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The map label for this gene is hemK [C]

Identifier: 158337450

GI number: 158337450

Start: 4355520

End: 4356458

Strand: Direct

Name: hemK [C]

Synonym: AM1_4329

Alternate gene names: 158337450

Gene position: 4355520-4356458 (Clockwise)

Preceding gene: 158337449

Following gene: 158337451

Centisome position: 66.97

GC content: 48.88

Gene sequence:

>939_bases
GTGCAACCCCAGCGGCAACCCCTAAGAAGTAACGCCTTCCAGGTCTCGGGTCAGAGACTTTGGCAATGGTATCAACAAGC
GATCGCAAATCTGTCTCAAGAACAGGAGCGATCGCTTGTTGATTTAAGGCAGGAATTGGATTGGCTGTTGTTAGAGATCT
CTAACCTTACCCCTCTAGATTTGAAGTTAACGCCATCTGCGCCCCCGATCGTTCAGATGCAGGTGTCTTTAGAAGAACTG
CAGCAGCTCTGGCAGCAACGACTGACTGAGAATAAGCCGGTTCAACATCTGACGGGGACAACCCATTGGCGTCAGTTTCA
TTTACAGGTATCAAAGGATGTCCTGATTCCTCGTCCAGAAACAGAATTGTTGATTGACTTGGTTGTGGATGCCGCTCAAA
ATTCTGCGCGTTTAGATCACTTGAATTTATGGGCCGATCTGGGTACGGGGAGTGGGGCCATTGCTTTGGGGTTAGCGACG
GCTTTTCCCCAAGGGACTGTGCATACTGTGGACTGTAGTCGGGAAGCGTTAGCGGTTGCTCAACGTAATAGCCAGACCTA
TGGCCTAGATCCGCAAATCCACTTTCATTGGGGACAGTGGTTTGGACCTTTAGTAGGGTTAGAAGGTCAATTTTCTGGGA
TTGTCAGTAATCCGCCCTATATTCCGACGGAGATTTTACCGACCCTGCAGCCTGAAGTGTTTGAGCATGAACCCCATCTG
GCCTTGGATGGTGGTGAAGATGGATTAGATGCGATACAGGAGATTGTTGCGATCGCACCCCAATACCTCCAACCTGGTGG
TTTCTTACTCCTGGAGATGATGTGTGGCCAAGATGCAGCCGTTAAAACACTCCTTATCAACCAAGGCCAGTACGAACAGA
TTCAAATTCATCCAGATTTAGCGGGTATTCCTCGATTTGCCCAAGCCTATCGAATATAA

Upstream 100 bases:

>100_bases
GAAGATGCTACCGCTAAGCAAATTGTGCTGATTCCGGCCCGAGATGCCTTAGAGTATGCTGTTCAGCAGCAGAAGAAAAA
TGGCGCTCAGCAGAAGCCTA

Downstream 100 bases:

>100_bases
GTTACGGTTCGAGTAGCAGTATTTGTGACGACCATGACCATTCTGGAGCGCCTTCAAGCAGACTACGACCGTTTCCCCGA
GAATCAGTCTTTTGACTTGT

Product: protoporphyrinogen IX oxidase

Products: NA

Alternate protein names: M.Ssp6803HemKP [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MQPQRQPLRSNAFQVSGQRLWQWYQQAIANLSQEQERSLVDLRQELDWLLLEISNLTPLDLKLTPSAPPIVQMQVSLEEL
QQLWQQRLTENKPVQHLTGTTHWRQFHLQVSKDVLIPRPETELLIDLVVDAAQNSARLDHLNLWADLGTGSGAIALGLAT
AFPQGTVHTVDCSREALAVAQRNSQTYGLDPQIHFHWGQWFGPLVGLEGQFSGIVSNPPYIPTEILPTLQPEVFEHEPHL
ALDGGEDGLDAIQEIVAIAPQYLQPGGFLLLEMMCGQDAAVKTLLINQGQYEQIQIHPDLAGIPRFAQAYRI

Sequences:

>Translated_312_residues
MQPQRQPLRSNAFQVSGQRLWQWYQQAIANLSQEQERSLVDLRQELDWLLLEISNLTPLDLKLTPSAPPIVQMQVSLEEL
QQLWQQRLTENKPVQHLTGTTHWRQFHLQVSKDVLIPRPETELLIDLVVDAAQNSARLDHLNLWADLGTGSGAIALGLAT
AFPQGTVHTVDCSREALAVAQRNSQTYGLDPQIHFHWGQWFGPLVGLEGQFSGIVSNPPYIPTEILPTLQPEVFEHEPHL
ALDGGEDGLDAIQEIVAIAPQYLQPGGFLLLEMMCGQDAAVKTLLINQGQYEQIQIHPDLAGIPRFAQAYRI
>Mature_312_residues
MQPQRQPLRSNAFQVSGQRLWQWYQQAIANLSQEQERSLVDLRQELDWLLLEISNLTPLDLKLTPSAPPIVQMQVSLEEL
QQLWQQRLTENKPVQHLTGTTHWRQFHLQVSKDVLIPRPETELLIDLVVDAAQNSARLDHLNLWADLGTGSGAIALGLAT
AFPQGTVHTVDCSREALAVAQRNSQTYGLDPQIHFHWGQWFGPLVGLEGQFSGIVSNPPYIPTEILPTLQPEVFEHEPHL
ALDGGEDGLDAIQEIVAIAPQYLQPGGFLLLEMMCGQDAAVKTLLINQGQYEQIQIHPDLAGIPRFAQAYRI

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:
GO:0003676: Protoporphyrinogen IX oxidase
GO:0006479: Protoporphyrinogen IX oxidase
GO:0008168: Protoporphyrinogen IX oxidase
GO:0008276: Protoporphyrinogen IX oxidase
GO:0032259: Protoporphyrinogen IX oxidase

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=254, Percent_Identity=31.496062992126, Blast_Score=96, Evalue=6e-20,
Organism=Escherichia coli, GI1787463, Length=224, Percent_Identity=38.8392857142857, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI87082085, Length=189, Percent_Identity=35.978835978836, Blast_Score=95, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24582226, Length=242, Percent_Identity=32.2314049586777, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.-

Molecular weight: Translated: 34995; Mature: 34995

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPQRQPLRSNAFQVSGQRLWQWYQQAIANLSQEQERSLVDLRQELDWLLLEISNLTPLD
CCCCCCCHHCCCEEECHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEE
LKLTPSAPPIVQMQVSLEELQQLWQQRLTENKPVQHLTGTTHWRQFHLQVSKDVLIPRPE
EEECCCCCCEEEEEECHHHHHHHHHHHCCCCCCCHHHCCCCCEEEEEEEECCCEECCCCC
TELLIDLVVDAAQNSARLDHLNLWADLGTGSGAIALGLATAFPQGTVHTVDCSREALAVA
HHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHEEHHHHHCCCCCEEEECCCHHHHHHH
QRNSQTYGLDPQIHFHWGQWFGPLVGLEGQFSGIVSNPPYIPTEILPTLQPEVFEHEPHL
HCCCCCCCCCCEEEEECCCHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCHHHCCCCCE
ALDGGEDGLDAIQEIVAIAPQYLQPGGFLLLEMMCGQDAAVKTLLINQGQYEQIQIHPDL
EECCCCCHHHHHHHHHHHCHHHCCCCCCEEHHHHHCCCHHHHEEEECCCCCEEEEECCCC
AGIPRFAQAYRI
CCCCHHHHHHCC
>Mature Secondary Structure
MQPQRQPLRSNAFQVSGQRLWQWYQQAIANLSQEQERSLVDLRQELDWLLLEISNLTPLD
CCCCCCCHHCCCEEECHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEE
LKLTPSAPPIVQMQVSLEELQQLWQQRLTENKPVQHLTGTTHWRQFHLQVSKDVLIPRPE
EEECCCCCCEEEEEECHHHHHHHHHHHCCCCCCCHHHCCCCCEEEEEEEECCCEECCCCC
TELLIDLVVDAAQNSARLDHLNLWADLGTGSGAIALGLATAFPQGTVHTVDCSREALAVA
HHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHEEHHHHHCCCCCEEEECCCHHHHHHH
QRNSQTYGLDPQIHFHWGQWFGPLVGLEGQFSGIVSNPPYIPTEILPTLQPEVFEHEPHL
HCCCCCCCCCCEEEEECCCHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCHHHCCCCCE
ALDGGEDGLDAIQEIVAIAPQYLQPGGFLLLEMMCGQDAAVKTLLINQGQYEQIQIHPDL
EECCCCCHHHHHHHHHHHCHHHCCCCCCEEHHHHHCCCHHHHEEEECCCCCEEEEECCCC
AGIPRFAQAYRI
CCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]