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The map label for this gene is pdxA [H]

Identifier: 158337671

GI number: 158337671

Start: 4588355

End: 4589413

Strand: Reverse

Name: pdxA [H]

Synonym: AM1_4554

Alternate gene names: 158337671

Gene position: 4589413-4588355 (Counterclockwise)

Preceding gene: 158337672

Following gene: 158337669

Centisome position: 70.57

GC content: 51.94

Gene sequence:

>1059_bases
ATGGCTGACTCTCATCCGCTACCCCAGCTTGCCATTCCCATGGGCGATTCTGCAGGGATTGGTCCTGAGGTCATTCTCAA
AGCTTTAAGTTTTCCGCTTCTCAAAGACGTAGCTCATGTTTGCGTCATTGGGGAGCGGTCTTTATTTGAGGCCGTTTATG
AACATCTCCAAAAGCAGACAGGTTTGGATGTAGATCAGACCCTAGCAAATCCAAAGAATCTTGATTTTTTGGAGGTAGGA
TTGAAACTATCTCCTATTCCATGGGGAAAGCCTTCAGCAGCGACGGGGGCAGCCAGTTTTCAGTGTTTGTCTACTGCGAT
TACAGGTGCCCTGGAAGGACGATTTGGTGGCATCGTCACTGGCCCCATTGCTAAGTCAGCTTGGAAGGCTGCCGGTCATC
ACTATCCTGGGCAAACCGAATATTTGGCGGAGCGATCTCAAACCTCAGAATATGGCATGTTCTTTGTGGGTTCTTCCCCC
TATACCGGGTGGCAACTCCGGACCTTATTGGCAACCACCCATATTCCACTGTCGGAGGTCCCTCGTCAGCTTTCTCCTGA
GTTGTTGACGATGAAGGTGAGACTGCTGAAGAAGACCCTGCAGCATGAGTTTGGTATAGAGCATCCGAGGGTTGCGATCT
CAGGTCTGAATCCTCACAGCGGTGAGCAAGGGCAGTTGGGGCGCGAAGAAATCGACTGGCTAATTCCGTGGATACGGGAG
ATGCGATCGCAACACCCTGATCTGACCTTATCAGACCCCATTCCCCCGGACACCCTTTGGGTGGGACCAGGGCAAGCTTG
GTATGGTCCCCGCGATAAAACAGCACAACCCACCACCTACGACGCCTACTTAGCCCTCTATCACGACCAAGGCTTAATTC
CCGTTAAGCTGATGGCTTTTGACCGGGCCGTCAATACCACCATTGGTTTACCCTTTGTCCGCACATCTCCAGACCACGGT
ACAGCCTTTGATATCGCAGGAAAAGGGATTGCCGATCCCACCAGTATGATTGCTGCGATTCAATTGGCCGCCAACCTAGT
TCGCCAACGTTCCGGTTAG

Upstream 100 bases:

>100_bases
ATGCTTCTGCTGAGGAAGCAGCTTCGGAACCCGAAGAAGTCACCTCTCCTGCATAAGGACTGTTCTTCACTCGATGCATA
TGTTTGGATGATGAATCACA

Downstream 100 bases:

>100_bases
CCAAATGTGAATGGAGAACAGCGTTGTCCAATACATGTATTTTTGCAGACCTCAGTTCAACCCAATATTTTGTGCTGCAT
TTAGCTGTCAGATGATGCAG

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase [H]

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MADSHPLPQLAIPMGDSAGIGPEVILKALSFPLLKDVAHVCVIGERSLFEAVYEHLQKQTGLDVDQTLANPKNLDFLEVG
LKLSPIPWGKPSAATGAASFQCLSTAITGALEGRFGGIVTGPIAKSAWKAAGHHYPGQTEYLAERSQTSEYGMFFVGSSP
YTGWQLRTLLATTHIPLSEVPRQLSPELLTMKVRLLKKTLQHEFGIEHPRVAISGLNPHSGEQGQLGREEIDWLIPWIRE
MRSQHPDLTLSDPIPPDTLWVGPGQAWYGPRDKTAQPTTYDAYLALYHDQGLIPVKLMAFDRAVNTTIGLPFVRTSPDHG
TAFDIAGKGIADPTSMIAAIQLAANLVRQRSG

Sequences:

>Translated_352_residues
MADSHPLPQLAIPMGDSAGIGPEVILKALSFPLLKDVAHVCVIGERSLFEAVYEHLQKQTGLDVDQTLANPKNLDFLEVG
LKLSPIPWGKPSAATGAASFQCLSTAITGALEGRFGGIVTGPIAKSAWKAAGHHYPGQTEYLAERSQTSEYGMFFVGSSP
YTGWQLRTLLATTHIPLSEVPRQLSPELLTMKVRLLKKTLQHEFGIEHPRVAISGLNPHSGEQGQLGREEIDWLIPWIRE
MRSQHPDLTLSDPIPPDTLWVGPGQAWYGPRDKTAQPTTYDAYLALYHDQGLIPVKLMAFDRAVNTTIGLPFVRTSPDHG
TAFDIAGKGIADPTSMIAAIQLAANLVRQRSG
>Mature_351_residues
ADSHPLPQLAIPMGDSAGIGPEVILKALSFPLLKDVAHVCVIGERSLFEAVYEHLQKQTGLDVDQTLANPKNLDFLEVGL
KLSPIPWGKPSAATGAASFQCLSTAITGALEGRFGGIVTGPIAKSAWKAAGHHYPGQTEYLAERSQTSEYGMFFVGSSPY
TGWQLRTLLATTHIPLSEVPRQLSPELLTMKVRLLKKTLQHEFGIEHPRVAISGLNPHSGEQGQLGREEIDWLIPWIREM
RSQHPDLTLSDPIPPDTLWVGPGQAWYGPRDKTAQPTTYDAYLALYHDQGLIPVKLMAFDRAVNTTIGLPFVRTSPDHGT
AFDIAGKGIADPTSMIAAIQLAANLVRQRSG

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:
GO:0005737: 4-hydroxythreonine-4-phosphate dehydrogenase
GO:0008615: 4-hydroxythreonine-4-phosphate dehydrogenase
GO:0016491: 4-hydroxythreonine-4-phosphate dehydrogenase
GO:0016616: 4-hydroxythreonine-4-phosphate dehydrogenase
GO:0042823: 4-hydroxythreonine-4-phosphate dehydrogenase
GO:0046872: 4-hydroxythreonine-4-phosphate dehydrogenase
GO:0050570: 4-hydroxythreonine-4-phosphate dehydrogenase
GO:0051287: 4-hydroxythreonine-4-phosphate dehydrogenase
GO:0055114: 4-hydroxythreonine-4-phosphate dehydrogenase

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=274, Percent_Identity=40.1459854014599, Blast_Score=198, Evalue=5e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 38263; Mature: 38132

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADSHPLPQLAIPMGDSAGIGPEVILKALSFPLLKDVAHVCVIGERSLFEAVYEHLQKQT
CCCCCCCCEEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
GLDVDQTLANPKNLDFLEVGLKLSPIPWGKPSAATGAASFQCLSTAITGALEGRFGGIVT
CCCHHHHHCCCCCCCEEEECCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEE
GPIAKSAWKAAGHHYPGQTEYLAERSQTSEYGMFFVGSSPYTGWQLRTLLATTHIPLSEV
CHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHCCCCHHHH
PRQLSPELLTMKVRLLKKTLQHEFGIEHPRVAISGLNPHSGEQGQLGREEIDWLIPWIRE
HHHHCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHH
MRSQHPDLTLSDPIPPDTLWVGPGQAWYGPRDKTAQPTTYDAYLALYHDQGLIPVKLMAF
HHHCCCCEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEHHHH
DRAVNTTIGLPFVRTSPDHGTAFDIAGKGIADPTSMIAAIQLAANLVRQRSG
HHHHHHHCCCCEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ADSHPLPQLAIPMGDSAGIGPEVILKALSFPLLKDVAHVCVIGERSLFEAVYEHLQKQT
CCCCCCCEEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
GLDVDQTLANPKNLDFLEVGLKLSPIPWGKPSAATGAASFQCLSTAITGALEGRFGGIVT
CCCHHHHHCCCCCCCEEEECCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEE
GPIAKSAWKAAGHHYPGQTEYLAERSQTSEYGMFFVGSSPYTGWQLRTLLATTHIPLSEV
CHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHCCCCHHHH
PRQLSPELLTMKVRLLKKTLQHEFGIEHPRVAISGLNPHSGEQGQLGREEIDWLIPWIRE
HHHHCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHH
MRSQHPDLTLSDPIPPDTLWVGPGQAWYGPRDKTAQPTTYDAYLALYHDQGLIPVKLMAF
HHHCCCCEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEHHHH
DRAVNTTIGLPFVRTSPDHGTAFDIAGKGIADPTSMIAAIQLAANLVRQRSG
HHHHHHHCCCCEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]