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The map label for this gene is trx [H]

Identifier: 158337952

GI number: 158337952

Start: 4879757

End: 4880080

Strand: Direct

Name: trx [H]

Synonym: AM1_4839

Alternate gene names: 158337952

Gene position: 4879757-4880080 (Clockwise)

Preceding gene: 158337950

Following gene: 158337953

Centisome position: 75.03

GC content: 49.07

Gene sequence:

>324_bases
ATGTCTTCTACTACTGCTATCAATGACACCACCTTTACTGCAGAGGTGCTTGAGAGCCAGCAACCCGTTCTCGTCGATTT
TTGGGCCCCTTGGTGTGGGCCTTGCCGTATGGTCGGTCCCATCGTTGATGACATCGCTGCGGACTACCAAGATCAAGTCA
AAGTCGTTAAGTTCAATGTGGATGAGAGCAGTGATGTTGCCAGCCGATATGGCATTCGTAGCATTCCAACGCTGATCGTC
TTTAAGGAAGGCCAACCCGTTGAAACGCTGGTAGGGGCATCTCCTAAAGCAACCTTGGTTGAATCCTTAGACAAACATTT
GTAA

Upstream 100 bases:

>100_bases
TGGGTGGAACAAAATTTTCATAGTTGCATTATGCCATGGGATGATTTATATTTTAATTGTTCGAGATTCTCGAATATACG
AACAATAAGGAGGCCCCATT

Downstream 100 bases:

>100_bases
GACGCCTGATTTTTCGTTCCTGACGGTAAGGCGAAGCGCGCGCCGCCTTACCGTTTACTTTGTCCTGCTTGGCAGGCAAG
TTCAGTTCTTATACTCCAAA

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MSSTTAINDTTFTAEVLESQQPVLVDFWAPWCGPCRMVGPIVDDIAADYQDQVKVVKFNVDESSDVASRYGIRSIPTLIV
FKEGQPVETLVGASPKATLVESLDKHL

Sequences:

>Translated_107_residues
MSSTTAINDTTFTAEVLESQQPVLVDFWAPWCGPCRMVGPIVDDIAADYQDQVKVVKFNVDESSDVASRYGIRSIPTLIV
FKEGQPVETLVGASPKATLVESLDKHL
>Mature_106_residues
SSTTAINDTTFTAEVLESQQPVLVDFWAPWCGPCRMVGPIVDDIAADYQDQVKVVKFNVDESSDVASRYGIRSIPTLIVF
KEGQPVETLVGASPKATLVESLDKHL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=110, Percent_Identity=34.5454545454545, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI5031973, Length=103, Percent_Identity=33.0097087378641, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI87082331, Length=101, Percent_Identity=48.5148514851485, Blast_Score=114, Evalue=2e-27,
Organism=Escherichia coli, GI1788936, Length=93, Percent_Identity=47.3118279569892, Blast_Score=102, Evalue=5e-24,
Organism=Escherichia coli, GI87081747, Length=103, Percent_Identity=34.9514563106796, Blast_Score=71, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=81, Percent_Identity=40.7407407407407, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17507705, Length=89, Percent_Identity=35.9550561797753, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17509965, Length=74, Percent_Identity=39.1891891891892, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71998175, Length=85, Percent_Identity=41.1764705882353, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71980562, Length=82, Percent_Identity=35.3658536585366, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=82, Percent_Identity=35.3658536585366, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=81, Percent_Identity=38.2716049382716, Blast_Score=65, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=75, Percent_Identity=48, Blast_Score=80, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323072, Length=75, Percent_Identity=44, Blast_Score=78, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319925, Length=96, Percent_Identity=34.375, Blast_Score=75, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24639826, Length=91, Percent_Identity=38.4615384615385, Blast_Score=85, Evalue=8e-18,
Organism=Drosophila melanogaster, GI17648013, Length=78, Percent_Identity=42.3076923076923, Blast_Score=79, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24583090, Length=78, Percent_Identity=42.3076923076923, Blast_Score=79, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24664269, Length=76, Percent_Identity=39.4736842105263, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28573567, Length=94, Percent_Identity=31.9148936170213, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17530795, Length=93, Percent_Identity=32.258064516129, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21358065, Length=81, Percent_Identity=38.2716049382716, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11685; Mature: 11554

Theoretical pI: Translated: 4.18; Mature: 4.18

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTTAINDTTFTAEVLESQQPVLVDFWAPWCGPCRMVGPIVDDIAADYQDQVKVVKFNV
CCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEC
DESSDVASRYGIRSIPTLIVFKEGQPVETLVGASPKATLVESLDKHL
CCCCHHHHHCCCCCCCEEEEEECCCCHHHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
SSTTAINDTTFTAEVLESQQPVLVDFWAPWCGPCRMVGPIVDDIAADYQDQVKVVKFNV
CCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEC
DESSDVASRYGIRSIPTLIVFKEGQPVETLVGASPKATLVESLDKHL
CCCCHHHHHCCCCCCCEEEEEECCCCHHHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2492995 [H]