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The map label for this gene is ung [H]

Identifier: 158337272

GI number: 158337272

Start: 4185982

End: 4186683

Strand: Reverse

Name: ung [H]

Synonym: AM1_4149

Alternate gene names: 158337272

Gene position: 4186683-4185982 (Counterclockwise)

Preceding gene: 158337273

Following gene: 158337270

Centisome position: 64.37

GC content: 47.58

Gene sequence:

>702_bases
ATGACAACAGAAGCCACTCCCTCCTCTAGCAGCACGATTAAACTTGACCCCAGCTGGAAAGCTGTGCTGGAGCATGTATT
TGCCATGTCCTATATGCAGGAGCTAAAACAGTTTCTCAAGGCAGAAAAGGCTGCTGGCAAAACGATTTACCCCCGTGGCT
CACTGATGTTCAATGCCATGGATAGTACCCCTTTTGATCACGTCAAAGTTGTGATTCTTGGCCAAGACCCCTATCACGGT
CCCAGGCAAGCTCATGGTTTATGCTTTTCCGTTCCAGAGGGCGTTGCACCACCCCCTTCTTTAGTCAATATTTTTAAAGA
AATTGAACAAGACCTGGGGATTAAACCACCTAGACACGGTTGCCTGCAAAGTTGGGCAGCCCAAGGTGTTTTACTACTCA
ATAGTGTCCTCACCGTAGAGCAGCATAAAGCTGCCTCTCATCGAAACAAAGGTTGGGAGCAATTTACCGATGCCATTATC
AGTGCCTTAAACCAACAGCGCGAACATCTTGTATTTCTGCTATGGGGCAGTTATGCCCAACAGAAAGGGAAAATCATTGA
CCGTCGACGGCACCTAGTTTTAACCTCGCCCCACCCATCACCGCTATCCGCCCATCGGGGCTTCTTTGGCAACCAGCATT
TTTCTAAAGCTAATGCGTATTTGCAAAAGAATGGCATTGAGCCCATTTCCTGGTCTTTATAG

Upstream 100 bases:

>100_bases
GCAGCTCAACTAATTGGTGCTGAATAGCCTTAGTACTGCGCCTTTGCCAAACAACCCCAAATCAGTGAATTTCCTTCTTC
TTTGACAGACAGATCCTCTT

Downstream 100 bases:

>100_bases
CCGTTTAACTGAAGAGATAGTTCTCTGTCACAGAAAAACTTCCATGCCAGAGAGTTTGTAAGCAAAAGGTATTGGCTACT
TTAGAGACTAGATTGACCAG

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 233; Mature: 232

Protein sequence:

>233_residues
MTTEATPSSSSTIKLDPSWKAVLEHVFAMSYMQELKQFLKAEKAAGKTIYPRGSLMFNAMDSTPFDHVKVVILGQDPYHG
PRQAHGLCFSVPEGVAPPPSLVNIFKEIEQDLGIKPPRHGCLQSWAAQGVLLLNSVLTVEQHKAASHRNKGWEQFTDAII
SALNQQREHLVFLLWGSYAQQKGKIIDRRRHLVLTSPHPSPLSAHRGFFGNQHFSKANAYLQKNGIEPISWSL

Sequences:

>Translated_233_residues
MTTEATPSSSSTIKLDPSWKAVLEHVFAMSYMQELKQFLKAEKAAGKTIYPRGSLMFNAMDSTPFDHVKVVILGQDPYHG
PRQAHGLCFSVPEGVAPPPSLVNIFKEIEQDLGIKPPRHGCLQSWAAQGVLLLNSVLTVEQHKAASHRNKGWEQFTDAII
SALNQQREHLVFLLWGSYAQQKGKIIDRRRHLVLTSPHPSPLSAHRGFFGNQHFSKANAYLQKNGIEPISWSL
>Mature_232_residues
TTEATPSSSSTIKLDPSWKAVLEHVFAMSYMQELKQFLKAEKAAGKTIYPRGSLMFNAMDSTPFDHVKVVILGQDPYHGP
RQAHGLCFSVPEGVAPPPSLVNIFKEIEQDLGIKPPRHGCLQSWAAQGVLLLNSVLTVEQHKAASHRNKGWEQFTDAIIS
ALNQQREHLVFLLWGSYAQQKGKIIDRRRHLVLTSPHPSPLSAHRGFFGNQHFSKANAYLQKNGIEPISWSL

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=215, Percent_Identity=57.6744186046512, Blast_Score=241, Evalue=5e-64,
Organism=Homo sapiens, GI6224979, Length=215, Percent_Identity=57.6744186046512, Blast_Score=240, Evalue=8e-64,
Organism=Escherichia coli, GI1788934, Length=215, Percent_Identity=56.7441860465116, Blast_Score=242, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17556304, Length=217, Percent_Identity=47.4654377880184, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6323620, Length=236, Percent_Identity=43.6440677966102, Blast_Score=172, Evalue=5e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 26029; Mature: 25898

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTEATPSSSSTIKLDPSWKAVLEHVFAMSYMQELKQFLKAEKAAGKTIYPRGSLMFNAM
CCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCEEEEEC
DSTPFDHVKVVILGQDPYHGPRQAHGLCFSVPEGVAPPPSLVNIFKEIEQDLGIKPPRHG
CCCCCCCEEEEEECCCCCCCCHHHCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCHHH
CLQSWAAQGVLLLNSVLTVEQHKAASHRNKGWEQFTDAIISALNQQREHLVFLLWGSYAQ
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEEEEECCHHH
QKGKIIDRRRHLVLTSPHPSPLSAHRGFFGNQHFSKANAYLQKNGIEPISWSL
HCCHHHHCCCCEEEECCCCCCCHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TTEATPSSSSTIKLDPSWKAVLEHVFAMSYMQELKQFLKAEKAAGKTIYPRGSLMFNAM
CCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCEEEEEC
DSTPFDHVKVVILGQDPYHGPRQAHGLCFSVPEGVAPPPSLVNIFKEIEQDLGIKPPRHG
CCCCCCCEEEEEECCCCCCCCHHHCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCHHH
CLQSWAAQGVLLLNSVLTVEQHKAASHRNKGWEQFTDAIISALNQQREHLVFLLWGSYAQ
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEEEEECCHHH
QKGKIIDRRRHLVLTSPHPSPLSAHRGFFGNQHFSKANAYLQKNGIEPISWSL
HCCHHHHCCCCEEEECCCCCCCHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]