Click here to switch to the map view.

The map label for this gene is ald [H]

Identifier: 158337452

GI number: 158337452

Start: 4356911

End: 4358008

Strand: Direct

Name: ald [H]

Synonym: AM1_4331

Alternate gene names: 158337452

Gene position: 4356911-4358008 (Clockwise)

Preceding gene: 158337451

Following gene: 158337453

Centisome position: 66.99

GC content: 51.28

Gene sequence:

>1098_bases
ATGGAAATCGGTTTACCGAAAGAAATCAAGGATCAAGAATTTCGTGTTGGTCTTAGCCCTGCTAGCGTTCAATCTTTATG
TCAGCAAGGTCACCAAGTTTTTGTCGAGACCCATGCTGGGATAGGGGCAGGCTTTCCAGATGAGGACTATTTGCAGGCTG
GGGCCAAGATCGTCACCACTTCCGATCAAGCCTGGAACCGTGAGCTAGTCGTCAAAGTTAAAGAACCTTTGCCAGCAGAG
TATGGTTTGCTGCAGTCGGGGCAACTTCTATTTACCTATCTGCACTTAGCGGCAGATCGCACCTTGACGGAGCAGTTAAT
ACAAACCAATGTGAGTGCGATCGCCTATGAAACGGTAGAAGTAACCTTACCCGATCGCATTTCCCTCCCCCTACTGACTC
CCATGAGTGTGATCGCCGGTCGCCTCTCCATTCAATTTGGCGCGCGGTTTCTGGAGCGACAACAAGGCGGGCGAGGCGTC
TTACTAGGGGGAATTCCCGGGGTTAAACCTGGCAAAGTGGTGATTCTCGGTGGCGGTGTGGTGGGCACAGAAGCGGCTCG
TATTGCCGTTGGCATGGGGGCTCAAGTCACGATTTTGGATATTAATGTGGAACGGCTTTCCTATTTAGAGACCCTCTTTG
GCTCTCGGGTAGAGTTACTGTACAGCAGCTCCCGACATCTAGAGCAGGTATTACCCACTGCTGATCTATTGGTTGGTGCT
GTTCTTGTACCTGGCAAACGGGCTCCAATCTTAGTGTCTCGTGCATTAGTCCAGAAAATGGCGGCGGGTTCGGTAATTGT
GGATGTGGCAGTCGATCAAGGCGGCTGTATCGAAACACTGCACACGACCTCTCACACTGATCCAGTCTATGAAGCCGAGG
GGGTTCTCCATTATGGAGTTCCCAATATGCCGGGGGCAGTACCGTGGACAGCGACGCAAGCTTTAAACCACAGTACCTTC
CCGTTTGTGGCCAAGCTTGCCAACCATGGCTTAAAGGCTCTTGAAAAAGATGCTGCCTTGCAAAAGGGTTTGAATGTTTA
TCAGCAACGTTTGGTTCACCCGGCAGTTCAGCAAGTGTTCCCCGACTTAGCTGCCTAA

Upstream 100 bases:

>100_bases
ATATCGATTATTGGGATTGTTCGCGTTTCTCGGTGTTTAAACAACTCTTTTTCCCAGTCTCATCGTCTACCTTGTAGATA
GGCGGTTAGCAAGGTGGGGT

Downstream 100 bases:

>100_bases
ATCAGCTCTGGGGGAGCGGCTCAACGGTATGCTGAAAGGGAAGTCTTGAGTGGTTGGGCGCGAACCTATGTCCCATGCTG
GTGAATTAAATCCTGAGTCT

Product: alanine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MEIGLPKEIKDQEFRVGLSPASVQSLCQQGHQVFVETHAGIGAGFPDEDYLQAGAKIVTTSDQAWNRELVVKVKEPLPAE
YGLLQSGQLLFTYLHLAADRTLTEQLIQTNVSAIAYETVEVTLPDRISLPLLTPMSVIAGRLSIQFGARFLERQQGGRGV
LLGGIPGVKPGKVVILGGGVVGTEAARIAVGMGAQVTILDINVERLSYLETLFGSRVELLYSSSRHLEQVLPTADLLVGA
VLVPGKRAPILVSRALVQKMAAGSVIVDVAVDQGGCIETLHTTSHTDPVYEAEGVLHYGVPNMPGAVPWTATQALNHSTF
PFVAKLANHGLKALEKDAALQKGLNVYQQRLVHPAVQQVFPDLAA

Sequences:

>Translated_365_residues
MEIGLPKEIKDQEFRVGLSPASVQSLCQQGHQVFVETHAGIGAGFPDEDYLQAGAKIVTTSDQAWNRELVVKVKEPLPAE
YGLLQSGQLLFTYLHLAADRTLTEQLIQTNVSAIAYETVEVTLPDRISLPLLTPMSVIAGRLSIQFGARFLERQQGGRGV
LLGGIPGVKPGKVVILGGGVVGTEAARIAVGMGAQVTILDINVERLSYLETLFGSRVELLYSSSRHLEQVLPTADLLVGA
VLVPGKRAPILVSRALVQKMAAGSVIVDVAVDQGGCIETLHTTSHTDPVYEAEGVLHYGVPNMPGAVPWTATQALNHSTF
PFVAKLANHGLKALEKDAALQKGLNVYQQRLVHPAVQQVFPDLAA
>Mature_365_residues
MEIGLPKEIKDQEFRVGLSPASVQSLCQQGHQVFVETHAGIGAGFPDEDYLQAGAKIVTTSDQAWNRELVVKVKEPLPAE
YGLLQSGQLLFTYLHLAADRTLTEQLIQTNVSAIAYETVEVTLPDRISLPLLTPMSVIAGRLSIQFGARFLERQQGGRGV
LLGGIPGVKPGKVVILGGGVVGTEAARIAVGMGAQVTILDINVERLSYLETLFGSRVELLYSSSRHLEQVLPTADLLVGA
VLVPGKRAPILVSRALVQKMAAGSVIVDVAVDQGGCIETLHTTSHTDPVYEAEGVLHYGVPNMPGAVPWTATQALNHSTF
PFVAKLANHGLKALEKDAALQKGLNVYQQRLVHPAVQQVFPDLAA

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=343, Percent_Identity=31.7784256559767, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI122939153, Length=343, Percent_Identity=31.7784256559767, Blast_Score=137, Evalue=2e-32,
Organism=Escherichia coli, GI1787887, Length=336, Percent_Identity=32.4404761904762, Blast_Score=139, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17550456, Length=350, Percent_Identity=28.5714285714286, Blast_Score=144, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 39038; Mature: 39038

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIGLPKEIKDQEFRVGLSPASVQSLCQQGHQVFVETHAGIGAGFPDEDYLQAGAKIVTT
CCCCCCCCCCCCCEEECCCHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHCCCEEEEE
SDQAWNRELVVKVKEPLPAEYGLLQSGQLLFTYLHLAADRTLTEQLIQTNVSAIAYETVE
CCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHCHHHEEEEEEE
VTLPDRISLPLLTPMSVIAGRLSIQFGARFLERQQGGRGVLLGGIPGVKPGKVVILGGGV
EECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEECCCE
VGTEAARIAVGMGAQVTILDINVERLSYLETLFGSRVELLYSSSRHLEQVLPTADLLVGA
ECCCHHEEEECCCCEEEEEECCHHHHHHHHHHHCCHHEEHHCCHHHHHHHCCHHHHHHHH
VLVPGKRAPILVSRALVQKMAAGSVIVDVAVDQGGCIETLHTTSHTDPVYEAEGVLHYGV
HCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEECCCCCCCCCCCCCEEEECC
PNMPGAVPWTATQALNHSTFPFVAKLANHGLKALEKDAALQKGLNVYQQRLVHPAVQQVF
CCCCCCCCCHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PDLAA
HHHCC
>Mature Secondary Structure
MEIGLPKEIKDQEFRVGLSPASVQSLCQQGHQVFVETHAGIGAGFPDEDYLQAGAKIVTT
CCCCCCCCCCCCCEEECCCHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHCCCEEEEE
SDQAWNRELVVKVKEPLPAEYGLLQSGQLLFTYLHLAADRTLTEQLIQTNVSAIAYETVE
CCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHCHHHEEEEEEE
VTLPDRISLPLLTPMSVIAGRLSIQFGARFLERQQGGRGVLLGGIPGVKPGKVVILGGGV
EECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEECCCE
VGTEAARIAVGMGAQVTILDINVERLSYLETLFGSRVELLYSSSRHLEQVLPTADLLVGA
ECCCHHEEEECCCCEEEEEECCHHHHHHHHHHHCCHHEEHHCCHHHHHHHCCHHHHHHHH
VLVPGKRAPILVSRALVQKMAAGSVIVDVAVDQGGCIETLHTTSHTDPVYEAEGVLHYGV
HCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEECCCCCCCCCCCCCEEEECC
PNMPGAVPWTATQALNHSTFPFVAKLANHGLKALEKDAALQKGLNVYQQRLVHPAVQQVF
CCCCCCCCCHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PDLAA
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA