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The map label for this gene is gluP [H]

Identifier: 158337464

GI number: 158337464

Start: 4372156

End: 4373769

Strand: Direct

Name: gluP [H]

Synonym: AM1_4343

Alternate gene names: 158337464

Gene position: 4372156-4373769 (Clockwise)

Preceding gene: 158337462

Following gene: 158337465

Centisome position: 67.23

GC content: 49.63

Gene sequence:

>1614_bases
ATGGACTTCAATCAACTGTTGCTGTGGATGGTCTATGTATCCTGTATTAGTTTGTTAATCGTTGGTTTCAAACGAGGCAA
GGCGGCTAGAGGTTGGCTGCTGATTGCGGCATTGCTCCTGGGATTAACGCTCTTTCTCCAGCAAGTTTTACCCAATCATG
TTGGGCTCATCAGTGGTGCCCTTTGGTTCCTCGTGATCCTGATCCCTCAACGAGGCTCGGTTCGCATCAATCAACTCGCC
TGGCAGCATCGATTTAAGCCTGCGCGTCAATGGGCTCAAGTGCTACGACTGTTGCATCCTATGGATAGTTTTTGGCAATG
GCCTCGTTATCTCCATGCCATGGAACTCGCTCAAGCGGGTCAACTGCCGGAGGCGGAAACCAAACTGCGACCGTTTAGCC
AATCGCAATCCCTGATGAGTATTGTGGCTCGCTGCCAAGTCTCTCGCTTTCGAGGAGATTGGCCAGGAATCTTGGACTGG
ATGACCCAGGAAATCCCCAAAGTCACGGTTATGAGTAGCACTTCGCTAATGGTGACCTACATGATGGCCCTAGGAGAGAC
CAATCGCCTCAATGAGATGATTCTGGAGTTAGAGCGATTCCAGCCTCAACTGGCCAATGCTGCTAGCAAATACTACTGGG
ATTTCAGTCGCCTGATCGTGTTTGCTTTTTGTGGACAGCCAGAACTGGTTGCTCGCTTGCTCAAAGGCCCTCTGGCGAAA
ATAGCGGATTCAGCCCAACAATTTTGGACTGCAACAGCGGCCATGGCAGCGGGTGAAACCGAGTTTGCTCAAACAGAGTT
CGATCGATTGATTGCCAGTGGCAATGGTCTCTATGCCAATACGCTACGCCAGCGTAATCCCCAAGCCTGTGTTGATGACG
CCTTAGATGATCATTCACGCCACCAATTAAAGGTGTGGGGAGATGCCTTATTCGTAGAATTGCCAGATCGGGAACGACAA
CGCGTCAAGATCTGGCAGTCGCCGATAACTCTAGGCTTGATTGTCATAAATCTCGCCTTCTTTGTTGCTGAGGTCATTCT
GGGCAGTCGTGCGAATGGACTCAATTTGGGGACAGATACCAATGCGTTGTACACCTTAGGAGCACTTATCCCGTCAGAAG
TGGTCGCCGGGGACTGGTGGAGACTCTTGGCAGCAGCTTTTCTGCACTTTGGCATTGAGCACCTTAGCCTCAATATGTTT
GGGTTAGGGCTGCTCGGGCCGTTTGTGGAGAAAATGTTGGGCACTTGGCGCTTTATCGTCTCGTATTTGATGACAGCGAT
TGGCTCAATGCTGACATTAACCCTATTAACGATTACCGGTATTTTTGTCACCCCAGCAGCAGTGGGGGCATCTGGAGCCA
TTATGGGTTTGATTGGGACTGAAGCTGCGATTCAGATGCGTATTATCAGACAGCAATCTTCTAAGGTGGCAGCGACTCGT
TTAAGGCTGATTGGTCTGTTTGTGGTTATCCAAATGATCTTCGATGCTGTGACTCCTCAAGTGAGTTTTATCGGCCATGC
CTCCGGTTTAGTGATTGGATTTGGGGTGGGTTGCATACTGAAGCTAAATGATCTGGTATCTGTTACTAAGCCAACGGCAC
TGAAATCTTTCTAA

Upstream 100 bases:

>100_bases
TCAGACAACCGCCTCCCAAAGGGAATTATCATGACAGGAACGTCCGGTTGTTTAGCTAAGCGTCCTATATGACCATCAAC
CCAGCCTCTGAGGAGCAGTA

Downstream 100 bases:

>100_bases
ACCCAGGGGGCCTCAATGGTAAGGCTAACTATGAAAAGAGGAATCTCTATCAATCTGGTGCGGATTATCATGTTTTGCTG
CATGGACTTGTCGTTTCCTT

Product: rhomboid family protein

Products: NA

Alternate protein names: Intramembrane serine protease [H]

Number of amino acids: Translated: 537; Mature: 537

Protein sequence:

>537_residues
MDFNQLLLWMVYVSCISLLIVGFKRGKAARGWLLIAALLLGLTLFLQQVLPNHVGLISGALWFLVILIPQRGSVRINQLA
WQHRFKPARQWAQVLRLLHPMDSFWQWPRYLHAMELAQAGQLPEAETKLRPFSQSQSLMSIVARCQVSRFRGDWPGILDW
MTQEIPKVTVMSSTSLMVTYMMALGETNRLNEMILELERFQPQLANAASKYYWDFSRLIVFAFCGQPELVARLLKGPLAK
IADSAQQFWTATAAMAAGETEFAQTEFDRLIASGNGLYANTLRQRNPQACVDDALDDHSRHQLKVWGDALFVELPDRERQ
RVKIWQSPITLGLIVINLAFFVAEVILGSRANGLNLGTDTNALYTLGALIPSEVVAGDWWRLLAAAFLHFGIEHLSLNMF
GLGLLGPFVEKMLGTWRFIVSYLMTAIGSMLTLTLLTITGIFVTPAAVGASGAIMGLIGTEAAIQMRIIRQQSSKVAATR
LRLIGLFVVIQMIFDAVTPQVSFIGHASGLVIGFGVGCILKLNDLVSVTKPTALKSF

Sequences:

>Translated_537_residues
MDFNQLLLWMVYVSCISLLIVGFKRGKAARGWLLIAALLLGLTLFLQQVLPNHVGLISGALWFLVILIPQRGSVRINQLA
WQHRFKPARQWAQVLRLLHPMDSFWQWPRYLHAMELAQAGQLPEAETKLRPFSQSQSLMSIVARCQVSRFRGDWPGILDW
MTQEIPKVTVMSSTSLMVTYMMALGETNRLNEMILELERFQPQLANAASKYYWDFSRLIVFAFCGQPELVARLLKGPLAK
IADSAQQFWTATAAMAAGETEFAQTEFDRLIASGNGLYANTLRQRNPQACVDDALDDHSRHQLKVWGDALFVELPDRERQ
RVKIWQSPITLGLIVINLAFFVAEVILGSRANGLNLGTDTNALYTLGALIPSEVVAGDWWRLLAAAFLHFGIEHLSLNMF
GLGLLGPFVEKMLGTWRFIVSYLMTAIGSMLTLTLLTITGIFVTPAAVGASGAIMGLIGTEAAIQMRIIRQQSSKVAATR
LRLIGLFVVIQMIFDAVTPQVSFIGHASGLVIGFGVGCILKLNDLVSVTKPTALKSF
>Mature_537_residues
MDFNQLLLWMVYVSCISLLIVGFKRGKAARGWLLIAALLLGLTLFLQQVLPNHVGLISGALWFLVILIPQRGSVRINQLA
WQHRFKPARQWAQVLRLLHPMDSFWQWPRYLHAMELAQAGQLPEAETKLRPFSQSQSLMSIVARCQVSRFRGDWPGILDW
MTQEIPKVTVMSSTSLMVTYMMALGETNRLNEMILELERFQPQLANAASKYYWDFSRLIVFAFCGQPELVARLLKGPLAK
IADSAQQFWTATAAMAAGETEFAQTEFDRLIASGNGLYANTLRQRNPQACVDDALDDHSRHQLKVWGDALFVELPDRERQ
RVKIWQSPITLGLIVINLAFFVAEVILGSRANGLNLGTDTNALYTLGALIPSEVVAGDWWRLLAAAFLHFGIEHLSLNMF
GLGLLGPFVEKMLGTWRFIVSYLMTAIGSMLTLTLLTITGIFVTPAAVGASGAIMGLIGTEAAIQMRIIRQQSSKVAATR
LRLIGLFVVIQMIFDAVTPQVSFIGHASGLVIGFGVGCILKLNDLVSVTKPTALKSF

Specific function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis. Important for normal cell division and sporulation. May act as a glucose exporter [H]

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002610
- InterPro:   IPR022764
- InterPro:   IPR001440
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734 [H]

Pfam domain/function: PF01694 Rhomboid; PF00515 TPR_1 [H]

EC number: =3.4.21.105 [H]

Molecular weight: Translated: 59677; Mature: 59677

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFNQLLLWMVYVSCISLLIVGFKRGKAARGWLLIAALLLGLTLFLQQVLPNHVGLISGA
CCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LWFLVILIPQRGSVRINQLAWQHRFKPARQWAQVLRLLHPMDSFWQWPRYLHAMELAQAG
HHHHHHHCCCCCCEEHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
QLPEAETKLRPFSQSQSLMSIVARCQVSRFRGDWPGILDWMTQEIPKVTVMSSTSLMVTY
CCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEECCHHHHHHH
MMALGETNRLNEMILELERFQPQLANAASKYYWDFSRLIVFAFCGQPELVARLLKGPLAK
HHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHH
IADSAQQFWTATAAMAAGETEFAQTEFDRLIASGNGLYANTLRQRNPQACVDDALDDHSR
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHCCCCC
HQLKVWGDALFVELPDRERQRVKIWQSPITLGLIVINLAFFVAEVILGSRANGLNLGTDT
CEEEEECCEEEEECCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
NALYTLGALIPSEVVAGDWWRLLAAAFLHFGIEHLSLNMFGLGLLGPFVEKMLGTWRFIV
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SYLMTAIGSMLTLTLLTITGIFVTPAAVGASGAIMGLIGTEAAIQMRIIRQQSSKVAATR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHCCHHHHHHHHHHHHHHHHHHHH
LRLIGLFVVIQMIFDAVTPQVSFIGHASGLVIGFGVGCILKLNDLVSVTKPTALKSF
HHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHCCHHHHHHHHHHHHHCCCHHHCCC
>Mature Secondary Structure
MDFNQLLLWMVYVSCISLLIVGFKRGKAARGWLLIAALLLGLTLFLQQVLPNHVGLISGA
CCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LWFLVILIPQRGSVRINQLAWQHRFKPARQWAQVLRLLHPMDSFWQWPRYLHAMELAQAG
HHHHHHHCCCCCCEEHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
QLPEAETKLRPFSQSQSLMSIVARCQVSRFRGDWPGILDWMTQEIPKVTVMSSTSLMVTY
CCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEECCHHHHHHH
MMALGETNRLNEMILELERFQPQLANAASKYYWDFSRLIVFAFCGQPELVARLLKGPLAK
HHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHH
IADSAQQFWTATAAMAAGETEFAQTEFDRLIASGNGLYANTLRQRNPQACVDDALDDHSR
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHCCCCC
HQLKVWGDALFVELPDRERQRVKIWQSPITLGLIVINLAFFVAEVILGSRANGLNLGTDT
CEEEEECCEEEEECCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
NALYTLGALIPSEVVAGDWWRLLAAAFLHFGIEHLSLNMFGLGLLGPFVEKMLGTWRFIV
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SYLMTAIGSMLTLTLLTITGIFVTPAAVGASGAIMGLIGTEAAIQMRIIRQQSSKVAATR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHCCHHHHHHHHHHHHHHHHHHHH
LRLIGLFVVIQMIFDAVTPQVSFIGHASGLVIGFGVGCILKLNDLVSVTKPTALKSF
HHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHCCHHHHHHHHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]