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The map label for this gene is icd [H]

Identifier: 158338840

GI number: 158338840

Start: 5830704

End: 5831750

Strand: Reverse

Name: icd [H]

Synonym: AM1_5753

Alternate gene names: 158338840

Gene position: 5831750-5830704 (Counterclockwise)

Preceding gene: 158338843

Following gene: 158338833

Centisome position: 89.67

GC content: 47.47

Gene sequence:

>1047_bases
ATGGGATATCCGGTGGTCTTGATTCAGGAGGGGGAACTAGGGGCGCAGGTGACGAATGCCTTGCAGATGGCTATTGCTGC
AACAGGGGTCGACATTACTTGGCAGATTGTCGATATCGGTGGAGAGGATCAGCAGGGTCTATTACCGAACTATATTTTTG
ATATTATCCGAACGGCTAAAACTGCTGTCATTGGACCATTGATGATGCCGGATAATTATCGTCAGATGGAAGCAGACATC
CGGGAAAAGCTAGATCTTTATGTCAACTTGCGACCCGCAAAAACGATGGTGGGGATTCCCAGCAATTATCAGAATGTTGA
CATAATGATTGTGCGAGAAACGACAGAGGGAATCTATGCTGGCATCGAATTTGAGCGCACTTCAGTAGAAGCTGCAGATG
CTCGTTCTTTTCTGTCAAAACTGTCTGGCAAACGAATACGAGAAGATGCTGCGGTAGGCATTAAACCGATTTCCGTTAAA
GGCTGTGGTCAAATCATTGAATTTGCCTTTAATTATGCTCGAAAGACCAAACGGCACCAAGTGATTGCGGTTCATCAAGC
GCATTTTATGGCCCATACAGACGGTCTTTTTCTTGAGATTGCCCGTGATATTGCCCAAGAGTTTCCAGACATAGCGTTTG
CGGATCGCTCCATAGAGGTGATATGCCAGGAATTAATGCAGAAACCCGAAAGATTTGATGTGCTGGTGATGCCAAATTTA
TATGGTGATTTGCTTGCCCATCTCTGTGCTGGCATGGTAGGTGGATTGAGTGTACCGATTGCGCATGTCGGCGATAAATA
TGCAGTGTTTGGTGCCCAATCAACGGGCACAGATGACGTGGGGCATGATCCGACCTCGCTCATCCTAGCCGGTGCGCTAA
TGTTGCGCCATTTAGGAGAACAGGAGGCTGCTCAAAGATTACAGGCCGCAGTGGAGGCTGTGGTTGCAAGCCATGTCGAT
ACGACTGCTGATTTAAATCCCGTTGGTTTTGAAGGGGTTGATTCCCAAGCGATGGCTCAAGCTATTACTCAAGCCATTGC
TGCTTGA

Upstream 100 bases:

>100_bases
TGAGGTTACGAGGACAGGAATAGGGTGCCTGTGCAAGTGTTAACTAGATTCGGATGATGAACGATCGCGGCTAAAGTCCT
AAATTGAGGGGGATAAGTAA

Downstream 100 bases:

>100_bases
GACCCTAAGCTCCCATTCCTGAGTAATGTTTGATGCCTCGACGCCACAGCCAGCGATTCATTACTAGGCCCAACACACAC
CAGGCCAGCATGATACCAAA

Product: isocitrate dehydrogenase NAD-dependent

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MGYPVVLIQEGELGAQVTNALQMAIAATGVDITWQIVDIGGEDQQGLLPNYIFDIIRTAKTAVIGPLMMPDNYRQMEADI
REKLDLYVNLRPAKTMVGIPSNYQNVDIMIVRETTEGIYAGIEFERTSVEAADARSFLSKLSGKRIREDAAVGIKPISVK
GCGQIIEFAFNYARKTKRHQVIAVHQAHFMAHTDGLFLEIARDIAQEFPDIAFADRSIEVICQELMQKPERFDVLVMPNL
YGDLLAHLCAGMVGGLSVPIAHVGDKYAVFGAQSTGTDDVGHDPTSLILAGALMLRHLGEQEAAQRLQAAVEAVVASHVD
TTADLNPVGFEGVDSQAMAQAITQAIAA

Sequences:

>Translated_348_residues
MGYPVVLIQEGELGAQVTNALQMAIAATGVDITWQIVDIGGEDQQGLLPNYIFDIIRTAKTAVIGPLMMPDNYRQMEADI
REKLDLYVNLRPAKTMVGIPSNYQNVDIMIVRETTEGIYAGIEFERTSVEAADARSFLSKLSGKRIREDAAVGIKPISVK
GCGQIIEFAFNYARKTKRHQVIAVHQAHFMAHTDGLFLEIARDIAQEFPDIAFADRSIEVICQELMQKPERFDVLVMPNL
YGDLLAHLCAGMVGGLSVPIAHVGDKYAVFGAQSTGTDDVGHDPTSLILAGALMLRHLGEQEAAQRLQAAVEAVVASHVD
TTADLNPVGFEGVDSQAMAQAITQAIAA
>Mature_347_residues
GYPVVLIQEGELGAQVTNALQMAIAATGVDITWQIVDIGGEDQQGLLPNYIFDIIRTAKTAVIGPLMMPDNYRQMEADIR
EKLDLYVNLRPAKTMVGIPSNYQNVDIMIVRETTEGIYAGIEFERTSVEAADARSFLSKLSGKRIREDAAVGIKPISVKG
CGQIIEFAFNYARKTKRHQVIAVHQAHFMAHTDGLFLEIARDIAQEFPDIAFADRSIEVICQELMQKPERFDVLVMPNLY
GDLLAHLCAGMVGGLSVPIAHVGDKYAVFGAQSTGTDDVGHDPTSLILAGALMLRHLGEQEAAQRLQAAVEAVVASHVDT
TADLNPVGFEGVDSQAMAQAITQAIAA

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:
GO:0000287: Isocitrate dehydrogenase NAD-dependent
GO:0016616: Isocitrate dehydrogenase NAD-dependent
GO:0051287: Isocitrate dehydrogenase NAD-dependent
GO:0055114: Isocitrate dehydrogenase NAD-dependent

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=332, Percent_Identity=34.6385542168675, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI28178816, Length=339, Percent_Identity=30.9734513274336, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI28178821, Length=312, Percent_Identity=32.0512820512821, Blast_Score=158, Evalue=5e-39,
Organism=Homo sapiens, GI4758582, Length=302, Percent_Identity=32.4503311258278, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI28178838, Length=256, Percent_Identity=33.984375, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI28178819, Length=141, Percent_Identity=44.6808510638298, Blast_Score=118, Evalue=9e-27,
Organism=Escherichia coli, GI1787381, Length=364, Percent_Identity=30.4945054945055, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1788101, Length=291, Percent_Identity=27.1477663230241, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI87081683, Length=369, Percent_Identity=25.4742547425474, Blast_Score=89, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71986051, Length=335, Percent_Identity=35.2238805970149, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI25144293, Length=254, Percent_Identity=36.2204724409449, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17505779, Length=262, Percent_Identity=35.4961832061069, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17550882, Length=255, Percent_Identity=36.8627450980392, Blast_Score=144, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6324709, Length=336, Percent_Identity=30.3571428571429, Blast_Score=162, Evalue=9e-41,
Organism=Saccharomyces cerevisiae, GI6324291, Length=333, Percent_Identity=30.9309309309309, Blast_Score=155, Evalue=7e-39,
Organism=Saccharomyces cerevisiae, GI6322097, Length=275, Percent_Identity=30.5454545454545, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24643270, Length=331, Percent_Identity=34.7432024169184, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24643268, Length=331, Percent_Identity=34.7432024169184, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24661184, Length=338, Percent_Identity=29.585798816568, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI161078635, Length=334, Percent_Identity=27.2455089820359, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI161078633, Length=334, Percent_Identity=27.2455089820359, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24650122, Length=334, Percent_Identity=27.2455089820359, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI161078637, Length=334, Percent_Identity=27.2455089820359, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI161078639, Length=254, Percent_Identity=31.496062992126, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI281362242, Length=304, Percent_Identity=29.9342105263158, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24648872, Length=304, Percent_Identity=29.9342105263158, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI20130355, Length=317, Percent_Identity=28.0757097791798, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI45550436, Length=288, Percent_Identity=22.2222222222222, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 37750; Mature: 37619

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYPVVLIQEGELGAQVTNALQMAIAATGVDITWQIVDIGGEDQQGLLPNYIFDIIRTAK
CCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHH
TAVIGPLMMPDNYRQMEADIREKLDLYVNLRPAKTMVGIPSNYQNVDIMIVRETTEGIYA
HHHHCCCCCCCCHHHHHHHHHHCCEEEEEEECCCEEEECCCCCCCEEEEEEEECCCCEEE
GIEFERTSVEAADARSFLSKLSGKRIREDAAVGIKPISVKGCGQIIEFAFNYARKTKRHQ
CEEEECCCCCHHHHHHHHHHHCCCHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCCE
VIAVHQAHFMAHTDGLFLEIARDIAQEFPDIAFADRSIEVICQELMQKPERFDVLVMPNL
EEEEEHHHHHHCCCCHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHCCCCCCEEEECCHH
YGDLLAHLCAGMVGGLSVPIAHVGDKYAVFGAQSTGTDDVGHDPTSLILAGALMLRHLGE
HHHHHHHHHHHHHCCCCCCHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCH
QEAAQRLQAAVEAVVASHVDTTADLNPVGFEGVDSQAMAQAITQAIAA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
GYPVVLIQEGELGAQVTNALQMAIAATGVDITWQIVDIGGEDQQGLLPNYIFDIIRTAK
CCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHH
TAVIGPLMMPDNYRQMEADIREKLDLYVNLRPAKTMVGIPSNYQNVDIMIVRETTEGIYA
HHHHCCCCCCCCHHHHHHHHHHCCEEEEEEECCCEEEECCCCCCCEEEEEEEECCCCEEE
GIEFERTSVEAADARSFLSKLSGKRIREDAAVGIKPISVKGCGQIIEFAFNYARKTKRHQ
CEEEECCCCCHHHHHHHHHHHCCCHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCCE
VIAVHQAHFMAHTDGLFLEIARDIAQEFPDIAFADRSIEVICQELMQKPERFDVLVMPNL
EEEEEHHHHHHCCCCHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHCCCCCCEEEECCHH
YGDLLAHLCAGMVGGLSVPIAHVGDKYAVFGAQSTGTDDVGHDPTSLILAGALMLRHLGE
HHHHHHHHHHHHHCCCCCCHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCH
QEAAQRLQAAVEAVVASHVDTTADLNPVGFEGVDSQAMAQAITQAIAA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9325430; 9389475 [H]