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The map label for this gene is trx [H]

Identifier: 158338541

GI number: 158338541

Start: 5501626

End: 5501946

Strand: Direct

Name: trx [H]

Synonym: AM1_5443

Alternate gene names: 158338541

Gene position: 5501626-5501946 (Clockwise)

Preceding gene: 158338540

Following gene: 158338542

Centisome position: 84.59

GC content: 45.17

Gene sequence:

>321_bases
ATGAGTACCGTAGCTTACATACAAGACAACGAGTTTGAACAGTTGCTTAAGGATGAGTCCATCCTTGTGATCGACTTTAC
AGCCACCTGGTGTGGTCCCTGCAAACAAGTGAGTCCCATGATGGACAAATTGGCCACTGATTATGATGGTCGAGCCAAAG
TCACCAAAGTTGACGTTGACAAGAATAAAGGTATTGCCAAGCAATTTGGCATTCGCAGCATTCCAGCAGTCTTAGTCTTT
AAATCGGGCGAACTCGTCGAAACTCTGGTGGGCATGAGTCCCTATGAGAAATTTACCAGCGCTGTGGATAAACACCTTTA
A

Upstream 100 bases:

>100_bases
TGGCGGCTGGATTCGTGCTGACCTGCGTTGCCTACCCTGCATCAGACTGCACGATTCAAACCCACCAAGAAGATGCTCTA
CTTTAGGTTTTGAAAAGATT

Downstream 100 bases:

>100_bases
ACCGTCGATCCATTCCTTTCGACCAGGATATACCCATGAGTCAAATTGGCACGAATACCACCCAAACCATTTGCTGCCCT
CAATGCGGCTCCCCTGCAAG

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 106; Mature: 105

Protein sequence:

>106_residues
MSTVAYIQDNEFEQLLKDESILVIDFTATWCGPCKQVSPMMDKLATDYDGRAKVTKVDVDKNKGIAKQFGIRSIPAVLVF
KSGELVETLVGMSPYEKFTSAVDKHL

Sequences:

>Translated_106_residues
MSTVAYIQDNEFEQLLKDESILVIDFTATWCGPCKQVSPMMDKLATDYDGRAKVTKVDVDKNKGIAKQFGIRSIPAVLVF
KSGELVETLVGMSPYEKFTSAVDKHL
>Mature_105_residues
STVAYIQDNEFEQLLKDESILVIDFTATWCGPCKQVSPMMDKLATDYDGRAKVTKVDVDKNKGIAKQFGIRSIPAVLVFK
SGELVETLVGMSPYEKFTSAVDKHL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=92, Percent_Identity=34.7826086956522, Blast_Score=71, Evalue=2e-13,
Organism=Homo sapiens, GI5803121, Length=86, Percent_Identity=34.8837209302326, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87082331, Length=104, Percent_Identity=37.5, Blast_Score=94, Evalue=2e-21,
Organism=Escherichia coli, GI1788936, Length=95, Percent_Identity=37.8947368421053, Blast_Score=89, Evalue=6e-20,
Organism=Escherichia coli, GI87081747, Length=73, Percent_Identity=38.3561643835616, Blast_Score=65, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=92, Percent_Identity=38.0434782608696, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71980565, Length=84, Percent_Identity=38.0952380952381, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71998175, Length=93, Percent_Identity=32.258064516129, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17509965, Length=83, Percent_Identity=31.3253012048193, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=70, Percent_Identity=41.4285714285714, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=80, Percent_Identity=30, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=85, Percent_Identity=37.6470588235294, Blast_Score=76, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=85, Percent_Identity=40, Blast_Score=73, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321648, Length=80, Percent_Identity=38.75, Blast_Score=70, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24639826, Length=91, Percent_Identity=38.4615384615385, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24664269, Length=101, Percent_Identity=36.6336633663366, Blast_Score=75, Evalue=7e-15,
Organism=Drosophila melanogaster, GI28573567, Length=95, Percent_Identity=29.4736842105263, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17530795, Length=91, Percent_Identity=31.8681318681319, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17648013, Length=71, Percent_Identity=43.6619718309859, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24583090, Length=71, Percent_Identity=43.6619718309859, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11792; Mature: 11661

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVAYIQDNEFEQLLKDESILVIDFTATWCGPCKQVSPMMDKLATDYDGRAKVTKVDVD
CCEEEEEECCHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECC
KNKGIAKQFGIRSIPAVLVFKSGELVETLVGMSPYEKFTSAVDKHL
CCCCHHHHCCCCCCCEEEEECCCHHHHHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
STVAYIQDNEFEQLLKDESILVIDFTATWCGPCKQVSPMMDKLATDYDGRAKVTKVDVD
CEEEEEECCHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECC
KNKGIAKQFGIRSIPAVLVFKSGELVETLVGMSPYEKFTSAVDKHL
CCCCHHHHCCCCCCCEEEEECCCHHHHHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2492995 [H]