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The map label for this gene is ubiH [C]

Identifier: 158337158

GI number: 158337158

Start: 4080709

End: 4082016

Strand: Direct

Name: ubiH [C]

Synonym: AM1_4033

Alternate gene names: 158337158

Gene position: 4080709-4082016 (Clockwise)

Preceding gene: 158337157

Following gene: 158337160

Centisome position: 62.74

GC content: 51.07

Gene sequence:

>1308_bases
ATGGCTTCAGTTCAACCCACCACGAAACATACTGCTGTCGCGGAAGTTAATGCCCCGTCTTCCACCAGCTTTGACTATGA
CGTCGCCATCGTCGGGGGTGGAATCGTTGGCGCAACTCTCGCTGCAGCCCTCAAAGATACAAACTTGCGGGTGGTCGTGA
TTGAAGCACAACCCCGCTCAGTGGCCGTCGCGAAAGGACAAGCCTATGCGATTCACCTCAGTTCTAGTCGAATTTATCAG
GGAATTGGCGTTTGGGAGGCTATTGCTCCTCAAGTCGAATATTTTTCCCAGGTGCATCTCTCGGATGGCAATTGTCCCAG
TGTCGTCAAATTTAAGCCGAGAGATTTGGGGACGCCTGTTTTAGGTTATGTTGCCGAACATCGAGTGTTACTCAAAGAGC
TACTTCAGTTTCTGGAAACGTGTGAGCATGTTGACTGGTGCTGTCCTGCTCAAGTAACAACCACCCATTACCATCCTCAT
GGTGTAGAGGTTCAATTGGCACCCAGCTCTGCTGGAGTAGAAGCAGCCCATCGGCATGAGGTCGAGTCTCTTCCCCAAAC
TTTAAACGTCAGAATGTTGGTGGCGGCAGATGGATCCCGATCTCAAGTTCGTCAGCAGGCTGGTATTACCACTCAAGGCT
GGGATTATTGGCAATCCTGTCTTGTGGCGACCATTGCTCCCGAGAAGTTTCATAACCATATTGCCTATGAGCGGTTTTGG
CCCAGTGGTCCTTTTGCTATTTTGCCGATTGCAAATCGCCAATGTCGAATTGTGTGGACGGCTCCCCATGCTCAAGCCCA
AGCATTATTAGAATTAGAAGAAGATCAGTTTCTAGACTTACTTCAGCAGCGATACGGATCGCAAATGGGCAAACTTTCTC
TAGTGGGACACCGTTTCCTATTTCCAGCGAAATGGATGCATTCCACTCAATATACGGGGCACCGACTTGCTTTGGTCGGT
GATGCTGCCCATACCTGCCATCCGGTCGGAGGCCAAGGATTAAACTTAGGCATTCGGGATGCAGCAGCCTTAGCCCAAGT
CCTGCATGTCGCTCATCAAGCCGGTCAAGATATCGGGAGTGTTCAGGTACTGCGGCAATATCAGCGTTGGCGTCGCCGCC
AAAATTGGCTAGCCCTCGGTTTTACCGACATTCTCAATCGAGTCTTTTCCAATCGGTGGTTCTTAGTGGTTCAAGGACGG
CGCTTGGGCTTGCGTATATTGCAATGGATTGCTCCCCTGCGGATCCTGGCGCTCCGCTTTATGGCTGGTTTGAGTGGCCG
TTTGCCGAACCTGGCACAACCTAAGTAG

Upstream 100 bases:

>100_bases
CCGTTGTTGCTCTGTGAACGCTCAATCCTAGAAGCCTCCAGTTGCCTACCGTTCAAAAAACAGGCAACAATGAAAGATGT
ATTACACTCTTTCTCATTCC

Downstream 100 bases:

>100_bases
ACTCATAGGAACTCATCTATACTTTCAAGGGACCCAGAAGAAATGGCTGCAAGGCACCATAGTAGAGTCAATGCCTCAGT
ATTCTGGGATGTGATCTGTT

Product: 2-octaprenyl-6-methoxyphenyl hydroxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MASVQPTTKHTAVAEVNAPSSTSFDYDVAIVGGGIVGATLAAALKDTNLRVVVIEAQPRSVAVAKGQAYAIHLSSSRIYQ
GIGVWEAIAPQVEYFSQVHLSDGNCPSVVKFKPRDLGTPVLGYVAEHRVLLKELLQFLETCEHVDWCCPAQVTTTHYHPH
GVEVQLAPSSAGVEAAHRHEVESLPQTLNVRMLVAADGSRSQVRQQAGITTQGWDYWQSCLVATIAPEKFHNHIAYERFW
PSGPFAILPIANRQCRIVWTAPHAQAQALLELEEDQFLDLLQQRYGSQMGKLSLVGHRFLFPAKWMHSTQYTGHRLALVG
DAAHTCHPVGGQGLNLGIRDAAALAQVLHVAHQAGQDIGSVQVLRQYQRWRRRQNWLALGFTDILNRVFSNRWFLVVQGR
RLGLRILQWIAPLRILALRFMAGLSGRLPNLAQPK

Sequences:

>Translated_435_residues
MASVQPTTKHTAVAEVNAPSSTSFDYDVAIVGGGIVGATLAAALKDTNLRVVVIEAQPRSVAVAKGQAYAIHLSSSRIYQ
GIGVWEAIAPQVEYFSQVHLSDGNCPSVVKFKPRDLGTPVLGYVAEHRVLLKELLQFLETCEHVDWCCPAQVTTTHYHPH
GVEVQLAPSSAGVEAAHRHEVESLPQTLNVRMLVAADGSRSQVRQQAGITTQGWDYWQSCLVATIAPEKFHNHIAYERFW
PSGPFAILPIANRQCRIVWTAPHAQAQALLELEEDQFLDLLQQRYGSQMGKLSLVGHRFLFPAKWMHSTQYTGHRLALVG
DAAHTCHPVGGQGLNLGIRDAAALAQVLHVAHQAGQDIGSVQVLRQYQRWRRRQNWLALGFTDILNRVFSNRWFLVVQGR
RLGLRILQWIAPLRILALRFMAGLSGRLPNLAQPK
>Mature_434_residues
ASVQPTTKHTAVAEVNAPSSTSFDYDVAIVGGGIVGATLAAALKDTNLRVVVIEAQPRSVAVAKGQAYAIHLSSSRIYQG
IGVWEAIAPQVEYFSQVHLSDGNCPSVVKFKPRDLGTPVLGYVAEHRVLLKELLQFLETCEHVDWCCPAQVTTTHYHPHG
VEVQLAPSSAGVEAAHRHEVESLPQTLNVRMLVAADGSRSQVRQQAGITTQGWDYWQSCLVATIAPEKFHNHIAYERFWP
SGPFAILPIANRQCRIVWTAPHAQAQALLELEEDQFLDLLQQRYGSQMGKLSLVGHRFLFPAKWMHSTQYTGHRLALVGD
AAHTCHPVGGQGLNLGIRDAAALAQVLHVAHQAGQDIGSVQVLRQYQRWRRRQNWLALGFTDILNRVFSNRWFLVVQGRR
LGLRILQWIAPLRILALRFMAGLSGRLPNLAQPK

Specific function: Oxygenase That Introduces The Hydroxyl Group At Carbon Four Of 2-Octaprenyl-6-Methoxyphenol Resulting In The Formation Of 2-Octaprenyl-6-Methoxy-1,4-Benzoquinone. [C]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:
GO:0006744: 2-octaprenyl-6-methoxyphenyl hydroxylase
GO:0008152: 2-octaprenyl-6-methoxyphenyl hydroxylase
GO:0016491: 2-octaprenyl-6-methoxyphenyl hydroxylase
GO:0016709: 2-octaprenyl-6-methoxyphenyl hydroxylase
GO:0050660: 2-octaprenyl-6-methoxyphenyl hydroxylase
GO:0055114: 2-octaprenyl-6-methoxyphenyl hydroxylase

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiH/COQ6 family [H]

Homologues:

Organism=Homo sapiens, GI32967305, Length=457, Percent_Identity=28.6652078774617, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI32967307, Length=383, Percent_Identity=28.4595300261097, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1789274, Length=402, Percent_Identity=34.3283582089552, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1789273, Length=409, Percent_Identity=30.3178484107579, Blast_Score=181, Evalue=7e-47,
Organism=Escherichia coli, GI1786883, Length=403, Percent_Identity=32.258064516129, Blast_Score=181, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI25146631, Length=446, Percent_Identity=25.7847533632287, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6321694, Length=479, Percent_Identity=25.0521920668058, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI19920760, Length=466, Percent_Identity=26.8240343347639, Blast_Score=142, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042
- InterPro:   IPR018168
- InterPro:   IPR010971 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: 1.14.13.-

Molecular weight: Translated: 48166; Mature: 48035

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: PS01304 UBIH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASVQPTTKHTAVAEVNAPSSTSFDYDVAIVGGGIVGATLAAALKDTNLRVVVIEAQPRS
CCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCEEEEEEECCCCE
VAVAKGQAYAIHLSSSRIYQGIGVWEAIAPQVEYFSQVHLSDGNCPSVVKFKPRDLGTPV
EEEECCCEEEEEECCCHHHHCCCHHHHHHHHHHHHHEEECCCCCCCCEEEECCCCCCCHH
LGYVAEHRVLLKELLQFLETCEHVDWCCPAQVTTTHYHPHGVEVQLAPSSAGVEAAHRHE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEECCCCCCCHHHHHHH
VESLPQTLNVRMLVAADGSRSQVRQQAGITTQGWDYWQSCLVATIAPEKFHNHIAYERFW
HHHCCHHCCEEEEEEECCCHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHCCCCHHHCC
PSGPFAILPIANRQCRIVWTAPHAQAQALLELEEDQFLDLLQQRYGSQMGKLSLVGHRFL
CCCCEEEEEECCCEEEEEEECCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEECHHHC
FPAKWMHSTQYTGHRLALVGDAAHTCHPVGGQGLNLGIRDAAALAQVLHVAHQAGQDIGS
CCHHHHCCCCCCCCEEEEEECCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHH
VQVLRQYQRWRRRQNWLALGFTDILNRVFSNRWFLVVQGRRLGLRILQWIAPLRILALRF
HHHHHHHHHHHHHCCEEEEEHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHH
MAGLSGRLPNLAQPK
HHHCCCCCCCCCCCC
>Mature Secondary Structure 
ASVQPTTKHTAVAEVNAPSSTSFDYDVAIVGGGIVGATLAAALKDTNLRVVVIEAQPRS
CCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCEEEEEEECCCCE
VAVAKGQAYAIHLSSSRIYQGIGVWEAIAPQVEYFSQVHLSDGNCPSVVKFKPRDLGTPV
EEEECCCEEEEEECCCHHHHCCCHHHHHHHHHHHHHEEECCCCCCCCEEEECCCCCCCHH
LGYVAEHRVLLKELLQFLETCEHVDWCCPAQVTTTHYHPHGVEVQLAPSSAGVEAAHRHE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEECCCCCCCHHHHHHH
VESLPQTLNVRMLVAADGSRSQVRQQAGITTQGWDYWQSCLVATIAPEKFHNHIAYERFW
HHHCCHHCCEEEEEEECCCHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHCCCCHHHCC
PSGPFAILPIANRQCRIVWTAPHAQAQALLELEEDQFLDLLQQRYGSQMGKLSLVGHRFL
CCCCEEEEEECCCEEEEEEECCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEECHHHC
FPAKWMHSTQYTGHRLALVGDAAHTCHPVGGQGLNLGIRDAAALAQVLHVAHQAGQDIGS
CCHHHHCCCCCCCCEEEEEECCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHH
VQVLRQYQRWRRRQNWLALGFTDILNRVFSNRWFLVVQGRRLGLRILQWIAPLRILALRF
HHHHHHHHHHHHHCCEEEEEHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHH
MAGLSGRLPNLAQPK
HHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]