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The map label for this gene is glmS [H]

Identifier: 158337685

GI number: 158337685

Start: 4603381

End: 4605267

Strand: Direct

Name: glmS [H]

Synonym: AM1_4569

Alternate gene names: 158337685

Gene position: 4603381-4605267 (Clockwise)

Preceding gene: 158337684

Following gene: 158337694

Centisome position: 70.78

GC content: 53.1

Gene sequence:

>1887_bases
ATGTGCGGTATTGTCGGTTATATTGGCCCTCAAACGGCCAGCGGAATTCTGCTTTCGGGTCTACAAAAACTGGAATATCG
GGGGTACGATTCAGCGGGGATTGCTACGGTATCCGAGGCTCAACTCCAATGCATTCGGGCTAAAGGCAAACTGCACCATC
TGCAAGAGAAGTTAGCCAGCTGGGAAAATTCGGCGGTTCTGGGCATTGGCCACACACGCTGGGCAACTCACGGCAAACCG
GAAGAACATAACGCCCATCCCCACCGAGATGCTCGCGATCGTTTGGCAGTCGTGCAAAACGGCATTATCGAAAATTATCG
GGAACTGCGAGAAGAACTGAAAGAACGGGGCTGTACGTTTCGCTCTGAAACTGATACGGAAGTTATTCCCCATTTAATCT
CTGAAAAGCTGGACGGTCTAAAGGCAAAAGGAGAGCCTTCTCTGCTGGAAGCAGTTCGACAGGCCGTCAATCATTTAGAA
GGGGCCTTTGCGATCGCAGTCGTGTCTGCCGATTTCCCGGATGAACTGATCGTAGCTCGTCAACAGGCTCCCTTAGTGGT
CGGTTTTGGCGATGGCGAATATTTCTGTGCCTCTGATCCCCCCGCCTTGATTCACCACACCCGCACCGTCTTAACCCTAG
AGAACCAAGAACTGGCTCGCCTGACCACTCAAGGGGTGGAGCTTTACCACTTTGAGGGAAACCGCGTGCGTCGTCCGCCC
CGCACCCTGAACTGGAACCCCGTGATGGTGGAGAAACAGGGCTTTAAGCACTTTATGCTTAAGGAAATCTATGAGCAGCC
TGGGGTGGTGCGAACATGCCTGGAAAAGTATGTAGATAGCACCTGGCAACCGGGGCAAGCCACCAGTCCCATTCGCCTCA
ATTTGGCCCCAGAGTTAACCGCGAACTTGGAAAATATCCAAATTATGGCCTGCGGGACGAGTTGGCACGCCAGCTTAGTC
GGTAAGCATTTACTGGAGCAGTTAGCAGGTATCCCAACGGTGGTGCAGTACGCCTCTGAATTTCGGTACGCCCCTTCACC
CATGACGGCCAATACCCTCACCATTGGCGTCACCCAGTCGGGGGAAACCGCTGATACACTTGCTGCCCTGGAAACGGAGC
AGCAACGTCGTTCTCAGCAACCCGCTCATCTCCAGGCCCGCCTGTTGGGCATTACCAATCGCCCCGAAAGCTCTTTGGCC
CGTTTAGTTCCTGCCATTATTGATACCCATGCTGGGATTGAGATTGGCGTGGCCGCCACCAAAACCTTTATGGCTCAACT
GATGGCCTTTTACTTTTTGGCGATTGAGGTGGCTTATCAGCGTAAAACTGTTGCCCCTCAGCGCTTGGGGGAAATCATTG
ATGGTTTGCAACAGCTTCCCGCTCAGCTAGAGCAGGTGTTGGAAAGCCAGGAGCGGTATGTGGAAACCTTGGCCCATGAT
TTTGTCGAAACCCAGGACTTTATCTATATTGGTCGAGGTATCAATTTTCCCATTGCTCTGGAAGGGGCGCTGAAGCTGAA
AGAGATTAGCTATATCCATGCGGAGGGATATCCGGCAGGGGAGATGAAGCATGGCCCCATCGCATTGCTGGATGCCAAGG
TTCCTGTGGTGGCCATTGCAATGCCGGGAACGGTGTTTGAAAAGGTGCTCTCCAACGCCCAAGAAGCCCGAGCCCGAGAT
GCTCGCCTGATTGGGGTTACCCCAATGAATGAGCAGGAAGCCAAAGAGACCTTCGATACGTTGCTGCCTGTACCTGCAGT
GGATGAGATTATTTCACCACTGCTAACGGTGGTGCCGTTGCAGTTGCTGTCCTACCATATTGCAGCTCTACGTGGACTGG
ATGTGGATCAGCCTCGTAATTTGGCGAAATCCGTGACGGTTGAGTAG

Upstream 100 bases:

>100_bases
CCAACAGATACCAAAGATAGATACCGTTAGGGATTGCCATTTCTAGCAGAGTTGAGTCAAACTGCCTTTGTGTTGATCAA
TAGCGAGTCTCTCCAGAATT

Downstream 100 bases:

>100_bases
ACCCAAACCCTAGGACGCTGTGGGGCGAGTGTAGCGATGCTTCACTCCTATAGGGAAATAGGCCGGATCACCATTGGGCC
GTAAATAAATCTGCGGCATT

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 628; Mature: 628

Protein sequence:

>628_residues
MCGIVGYIGPQTASGILLSGLQKLEYRGYDSAGIATVSEAQLQCIRAKGKLHHLQEKLASWENSAVLGIGHTRWATHGKP
EEHNAHPHRDARDRLAVVQNGIIENYRELREELKERGCTFRSETDTEVIPHLISEKLDGLKAKGEPSLLEAVRQAVNHLE
GAFAIAVVSADFPDELIVARQQAPLVVGFGDGEYFCASDPPALIHHTRTVLTLENQELARLTTQGVELYHFEGNRVRRPP
RTLNWNPVMVEKQGFKHFMLKEIYEQPGVVRTCLEKYVDSTWQPGQATSPIRLNLAPELTANLENIQIMACGTSWHASLV
GKHLLEQLAGIPTVVQYASEFRYAPSPMTANTLTIGVTQSGETADTLAALETEQQRRSQQPAHLQARLLGITNRPESSLA
RLVPAIIDTHAGIEIGVAATKTFMAQLMAFYFLAIEVAYQRKTVAPQRLGEIIDGLQQLPAQLEQVLESQERYVETLAHD
FVETQDFIYIGRGINFPIALEGALKLKEISYIHAEGYPAGEMKHGPIALLDAKVPVVAIAMPGTVFEKVLSNAQEARARD
ARLIGVTPMNEQEAKETFDTLLPVPAVDEIISPLLTVVPLQLLSYHIAALRGLDVDQPRNLAKSVTVE

Sequences:

>Translated_628_residues
MCGIVGYIGPQTASGILLSGLQKLEYRGYDSAGIATVSEAQLQCIRAKGKLHHLQEKLASWENSAVLGIGHTRWATHGKP
EEHNAHPHRDARDRLAVVQNGIIENYRELREELKERGCTFRSETDTEVIPHLISEKLDGLKAKGEPSLLEAVRQAVNHLE
GAFAIAVVSADFPDELIVARQQAPLVVGFGDGEYFCASDPPALIHHTRTVLTLENQELARLTTQGVELYHFEGNRVRRPP
RTLNWNPVMVEKQGFKHFMLKEIYEQPGVVRTCLEKYVDSTWQPGQATSPIRLNLAPELTANLENIQIMACGTSWHASLV
GKHLLEQLAGIPTVVQYASEFRYAPSPMTANTLTIGVTQSGETADTLAALETEQQRRSQQPAHLQARLLGITNRPESSLA
RLVPAIIDTHAGIEIGVAATKTFMAQLMAFYFLAIEVAYQRKTVAPQRLGEIIDGLQQLPAQLEQVLESQERYVETLAHD
FVETQDFIYIGRGINFPIALEGALKLKEISYIHAEGYPAGEMKHGPIALLDAKVPVVAIAMPGTVFEKVLSNAQEARARD
ARLIGVTPMNEQEAKETFDTLLPVPAVDEIISPLLTVVPLQLLSYHIAALRGLDVDQPRNLAKSVTVE
>Mature_628_residues
MCGIVGYIGPQTASGILLSGLQKLEYRGYDSAGIATVSEAQLQCIRAKGKLHHLQEKLASWENSAVLGIGHTRWATHGKP
EEHNAHPHRDARDRLAVVQNGIIENYRELREELKERGCTFRSETDTEVIPHLISEKLDGLKAKGEPSLLEAVRQAVNHLE
GAFAIAVVSADFPDELIVARQQAPLVVGFGDGEYFCASDPPALIHHTRTVLTLENQELARLTTQGVELYHFEGNRVRRPP
RTLNWNPVMVEKQGFKHFMLKEIYEQPGVVRTCLEKYVDSTWQPGQATSPIRLNLAPELTANLENIQIMACGTSWHASLV
GKHLLEQLAGIPTVVQYASEFRYAPSPMTANTLTIGVTQSGETADTLAALETEQQRRSQQPAHLQARLLGITNRPESSLA
RLVPAIIDTHAGIEIGVAATKTFMAQLMAFYFLAIEVAYQRKTVAPQRLGEIIDGLQQLPAQLEQVLESQERYVETLAHD
FVETQDFIYIGRGINFPIALEGALKLKEISYIHAEGYPAGEMKHGPIALLDAKVPVVAIAMPGTVFEKVLSNAQEARARD
ARLIGVTPMNEQEAKETFDTLLPVPAVDEIISPLLTVVPLQLLSYHIAALRGLDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=702, Percent_Identity=34.4729344729345, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI205277386, Length=698, Percent_Identity=33.9541547277937, Blast_Score=377, Evalue=1e-104,
Organism=Escherichia coli, GI1790167, Length=629, Percent_Identity=45.1510333863275, Blast_Score=499, Evalue=1e-142,
Organism=Escherichia coli, GI1788651, Length=218, Percent_Identity=28.8990825688073, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17532899, Length=441, Percent_Identity=36.0544217687075, Blast_Score=265, Evalue=8e-71,
Organism=Caenorhabditis elegans, GI17532897, Length=441, Percent_Identity=36.0544217687075, Blast_Score=264, Evalue=9e-71,
Organism=Caenorhabditis elegans, GI17539970, Length=466, Percent_Identity=35.6223175965665, Blast_Score=258, Evalue=5e-69,
Organism=Saccharomyces cerevisiae, GI6322745, Length=454, Percent_Identity=34.5814977973568, Blast_Score=263, Evalue=4e-71,
Organism=Saccharomyces cerevisiae, GI6323731, Length=449, Percent_Identity=28.0623608017817, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6323730, Length=204, Percent_Identity=36.7647058823529, Blast_Score=121, Evalue=3e-28,
Organism=Drosophila melanogaster, GI21357745, Length=705, Percent_Identity=36.7375886524823, Blast_Score=397, Evalue=1e-111,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 69268; Mature: 69268

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYIGPQTASGILLSGLQKLEYRGYDSAGIATVSEAQLQCIRAKGKLHHLQEKLAS
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
WENSAVLGIGHTRWATHGKPEEHNAHPHRDARDRLAVVQNGIIENYRELREELKERGCTF
CCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RSETDTEVIPHLISEKLDGLKAKGEPSLLEAVRQAVNHLEGAFAIAVVSADFPDELIVAR
CCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHH
QQAPLVVGFGDGEYFCASDPPALIHHTRTVLTLENQELARLTTQGVELYHFEGNRVRRPP
CCCCEEEEECCCCEEECCCCHHHHCCCEEEEEECCHHHHHHHHCCEEEEEECCCCCCCCC
RTLNWNPVMVEKQGFKHFMLKEIYEQPGVVRTCLEKYVDSTWQPGQATSPIRLNLAPELT
CCCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCHHH
ANLENIQIMACGTSWHASLVGKHLLEQLAGIPTVVQYASEFRYAPSPMTANTLTIGVTQS
CCCCCEEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCEEEEEEECC
GETADTLAALETEQQRRSQQPAHLQARLLGITNRPESSLARLVPAIIDTHAGIEIGVAAT
CCHHHHHHHHHHHHHHHCCCCHHHHHHEEECCCCCHHHHHHHHHHHHHCCCCCEEEHHHH
KTFMAQLMAFYFLAIEVAYQRKTVAPQRLGEIIDGLQQLPAQLEQVLESQERYVETLAHD
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVETQDFIYIGRGINFPIALEGALKLKEISYIHAEGYPAGEMKHGPIALLDAKVPVVAIA
HHCCCCEEEEECCCCCCEEECCCEEEHHEEEEECCCCCCCCCCCCCEEEEECCCCEEEEE
MPGTVFEKVLSNAQEARARDARLIGVTPMNEQEAKETFDTLLPVPAVDEIISPLLTVVPL
CCHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
QLLSYHIAALRGLDVDQPRNLAKSVTVE
HHHHHHHHHHHCCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MCGIVGYIGPQTASGILLSGLQKLEYRGYDSAGIATVSEAQLQCIRAKGKLHHLQEKLAS
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
WENSAVLGIGHTRWATHGKPEEHNAHPHRDARDRLAVVQNGIIENYRELREELKERGCTF
CCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RSETDTEVIPHLISEKLDGLKAKGEPSLLEAVRQAVNHLEGAFAIAVVSADFPDELIVAR
CCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHH
QQAPLVVGFGDGEYFCASDPPALIHHTRTVLTLENQELARLTTQGVELYHFEGNRVRRPP
CCCCEEEEECCCCEEECCCCHHHHCCCEEEEEECCHHHHHHHHCCEEEEEECCCCCCCCC
RTLNWNPVMVEKQGFKHFMLKEIYEQPGVVRTCLEKYVDSTWQPGQATSPIRLNLAPELT
CCCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCHHH
ANLENIQIMACGTSWHASLVGKHLLEQLAGIPTVVQYASEFRYAPSPMTANTLTIGVTQS
CCCCCEEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCEEEEEEECC
GETADTLAALETEQQRRSQQPAHLQARLLGITNRPESSLARLVPAIIDTHAGIEIGVAAT
CCHHHHHHHHHHHHHHHCCCCHHHHHHEEECCCCCHHHHHHHHHHHHHCCCCCEEEHHHH
KTFMAQLMAFYFLAIEVAYQRKTVAPQRLGEIIDGLQQLPAQLEQVLESQERYVETLAHD
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVETQDFIYIGRGINFPIALEGALKLKEISYIHAEGYPAGEMKHGPIALLDAKVPVVAIA
HHCCCCEEEEECCCCCCEEECCCEEEHHEEEEECCCCCCCCCCCCCEEEEECCCCEEEEE
MPGTVFEKVLSNAQEARARDARLIGVTPMNEQEAKETFDTLLPVPAVDEIISPLLTVVPL
CCHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
QLLSYHIAALRGLDVDQPRNLAKSVTVE
HHHHHHHHHHHCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12240834 [H]