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The map label for this gene is ham1 [C]

Identifier: 158337787

GI number: 158337787

Start: 4705284

End: 4705859

Strand: Direct

Name: ham1 [C]

Synonym: AM1_4672

Alternate gene names: 158337787

Gene position: 4705284-4705859 (Clockwise)

Preceding gene: 158337785

Following gene: 158337790

Centisome position: 72.35

GC content: 53.82

Gene sequence:

>576_bases
ATGCCCCCCTTGATTGTGGCTACCCAAAACCCTGGCAAATTGAAAGAGATGCAGCAACACCTGGCCGATTTGCCCTGGGA
GTTACAGCTAATGCCCCCGGATCTAGAGATTGAAGAAACCGGCACCACCTTTCGGGAAAATGCCATTCTCAAGGCAACTC
AGGTGGCAAAGCACTTGGGGCAATGGGCGATTGCCGATGATTCAGGCTTAGAAGTTATGGCTCTGGATGGAGCCCCCGGT
CTTTACTCGGCCCGATATGGCAAAACCGATATAGATCGGATTCAACGTCTGCTGACAGAACTCCAGGGAAAGACCGATCG
CAGTGCTCAATTCGTTTGCGTAATTGCGTTGGCCCGACCGGATGGCAGCGTAGCCTGTCAAGCAAAAGGCGTTTGTCCGG
GAGAAATTCTGCAGGCTCCGCAAGGCGAGGGGGGCTTTGGCTATGATCCCATTTTCTATGTTCCCTCTCAGCAGCAAACC
TTTGCCGAACTCTCGGCAACTGCCAAACGCCAGATCAGCCATCGGGGGGAAGCCATCAAGGTCCTGATGCCCCAGCTATT
GGCTTTGGAGACTTAG

Upstream 100 bases:

>100_bases
GCCGGCATGGTCCGTCATCATCAAAGCAAACGTCGCTCCTATCCTAGGTGATTGGTCGCAAGGATAACAGAACTGATTTT
TAACAGAGGAGATCCACCCC

Downstream 100 bases:

>100_bases
GGGGAAATAACTAAATGCCACTCAGCATCCGTCTGTTTAAGGGTGGGCTGTGGGGTATCTCCCACCACATAAGGCCCCCA
GTATTTTTGCGATCCATCGA

Product: RdgB/HAM1 family non-canonical purine NTP pyrophosphatase

Products: NA

Alternate protein names: Nucleoside triphosphate phosphohydrolase; NTPase [H]

Number of amino acids: Translated: 191; Mature: 190

Protein sequence:

>191_residues
MPPLIVATQNPGKLKEMQQHLADLPWELQLMPPDLEIEETGTTFRENAILKATQVAKHLGQWAIADDSGLEVMALDGAPG
LYSARYGKTDIDRIQRLLTELQGKTDRSAQFVCVIALARPDGSVACQAKGVCPGEILQAPQGEGGFGYDPIFYVPSQQQT
FAELSATAKRQISHRGEAIKVLMPQLLALET

Sequences:

>Translated_191_residues
MPPLIVATQNPGKLKEMQQHLADLPWELQLMPPDLEIEETGTTFRENAILKATQVAKHLGQWAIADDSGLEVMALDGAPG
LYSARYGKTDIDRIQRLLTELQGKTDRSAQFVCVIALARPDGSVACQAKGVCPGEILQAPQGEGGFGYDPIFYVPSQQQT
FAELSATAKRQISHRGEAIKVLMPQLLALET
>Mature_190_residues
PPLIVATQNPGKLKEMQQHLADLPWELQLMPPDLEIEETGTTFRENAILKATQVAKHLGQWAIADDSGLEVMALDGAPGL
YSARYGKTDIDRIQRLLTELQGKTDRSAQFVCVIALARPDGSVACQAKGVCPGEILQAPQGEGGFGYDPIFYVPSQQQTF
AELSATAKRQISHRGEAIKVLMPQLLALET

Specific function: Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions [H]

COG id: COG0127

COG function: function code F; Xanthosine triphosphate pyrophosphatase

Gene ontology:
GO:0000166: Non-canonical purine NTP pyrophosphatase
GO:0006163: Non-canonical purine NTP pyrophosphatase
GO:0009117: Non-canonical purine NTP pyrophosphatase
GO:0016787: Non-canonical purine NTP pyrophosphatase
GO:0017111: Non-canonical purine NTP pyrophosphatase
GO:0046872: Non-canonical purine NTP pyrophosphatase
GO:0047429: Non-canonical purine NTP pyrophosphatase

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAM1 NTPase family [H]

Homologues:

Organism=Escherichia coli, GI1789324, Length=195, Percent_Identity=45.6410256410256, Blast_Score=144, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17556833, Length=177, Percent_Identity=27.683615819209, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19920712, Length=181, Percent_Identity=28.7292817679558, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002637
- InterPro:   IPR020922 [H]

Pfam domain/function: PF01725 Ham1p_like [H]

EC number: =3.6.1.15 [H]

Molecular weight: Translated: 20811; Mature: 20680

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPLIVATQNPGKLKEMQQHLADLPWELQLMPPDLEIEETGTTFRENAILKATQVAKHLG
CCCEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHC
QWAIADDSGLEVMALDGAPGLYSARYGKTDIDRIQRLLTELQGKTDRSAQFVCVIALARP
CEEEECCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEEECC
DGSVACQAKGVCPGEILQAPQGEGGFGYDPIFYVPSQQQTFAELSATAKRQISHRGEAIK
CCCEEEEECCCCCHHHHCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCHH
VLMPQLLALET
HHHHHHHHCCC
>Mature Secondary Structure 
PPLIVATQNPGKLKEMQQHLADLPWELQLMPPDLEIEETGTTFRENAILKATQVAKHLG
CCEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHC
QWAIADDSGLEVMALDGAPGLYSARYGKTDIDRIQRLLTELQGKTDRSAQFVCVIALARP
CEEEECCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEEECC
DGSVACQAKGVCPGEILQAPQGEGGFGYDPIFYVPSQQQTFAELSATAKRQISHRGEAIK
CCCEEEEECCCCCHHHHCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCHH
VLMPQLLALET
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]