Click here to switch to the map view.

The map label for this gene is pepQ [H]

Identifier: 158421842

GI number: 158421842

Start: 260628

End: 262496

Strand: Direct

Name: pepQ [H]

Synonym: AZC_0218

Alternate gene names: 158421842

Gene position: 260628-262496 (Clockwise)

Preceding gene: 158421841

Following gene: 158421843

Centisome position: 4.85

GC content: 70.73

Gene sequence:

>1869_bases
ATGTCCGATCCTGCCTTCCCTGCTTCGTCGGCCCATGCGCCGCGCTTTCACGCCCGCTTCCAGTCCTTCGAGGAGACCGC
CGACGGCAGTGCCGGGCCCGGCCGGCTCGCCGCGTTGCGGGCGGAGCTCGCCCGGCGCGGCATCGGCGGCTATGTGGTGC
CGCGGGCCGATGCGCACCAGAATGAATATGTGGCGCCGGGAGAGGAGCGTCTTGCCTGGCTCACGGGCTTCACCGGCTCG
GCCGGCCTTCTGATCGTGCTGCCGGAGGTCGCGGCGCTTTTTGTGGATGGCCGCTACACGCTTCAGGCGGCGGCGCAGGT
GGACACCGGCGCCTTCACCGTCGTGCCGCTGGCCGAAACGAGCCCGGAACGCTGGCTGGAGGCCAACCTTCCGGTGGGGC
TCTCGCTCGGCTTCGATCCCTGGCGCACCACGCTCGACGGGCGCGATCGCTTCGCCCGCGCGGTGGCCAATGCGAAGGGC
GTGCTGGTGAGCGTGGCGGAGGATCCCGTCGCCCGGCTGTGGACCGACCGGCCGGAACCGCCCCGCGCCCCGCTGCGGCT
GCTCGATGCCGCTCTGGCGGGCGAGGAGACGCCGTCCAAGCTTGCCCGCGTACGCGAGGCGCTGGGCAAGGACCGGCTCG
ACGGAGCGCTCATCTCCGATCCCCATGCCACGGCGTGGCTCTTCAATGTGCGCGGCGGCGATGTGGCCCACACGCCATTG
CCGCTCGCCTGGTCTCTTGTGCCGGCGGAGGGGCGGCCGCAGCTCTTCCTCTCCCCCGCCAAGCTCTCCCATGAGGTCCG
CGCGGTCCTGTCGGACGTGGCGGATGTGCGCCATGAGGACGATCTGGAGGCAGCGCTCACCGATTTCGCCGCCGGCCGCA
CCGTGCGGCTCGATCAGGCGACGGCACCCGTCCATCTCGCCGAGGTGGTGGAGCGGGCGGGCGGCAAGGTGGCGAAGGGC
GCAGATCCGGTCTCGGCCCTGAAGGCGCGCAAGAATGCGGCCGAGATCGCCGGCATGCGGGCTGCCCATCTGCGCGACGG
CGTGGCGCTGACGCGCTTCCTCCACTGGTTCGATGGCGCGGCGGCGTCCGGCACGCTCACCGAGATCGACGCCGTGGAGG
CGCTGGAGACCTTCCGGCGCGAGACCGGCCAGCTCACAGACGTGTCCTTCCCCACCATTTCCGGGGCGGGGCCGAACGGC
GCCATCGTTCATTACCGCGTCACACGCGCCACCAACCGGACGCTCCAGCCCGGCGAGCTCTTCCTGCTCGATTCCGGCGC
GCAATATCCCGACGGCACGACGGATGTGACGCGCACGCTGGCGGTGGGCACGCCGACGGCGGACATGCGCGCGCATTTCA
CGCTGGTGCTGAAGGGGCATATCGCCCTCTCCCGCGCCATTTTCCCGAAGGGCACCACGGGCGCGCAGCTCGATACGCTG
GCGCGTCAGTTCCTGTGGGCGGCGGGACTCGATTTCGAGCACGGCACCGGACACGGGGTCGGGGCGGGGCTCTCCGTGCA
CGAGGGGCCGGCGCGCATTTCCAAGCTCGGCCACGTGGCGCTGGAGGAGGGGATGATCCTCTCCAACGAGCCCGGCTATT
ACCGCCCGGGCGCGTATGGCATCCGCATCGAGAATCTCATCCTGGTGGAGCCGCGGGCGATCGCCGGGGCGGAGAAGAGC
TTCTTCGGCTTCGAGACGCTGACCCTCGCCCCCATCGACCGGCGGCTGATCGACACAGACCTCCTGACAGCCGAGGAGAT
CGCCTGGATGGATGCCTATCACGCCCGTGTGGCGCGGGAGGTGGGGCCGGCGCTCGATGGCGACGAACAGGCCTGGCTTG
CGGCCGCTACCGCTCCGCTCAAGTCTTGA

Upstream 100 bases:

>100_bases
GCATGCGGTGGTCGCGACGGGCTCCGTCCGGGCGGCGCCCTCCTGCTTGCCCGCCGCAAGGGGGATGCGGATGCCGGACA
AGCTGCGCTAAGCTCGCGCC

Downstream 100 bases:

>100_bases
TGTGACGTCTTTGCCGCCTGGCTTCGCGATGGCCGGGCGGTCGCACTGCGGAACCTTTGCCGCAGCCCTGCGTTTGGGAA
GCAGAGGCGACAGAGGGACG

Product: aminopeptidase P

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 622; Mature: 621

Protein sequence:

>622_residues
MSDPAFPASSAHAPRFHARFQSFEETADGSAGPGRLAALRAELARRGIGGYVVPRADAHQNEYVAPGEERLAWLTGFTGS
AGLLIVLPEVAALFVDGRYTLQAAAQVDTGAFTVVPLAETSPERWLEANLPVGLSLGFDPWRTTLDGRDRFARAVANAKG
VLVSVAEDPVARLWTDRPEPPRAPLRLLDAALAGEETPSKLARVREALGKDRLDGALISDPHATAWLFNVRGGDVAHTPL
PLAWSLVPAEGRPQLFLSPAKLSHEVRAVLSDVADVRHEDDLEAALTDFAAGRTVRLDQATAPVHLAEVVERAGGKVAKG
ADPVSALKARKNAAEIAGMRAAHLRDGVALTRFLHWFDGAAASGTLTEIDAVEALETFRRETGQLTDVSFPTISGAGPNG
AIVHYRVTRATNRTLQPGELFLLDSGAQYPDGTTDVTRTLAVGTPTADMRAHFTLVLKGHIALSRAIFPKGTTGAQLDTL
ARQFLWAAGLDFEHGTGHGVGAGLSVHEGPARISKLGHVALEEGMILSNEPGYYRPGAYGIRIENLILVEPRAIAGAEKS
FFGFETLTLAPIDRRLIDTDLLTAEEIAWMDAYHARVAREVGPALDGDEQAWLAAATAPLKS

Sequences:

>Translated_622_residues
MSDPAFPASSAHAPRFHARFQSFEETADGSAGPGRLAALRAELARRGIGGYVVPRADAHQNEYVAPGEERLAWLTGFTGS
AGLLIVLPEVAALFVDGRYTLQAAAQVDTGAFTVVPLAETSPERWLEANLPVGLSLGFDPWRTTLDGRDRFARAVANAKG
VLVSVAEDPVARLWTDRPEPPRAPLRLLDAALAGEETPSKLARVREALGKDRLDGALISDPHATAWLFNVRGGDVAHTPL
PLAWSLVPAEGRPQLFLSPAKLSHEVRAVLSDVADVRHEDDLEAALTDFAAGRTVRLDQATAPVHLAEVVERAGGKVAKG
ADPVSALKARKNAAEIAGMRAAHLRDGVALTRFLHWFDGAAASGTLTEIDAVEALETFRRETGQLTDVSFPTISGAGPNG
AIVHYRVTRATNRTLQPGELFLLDSGAQYPDGTTDVTRTLAVGTPTADMRAHFTLVLKGHIALSRAIFPKGTTGAQLDTL
ARQFLWAAGLDFEHGTGHGVGAGLSVHEGPARISKLGHVALEEGMILSNEPGYYRPGAYGIRIENLILVEPRAIAGAEKS
FFGFETLTLAPIDRRLIDTDLLTAEEIAWMDAYHARVAREVGPALDGDEQAWLAAATAPLKS
>Mature_621_residues
SDPAFPASSAHAPRFHARFQSFEETADGSAGPGRLAALRAELARRGIGGYVVPRADAHQNEYVAPGEERLAWLTGFTGSA
GLLIVLPEVAALFVDGRYTLQAAAQVDTGAFTVVPLAETSPERWLEANLPVGLSLGFDPWRTTLDGRDRFARAVANAKGV
LVSVAEDPVARLWTDRPEPPRAPLRLLDAALAGEETPSKLARVREALGKDRLDGALISDPHATAWLFNVRGGDVAHTPLP
LAWSLVPAEGRPQLFLSPAKLSHEVRAVLSDVADVRHEDDLEAALTDFAAGRTVRLDQATAPVHLAEVVERAGGKVAKGA
DPVSALKARKNAAEIAGMRAAHLRDGVALTRFLHWFDGAAASGTLTEIDAVEALETFRRETGQLTDVSFPTISGAGPNGA
IVHYRVTRATNRTLQPGELFLLDSGAQYPDGTTDVTRTLAVGTPTADMRAHFTLVLKGHIALSRAIFPKGTTGAQLDTLA
RQFLWAAGLDFEHGTGHGVGAGLSVHEGPARISKLGHVALEEGMILSNEPGYYRPGAYGIRIENLILVEPRAIAGAEKSF
FGFETLTLAPIDRRLIDTDLLTAEEIAWMDAYHARVAREVGPALDGDEQAWLAAATAPLKS

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=612, Percent_Identity=40.6862745098039, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI264681565, Length=612, Percent_Identity=38.562091503268, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI93141226, Length=599, Percent_Identity=35.7262103505843, Blast_Score=372, Evalue=1e-103,
Organism=Escherichia coli, GI1788728, Length=200, Percent_Identity=37, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17509539, Length=593, Percent_Identity=36.5935919055649, Blast_Score=358, Evalue=4e-99,
Organism=Caenorhabditis elegans, GI25149105, Length=616, Percent_Identity=29.8701298701299, Blast_Score=278, Evalue=6e-75,
Organism=Saccharomyces cerevisiae, GI6322999, Length=655, Percent_Identity=31.6030534351145, Blast_Score=308, Evalue=2e-84,
Organism=Drosophila melanogaster, GI17137632, Length=612, Percent_Identity=33.1699346405229, Blast_Score=325, Evalue=6e-89,
Organism=Drosophila melanogaster, GI161078230, Length=617, Percent_Identity=26.580226904376, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI21357287, Length=617, Percent_Identity=26.580226904376, Blast_Score=239, Evalue=3e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 66323; Mature: 66191

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPAFPASSAHAPRFHARFQSFEETADGSAGPGRLAALRAELARRGIGGYVVPRADAHQ
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCC
NEYVAPGEERLAWLTGFTGSAGLLIVLPEVAALFVDGRYTLQAAAQVDTGAFTVVPLAET
CCCCCCCHHHEEEEECCCCCCCEEEEECCHHEEEECCCEEEEEEEEECCCCEEEEEECCC
SPERWLEANLPVGLSLGFDPWRTTLDGRDRFARAVANAKGVLVSVAEDPVARLWTDRPEP
CHHHHEECCCCEEEECCCCHHHCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHCCCCCC
PRAPLRLLDAALAGEETPSKLARVREALGKDRLDGALISDPHATAWLFNVRGGDVAHTPL
CCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCEEEEEECCCCCCCCCCC
PLAWSLVPAEGRPQLFLSPAKLSHEVRAVLSDVADVRHEDDLEAALTDFAAGRTVRLDQA
CEEEEEECCCCCCCEEECHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCC
TAPVHLAEVVERAGGKVAKGADPVSALKARKNAAEIAGMRAAHLRDGVALTRFLHWFDGA
CCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHCCC
AASGTLTEIDAVEALETFRRETGQLTDVSFPTISGAGPNGAIVHYRVTRATNRTLQPGEL
CCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCE
FLLDSGAQYPDGTTDVTRTLAVGTPTADMRAHFTLVLKGHIALSRAIFPKGTTGAQLDTL
EEECCCCCCCCCCHHHHEEEEECCCCCCCCEEEEEEEECCCHHHHEECCCCCCCCHHHHH
ARQFLWAAGLDFEHGTGHGVGAGLSVHEGPARISKLGHVALEEGMILSNEPGYYRPGAYG
HHHHHHHCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHCCEEEECCCCCCCCCCEE
IRIENLILVEPRAIAGAEKSFFGFETLTLAPIDRRLIDTDLLTAEEIAWMDAYHARVARE
EEEEEEEEECCHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGPALDGDEQAWLAAATAPLKS
HCCCCCCCCCCEEEEECCCCCC
>Mature Secondary Structure 
SDPAFPASSAHAPRFHARFQSFEETADGSAGPGRLAALRAELARRGIGGYVVPRADAHQ
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCC
NEYVAPGEERLAWLTGFTGSAGLLIVLPEVAALFVDGRYTLQAAAQVDTGAFTVVPLAET
CCCCCCCHHHEEEEECCCCCCCEEEEECCHHEEEECCCEEEEEEEEECCCCEEEEEECCC
SPERWLEANLPVGLSLGFDPWRTTLDGRDRFARAVANAKGVLVSVAEDPVARLWTDRPEP
CHHHHEECCCCEEEECCCCHHHCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHCCCCCC
PRAPLRLLDAALAGEETPSKLARVREALGKDRLDGALISDPHATAWLFNVRGGDVAHTPL
CCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCEEEEEECCCCCCCCCCC
PLAWSLVPAEGRPQLFLSPAKLSHEVRAVLSDVADVRHEDDLEAALTDFAAGRTVRLDQA
CEEEEEECCCCCCCEEECHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCC
TAPVHLAEVVERAGGKVAKGADPVSALKARKNAAEIAGMRAAHLRDGVALTRFLHWFDGA
CCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHCCC
AASGTLTEIDAVEALETFRRETGQLTDVSFPTISGAGPNGAIVHYRVTRATNRTLQPGEL
CCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCE
FLLDSGAQYPDGTTDVTRTLAVGTPTADMRAHFTLVLKGHIALSRAIFPKGTTGAQLDTL
EEECCCCCCCCCCHHHHEEEEECCCCCCCCEEEEEEEECCCHHHHEECCCCCCCCHHHHH
ARQFLWAAGLDFEHGTGHGVGAGLSVHEGPARISKLGHVALEEGMILSNEPGYYRPGAYG
HHHHHHHCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHCCEEEECCCCCCCCCCEE
IRIENLILVEPRAIAGAEKSFFGFETLTLAPIDRRLIDTDLLTAEEIAWMDAYHARVARE
EEEEEEEEECCHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGPALDGDEQAWLAAATAPLKS
HCCCCCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]