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The map label for this gene is hppD [H]

Identifier: 158337667

GI number: 158337667

Start: 4586469

End: 4587536

Strand: Direct

Name: hppD [H]

Synonym: AM1_4550

Alternate gene names: 158337667

Gene position: 4586469-4587536 (Clockwise)

Preceding gene: 158337666

Following gene: 158337670

Centisome position: 70.52

GC content: 45.97

Gene sequence:

>1068_bases
ATGGATTTTGATCATATTCATTTTTATGTTCATGATTCCAAGCAATGCCAGCGTTGGTTTACTAACGTTTTAGGATTTCA
ATATCTTGGGAGCAATACTACGGCTGATCGGCAGATTGAAGTTGTCTCTTCTGGGGCGATTGTCTGTATATTTTCCAGCC
CTCTAAACCGAACCAGCCCAGTTGCCCAGTATCTACAACAACACCCTCCTGGTGTCGTTGATTTGGCTTTCTTGGTCCCG
GACGTTCAGGCTACGCTTACCTGCGCTGTCCAGTCAGGAGCAACCCTTTTACAACCTTTGACCGAAGAAAAAAACGACCA
AGGAACGTTAACTTGGGGAAAAGTACGAGGGTGGGGAGCGTTAGAACATACCTTGGTAGAGCGAAGAGGGCAAACCTCCA
CTCTGCCATCCAGCATTTTTCCCATCTCAATTCATGGGCATGATGCCCATCAGAGTCTATTTACCCAGATTGATCATGGG
GTTTTGAATGTGGGTAAGCATCAGCTGCAAGCTGCTGTGAGTTGGTATCAGCGCATATTTGGATTTAAAACTCACCGATA
TTTTGATATTCAAACGCGTCGTTCAGGTCTGCGCAGTGAAGTGTTGACCCATCCCCAAGGCCAAATCAAGTTTCCGATCA
ATGAACCCACCTCAGCGAATTCCCAAATCCAAGAATTTCTAGAGGTCAATCGGGGGGCAGGTATTCAACATATCGCATTG
GGAACTTCTAATATTGTTGAAACGGTTACTCAGCTTAAGCATCGAGGGCTATCCATCCTAGATATTCCACCCAGCTACTA
TCAACGCTTACGACACCAGTTTGAGCAAGTCTATTCCCACCTCGATTGGCATGCCCTGGAAACACAACATATTCTGGCTG
ATTTTGAGGAAGATGCTGGAGCCGGAATTCTATTGCAAACCTTCACAAAGCCTATCTTTCCACAACCCACTTTTTTCTTT
GAAATTATTGAGCGCCAACGGCAGGCCCAAGGGTTCGGACAACGAAACTTTTTGGCCCTTTTTCAAGCCATGGAGCGGGA
ACAACAGAAACGGGGAGTATTGCTATAG

Upstream 100 bases:

>100_bases
GTAAACTTCTCAACATGTTGCTGTGCATCTCAGTCTAGAGGGGCCAGCAGCCTCCCAAATTACGTTTTCAACGTCAATTC
AAGATCGGTATTTGTGATCT

Downstream 100 bases:

>100_bases
GCTCATCTCAGTTTGCTGCATCCTGCAAAAAATATGCATGAAACATCACCTCTGCAATCCCTTCCGTCTGACTATTATGC
CCGGTGGACATTGCTCGATA

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MDFDHIHFYVHDSKQCQRWFTNVLGFQYLGSNTTADRQIEVVSSGAIVCIFSSPLNRTSPVAQYLQQHPPGVVDLAFLVP
DVQATLTCAVQSGATLLQPLTEEKNDQGTLTWGKVRGWGALEHTLVERRGQTSTLPSSIFPISIHGHDAHQSLFTQIDHG
VLNVGKHQLQAAVSWYQRIFGFKTHRYFDIQTRRSGLRSEVLTHPQGQIKFPINEPTSANSQIQEFLEVNRGAGIQHIAL
GTSNIVETVTQLKHRGLSILDIPPSYYQRLRHQFEQVYSHLDWHALETQHILADFEEDAGAGILLQTFTKPIFPQPTFFF
EIIERQRQAQGFGQRNFLALFQAMEREQQKRGVLL

Sequences:

>Translated_355_residues
MDFDHIHFYVHDSKQCQRWFTNVLGFQYLGSNTTADRQIEVVSSGAIVCIFSSPLNRTSPVAQYLQQHPPGVVDLAFLVP
DVQATLTCAVQSGATLLQPLTEEKNDQGTLTWGKVRGWGALEHTLVERRGQTSTLPSSIFPISIHGHDAHQSLFTQIDHG
VLNVGKHQLQAAVSWYQRIFGFKTHRYFDIQTRRSGLRSEVLTHPQGQIKFPINEPTSANSQIQEFLEVNRGAGIQHIAL
GTSNIVETVTQLKHRGLSILDIPPSYYQRLRHQFEQVYSHLDWHALETQHILADFEEDAGAGILLQTFTKPIFPQPTFFF
EIIERQRQAQGFGQRNFLALFQAMEREQQKRGVLL
>Mature_355_residues
MDFDHIHFYVHDSKQCQRWFTNVLGFQYLGSNTTADRQIEVVSSGAIVCIFSSPLNRTSPVAQYLQQHPPGVVDLAFLVP
DVQATLTCAVQSGATLLQPLTEEKNDQGTLTWGKVRGWGALEHTLVERRGQTSTLPSSIFPISIHGHDAHQSLFTQIDHG
VLNVGKHQLQAAVSWYQRIFGFKTHRYFDIQTRRSGLRSEVLTHPQGQIKFPINEPTSANSQIQEFLEVNRGAGIQHIAL
GTSNIVETVTQLKHRGLSILDIPPSYYQRLRHQFEQVYSHLDWHALETQHILADFEEDAGAGILLQTFTKPIFPQPTFFF
EIIERQRQAQGFGQRNFLALFQAMEREQQKRGVLL

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:
GO:0003868: 4-hydroxyphenylpyruvate dioxygenase
GO:0009072: 4-hydroxyphenylpyruvate dioxygenase
GO:0016701: 4-hydroxyphenylpyruvate dioxygenase
GO:0016702: 4-hydroxyphenylpyruvate dioxygenase
GO:0046872: 4-hydroxyphenylpyruvate dioxygenase
GO:0055114: 4-hydroxyphenylpyruvate dioxygenase

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=373, Percent_Identity=34.5844504021448, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI285002264, Length=350, Percent_Identity=35.4285714285714, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI14249394, Length=366, Percent_Identity=27.3224043715847, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17555220, Length=381, Percent_Identity=36.745406824147, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI17550752, Length=369, Percent_Identity=28.7262872628726, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24667510, Length=372, Percent_Identity=38.7096774193548, Blast_Score=218, Evalue=4e-57,
Organism=Drosophila melanogaster, GI21356105, Length=301, Percent_Identity=40.531561461794, Blast_Score=193, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 40322; Mature: 40322

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFDHIHFYVHDSKQCQRWFTNVLGFQYLGSNTTADRQIEVVSSGAIVCIFSSPLNRTSP
CCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCEEEEECCCCCCCHH
VAQYLQQHPPGVVDLAFLVPDVQATLTCAVQSGATLLQPLTEEKNDQGTLTWGKVRGWGA
HHHHHHHCCCCEEEHHHHHCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEECCCCCCCH
LEHTLVERRGQTSTLPSSIFPISIHGHDAHQSLFTQIDHGVLNVGKHQLQAAVSWYQRIF
HHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFKTHRYFDIQTRRSGLRSEVLTHPQGQIKFPINEPTSANSQIQEFLEVNRGAGIQHIAL
CCCCCEEEEHHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEC
GTSNIVETVTQLKHRGLSILDIPPSYYQRLRHQFEQVYSHLDWHALETQHILADFEEDAG
CCHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCC
AGILLQTFTKPIFPQPTFFFEIIERQRQAQGFGQRNFLALFQAMEREQQKRGVLL
CEEEHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDFDHIHFYVHDSKQCQRWFTNVLGFQYLGSNTTADRQIEVVSSGAIVCIFSSPLNRTSP
CCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCEEEEECCCCCCCHH
VAQYLQQHPPGVVDLAFLVPDVQATLTCAVQSGATLLQPLTEEKNDQGTLTWGKVRGWGA
HHHHHHHCCCCEEEHHHHHCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEECCCCCCCH
LEHTLVERRGQTSTLPSSIFPISIHGHDAHQSLFTQIDHGVLNVGKHQLQAAVSWYQRIF
HHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFKTHRYFDIQTRRSGLRSEVLTHPQGQIKFPINEPTSANSQIQEFLEVNRGAGIQHIAL
CCCCCEEEEHHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEC
GTSNIVETVTQLKHRGLSILDIPPSYYQRLRHQFEQVYSHLDWHALETQHILADFEEDAG
CCHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCC
AGILLQTFTKPIFPQPTFFFEIIERQRQAQGFGQRNFLALFQAMEREQQKRGVLL
CEEEHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8071207; 11572948; 12692562 [H]