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The map label for this gene is htrA [H]

Identifier: 158337197

GI number: 158337197

Start: 4121494

End: 4122660

Strand: Direct

Name: htrA [H]

Synonym: AM1_4074

Alternate gene names: 158337197

Gene position: 4121494-4122660 (Clockwise)

Preceding gene: 158337195

Following gene: 158337198

Centisome position: 63.37

GC content: 51.5

Gene sequence:

>1167_bases
ATGCAGCGATCCCTTAAACATCTAGTCTTTTCCCTATTGGTAGGAAGTGCGCTGCTCCAGACCGGCTGTCAAAGTTGGTT
TAATCGAGGGGGCGACACTGCTGAGAGTCCCCAAAGTACCCCCGAAATTCCGGCCACAGAAATTGCCAATCGCTCCCAGA
TTAGTTCTAACTTGATTGTCAAAATGGTGGACCAAGTCGGCCCTTCTGTGGTGCGTATTAATGCGGCCCGTAGCTCCAAA
GGGTCATTCGGTTTGTTTGACCGTCCTGATCGTTCCCTAGAGCAAGGGACGGGGTCTGGGTTTATTTTTGATGAGACCGG
CTTGGTCCTAACAAATGCCCATGTCGTTGAAGATGCAGATGAAGTAACGGTTGTGCTCAAGGACGGCCAGCAGTTTCCCG
GCACTGTCGAGGGAGCTGATCCCCTCACCGACATTGCTGTGATTAAAATAGAGGCCAAGGAGTCTCTGCCTGCCCTTGAA
CTGGGAGATTCAGATACGTTACAGCCTGGAGACTGGGCCATTGCCATTGGAAATCCCTTGGGGCTGAACAATACAGTGAC
CATGGGCATTATTAGCGCCACGGATCGGTCTAGTTCCCAGCTAGGAGCCCCGGACCAGCGCGTGAACTTTATCCAAACAG
ATGCTGCGATTAACCCAGGAAATTCAGGGGGACCGTTGCTCAATCTCAAAGGTGAGGTGATTGGGATTAATACGGCGATT
ATTCGCGAGTCCCAGGAGTCAGGGGTCACCGCTCAGGGGCTTGGTTTTGCCATTCCCGTGAAGATTGCTGCTCGCATTAG
TAAGCAATTATTGAATGATGGGACAGTTGCCCATCCCTATTTGGGAATTCGGATGGTGAGCGTTTCGGCAGAGACGAAGG
CGTTGTTACAAGAAGAGCTGGACCTACAAGTCGAGCAAGAGAAAGGGGTGCTGGTGGTGGATGTCTTGTCCGATTCGCCA
GCGGCAGTGGCTCAGTTAAAGTCTGGCGATGTGATTGTACAAATTGGCAAAACTCAAATTGATAATACTGAGCAACTGCA
GCAGCTCTTACAGTCTGTGACGCCGGGTGATCAGCTCTCCCTCACCATCATGCGGAAGAATCAGAAACGCCAAGCCCAAC
TGGAAGTGGGCACCCTCAAACCTAAAACCTTCTCGCGACGGTCTTAA

Upstream 100 bases:

>100_bases
AGATGGCAAAAGTTGAATTTGGCCATAATACCCAATTGCTCCCAGGTTAGAGTGGAGTAAAGAATCCAGATCACGCTGAA
TGCGCACTAGTTTTACGATA

Downstream 100 bases:

>100_bases
GCACTGAGGCGATGGATTTATTTGAGCAGCATCGTCAACAGCTTTTAGAAACGGAGGCTCCCCTGGCTGCACGGTTACGT
CCCCGCACTTTGGATGAGTT

Product: trypsin-like serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MQRSLKHLVFSLLVGSALLQTGCQSWFNRGGDTAESPQSTPEIPATEIANRSQISSNLIVKMVDQVGPSVVRINAARSSK
GSFGLFDRPDRSLEQGTGSGFIFDETGLVLTNAHVVEDADEVTVVLKDGQQFPGTVEGADPLTDIAVIKIEAKESLPALE
LGDSDTLQPGDWAIAIGNPLGLNNTVTMGIISATDRSSSQLGAPDQRVNFIQTDAAINPGNSGGPLLNLKGEVIGINTAI
IRESQESGVTAQGLGFAIPVKIAARISKQLLNDGTVAHPYLGIRMVSVSAETKALLQEELDLQVEQEKGVLVVDVLSDSP
AAVAQLKSGDVIVQIGKTQIDNTEQLQQLLQSVTPGDQLSLTIMRKNQKRQAQLEVGTLKPKTFSRRS

Sequences:

>Translated_388_residues
MQRSLKHLVFSLLVGSALLQTGCQSWFNRGGDTAESPQSTPEIPATEIANRSQISSNLIVKMVDQVGPSVVRINAARSSK
GSFGLFDRPDRSLEQGTGSGFIFDETGLVLTNAHVVEDADEVTVVLKDGQQFPGTVEGADPLTDIAVIKIEAKESLPALE
LGDSDTLQPGDWAIAIGNPLGLNNTVTMGIISATDRSSSQLGAPDQRVNFIQTDAAINPGNSGGPLLNLKGEVIGINTAI
IRESQESGVTAQGLGFAIPVKIAARISKQLLNDGTVAHPYLGIRMVSVSAETKALLQEELDLQVEQEKGVLVVDVLSDSP
AAVAQLKSGDVIVQIGKTQIDNTEQLQQLLQSVTPGDQLSLTIMRKNQKRQAQLEVGTLKPKTFSRRS
>Mature_388_residues
MQRSLKHLVFSLLVGSALLQTGCQSWFNRGGDTAESPQSTPEIPATEIANRSQISSNLIVKMVDQVGPSVVRINAARSSK
GSFGLFDRPDRSLEQGTGSGFIFDETGLVLTNAHVVEDADEVTVVLKDGQQFPGTVEGADPLTDIAVIKIEAKESLPALE
LGDSDTLQPGDWAIAIGNPLGLNNTVTMGIISATDRSSSQLGAPDQRVNFIQTDAAINPGNSGGPLLNLKGEVIGINTAI
IRESQESGVTAQGLGFAIPVKIAARISKQLLNDGTVAHPYLGIRMVSVSAETKALLQEELDLQVEQEKGVLVVDVLSDSP
AAVAQLKSGDVIVQIGKTQIDNTEQLQQLLQSVTPGDQLSLTIMRKNQKRQAQLEVGTLKPKTFSRRS

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=318, Percent_Identity=37.7358490566038, Blast_Score=188, Evalue=6e-48,
Organism=Homo sapiens, GI24308541, Length=318, Percent_Identity=35.5345911949685, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI22129776, Length=325, Percent_Identity=36.9230769230769, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI7019477, Length=321, Percent_Identity=37.3831775700935, Blast_Score=173, Evalue=2e-43,
Organism=Escherichia coli, GI1789629, Length=353, Percent_Identity=36.2606232294618, Blast_Score=188, Evalue=5e-49,
Organism=Escherichia coli, GI1786356, Length=281, Percent_Identity=41.6370106761566, Blast_Score=188, Evalue=6e-49,
Organism=Escherichia coli, GI1789630, Length=377, Percent_Identity=35.2785145888594, Blast_Score=186, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24646839, Length=323, Percent_Identity=37.1517027863777, Blast_Score=183, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 41234; Mature: 41234

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRSLKHLVFSLLVGSALLQTGCQSWFNRGGDTAESPQSTPEIPATEIANRSQISSNLIV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHH
KMVDQVGPSVVRINAARSSKGSFGLFDRPDRSLEQGTGSGFIFDETGLVLTNAHVVEDAD
HHHHHCCCCEEEEEECCCCCCCCCCCCCCCCHHHCCCCCEEEEECCCEEEECCEEECCCC
EVTVVLKDGQQFPGTVEGADPLTDIAVIKIEAKESLPALELGDSDTLQPGDWAIAIGNPL
EEEEEEECCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEECCCCCCCCCCCEEEEECCCC
GLNNTVTMGIISATDRSSSQLGAPDQRVNFIQTDAAINPGNSGGPLLNLKGEVIGINTAI
CCCCEEEEEEEEECCCCCCCCCCCHHHCEEEEECCEECCCCCCCCEEEECCCEEEEEHHE
IRESQESGVTAQGLGFAIPVKIAARISKQLLNDGTVAHPYLGIRMVSVSAETKALLQEEL
EECCHHCCCEECCCCEEEHHHHHHHHHHHHHCCCCEECCEEEEEEEEECHHHHHHHHHHH
DLQVEQEKGVLVVDVLSDSPAAVAQLKSGDVIVQIGKTQIDNTEQLQQLLQSVTPGDQLS
CCEEECCCCEEEEEECCCCCHHHHEECCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCEE
LTIMRKNQKRQAQLEVGTLKPKTFSRRS
EEEEECCCCCEEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MQRSLKHLVFSLLVGSALLQTGCQSWFNRGGDTAESPQSTPEIPATEIANRSQISSNLIV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHH
KMVDQVGPSVVRINAARSSKGSFGLFDRPDRSLEQGTGSGFIFDETGLVLTNAHVVEDAD
HHHHHCCCCEEEEEECCCCCCCCCCCCCCCCHHHCCCCCEEEEECCCEEEECCEEECCCC
EVTVVLKDGQQFPGTVEGADPLTDIAVIKIEAKESLPALELGDSDTLQPGDWAIAIGNPL
EEEEEEECCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEECCCCCCCCCCCEEEEECCCC
GLNNTVTMGIISATDRSSSQLGAPDQRVNFIQTDAAINPGNSGGPLLNLKGEVIGINTAI
CCCCEEEEEEEEECCCCCCCCCCCHHHCEEEEECCEECCCCCCCCEEEECCCEEEEEHHE
IRESQESGVTAQGLGFAIPVKIAARISKQLLNDGTVAHPYLGIRMVSVSAETKALLQEEL
EECCHHCCCEECCCCEEEHHHHHHHHHHHHHCCCCEECCEEEEEEEEECHHHHHHHHHHH
DLQVEQEKGVLVVDVLSDSPAAVAQLKSGDVIVQIGKTQIDNTEQLQQLLQSVTPGDQLS
CCEEECCCCEEEEEECCCCCHHHHEECCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCEE
LTIMRKNQKRQAQLEVGTLKPKTFSRRS
EEEEECCCCCEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]