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The map label for this gene is lktA [H]

Identifier: 158337688

GI number: 158337688

Start: 4609178

End: 4610785

Strand: Reverse

Name: lktA [H]

Synonym: AM1_4572

Alternate gene names: 158337688

Gene position: 4610785-4609178 (Counterclockwise)

Preceding gene: 158337689

Following gene: 158337687

Centisome position: 70.89

GC content: 48.82

Gene sequence:

>1608_bases
ATGAGAATTACCCTTGGAGATTTAACGAATATCTATGTCCTCGGGGATAGTCTATCTGACACAGGAAATATCTTCACGTT
CACTGCTGGTCAGATTCCTCCTCCTCCCTACTTCGAGGGACGGGTTTCTAATGGACCTGTGGCAATTGAGTATGTAGTAG
ATAGGCTCAATAATGCCGAATCAAATCTGAATTTAGCGCTAGCGCCGTCATTACTGGGTGGGAATAATTTTTCTTTTACT
GGAGCTGGAACAGGTCGCAACAACTCGAATGAAGATGACTTCAATTTAGATTTACCGGGGCTACTGGATCAAGTTGATGC
ATATCGACAATTAGGAACCGACTCTGCCAATAGCTTGTTCTTTGTCTGGGCAGGGCCAACAAATTTTCTCGATAACTTAG
GCGGCACGAATACAGACGATCGAGCGGTCTTAATTGAACAAGGGGTTGAGAACTTACTGGTTGGAGTAGAAGCGCTGGTG
GCATCGGGAGCGAGTAAATTCGTGATACCCAATATGCTAAACCTAGGCCGACTACCTACGAGCGCGGCATTTCAACGAGA
AGCACGAACAGTTGCGATCGCATTTAACGGACGCCTGGGATTATCCTTAGACAACCTGGAGCAAAAGGTTGGCAATCAGA
GCTTGGAGCTGGTTGAAGTTGATTTATTTGGGCTGGGAGAAACGATTGCTGAAAATCCTACCCGCTTTGGATTTACCAAT
ACCACCGACCCACTCCTGTCATTAGTCGCTACGGGGCAAGCGCTTCCCAATACCCCTGGATTTTTCTTTTGGGATCCGTT
ACATCCCACCACACAGGCCCATGCCATCATCGGTGAAACCATCTTCAATACGTTGATAGGGGACATTCCTCAACCTACTT
TGAATGACATTCTAGGGACTTCCCAACGGGATTTCTTATTTGGTACAAAGGCGGCAGACAATATCGATGGATTCGCAGGG
AATGATTTTCTCTTTGGTCTTTCGGGAGACGATCGCATTGAAGGGTGGCAAGGCCGGGATTGGCTATTTGGAAATACCGG
TAATGACACGATAGATGGTGGAGCGGGTCGGGATGTTGCCTGGGGCGGTTCTGGTGATGATTTAGTATTCGGTGGAGAGG
GCGGCGATTGGCTATCGGGGAATGAGGGGAGTGACATTCTGATTGGAGATGAGGGGGCTGATGCCCTATGGGGCAATCAA
GGAGATGACGATCTCCTTGGCGGTAGGGGAAATGACCGATTATGGGGGAATGCTGGAGATGATATTCTCCGTGGCGGAGA
GGGGCATGACTGGTTGTTTGGGGGGAATGGTGCCGACAAGTTAGTAGGCGGAAATGGCGATGATTGGTTAGCGGGCGGTG
CGGGGGATGATGTCTTTGTTGGTGGTCCCGGTCAAGATTCGTTGATTGGGGGACTGGGGAATGATGTTGTCCAATATCAA
GCGTTGATGAGTGACTTTACGTTCCGTGGTGGCCCTGAACAGTTCCAGGTAATTGGGGCAGGTGGAACCCAAACACTGCT
AGGAATAGAATTCTTGGAATTTGCCAATGAGCAAATCGCAGTGCATAGCCTTCCTTTTGCCTCCTCAATACCTTTGCTGG
AGATTTAG

Upstream 100 bases:

>100_bases
CTGGGGTATAACTCATATTCCAGCATGAATTTTGCAGCCTTTTTAAGCTTTGCTTAGCGCAGATTTCTAGCGCTTTAAGA
GAACTGTAGGAGGGATAAAG

Downstream 100 bases:

>100_bases
AAGCTGGAGGGGTGGATCTTTTAGACCGCAAGGTACTGGGGAGATATGAATAGGACTTCTATCAAGCACCTATTGGTCAG
GCGATGAGTGAAATTCTCAA

Product: hemolysin-type calcium-binding protein

Products: NA

Alternate protein names: Lkt [H]

Number of amino acids: Translated: 535; Mature: 535

Protein sequence:

>535_residues
MRITLGDLTNIYVLGDSLSDTGNIFTFTAGQIPPPPYFEGRVSNGPVAIEYVVDRLNNAESNLNLALAPSLLGGNNFSFT
GAGTGRNNSNEDDFNLDLPGLLDQVDAYRQLGTDSANSLFFVWAGPTNFLDNLGGTNTDDRAVLIEQGVENLLVGVEALV
ASGASKFVIPNMLNLGRLPTSAAFQREARTVAIAFNGRLGLSLDNLEQKVGNQSLELVEVDLFGLGETIAENPTRFGFTN
TTDPLLSLVATGQALPNTPGFFFWDPLHPTTQAHAIIGETIFNTLIGDIPQPTLNDILGTSQRDFLFGTKAADNIDGFAG
NDFLFGLSGDDRIEGWQGRDWLFGNTGNDTIDGGAGRDVAWGGSGDDLVFGGEGGDWLSGNEGSDILIGDEGADALWGNQ
GDDDLLGGRGNDRLWGNAGDDILRGGEGHDWLFGGNGADKLVGGNGDDWLAGGAGDDVFVGGPGQDSLIGGLGNDVVQYQ
ALMSDFTFRGGPEQFQVIGAGGTQTLLGIEFLEFANEQIAVHSLPFASSIPLLEI

Sequences:

>Translated_535_residues
MRITLGDLTNIYVLGDSLSDTGNIFTFTAGQIPPPPYFEGRVSNGPVAIEYVVDRLNNAESNLNLALAPSLLGGNNFSFT
GAGTGRNNSNEDDFNLDLPGLLDQVDAYRQLGTDSANSLFFVWAGPTNFLDNLGGTNTDDRAVLIEQGVENLLVGVEALV
ASGASKFVIPNMLNLGRLPTSAAFQREARTVAIAFNGRLGLSLDNLEQKVGNQSLELVEVDLFGLGETIAENPTRFGFTN
TTDPLLSLVATGQALPNTPGFFFWDPLHPTTQAHAIIGETIFNTLIGDIPQPTLNDILGTSQRDFLFGTKAADNIDGFAG
NDFLFGLSGDDRIEGWQGRDWLFGNTGNDTIDGGAGRDVAWGGSGDDLVFGGEGGDWLSGNEGSDILIGDEGADALWGNQ
GDDDLLGGRGNDRLWGNAGDDILRGGEGHDWLFGGNGADKLVGGNGDDWLAGGAGDDVFVGGPGQDSLIGGLGNDVVQYQ
ALMSDFTFRGGPEQFQVIGAGGTQTLLGIEFLEFANEQIAVHSLPFASSIPLLEI
>Mature_535_residues
MRITLGDLTNIYVLGDSLSDTGNIFTFTAGQIPPPPYFEGRVSNGPVAIEYVVDRLNNAESNLNLALAPSLLGGNNFSFT
GAGTGRNNSNEDDFNLDLPGLLDQVDAYRQLGTDSANSLFFVWAGPTNFLDNLGGTNTDDRAVLIEQGVENLLVGVEALV
ASGASKFVIPNMLNLGRLPTSAAFQREARTVAIAFNGRLGLSLDNLEQKVGNQSLELVEVDLFGLGETIAENPTRFGFTN
TTDPLLSLVATGQALPNTPGFFFWDPLHPTTQAHAIIGETIFNTLIGDIPQPTLNDILGTSQRDFLFGTKAADNIDGFAG
NDFLFGLSGDDRIEGWQGRDWLFGNTGNDTIDGGAGRDVAWGGSGDDLVFGGEGGDWLSGNEGSDILIGDEGADALWGNQ
GDDDLLGGRGNDRLWGNAGDDILRGGEGHDWLFGGNGADKLVGGNGDDWLAGGAGDDVFVGGPGQDSLIGGLGNDVVQYQ
ALMSDFTFRGGPEQFQVIGAGGTQTLLGIEFLEFANEQIAVHSLPFASSIPLLEI

Specific function: One of the virulence factors of A.actinomycetemcomitans might be a cytotoxin, possibly the membrane-bound hemolysin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein. Secreted (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: NA

Molecular weight: Translated: 56361; Mature: 56361

Theoretical pI: Translated: 3.73; Mature: 3.73

Prosite motif: PS01098 LIPASE_GDSL_SER ; PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRITLGDLTNIYVLGDSLSDTGNIFTFTAGQIPPPPYFEGRVSNGPVAIEYVVDRLNNAE
CEEEECCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEHHHHHHHHCCCC
SNLNLALAPSLLGGNNFSFTGAGTGRNNSNEDDFNLDLPGLLDQVDAYRQLGTDSANSLF
CCCEEEEECCEECCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEE
FVWAGPTNFLDNLGGTNTDDRAVLIEQGVENLLVGVEALVASGASKFVIPNMLNLGRLPT
EEECCCHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCEECCCHHHCCCCCC
SAAFQREARTVAIAFNGRLGLSLDNLEQKVGNQSLELVEVDLFGLGETIAENPTRFGFTN
HHHHHCCCCEEEEEECCEECCCHHHHHHHHCCCCEEEEEEEEECCCHHHHCCCCCCCCCC
TTDPLLSLVATGQALPNTPGFFFWDPLHPTTQAHAIIGETIFNTLIGDIPQPTLNDILGT
CHHHHHHHHHCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCC
SQRDFLFGTKAADNIDGFAGNDFLFGLSGDDRIEGWQGRDWLFGNTGNDTIDGGAGRDVA
CCCCEEEECCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCEE
WGGSGDDLVFGGEGGDWLSGNEGSDILIGDEGADALWGNQGDDDLLGGRGNDRLWGNAGD
ECCCCCCEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
DILRGGEGHDWLFGGNGADKLVGGNGDDWLAGGAGDDVFVGGPGQDSLIGGLGNDVVQYQ
HHHCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCHHHCCCCHHHHHHH
ALMSDFTFRGGPEQFQVIGAGGTQTLLGIEFLEFANEQIAVHSLPFASSIPLLEI
HHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MRITLGDLTNIYVLGDSLSDTGNIFTFTAGQIPPPPYFEGRVSNGPVAIEYVVDRLNNAE
CEEEECCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEHHHHHHHHCCCC
SNLNLALAPSLLGGNNFSFTGAGTGRNNSNEDDFNLDLPGLLDQVDAYRQLGTDSANSLF
CCCEEEEECCEECCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEE
FVWAGPTNFLDNLGGTNTDDRAVLIEQGVENLLVGVEALVASGASKFVIPNMLNLGRLPT
EEECCCHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCEECCCHHHCCCCCC
SAAFQREARTVAIAFNGRLGLSLDNLEQKVGNQSLELVEVDLFGLGETIAENPTRFGFTN
HHHHHCCCCEEEEEECCEECCCHHHHHHHHCCCCEEEEEEEEECCCHHHHCCCCCCCCCC
TTDPLLSLVATGQALPNTPGFFFWDPLHPTTQAHAIIGETIFNTLIGDIPQPTLNDILGT
CHHHHHHHHHCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCC
SQRDFLFGTKAADNIDGFAGNDFLFGLSGDDRIEGWQGRDWLFGNTGNDTIDGGAGRDVA
CCCCEEEECCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCEE
WGGSGDDLVFGGEGGDWLSGNEGSDILIGDEGADALWGNQGDDDLLGGRGNDRLWGNAGD
ECCCCCCEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
DILRGGEGHDWLFGGNGADKLVGGNGDDWLAGGAGDDVFVGGPGQDSLIGGLGNDVVQYQ
HHHCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCHHHCCCCHHHHHHH
ALMSDFTFRGGPEQFQVIGAGGTQTLLGIEFLEFANEQIAVHSLPFASSIPLLEI
HHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2670940 [H]