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The map label for this gene is ahcY [H]

Identifier: 158337067

GI number: 158337067

Start: 3989133

End: 3990518

Strand: Direct

Name: ahcY [H]

Synonym: AM1_3940

Alternate gene names: 158337067

Gene position: 3989133-3990518 (Clockwise)

Preceding gene: 158337066

Following gene: 158337068

Centisome position: 61.34

GC content: 48.05

Gene sequence:

>1386_bases
ATGAGCCCACAAGTTTTGACCCGAGACTATAAAGTTGCGGATATTTCCCTGGCAGATTGGGGACGTAAAGAGATGGCCAT
TGCTGAGGGTGAAATGCCGGCATTGATGGCGATTCGTGCAAAGTACCGTGATAGTAAGCCTTTGCAAGGGGCAAAAATCA
TTGGTTGTATTCACATGACCATTCAGACTGCGGTCTTGATTGAGACGCTCTGTGCCCTTGGTGCAGAAGTTCGCTGGTCT
TCCTGTAATATTTTTTCAACGCAAGATCATGCCGCAGCAGCGATTGCCGCTGCAGGAATCCCTGTATTTGCCTGGAAGGG
TGAGACTGAAGATGAATATATGTGGTGCATTGAGCAGACTTGCCGCACCCCTGAAGGTGCCCTTTGGGATGCCAATATGA
TTTTGGATGATGGCGGTGACTTGACGGGGCATATCCATGAGCACTATCCAGATATGCTGAACAACATTCATGGTGTGACT
GAAGAAACCACCACGGGTGTACATCGTTTATTGGAGATGTTGGAAAAGGGAGAACTCAAAGTTCCTGCCATCAATGTCAA
TGACTCGGTCACAAAGTCCAAAAATGACAACAAGTATGGTTGTCGCCACAGCCTCAATGACGCGATTAAGCGGGGTACAG
ACCACCTCATGTCTGGTAAGAAGGCTTTGGTGATTGGCTATGGTGATGTGGGTAAGGGGTCCGCAGCTTCTTTGCGACAA
GAAGGCATGATCGTTAAAGTGACTGAAGCGGATCCCATCTGCGCAATGCAGGCTTGTATGGACGGCTTTGAAGTCGTATC
GCCTTATACCAATGGTGTGAATGACGGTACCCTTAACTCCATCAACAAGGACCTGTTGGCCAATACGGATCTAGTCGTCA
CCACCACTGGCAACTTTAATGTTTGTGATGCCAATATGTTGGTTTCCCTCAAACAAGGGGCAGTCGTTTGCAATATTGGT
CATTTCGATAATGAAATTGATACGGCCTATATGCGCCAAACCTGGCGTTGGGAAGAGGTTAAGCCTCAGGTCCATCAGGT
TTACCGGAGTGATGATCCACAAGACTTTTTGATCCTTCTGTCAGAAGGGCGATTGGTGAACCTAGGAAATGCAACGGGTC
ACCCTTCACGGATTATGGATGGCTCTTTTGCGAACCAAGTCTTAGCGCAAATGTTTTTGTTTGAGCGTAAGTTTGCTGAC
TTACCCGCAGATCAGAAGGCTGCGGCCATCACGGTGGACGTGCTACCTAAGCAGCTAGATGAAGAAGTTGCCCGGTATAT
GGTAGAGGGCTTTGGGGGTGTGATTACCCAGCTCACTTCTGAACAAGCCCAGTATATCAACGTTCCTGTCCAGGGCCCCT
TCAAAACAGAGAGTTATAAGTACTAA

Upstream 100 bases:

>100_bases
ATAAAGCAACCATTCATTATTCCCCGCCAAATTTATATAAAATGCCTCACTATAATTAACAGAGGATCAAATAAGTACAC
CCATTGTTGAGAAGGATCAC

Downstream 100 bases:

>100_bases
GTCTTTACAGACGTGTGCTTTTCCTCAACCCTTAATAGGGTTGAGGTCTTTTAGGGCTCTTGTGTATGTTGATAATGCAA
AAGGTTTATAAGGATGTGTG

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MSPQVLTRDYKVADISLADWGRKEMAIAEGEMPALMAIRAKYRDSKPLQGAKIIGCIHMTIQTAVLIETLCALGAEVRWS
SCNIFSTQDHAAAAIAAAGIPVFAWKGETEDEYMWCIEQTCRTPEGALWDANMILDDGGDLTGHIHEHYPDMLNNIHGVT
EETTTGVHRLLEMLEKGELKVPAINVNDSVTKSKNDNKYGCRHSLNDAIKRGTDHLMSGKKALVIGYGDVGKGSAASLRQ
EGMIVKVTEADPICAMQACMDGFEVVSPYTNGVNDGTLNSINKDLLANTDLVVTTTGNFNVCDANMLVSLKQGAVVCNIG
HFDNEIDTAYMRQTWRWEEVKPQVHQVYRSDDPQDFLILLSEGRLVNLGNATGHPSRIMDGSFANQVLAQMFLFERKFAD
LPADQKAAAITVDVLPKQLDEEVARYMVEGFGGVITQLTSEQAQYINVPVQGPFKTESYKY

Sequences:

>Translated_461_residues
MSPQVLTRDYKVADISLADWGRKEMAIAEGEMPALMAIRAKYRDSKPLQGAKIIGCIHMTIQTAVLIETLCALGAEVRWS
SCNIFSTQDHAAAAIAAAGIPVFAWKGETEDEYMWCIEQTCRTPEGALWDANMILDDGGDLTGHIHEHYPDMLNNIHGVT
EETTTGVHRLLEMLEKGELKVPAINVNDSVTKSKNDNKYGCRHSLNDAIKRGTDHLMSGKKALVIGYGDVGKGSAASLRQ
EGMIVKVTEADPICAMQACMDGFEVVSPYTNGVNDGTLNSINKDLLANTDLVVTTTGNFNVCDANMLVSLKQGAVVCNIG
HFDNEIDTAYMRQTWRWEEVKPQVHQVYRSDDPQDFLILLSEGRLVNLGNATGHPSRIMDGSFANQVLAQMFLFERKFAD
LPADQKAAAITVDVLPKQLDEEVARYMVEGFGGVITQLTSEQAQYINVPVQGPFKTESYKY
>Mature_460_residues
SPQVLTRDYKVADISLADWGRKEMAIAEGEMPALMAIRAKYRDSKPLQGAKIIGCIHMTIQTAVLIETLCALGAEVRWSS
CNIFSTQDHAAAAIAAAGIPVFAWKGETEDEYMWCIEQTCRTPEGALWDANMILDDGGDLTGHIHEHYPDMLNNIHGVTE
ETTTGVHRLLEMLEKGELKVPAINVNDSVTKSKNDNKYGCRHSLNDAIKRGTDHLMSGKKALVIGYGDVGKGSAASLRQE
GMIVKVTEADPICAMQACMDGFEVVSPYTNGVNDGTLNSINKDLLANTDLVVTTTGNFNVCDANMLVSLKQGAVVCNIGH
FDNEIDTAYMRQTWRWEEVKPQVHQVYRSDDPQDFLILLSEGRLVNLGNATGHPSRIMDGSFANQVLAQMFLFERKFADL
PADQKAAAITVDVLPKQLDEEVARYMVEGFGGVITQLTSEQAQYINVPVQGPFKTESYKY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:
GO:0004013: Adenosylhomocysteinase
GO:0005737: Adenosylhomocysteinase
GO:0006730: Adenosylhomocysteinase
GO:0016787: Adenosylhomocysteinase

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=453, Percent_Identity=54.3046357615894, Blast_Score=447, Evalue=1e-125,
Organism=Homo sapiens, GI239937451, Length=431, Percent_Identity=53.1322505800464, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI24308043, Length=456, Percent_Identity=47.5877192982456, Blast_Score=411, Evalue=1e-115,
Organism=Homo sapiens, GI195539337, Length=456, Percent_Identity=47.5877192982456, Blast_Score=411, Evalue=1e-115,
Organism=Homo sapiens, GI298286489, Length=456, Percent_Identity=47.5877192982456, Blast_Score=411, Evalue=1e-115,
Organism=Homo sapiens, GI195539349, Length=456, Percent_Identity=47.5877192982456, Blast_Score=410, Evalue=1e-115,
Organism=Homo sapiens, GI21361647, Length=456, Percent_Identity=46.4912280701754, Blast_Score=389, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17506425, Length=453, Percent_Identity=56.2913907284768, Blast_Score=478, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6320882, Length=464, Percent_Identity=54.0948275862069, Blast_Score=459, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24642172, Length=453, Percent_Identity=55.6291390728477, Blast_Score=458, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24656245, Length=443, Percent_Identity=46.27539503386, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI45553387, Length=454, Percent_Identity=46.0352422907489, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI45553385, Length=453, Percent_Identity=45.916114790287, Blast_Score=372, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 50730; Mature: 50599

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPQVLTRDYKVADISLADWGRKEMAIAEGEMPALMAIRAKYRDSKPLQGAKIIGCIHMT
CCCCEEECCCEEEEEEHHCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCEEEEEHHHH
IQTAVLIETLCALGAEVRWSSCNIFSTQDHAAAAIAAAGIPVFAWKGETEDEYMWCIEQT
HHHHHHHHHHHHCCCCEEECCCCEECCCCHHHHHHHHCCCEEEEECCCCCCHHHHHHHHH
CRTPEGALWDANMILDDGGDLTGHIHEHYPDMLNNIHGVTEETTTGVHRLLEMLEKGELK
CCCCCCCEEECEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEE
VPAINVNDSVTKSKNDNKYGCRHSLNDAIKRGTDHLMSGKKALVIGYGDVGKGSAASLRQ
EEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCHHHHHCCCEEEEEECCCCCCCCHHHHHH
EGMIVKVTEADPICAMQACMDGFEVVSPYTNGVNDGTLNSINKDLLANTDLVVTTTGNFN
CCEEEEEECCCCHHHHHHHHCCCEECCCCCCCCCCCCHHHHCHHHHCCCCEEEEECCCCE
VCDANMLVSLKQGAVVCNIGHFDNEIDTAYMRQTWRWEEVKPQVHQVYRSDDPQDFLILL
EECHHHEEEECCCEEEEEECCCCCCHHHHHHHHHCCHHHCCHHHHHHHCCCCCCEEEEEE
SEGRLVNLGNATGHPSRIMDGSFANQVLAQMFLFERKFADLPADQKAAAITVDVLPKQLD
ECCCEEEECCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHH
EEVARYMVEGFGGVITQLTSEQAQYINVPVQGPFKTESYKY
HHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SPQVLTRDYKVADISLADWGRKEMAIAEGEMPALMAIRAKYRDSKPLQGAKIIGCIHMT
CCCEEECCCEEEEEEHHCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCEEEEEHHHH
IQTAVLIETLCALGAEVRWSSCNIFSTQDHAAAAIAAAGIPVFAWKGETEDEYMWCIEQT
HHHHHHHHHHHHCCCCEEECCCCEECCCCHHHHHHHHCCCEEEEECCCCCCHHHHHHHHH
CRTPEGALWDANMILDDGGDLTGHIHEHYPDMLNNIHGVTEETTTGVHRLLEMLEKGELK
CCCCCCCEEECEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEE
VPAINVNDSVTKSKNDNKYGCRHSLNDAIKRGTDHLMSGKKALVIGYGDVGKGSAASLRQ
EEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCHHHHHCCCEEEEEECCCCCCCCHHHHHH
EGMIVKVTEADPICAMQACMDGFEVVSPYTNGVNDGTLNSINKDLLANTDLVVTTTGNFN
CCEEEEEECCCCHHHHHHHHCCCEECCCCCCCCCCCCHHHHCHHHHCCCCEEEEECCCCE
VCDANMLVSLKQGAVVCNIGHFDNEIDTAYMRQTWRWEEVKPQVHQVYRSDDPQDFLILL
EECHHHEEEECCCEEEEEECCCCCCHHHHHHHHHCCHHHCCHHHHHHHCCCCCCEEEEEE
SEGRLVNLGNATGHPSRIMDGSFANQVLAQMFLFERKFADLPADQKAAAITVDVLPKQLD
ECCCEEEECCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHH
EEVARYMVEGFGGVITQLTSEQAQYINVPVQGPFKTESYKY
HHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA