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The map label for this gene is engA

Identifier: 158339018

GI number: 158339018

Start: 6003589

End: 6004950

Strand: Reverse

Name: engA

Synonym: AM1_5937

Alternate gene names: 158339018

Gene position: 6004950-6003589 (Counterclockwise)

Preceding gene: 158339019

Following gene: 158339017

Centisome position: 92.33

GC content: 50.37

Gene sequence:

>1362_bases
ATGGGGTTACCCATTGTTGCCATTGTTGGTCGCCCAAATGTGGGTAAGTCAACCCTCGTCAATCGACTGACGGGGATGAT
GGATGCGATTGTTCATGATTCGCCAGGAGTGACCCGCGATCGCACCTATCGTCCAGCTCTCTGGAATGGCCGAGATTTTT
CCCTAGTGGATACTGGCGGACTGGTGTTTGATGACCAAACGGAATTCCTTCCCTTTATTCGGCAGCAAGTCATGATTGCC
CTAGCGGAAGCCACCGTGGTGGTGATGGTGGTAGATGGACAAGCTGGCCCCACCCCCGCAGATCATGAGATTGCCCATTG
GCTGCGGCAGCAAGATACCCCTGTGCTGTTGGCGGTCAATAAATGCGAATCCCCAGAACAAGGCATCACTCAAGCGGCCC
AGTTTTGGGAATTGTCCTTAGACGAACCGTTACCGGTCTCAGGCATTCACGGTAATGGCACTGGCGATCTCCTCGATCAA
GTGGTGGAGTATTTTTCCGAAACCCCTGAATCTGAGGATGAACCGGAGATTAAGGTGGCGTTGGTGGGACGCCCGAATGT
GGGTAAATCCAGCTTGCTCAATGCCTTTGTGGGCGAGAATCGCTCGATTGTGAGTCCCATCTCCGGTACAACCCGCGATA
CCATTGATATGGTGGTCCGAAGGGGTGAGCAAACCTACCGCTTTATTGATACAGCAGGCATTCGTCGCAAGAAGAATGTC
TCCTATGGGCCGGAGTTCTTTGGCATTAATCGAGCGTTTAAAGCAATCCGGCGATCGCAAGTCGTATTGTTTGTGATTGA
TGCCTTGGATGGCGTTACAGAACAGGATCAGAAGCTAGCTGGCCGCATTATTGATGATGGTCGCGCTTGTGTTTTGGTGG
TGAATAAATGGGATGCCGTCACGAAAGACACCTACACCATCAATGAATTCAGCAAACAAATTCGATCTCGTCTCAATTTT
ATGGAATGGGCAGAGATGATTTTTGTCAGTGCTCAGACCGGGCAACGGGTGGAAAAAATTCTGAACTTGGTGGATACGGC
TGCTCGACAGTTTGAACAGCGGGTAACCACTTCGGTGATTAATGAGGTCTTGGAAGAAGCGGTGAGCTGGCATACACCTC
CAACCACTCGTCAAGGACGGCAAGGCAAAATTTACTACGGAACCCAAGTCAGCAGTCAACCACCGACGATTGCTCTGTTT
GTGAACAATCCTGACCATTTCAAAGACAATTATCGTCGCTATATCGAACGACAATTCCGAGAAAATTTAGACTTTACAGG
TACCCCGATTCGTCTACTCTGGCGAGGGAAGAAGCTGCGGGATGTGGAGCGGAATACTGCGAATCGAGCAACAAGAGCTT
GA

Upstream 100 bases:

>100_bases
ATGGGGGTTTTGCCCGAACCTGCGCCTGAAGAACTACCCCATGCCGCCTCAACCAAGTAAGCGGTAATCATTCAATTTAT
TTAGAAATAGGGATATCAGT

Downstream 100 bases:

>100_bases
AATGAATTTTAGCCTTGACGACTATTACCTTTCAAGTTCTTTATCGATCTAGTCTGGATGGAAATTATAGAAGGTAAAAA
AAGATTGAATTTATGAGTTA

Product: GTP-binding protein EngA

Products: NA

Alternate protein names: GTP-binding protein EngA

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MGLPIVAIVGRPNVGKSTLVNRLTGMMDAIVHDSPGVTRDRTYRPALWNGRDFSLVDTGGLVFDDQTEFLPFIRQQVMIA
LAEATVVVMVVDGQAGPTPADHEIAHWLRQQDTPVLLAVNKCESPEQGITQAAQFWELSLDEPLPVSGIHGNGTGDLLDQ
VVEYFSETPESEDEPEIKVALVGRPNVGKSSLLNAFVGENRSIVSPISGTTRDTIDMVVRRGEQTYRFIDTAGIRRKKNV
SYGPEFFGINRAFKAIRRSQVVLFVIDALDGVTEQDQKLAGRIIDDGRACVLVVNKWDAVTKDTYTINEFSKQIRSRLNF
MEWAEMIFVSAQTGQRVEKILNLVDTAARQFEQRVTTSVINEVLEEAVSWHTPPTTRQGRQGKIYYGTQVSSQPPTIALF
VNNPDHFKDNYRRYIERQFRENLDFTGTPIRLLWRGKKLRDVERNTANRATRA

Sequences:

>Translated_453_residues
MGLPIVAIVGRPNVGKSTLVNRLTGMMDAIVHDSPGVTRDRTYRPALWNGRDFSLVDTGGLVFDDQTEFLPFIRQQVMIA
LAEATVVVMVVDGQAGPTPADHEIAHWLRQQDTPVLLAVNKCESPEQGITQAAQFWELSLDEPLPVSGIHGNGTGDLLDQ
VVEYFSETPESEDEPEIKVALVGRPNVGKSSLLNAFVGENRSIVSPISGTTRDTIDMVVRRGEQTYRFIDTAGIRRKKNV
SYGPEFFGINRAFKAIRRSQVVLFVIDALDGVTEQDQKLAGRIIDDGRACVLVVNKWDAVTKDTYTINEFSKQIRSRLNF
MEWAEMIFVSAQTGQRVEKILNLVDTAARQFEQRVTTSVINEVLEEAVSWHTPPTTRQGRQGKIYYGTQVSSQPPTIALF
VNNPDHFKDNYRRYIERQFRENLDFTGTPIRLLWRGKKLRDVERNTANRATRA
>Mature_452_residues
GLPIVAIVGRPNVGKSTLVNRLTGMMDAIVHDSPGVTRDRTYRPALWNGRDFSLVDTGGLVFDDQTEFLPFIRQQVMIAL
AEATVVVMVVDGQAGPTPADHEIAHWLRQQDTPVLLAVNKCESPEQGITQAAQFWELSLDEPLPVSGIHGNGTGDLLDQV
VEYFSETPESEDEPEIKVALVGRPNVGKSSLLNAFVGENRSIVSPISGTTRDTIDMVVRRGEQTYRFIDTAGIRRKKNVS
YGPEFFGINRAFKAIRRSQVVLFVIDALDGVTEQDQKLAGRIIDDGRACVLVVNKWDAVTKDTYTINEFSKQIRSRLNFM
EWAEMIFVSAQTGQRVEKILNLVDTAARQFEQRVTTSVINEVLEEAVSWHTPPTTRQGRQGKIYYGTQVSSQPPTIALFV
NNPDHFKDNYRRYIERQFRENLDFTGTPIRLLWRGKKLRDVERNTANRATRA

Specific function: GTPase that plays an essential role in the late steps of ribosome biogenesis

COG id: COG1160

COG function: function code R; Predicted GTPases

Gene ontology:
GO:0000166: GTPase Der
GO:0005525: GTPase Der
GO:0005622: GTPase Der
GO:0017111: GTPase Der
GO:0042254: GTPase Der

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH-like domain

Homologues:

Organism=Escherichia coli, GI87082120, Length=478, Percent_Identity=37.2384937238494, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI2367268, Length=92, Percent_Identity=43.4782608695652, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788919, Length=122, Percent_Identity=33.6065573770492, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17507259, Length=91, Percent_Identity=40.6593406593407, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323665, Length=209, Percent_Identity=33.9712918660287, Blast_Score=90, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DER_ACAM1 (B0C1P2)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001520195.1
- ProteinModelPortal:   B0C1P2
- SMR:   B0C1P2
- GeneID:   5684721
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_5937
- HOGENOM:   HBG592135
- OMA:   TRDRTYQ
- ProtClustDB:   PRK00093
- BioCyc:   AMAR329726:AM1_5937-MONOMER
- GO:   GO:0005622
- HAMAP:   MF_00195
- InterPro:   IPR003593
- InterPro:   IPR016484
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PIRSF:   PIRSF006485
- PRINTS:   PR00326
- SMART:   SM00382
- TIGRFAMs:   TIGR03594
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01926 MMR_HSR1

EC number: NA

Molecular weight: Translated: 50921; Mature: 50790

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLPIVAIVGRPNVGKSTLVNRLTGMMDAIVHDSPGVTRDRTYRPALWNGRDFSLVDTGG
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCC
LVFDDQTEFLPFIRQQVMIALAEATVVVMVVDGQAGPTPADHEIAHWLRQQDTPVLLAVN
EEECCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEC
KCESPEQGITQAAQFWELSLDEPLPVSGIHGNGTGDLLDQVVEYFSETPESEDEPEIKVA
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEE
LVGRPNVGKSSLLNAFVGENRSIVSPISGTTRDTIDMVVRRGEQTYRFIDTAGIRRKKNV
EEECCCCCHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHCCCHHEEEHHHHCCCCCCCC
SYGPEFFGINRAFKAIRRSQVVLFVIDALDGVTEQDQKLAGRIIDDGRACVLVVNKWDAV
CCCCCHHHHHHHHHHHHHCCEEEEEEEHHCCCCHHHHHHHHHHCCCCCEEEEEEECCCCC
TKDTYTINEFSKQIRSRLNFMEWAEMIFVSAQTGQRVEKILNLVDTAARQFEQRVTTSVI
CCCCEEHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NEVLEEAVSWHTPPTTRQGRQGKIYYGTQVSSQPPTIALFVNNPDHFKDNYRRYIERQFR
HHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHH
ENLDFTGTPIRLLWRGKKLRDVERNTANRATRA
CCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GLPIVAIVGRPNVGKSTLVNRLTGMMDAIVHDSPGVTRDRTYRPALWNGRDFSLVDTGG
CCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCC
LVFDDQTEFLPFIRQQVMIALAEATVVVMVVDGQAGPTPADHEIAHWLRQQDTPVLLAVN
EEECCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEC
KCESPEQGITQAAQFWELSLDEPLPVSGIHGNGTGDLLDQVVEYFSETPESEDEPEIKVA
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEE
LVGRPNVGKSSLLNAFVGENRSIVSPISGTTRDTIDMVVRRGEQTYRFIDTAGIRRKKNV
EEECCCCCHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHCCCHHEEEHHHHCCCCCCCC
SYGPEFFGINRAFKAIRRSQVVLFVIDALDGVTEQDQKLAGRIIDDGRACVLVVNKWDAV
CCCCCHHHHHHHHHHHHHCCEEEEEEEHHCCCCHHHHHHHHHHCCCCCEEEEEEECCCCC
TKDTYTINEFSKQIRSRLNFMEWAEMIFVSAQTGQRVEKILNLVDTAARQFEQRVTTSVI
CCCCEEHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NEVLEEAVSWHTPPTTRQGRQGKIYYGTQVSSQPPTIALFVNNPDHFKDNYRRYIERQFR
HHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHH
ENLDFTGTPIRLLWRGKKLRDVERNTANRATRA
CCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA