCGGCACGGTAGCGCCCTGCGCGGAAGCGGGCGTGCTCGGCGCGCTCGCGGGCATCGCCGGCTCCATGGCGGCGCTGG
AGGCCATCCGCGCCATTGTCGGCTTCGGCGAGGGGCTGGTGGGCAAGCTGCTGATGATGGACGCTCGGTCCATGCGCTTC
GAGACGCTGAGCTACGGCTGGGACGAAGACAATCCGCTCACCGGCACGGGCGCCCGGATCACCGACCTCTCCGCACATGA
AAAGGCCGCCTGA

Upstream 100 bases:

>100_bases
TTGACCCCGCGCCCCGGACTGCCCAGATCTGAGCGATCCCTCGCGCCCTCAGGGTCGCGCCTCTCAGAGCCTGAACCGTC
AGGCCCCAGGACACCCTTTC

Downstream 100 bases:

>100_bases
ACGGCGGCCTTTCGGAATATCTGGATCAGAGCATGGAGGGCAGGACGCGGTCCGGTGGACGGTGCCCGTCCATGAAGGTG
CGGATGTTCACGATCACCTT

Product: molybdenum cofactor biosynthesis protein

Products: NA

Alternate protein names: Sulfur carrier protein CysO adenylyltransferase; Sulfur carrier protein CysO sulfurtransferase [H]

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MAFSADEIERYARHIVLHDVGGPGQQKLKAAKVLVVGAGGLGAPALLYLAAAGVGRLIIVDDDAVSLSNLQRQVIHRTAD
IGRPKTDSAKEAVEALNPHVEVETHAVRLTPANALDLISRADVVLDGSDNFATRYLVSDACVLAKKTLVTAALGTFDATL
TTISAHETGPDGTPNPTYRCLFPEPPPPGTVAPCAEAGVLGALAGIAGSMAALEAIRAIVGFGEGLVGKLLMMDARSMRF
ETLSYGWDEDNPLTGTGARITDLSAHEKAA

Sequences:

>Translated_270_residues
MAFSADEIERYARHIVLHDVGGPGQQKLKAAKVLVVGAGGLGAPALLYLAAAGVGRLIIVDDDAVSLSNLQRQVIHRTAD
IGRPKTDSAKEAVEALNPHVEVETHAVRLTPANALDLISRADVVLDGSDNFATRYLVSDACVLAKKTLVTAALGTFDATL
TTISAHETGPDGTPNPTYRCLFPEPPPPGTVAPCAEAGVLGALAGIAGSMAALEAIRAIVGFGEGLVGKLLMMDARSMRF
ETLSYGWDEDNPLTGTGARITDLSAHEKAA
>Mature_269_residues
AFSADEIERYARHIVLHDVGGPGQQKLKAAKVLVVGAGGLGAPALLYLAAAGVGRLIIVDDDAVSLSNLQRQVIHRTADI
GRPKTDSAKEAVEALNPHVEVETHAVRLTPANALDLISRADVVLDGSDNFATRYLVSDACVLAKKTLVTAALGTFDATLT
TISAHETGPDGTPNPTYRCLFPEPPPPGTVAPCAEAGVLGALAGIAGSMAALEAIRAIVGFGEGLVGKLLMMDARSMRFE
TLSYGWDEDNPLTGTGARITDLSAHEKAA

Specific function: Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps:first, ATP-dependent activation of CysO as acyl- adenylate (CysO-COOAMP), followed by sulfur transfer to give CysO- thioca

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=239, Percent_Identity=49.3723849372385, Blast_Score=193, Evalue=1e-49,
Organism=Homo sapiens, GI23510338, Length=146, Percent_Identity=33.5616438356164, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI23510340, Length=146, Percent_Identity=33.5616438356164, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4885649, Length=154, Percent_Identity=31.8181818181818, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI38045948, Length=153, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI38045944, Length=115, Percent_Identity=35.6521739130435, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI38045942, Length=115, Percent_Identity=35.6521739130435, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787048, Length=252, Percent_Identity=40.8730158730159, Blast_Score=171, Evalue=5e-44,
Organism=Escherichia coli, GI87082356, Length=239, Percent_Identity=41.8410041841004, Blast_Score=164, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17540406, Length=234, Percent_Identity=41.025641025641, Blast_Score=190, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI193203301, Length=140, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6321903, Length=221, Percent_Identity=46.606334841629, Blast_Score=199, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6320598, Length=153, Percent_Identity=29.4117647058824, Blast_Score=73, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6322639, Length=143, Percent_Identity=32.1678321678322, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24582879, Length=241, Percent_Identity=47.7178423236515, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI28573937, Length=156, Percent_Identity=30.1282051282051, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24660640, Length=140, Percent_Identity=30.7142857142857, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR001763
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00581 Rhodanese; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 28070; Mature: 27939

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFSADEIERYARHIVLHDVGGPGQQKLKAAKVLVVGAGGLGAPALLYLAAAGVGRLIIV
CCCCHHHHHHHHHEEEEECCCCCCHHHHHEEEEEEEECCCCCHHHHHHHHHCCCCEEEEE
DDDAVSLSNLQRQVIHRTADIGRPKTDSAKEAVEALNPHVEVETHAVRLTPANALDLISR
ECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEEEEEEECCCHHHHHHHH
ADVVLDGSDNFATRYLVSDACVLAKKTLVTAALGTFDATLTTISAHETGPDGTPNPTYRC
CCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCEEE
LFPEPPPPGTVAPCAEAGVLGALAGIAGSMAALEAIRAIVGFGEGLVGKLLMMDARSMRF
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHE
ETLSYGWDEDNPLTGTGARITDLSAHEKAA
EHEECCCCCCCCCCCCCCEEEECCCCCCCC
>Mature Secondary Structure 
AFSADEIERYARHIVLHDVGGPGQQKLKAAKVLVVGAGGLGAPALLYLAAAGVGRLIIV
CCCHHHHHHHHHEEEEECCCCCCHHHHHEEEEEEEECCCCCHHHHHHHHHCCCCEEEEE
DDDAVSLSNLQRQVIHRTADIGRPKTDSAKEAVEALNPHVEVETHAVRLTPANALDLISR
ECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEEEEEEECCCHHHHHHHH
ADVVLDGSDNFATRYLVSDACVLAKKTLVTAALGTFDATLTTISAHETGPDGTPNPTYRC
CCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCEEE
LFPEPPPPGTVAPCAEAGVLGALAGIAGSMAALEAIRAIVGFGEGLVGKLLMMDARSMRF
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHE
ETLSYGWDEDNPLTGTGARITDLSAHEKAA
EHEECCCCCCCCCCCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]