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The map label for this gene is trpC

Identifier: 158337481

GI number: 158337481

Start: 4388751

End: 4389662

Strand: Reverse

Name: trpC

Synonym: AM1_4360

Alternate gene names: 158337481

Gene position: 4389662-4388751 (Counterclockwise)

Preceding gene: 158337482

Following gene: 158337480

Centisome position: 67.49

GC content: 46.6

Gene sequence:

>912_bases
ATGCAAATTCGCCGTCGTCCCCCCAGTGTGGCCGTTAATGTTCAAGAGTTACAATATCAGGTTAAAACCCCTGAAAATGA
ACCTCGCAATATCCTAGAAAAGATTGTTTGGTTCAAAGAAACGGAAGTCGAGCAGATGCGGGACTCTGTCTCCCTTCTAG
ATTTACGCAAGCAAGTTGCCAATTGTGAGCCCCCCCTATCCTTCCTGGATGCGTTAAAGCATGGCAAGACCCAGCCTGCC
CTAATTGCTGAAGTCAAAAAAGCATCGCCCAGCAAAGGCGTGCTGCGGGAAAACTTCGATCCTGTTGCCATTGCTCAGGC
CTATGAAGCCGCTGGGGCTTCGTGTCTATCGGTATTGACAGATGCAGAATTTTTCCAGGGCAGCTTTGATTATTTACAAC
AGATTCGTGCCGCCGTCAGCCTTCCCTTGCTTTGCAAAGAATTTGTGATCTATCCCTACCAAATTTATCTAGCGCGATCT
CGGGGAGCAGATGCAGTTTTGCTGATTGCCGCCATTTTGAGCGATCAAGACCTCACCTATTTTCTCAAGATTATTAAATC
TTTAGGGATGACTGCCTTAGTTGAGGTGCATACCCTCCCAGAGTTAGAGAGAGTCATGGATATTCCTGGAATTGAGCTTA
TCGGTATCAATAACCGGGATTTAGAGACGTTTACAGTCGATTTAGAGGTCACCTGCCAATTACTGGCTCAGCAGGGAACC
TCTCTTCAAGACCAAGATATCTTAGTGGTCAGTGAGTCAGGTTTACATACCTCCGCAGACCTGGCCCAAGTCAAGCAGGC
AGGGGCAGGTGCGGTCTTAATTGGGGAATCCTTAGTAAAAGAAACGGGCAATGCATCTACCCATAGTGAAACAGAACAAA
TGCAAGCTAAAATTTCTGCTCTTTTTTCCTAA

Upstream 100 bases:

>100_bases
TTCGCCCATTGATGGCAATCTGTTCTCGCTAAAAGCCCTGGAACAGTAAGGGGGGTGCTTAAATCGTTATAATTGTTGGA
CCCTAGCTGTTTTGGTCTCC

Downstream 100 bases:

>100_bases
ATCGATTCAGCCCCTTCAGTCTATTGAAGATGATTTGACTCTTATGAGCGGCCAGCTAGCATCACTATTTAACAGTTACC
CGTTGAACCTATTCAATAAT

Product: indole-3-glycerol phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MQIRRRPPSVAVNVQELQYQVKTPENEPRNILEKIVWFKETEVEQMRDSVSLLDLRKQVANCEPPLSFLDALKHGKTQPA
LIAEVKKASPSKGVLRENFDPVAIAQAYEAAGASCLSVLTDAEFFQGSFDYLQQIRAAVSLPLLCKEFVIYPYQIYLARS
RGADAVLLIAAILSDQDLTYFLKIIKSLGMTALVEVHTLPELERVMDIPGIELIGINNRDLETFTVDLEVTCQLLAQQGT
SLQDQDILVVSESGLHTSADLAQVKQAGAGAVLIGESLVKETGNASTHSETEQMQAKISALFS

Sequences:

>Translated_303_residues
MQIRRRPPSVAVNVQELQYQVKTPENEPRNILEKIVWFKETEVEQMRDSVSLLDLRKQVANCEPPLSFLDALKHGKTQPA
LIAEVKKASPSKGVLRENFDPVAIAQAYEAAGASCLSVLTDAEFFQGSFDYLQQIRAAVSLPLLCKEFVIYPYQIYLARS
RGADAVLLIAAILSDQDLTYFLKIIKSLGMTALVEVHTLPELERVMDIPGIELIGINNRDLETFTVDLEVTCQLLAQQGT
SLQDQDILVVSESGLHTSADLAQVKQAGAGAVLIGESLVKETGNASTHSETEQMQAKISALFS
>Mature_303_residues
MQIRRRPPSVAVNVQELQYQVKTPENEPRNILEKIVWFKETEVEQMRDSVSLLDLRKQVANCEPPLSFLDALKHGKTQPA
LIAEVKKASPSKGVLRENFDPVAIAQAYEAAGASCLSVLTDAEFFQGSFDYLQQIRAAVSLPLLCKEFVIYPYQIYLARS
RGADAVLLIAAILSDQDLTYFLKIIKSLGMTALVEVHTLPELERVMDIPGIELIGINNRDLETFTVDLEVTCQLLAQQGT
SLQDQDILVVSESGLHTSADLAQVKQAGAGAVLIGESLVKETGNASTHSETEQMQAKISALFS

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=252, Percent_Identity=40.4761904761905, Blast_Score=160, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6322638, Length=230, Percent_Identity=39.5652173913043, Blast_Score=135, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_ACAM1 (B0CEU2)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001518656.1
- ProteinModelPortal:   B0CEU2
- SMR:   B0CEU2
- GeneID:   5683163
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_4360
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- ProtClustDB:   CLSK2475852
- BioCyc:   AMAR329726:AM1_4360-MONOMER
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 33344; Mature: 33344

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIRRRPPSVAVNVQELQYQVKTPENEPRNILEKIVWFKETEVEQMRDSVSLLDLRKQVA
CCCCCCCCCEEEEHHHHEEEECCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
NCEPPLSFLDALKHGKTQPALIAEVKKASPSKGVLRENFDPVAIAQAYEAAGASCLSVLT
CCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHH
DAEFFQGSFDYLQQIRAAVSLPLLCKEFVIYPYQIYLARSRGADAVLLIAAILSDQDLTY
HHHHHCCHHHHHHHHHHHHCHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCCHHH
FLKIIKSLGMTALVEVHTLPELERVMDIPGIELIGINNRDLETFTVDLEVTCQLLAQQGT
HHHHHHHCCHHEEHHHHCCHHHHHHHCCCCEEEEECCCCCCEEEEEHHHHHHHHHHHCCC
SLQDQDILVVSESGLHTSADLAQVKQAGAGAVLIGESLVKETGNASTHSETEQMQAKISA
CCCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEECHHHHHHCCCCCCCHHHHHHHHHHHH
LFS
HCC
>Mature Secondary Structure
MQIRRRPPSVAVNVQELQYQVKTPENEPRNILEKIVWFKETEVEQMRDSVSLLDLRKQVA
CCCCCCCCCEEEEHHHHEEEECCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
NCEPPLSFLDALKHGKTQPALIAEVKKASPSKGVLRENFDPVAIAQAYEAAGASCLSVLT
CCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHH
DAEFFQGSFDYLQQIRAAVSLPLLCKEFVIYPYQIYLARSRGADAVLLIAAILSDQDLTY
HHHHHCCHHHHHHHHHHHHCHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCCHHH
FLKIIKSLGMTALVEVHTLPELERVMDIPGIELIGINNRDLETFTVDLEVTCQLLAQQGT
HHHHHHHCCHHEEHHHHCCHHHHHHHCCCCEEEEECCCCCCEEEEEHHHHHHHHHHHCCC
SLQDQDILVVSESGLHTSADLAQVKQAGAGAVLIGESLVKETGNASTHSETEQMQAKISA
CCCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEECHHHHHHCCCCCCCHHHHHHHHHHHH
LFS
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA