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The map label for this gene is shc [H]

Identifier: 158337958

GI number: 158337958

Start: 4885716

End: 4887635

Strand: Reverse

Name: shc [H]

Synonym: AM1_4845

Alternate gene names: 158337958

Gene position: 4887635-4885716 (Counterclockwise)

Preceding gene: 158337960

Following gene: 158337955

Centisome position: 75.15

GC content: 52.76

Gene sequence:

>1920_bases
ATGGCTGTTCGAGACAGAGTGAATCCCAAAACCCTTGAAGCTGCGATCGCAGCTTCGCAAAGCTATCTGCTCACCCAACA
AGACGAGACGGGCTATTGGTGGGCAGAGCTTGAATCCAATGTTTCGATTACTTCTGAAGTGGTGCTGCTGCACAAGATTT
GGGGAACAGATCGTAGTCGGCCCTTGGAGAAGGTGGAAACATATTTGCGATCGCAACAGCGAGACCACGGTGGCTGGGAA
CTCTACTTCGACGACGGGGGAGAAATCAGCGTCTCTGTCGAAGCCTACATGGCCCTGAAGCTCTTAGGCGTGCCCATGGA
AGATCCGGCCATGGTGCGGGCACGGCAGTTTATTTTGGAGCATGGGGGAATTAGCCGCACCCGCGTGTTTACCAAGCTGC
ATTTAGCCCTGATTGGCTGCTATGAATGGCGAGGGATTCCCTCTCTTCCGCCCTGGGTGATGTTGTTGCCCGAACAGTTT
CCTTTCACCATTTATGAGATGTCGAGTTGGGCCAGGGGCAGCACCGTCCCCTTGCTGATCGTGATGGATCGGGAGCCAGT
CTATGCCGTGGAAGCTGGGTTCAACTTGGATGAACTCTATGTAGAAGGCCGCCATCGCGCCCAGTTTGATCTGCCCCTCA
GCAACGAATGGACCGATGCCTTTATCTATTTAGATGGCCTATTCAAATTTGCTGAATCGACCAATCTTGTCCCCTTTCGA
GAAGAAGGAATTCGCGCTGCTGAACGTTGGATTTTGGAACGTCAAGAAGCAACGGGGGATTGGGGAGGGATTATCCCGGC
CATGCTCAATTCTCTTTTGGGTCTTAAGGCCCTGGACTATGATGTCCACGATCCGATTATTGAACGGGGCATGGCAGCTC
TGGATGCCTTTGCCCTCGAAACCGAAGACCAATATTGGATTCAACCCTGTATCTCTCCTGTATGGGATACGGCCTTGGTC
GTGCGAGGGCTGGCTGAGTCCGGGTTAGCGCCCGATCATCCTGCCCTAGTGAAAGCGGGAGAATGGCTGCTGAATAAGCA
AATCCTAGATTACGGAGATTGGTCCGTGAAAAATCCAGGGGGTTTACCTGGGGGCTGGGCCTTTGAGTTTGACAATCGCT
TTTATCCCGATGTGGATGATACCGCCGTTGTGGTCATGGCCTTAAACGAAGTCCAGCTACCGGACGAGCAGGCTAAGGAT
GCAGCCATTGCCAGAGCCGTTAACTGGATTGCCACGATGCAATGCCGTCCTGGAGGGTGGGCTGCCTTTGATATCAATAA
TGATCAAGACTGGCTGAACGCCTTGCCCTACGGGGATCTGAAAGCCATGATTGACCCCAATACTGCCGATGTCACGGCCC
GAGTGTTAGAAATGATCGGTCGTTGCCATCAAACAACAGGGAAAAACAGTGTGGATCGAGCCCTTCGATATTTGCGAACT
GAGCAAGAACCGGAGGGGTGCTGGTTTGGACGCTGGGGGGTTAATTATATTTACGGCACGAGTGGCGTACTGGCTGCTCT
AGCCTTGATCGATCCCCAGGGCTGGCAATCCCAAATTCAGCAAGCAGCAGCTTGGTTAGTAAGTTGCCAAAATACGGATG
GGGGTTGGGGCGAGACTTGTGCCAGCTACGATAACCCTAAGCTTAAAGGCCAAGGTCCTAGCACAGCCTCCCAAACGGCT
TGGGCTATTATGGGGCTATTGTCGGCGGGGGAAGCGACCTCTGTCTATGCCGAGGCTGCAATTGAGCGGGGCGTGAATTA
CCTCACGACGACGCAAAAGATGGATGGCACTTGGGATGAAGACTATTTCACAGGGACTGGTTTTCCCGGCCATTTCTATC
TGAAATATCACCTTTACCAGCAGCATTTTCCCTTAACGGCTTTGGGCAGGTACCAGGCCATGTTGCAACAAAAGAGTTAG

Upstream 100 bases:

>100_bases
GTGTTCCAGATAGGAGAGTGGAACCACCATCGTGCTGTACCTTTGCGGAATCCGGTAAGATGAATCGACCGTCGTCACAA
TTGACTGAGTTTTAAGCGCT

Downstream 100 bases:

>100_bases
GTCATCTGAGAATGAGGCCCATAAATGGGGTTACTGAATGCTATTGGCTTCAGTTAATAGCTCTTTGACAGCCGCTTTAT
CGGTCTGGGTCAATAGCCGG

Product: squalene-hopene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 639; Mature: 638

Protein sequence:

>639_residues
MAVRDRVNPKTLEAAIAASQSYLLTQQDETGYWWAELESNVSITSEVVLLHKIWGTDRSRPLEKVETYLRSQQRDHGGWE
LYFDDGGEISVSVEAYMALKLLGVPMEDPAMVRARQFILEHGGISRTRVFTKLHLALIGCYEWRGIPSLPPWVMLLPEQF
PFTIYEMSSWARGSTVPLLIVMDREPVYAVEAGFNLDELYVEGRHRAQFDLPLSNEWTDAFIYLDGLFKFAESTNLVPFR
EEGIRAAERWILERQEATGDWGGIIPAMLNSLLGLKALDYDVHDPIIERGMAALDAFALETEDQYWIQPCISPVWDTALV
VRGLAESGLAPDHPALVKAGEWLLNKQILDYGDWSVKNPGGLPGGWAFEFDNRFYPDVDDTAVVVMALNEVQLPDEQAKD
AAIARAVNWIATMQCRPGGWAAFDINNDQDWLNALPYGDLKAMIDPNTADVTARVLEMIGRCHQTTGKNSVDRALRYLRT
EQEPEGCWFGRWGVNYIYGTSGVLAALALIDPQGWQSQIQQAAAWLVSCQNTDGGWGETCASYDNPKLKGQGPSTASQTA
WAIMGLLSAGEATSVYAEAAIERGVNYLTTTQKMDGTWDEDYFTGTGFPGHFYLKYHLYQQHFPLTALGRYQAMLQQKS

Sequences:

>Translated_639_residues
MAVRDRVNPKTLEAAIAASQSYLLTQQDETGYWWAELESNVSITSEVVLLHKIWGTDRSRPLEKVETYLRSQQRDHGGWE
LYFDDGGEISVSVEAYMALKLLGVPMEDPAMVRARQFILEHGGISRTRVFTKLHLALIGCYEWRGIPSLPPWVMLLPEQF
PFTIYEMSSWARGSTVPLLIVMDREPVYAVEAGFNLDELYVEGRHRAQFDLPLSNEWTDAFIYLDGLFKFAESTNLVPFR
EEGIRAAERWILERQEATGDWGGIIPAMLNSLLGLKALDYDVHDPIIERGMAALDAFALETEDQYWIQPCISPVWDTALV
VRGLAESGLAPDHPALVKAGEWLLNKQILDYGDWSVKNPGGLPGGWAFEFDNRFYPDVDDTAVVVMALNEVQLPDEQAKD
AAIARAVNWIATMQCRPGGWAAFDINNDQDWLNALPYGDLKAMIDPNTADVTARVLEMIGRCHQTTGKNSVDRALRYLRT
EQEPEGCWFGRWGVNYIYGTSGVLAALALIDPQGWQSQIQQAAAWLVSCQNTDGGWGETCASYDNPKLKGQGPSTASQTA
WAIMGLLSAGEATSVYAEAAIERGVNYLTTTQKMDGTWDEDYFTGTGFPGHFYLKYHLYQQHFPLTALGRYQAMLQQKS
>Mature_638_residues
AVRDRVNPKTLEAAIAASQSYLLTQQDETGYWWAELESNVSITSEVVLLHKIWGTDRSRPLEKVETYLRSQQRDHGGWEL
YFDDGGEISVSVEAYMALKLLGVPMEDPAMVRARQFILEHGGISRTRVFTKLHLALIGCYEWRGIPSLPPWVMLLPEQFP
FTIYEMSSWARGSTVPLLIVMDREPVYAVEAGFNLDELYVEGRHRAQFDLPLSNEWTDAFIYLDGLFKFAESTNLVPFRE
EGIRAAERWILERQEATGDWGGIIPAMLNSLLGLKALDYDVHDPIIERGMAALDAFALETEDQYWIQPCISPVWDTALVV
RGLAESGLAPDHPALVKAGEWLLNKQILDYGDWSVKNPGGLPGGWAFEFDNRFYPDVDDTAVVVMALNEVQLPDEQAKDA
AIARAVNWIATMQCRPGGWAAFDINNDQDWLNALPYGDLKAMIDPNTADVTARVLEMIGRCHQTTGKNSVDRALRYLRTE
QEPEGCWFGRWGVNYIYGTSGVLAALALIDPQGWQSQIQQAAAWLVSCQNTDGGWGETCASYDNPKLKGQGPSTASQTAW
AIMGLLSAGEATSVYAEAAIERGVNYLTTTQKMDGTWDEDYFTGTGFPGHFYLKYHLYQQHFPLTALGRYQAMLQQKS

Specific function: Catalyzes the cyclization of squalene into hopene [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI224177558, Length=626, Percent_Identity=25.5591054313099, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI47933395, Length=626, Percent_Identity=25.5591054313099, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI47933397, Length=626, Percent_Identity=25.5591054313099, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI224177556, Length=607, Percent_Identity=24.7116968698517, Blast_Score=128, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6321863, Length=694, Percent_Identity=21.7579250720461, Blast_Score=115, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006400
- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR002365
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 71644; Mature: 71512

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVRDRVNPKTLEAAIAASQSYLLTQQDETGYWWAELESNVSITSEVVLLHKIWGTDRSR
CCCCCCCCHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCCHHHHEEEHHHHCCCCCC
PLEKVETYLRSQQRDHGGWELYFDDGGEISVSVEAYMALKLLGVPMEDPAMVRARQFILE
CHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEHHHEEEHHHHCCCCCCHHHHHHHHHHHH
HGGISRTRVFTKLHLALIGCYEWRGIPSLPPWVMLLPEQFPFTIYEMSSWARGSTVPLLI
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCEEEEECCCCCCCCCCEEEE
VMDREPVYAVEAGFNLDELYVEGRHRAQFDLPLSNEWTDAFIYLDGLFKFAESTNLVPFR
EECCCCEEEEECCCCHHHHEECCCCCEEECCCCCCCCCCEEEEHHHHHHHHHCCCCCCCH
EEGIRAAERWILERQEATGDWGGIIPAMLNSLLGLKALDYDVHDPIIERGMAALDAFALE
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCC
TEDQYWIQPCISPVWDTALVVRGLAESGLAPDHPALVKAGEWLLNKQILDYGDWSVKNPG
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
GLPGGWAFEFDNRFYPDVDDTAVVVMALNEVQLPDEQAKDAAIARAVNWIATMQCRPGGW
CCCCCEEEEECCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHEEEEECCCCE
AAFDINNDQDWLNALPYGDLKAMIDPNTADVTARVLEMIGRCHQTTGKNSVDRALRYLRT
EEEECCCCHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
EQEPEGCWFGRWGVNYIYGTSGVLAALALIDPQGWQSQIQQAAAWLVSCQNTDGGWGETC
CCCCCCCEEECCCCCEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHEEECCCCCCCCHHH
ASYDNPKLKGQGPSTASQTAWAIMGLLSAGEATSVYAEAAIERGVNYLTTTQKMDGTWDE
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCC
DYFTGTGFPGHFYLKYHLYQQHFPLTALGRYQAMLQQKS
CCEECCCCCCEEEEEEEEEHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AVRDRVNPKTLEAAIAASQSYLLTQQDETGYWWAELESNVSITSEVVLLHKIWGTDRSR
CCCCCCCHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCCHHHHEEEHHHHCCCCCC
PLEKVETYLRSQQRDHGGWELYFDDGGEISVSVEAYMALKLLGVPMEDPAMVRARQFILE
CHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEHHHEEEHHHHCCCCCCHHHHHHHHHHHH
HGGISRTRVFTKLHLALIGCYEWRGIPSLPPWVMLLPEQFPFTIYEMSSWARGSTVPLLI
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCEEEEECCCCCCCCCCEEEE
VMDREPVYAVEAGFNLDELYVEGRHRAQFDLPLSNEWTDAFIYLDGLFKFAESTNLVPFR
EECCCCEEEEECCCCHHHHEECCCCCEEECCCCCCCCCCEEEEHHHHHHHHHCCCCCCCH
EEGIRAAERWILERQEATGDWGGIIPAMLNSLLGLKALDYDVHDPIIERGMAALDAFALE
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCC
TEDQYWIQPCISPVWDTALVVRGLAESGLAPDHPALVKAGEWLLNKQILDYGDWSVKNPG
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
GLPGGWAFEFDNRFYPDVDDTAVVVMALNEVQLPDEQAKDAAIARAVNWIATMQCRPGGW
CCCCCEEEEECCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHEEEEECCCCE
AAFDINNDQDWLNALPYGDLKAMIDPNTADVTARVLEMIGRCHQTTGKNSVDRALRYLRT
EEEECCCCHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
EQEPEGCWFGRWGVNYIYGTSGVLAALALIDPQGWQSQIQQAAAWLVSCQNTDGGWGETC
CCCCCCCEEECCCCCEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHEEECCCCCCCCHHH
ASYDNPKLKGQGPSTASQTAWAIMGLLSAGEATSVYAEAAIERGVNYLTTTQKMDGTWDE
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCC
DYFTGTGFPGHFYLKYHLYQQHFPLTALGRYQAMLQQKS
CCEECCCCCCEEEEEEEEEHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1729216; 9532806; 2253626; 9295270; 9931258 [H]