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The map label for this gene is mpg1 [H]

Identifier: 158337664

GI number: 158337664

Start: 4583633

End: 4584604

Strand: Direct

Name: mpg1 [H]

Synonym: AM1_4547

Alternate gene names: 158337664

Gene position: 4583633-4584604 (Clockwise)

Preceding gene: 158337661

Following gene: 158337666

Centisome position: 70.48

GC content: 48.56

Gene sequence:

>972_bases
ATGCAAGCCGTAATCATTGCTGGTGGAAAAGGAACAAGGCTATCCCCTCTAACATTACGTAGTCCTAAACCCATGCTGCC
CCTTTTCGAGCGCCCTTTTCTCAGTTGGATGGTTGAGCGGTGTAAAGCAGTCGGATTAACCGATATTTTGATGAATATTC
GGTACCAGGCTACTCAAATCCAAGAGTATTTCGGAGATGGCCAAAAGTTTGGCGTCAAGATTCGCTATGTCATTGAGAAA
GAAGCCCTGGATACAGCAGGAGCGATGAAGCTAGCAGAGCCTTTTTATACGGGAGAGCCTTTGGTCGTCTTTAATGCGGA
TATTCTCACAAATCTGAATCTGCAGGCTTTGATGCAAGCCCATGAACAGACTCAAGCCCAAGCCACCATTGCTTTAGCCA
GAGTTGCAGATCCCACCGCATTTGGCCTAGTCGAATTGACAGATATTACGGCCAGTGAGCACTCATCCACAGGTACCATC
CAATCCTTCCGGGAGAAACCCACCCCCGAAGAAGCCGCAACATTAGGCATTGATACAGTTAACGCAGGAACCTATGTTCT
CAATCCCGAGATTTTCGCGCAGTATCCAGCCGATCAGCCCCTCAGCTTTGAACGCACGGTTTTTCCCAATCTTTTATCAA
ACCAACAGAAAATTTCTGGGTTTGTCTGGGAGGGGTATTGGATGGATCTAGGAACACCGGCTAAATTCTACGGGGCTCAC
TTAGATATTTTGCAGGGAAAGATGCCGTTCCCTTTACCTGAAGCCATGGAAGAGCGTCAACCTCAAGTCTGGGTTGCAAA
TAATGCCATTATTGATCCTCAAGCGAAGATATCTGGACCTTGCTTTTTGGGTGAGAACGCTAAGCTTGGTCCCCAGGCAG
AGATCTCTAGTGGGGTCATCTTAGGGGCTAGCGGGTTAATCGACCGCCCCTTGTCACCCGGTATCTATCCTCCAGGGACG
GTCGCAGTATAG

Upstream 100 bases:

>100_bases
AACGCTACGATTCTACACAATTAGATTGGAATGGCAAGGGGATTGGTTATATTGACTGACAGTTTACCCAAATTCTTCTT
AGAACTTAAGGTTGTTAACT

Downstream 100 bases:

>100_bases
GGCGTTAGGTATGAGGTAGGATGACCGCTTTGATGGTTTTGCGATCTCGCATATCAGCAAACACCTGCCCTAGATGATTG
AGGGGTTGGGTATCGTTCAG

Product: nucleotidyl transferase protein

Products: NA

Alternate protein names: ATP-mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; NDP-hexose pyrophosphorylase [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MQAVIIAGGKGTRLSPLTLRSPKPMLPLFERPFLSWMVERCKAVGLTDILMNIRYQATQIQEYFGDGQKFGVKIRYVIEK
EALDTAGAMKLAEPFYTGEPLVVFNADILTNLNLQALMQAHEQTQAQATIALARVADPTAFGLVELTDITASEHSSTGTI
QSFREKPTPEEAATLGIDTVNAGTYVLNPEIFAQYPADQPLSFERTVFPNLLSNQQKISGFVWEGYWMDLGTPAKFYGAH
LDILQGKMPFPLPEAMEERQPQVWVANNAIIDPQAKISGPCFLGENAKLGPQAEISSGVILGASGLIDRPLSPGIYPPGT
VAV

Sequences:

>Translated_323_residues
MQAVIIAGGKGTRLSPLTLRSPKPMLPLFERPFLSWMVERCKAVGLTDILMNIRYQATQIQEYFGDGQKFGVKIRYVIEK
EALDTAGAMKLAEPFYTGEPLVVFNADILTNLNLQALMQAHEQTQAQATIALARVADPTAFGLVELTDITASEHSSTGTI
QSFREKPTPEEAATLGIDTVNAGTYVLNPEIFAQYPADQPLSFERTVFPNLLSNQQKISGFVWEGYWMDLGTPAKFYGAH
LDILQGKMPFPLPEAMEERQPQVWVANNAIIDPQAKISGPCFLGENAKLGPQAEISSGVILGASGLIDRPLSPGIYPPGT
VAV
>Mature_323_residues
MQAVIIAGGKGTRLSPLTLRSPKPMLPLFERPFLSWMVERCKAVGLTDILMNIRYQATQIQEYFGDGQKFGVKIRYVIEK
EALDTAGAMKLAEPFYTGEPLVVFNADILTNLNLQALMQAHEQTQAQATIALARVADPTAFGLVELTDITASEHSSTGTI
QSFREKPTPEEAATLGIDTVNAGTYVLNPEIFAQYPADQPLSFERTVFPNLLSNQQKISGFVWEGYWMDLGTPAKFYGAH
LDILQGKMPFPLPEAMEERQPQVWVANNAIIDPQAKISGPCFLGENAKLGPQAEISSGVILGASGLIDRPLSPGIYPPGT
VAV

Specific function: Catalyzes The Formation Of Dtdp-Glucose, From Dttp And Glucose 1-Phosphate, As Well As Its Pyrophosphorolysis. [C]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=309, Percent_Identity=30.0970873786408, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI11761621, Length=309, Percent_Identity=30.0970873786408, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI31881779, Length=334, Percent_Identity=26.6467065868263, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI45447090, Length=334, Percent_Identity=26.6467065868263, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1788351, Length=238, Percent_Identity=26.890756302521, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1787488, Length=275, Percent_Identity=23.6363636363636, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790224, Length=150, Percent_Identity=29.3333333333333, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788355, Length=272, Percent_Identity=22.0588235294118, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI133931050, Length=328, Percent_Identity=28.3536585365854, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17509979, Length=314, Percent_Identity=25.796178343949, Blast_Score=81, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6320148, Length=307, Percent_Identity=32.8990228013029, Blast_Score=155, Evalue=9e-39,
Organism=Drosophila melanogaster, GI21355443, Length=313, Percent_Identity=30.9904153354633, Blast_Score=158, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24644084, Length=313, Percent_Identity=30.9904153354633, Blast_Score=158, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24653912, Length=206, Percent_Identity=31.5533980582524, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 35211; Mature: 35211

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAVIIAGGKGTRLSPLTLRSPKPMLPLFERPFLSWMVERCKAVGLTDILMNIRYQATQI
CCEEEEECCCCCEECCEEECCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
QEYFGDGQKFGVKIRYVIEKEALDTAGAMKLAEPFYTGEPLVVFNADILTNLNLQALMQA
HHHHCCCCEECEEEEEEEEHHHHCHHCHHHHHCCCCCCCCEEEEECHHHHCCCHHHHHHH
HEQTQAQATIALARVADPTAFGLVELTDITASEHSSTGTIQSFREKPTPEEAATLGIDTV
HHHHHHHHHEEEEHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHCCCCCHHHHEECCEEE
NAGTYVLNPEIFAQYPADQPLSFERTVFPNLLSNQQKISGFVWEGYWMDLGTPAKFYGAH
CCCEEEECCHHEEECCCCCCCCCCHHHHHHHHCCCHHHCEEEEEEEEEECCCCHHHHCCC
LDILQGKMPFPLPEAMEERQPQVWVANNAIIDPQAKISGPCFLGENAKLGPQAEISSGVI
HHEECCCCCCCCHHHHHHCCCCEEEECCEEECCCCCCCCCEEECCCCCCCCCCCCCCCEE
LGASGLIDRPLSPGIYPPGTVAV
EECCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQAVIIAGGKGTRLSPLTLRSPKPMLPLFERPFLSWMVERCKAVGLTDILMNIRYQATQI
CCEEEEECCCCCEECCEEECCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
QEYFGDGQKFGVKIRYVIEKEALDTAGAMKLAEPFYTGEPLVVFNADILTNLNLQALMQA
HHHHCCCCEECEEEEEEEEHHHHCHHCHHHHHCCCCCCCCEEEEECHHHHCCCHHHHHHH
HEQTQAQATIALARVADPTAFGLVELTDITASEHSSTGTIQSFREKPTPEEAATLGIDTV
HHHHHHHHHEEEEHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHCCCCCHHHHEECCEEE
NAGTYVLNPEIFAQYPADQPLSFERTVFPNLLSNQQKISGFVWEGYWMDLGTPAKFYGAH
CCCEEEECCHHEEECCCCCCCCCCHHHHHHHHCCCHHHCEEEEEEEEEECCCCHHHHCCC
LDILQGKMPFPLPEAMEERQPQVWVANNAIIDPQAKISGPCFLGENAKLGPQAEISSGVI
HHEECCCCCCCCHHHHHHCCCCEEEECCEEECCCCCCCCCEEECCCCCCCCCCCCCCCEE
LGASGLIDRPLSPGIYPPGTVAV
EECCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8334170 [H]