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The map label for this gene is pcoR [H]

Identifier: 158338273

GI number: 158338273

Start: 5232753

End: 5233526

Strand: Reverse

Name: pcoR [H]

Synonym: AM1_5169

Alternate gene names: 158338273

Gene position: 5233526-5232753 (Counterclockwise)

Preceding gene: 158338275

Following gene: 158338272

Centisome position: 80.47

GC content: 48.84

Gene sequence:

>774_bases
ATGCAGAAGATCCTGATCATTGAAGATGAAACGCAAACCCGCAACTTATTTTTGAATTGCTTAAAATTTGAGGGATTTGA
AGCCCTGGGAGCAGACAACGGATCCTTCGGCGTTCAACTTGCCCAGAAGTTTCATCCTGGGCTGGTGGTTTGCGACATTA
TGATGCCAGATATGGATGGCTATCAGGTGCTGTCTCAATTGCGGCAACATCCAGAGACTGCGACAATACCGTTTATCTTT
CTGACAGCCAAAGTGACCATGTCAGAATTGCGCCAGGGGATGACCTTGGGGGCAGATGACTATTTAACGAAGCCCTGTAC
GATTGATGATTTTTTAGCTGCGATCGCAACCCGTTTCCAAAGACAATCCGAGCTGCGGGGTCAGATGGGGACTCCACCTG
CCCCAGACCTCTCTACCGCTGATCGCATCTTTCCCCATTGCCCCCAATTGAATGCGGTTTTTGATTTTATTGAAGCGAAC
TACTGCCAGCCCTTGCATCTAAAAGATGTGGCAACTGTCGCCGGTTACTCTCCTGCCTATCTGACCCACCTGATGCAAAC
TCAAACGGGGCGTACCGTTAAGCAATGGATTGTGGAACGACGGATGAGTGAAGCACGGACCTTGCTGTTGCAGACTAAAC
AGTCCATCAAGAAAATAGCGATTACCCTTGGCTATGCTGATCCAGGTTATTTTATCCGTCAATTTCGCCAGCATCATGGT
ACCTCCCCTCACGGATGGCGACGACAATCCCATATTGAGTCCTCCCTGAGTTAA

Upstream 100 bases:

>100_bases
ACTCTAGGGTTGGCAACAACGTACAGATTAATCAGGGAGCAGTTAAAAACCAATTCATCCAATCTCAAAAAATGCCCTGC
CTGACTGGGGTATTGCCGTT

Downstream 100 bases:

>100_bases
ATCAAAAATCTAAAAAAAATCCTATTGACTTCTAAAATATGTCCACTTTCAGCGTCTAGGTTCGTTGGTAAGCTAATAAA
TGAGCAGTAATTATCAGAAA

Product: two component AraC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MQKILIIEDETQTRNLFLNCLKFEGFEALGADNGSFGVQLAQKFHPGLVVCDIMMPDMDGYQVLSQLRQHPETATIPFIF
LTAKVTMSELRQGMTLGADDYLTKPCTIDDFLAAIATRFQRQSELRGQMGTPPAPDLSTADRIFPHCPQLNAVFDFIEAN
YCQPLHLKDVATVAGYSPAYLTHLMQTQTGRTVKQWIVERRMSEARTLLLQTKQSIKKIAITLGYADPGYFIRQFRQHHG
TSPHGWRRQSHIESSLS

Sequences:

>Translated_257_residues
MQKILIIEDETQTRNLFLNCLKFEGFEALGADNGSFGVQLAQKFHPGLVVCDIMMPDMDGYQVLSQLRQHPETATIPFIF
LTAKVTMSELRQGMTLGADDYLTKPCTIDDFLAAIATRFQRQSELRGQMGTPPAPDLSTADRIFPHCPQLNAVFDFIEAN
YCQPLHLKDVATVAGYSPAYLTHLMQTQTGRTVKQWIVERRMSEARTLLLQTKQSIKKIAITLGYADPGYFIRQFRQHHG
TSPHGWRRQSHIESSLS
>Mature_257_residues
MQKILIIEDETQTRNLFLNCLKFEGFEALGADNGSFGVQLAQKFHPGLVVCDIMMPDMDGYQVLSQLRQHPETATIPFIF
LTAKVTMSELRQGMTLGADDYLTKPCTIDDFLAAIATRFQRQSELRGQMGTPPAPDLSTADRIFPHCPQLNAVFDFIEAN
YCQPLHLKDVATVAGYSPAYLTHLMQTQTGRTVKQWIVERRMSEARTLLLQTKQSIKKIAITLGYADPGYFIRQFRQHHG
TSPHGWRRQSHIESSLS

Specific function: Probable member of a two-component regulatory system pcoS/pcoR. May be involved in the activation of copper resistance gene operon pcoABCD by binding to a specific site on the cop operon promoter (copper box) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=123, Percent_Identity=34.9593495934959, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1786784, Length=119, Percent_Identity=37.8151260504202, Blast_Score=80, Evalue=9e-17,
Organism=Escherichia coli, GI87082012, Length=127, Percent_Identity=33.8582677165354, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1786599, Length=124, Percent_Identity=30.6451612903226, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790552, Length=121, Percent_Identity=33.0578512396694, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1786911, Length=123, Percent_Identity=31.7073170731707, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1790863, Length=102, Percent_Identity=35.2941176470588, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788394, Length=134, Percent_Identity=28.3582089552239, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790391, Length=102, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1789809, Length=123, Percent_Identity=32.520325203252, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI145693157, Length=106, Percent_Identity=32.0754716981132, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 29064; Mature: 29064

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKILIIEDETQTRNLFLNCLKFEGFEALGADNGSFGVQLAQKFHPGLVVCDIMMPDMDG
CCEEEEEECCCHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHCCCCEEEEEEECCCCCH
YQVLSQLRQHPETATIPFIFLTAKVTMSELRQGMTLGADDYLTKPCTIDDFLAAIATRFQ
HHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHCCCCCCCCHHCCCCCCHHHHHHHHHHHHH
RQSELRGQMGTPPAPDLSTADRIFPHCPQLNAVFDFIEANYCQPLHLKDVATVAGYSPAY
HHHHHCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHH
LTHLMQTQTGRTVKQWIVERRMSEARTLLLQTKQSIKKIAITLGYADPGYFIRQFRQHHG
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHEECCCCHHHHHHHHHHHCC
TSPHGWRRQSHIESSLS
CCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MQKILIIEDETQTRNLFLNCLKFEGFEALGADNGSFGVQLAQKFHPGLVVCDIMMPDMDG
CCEEEEEECCCHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHCCCCEEEEEEECCCCCH
YQVLSQLRQHPETATIPFIFLTAKVTMSELRQGMTLGADDYLTKPCTIDDFLAAIATRFQ
HHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHCCCCCCCCHHCCCCCCHHHHHHHHHHHHH
RQSELRGQMGTPPAPDLSTADRIFPHCPQLNAVFDFIEANYCQPLHLKDVATVAGYSPAY
HHHHHCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHH
LTHLMQTQTGRTVKQWIVERRMSEARTLLLQTKQSIKKIAITLGYADPGYFIRQFRQHHG
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHEECCCCHHHHHHHHHHHCC
TSPHGWRRQSHIESSLS
CCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8594334; 9141682 [H]