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The map label for this gene is ribD [H]

Identifier: 158336980

GI number: 158336980

Start: 3905954

End: 3907117

Strand: Direct

Name: ribD [H]

Synonym: AM1_3853

Alternate gene names: 158336980

Gene position: 3905954-3907117 (Clockwise)

Preceding gene: 158336978

Following gene: 158336986

Centisome position: 60.06

GC content: 53.01

Gene sequence:

>1164_bases
ATGGAGATTCATCCTTTGTCAGACCAGCCCTCTCTCTCCAAGGATGCTGTGAATATTGATCCGCACCACCAACAGATGAT
GCAGCGTTGTTTACAGCTGGCTCAGAAGGCTGCTGGTTTTACGACGCCTAATCCCCTTGTGGGCTGTGTGATTGAACGGG
ATGGAGAAATTGTCGGTGAAGGCTATCATCCTAAGGCTGGAGAACCCCATGCTGAAGTATTTGCCCTAAGAGCGGCGGGG
GATAAAGCCAAGGGTGCTACCGCCTACGTCAGTTTAGAGCCGTGTAATCACTTTGGGCGCACTCCGCCGTGTTCCGAAGC
GTTAGTCAAAGCAGGGGTGGCTACGGTGGTGGTGGGGATGGTCGATCCAGATCCACGAGTCTCAGGTAAAGGGATTGAGC
GACTTCGGGCGGCAGGCATTCAGGTGATTACAGGGGTAGAAGAGGCTGACTGTCAACGCGTGAATGAAGCCTTTGTTCAT
CGGATCCTCTATCAGCGCCCGTTTGGCATCCTTAAATATGCCATGACCTTAGATGGCAAAATTGCCACGACTGCAGGCCA
CAGTGCTTGGATTACCAAGGAAGTCGCCCGCGCCCATGTGCACCGACTCCGGGCCACTTGTGATGCCGTGATCGTCGGTG
GCAATACAGTCCGCCGGGATAATCCTCATTTAACAACCCATCACAAAGCAGATGCAAATCAGCCCCCCAATAATCCCCTA
CGGGTGGTGTTAAGCCGGACCCTTGATCTACCGCCAACGGCACATTTGTGGGAAACAGATATCGCTCCTACGATTGTGCT
CACCCAAGGTCATCCGAATGGGGAGGGTCAGGCCTACCTAGAACAGCAGGGCGTAGAAGTCGTGAACTTAGACGAACTAA
CCCCAGCAACGGTGATGGCTTATTTGGGCAAGAAGGAACTGCTATCGGTATTGTGGGAATGTGGAGGGACCTTGTCTGCC
CGTGCGATCGCAGATGGTTCGGTCCAAAAAGTCTTGGCCTTTATTGCCCCCAAAATTGTCGGAGGCCAAAATGCGCCTTC
CCCGGTGGGAGACTTGGGTTTCAATAAGATGACTGAGGCCCTTCAGTTAGAGCGAGTACGCTGGCATATTGTCGGTGAAG
ACTGCCTCGTAGAAGGATATCTACCTAAACCAGCCTCTGAATAA

Upstream 100 bases:

>100_bases
AGCAGTTTGATTCATACCGCCTCAGCACCATTCCACGCTACTCTCAACTAGAGTAGGGATATGCCTGCCTCTCTGTAGTC
CTGTTCTGTGAATAGCCGTA

Downstream 100 bases:

>100_bases
TTCTCTTCGGCATGGGGCGTTTACTTATTCCGCAGGGCCATCTCAGGATGCTGAAGCCTAGTTGCCCCTGAAGTCACTGC
TATCCAACATACGTGATCGC

Product: riboflavin biosynthesis protein RibD

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MEIHPLSDQPSLSKDAVNIDPHHQQMMQRCLQLAQKAAGFTTPNPLVGCVIERDGEIVGEGYHPKAGEPHAEVFALRAAG
DKAKGATAYVSLEPCNHFGRTPPCSEALVKAGVATVVVGMVDPDPRVSGKGIERLRAAGIQVITGVEEADCQRVNEAFVH
RILYQRPFGILKYAMTLDGKIATTAGHSAWITKEVARAHVHRLRATCDAVIVGGNTVRRDNPHLTTHHKADANQPPNNPL
RVVLSRTLDLPPTAHLWETDIAPTIVLTQGHPNGEGQAYLEQQGVEVVNLDELTPATVMAYLGKKELLSVLWECGGTLSA
RAIADGSVQKVLAFIAPKIVGGQNAPSPVGDLGFNKMTEALQLERVRWHIVGEDCLVEGYLPKPASE

Sequences:

>Translated_387_residues
MEIHPLSDQPSLSKDAVNIDPHHQQMMQRCLQLAQKAAGFTTPNPLVGCVIERDGEIVGEGYHPKAGEPHAEVFALRAAG
DKAKGATAYVSLEPCNHFGRTPPCSEALVKAGVATVVVGMVDPDPRVSGKGIERLRAAGIQVITGVEEADCQRVNEAFVH
RILYQRPFGILKYAMTLDGKIATTAGHSAWITKEVARAHVHRLRATCDAVIVGGNTVRRDNPHLTTHHKADANQPPNNPL
RVVLSRTLDLPPTAHLWETDIAPTIVLTQGHPNGEGQAYLEQQGVEVVNLDELTPATVMAYLGKKELLSVLWECGGTLSA
RAIADGSVQKVLAFIAPKIVGGQNAPSPVGDLGFNKMTEALQLERVRWHIVGEDCLVEGYLPKPASE
>Mature_387_residues
MEIHPLSDQPSLSKDAVNIDPHHQQMMQRCLQLAQKAAGFTTPNPLVGCVIERDGEIVGEGYHPKAGEPHAEVFALRAAG
DKAKGATAYVSLEPCNHFGRTPPCSEALVKAGVATVVVGMVDPDPRVSGKGIERLRAAGIQVITGVEEADCQRVNEAFVH
RILYQRPFGILKYAMTLDGKIATTAGHSAWITKEVARAHVHRLRATCDAVIVGGNTVRRDNPHLTTHHKADANQPPNNPL
RVVLSRTLDLPPTAHLWETDIAPTIVLTQGHPNGEGQAYLEQQGVEVVNLDELTPATVMAYLGKKELLSVLWECGGTLSA
RAIADGSVQKVLAFIAPKIVGGQNAPSPVGDLGFNKMTEALQLERVRWHIVGEDCLVEGYLPKPASE

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG1985

COG function: function code H; Pyrimidine reductase, riboflavin biosynthesis

Gene ontology:
GO:0003824: Riboflavin biosynthesis protein RibD
GO:0008270: Riboflavin biosynthesis protein RibD
GO:0008703: Riboflavin biosynthesis protein RibD
GO:0008835: Riboflavin biosynthesis protein RibD
GO:0009231: Riboflavin biosynthesis protein RibD
GO:0016491: Riboflavin biosynthesis protein RibD
GO:0016787: Riboflavin biosynthesis protein RibD
GO:0050661: Riboflavin biosynthesis protein RibD
GO:0055114: Riboflavin biosynthesis protein RibD

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=364, Percent_Identity=40.9340659340659, Blast_Score=237, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 41694; Mature: 41694

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIHPLSDQPSLSKDAVNIDPHHQQMMQRCLQLAQKAAGFTTPNPLVGCVIERDGEIVGE
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCEECC
GYHPKAGEPHAEVFALRAAGDKAKGATAYVSLEPCNHFGRTPPCSEALVKAGVATVVVGM
CCCCCCCCCHHHEEEEEECCCCCCCCEEEEEECCHHHCCCCCCHHHHHHHCCHHHEEEEE
VDPDPRVSGKGIERLRAAGIQVITGVEEADCQRVNEAFVHRILYQRPFGILKYAMTLDGK
CCCCCCCCCCHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCE
IATTAGHSAWITKEVARAHVHRLRATCDAVIVGGNTVRRDNPHLTTHHKADANQPPNNPL
EEECCCCHHHHHHHHHHHHHHHHHHHHCEEEECCCEEECCCCCEEECCCCCCCCCCCCHH
RVVLSRTLDLPPTAHLWETDIAPTIVLTQGHPNGEGQAYLEQQGVEVVNLDELTPATVMA
HHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHCCCEEEECCCCCHHHHHH
YLGKKELLSVLWECGGTLSARAIADGSVQKVLAFIAPKIVGGQNAPSPVGDLGFNKMTEA
HHCHHHHHHHHHHCCCCCEEHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
LQLERVRWHIVGEDCLVEGYLPKPASE
HHHHHHEEEEECCCCEEECCCCCCCCC
>Mature Secondary Structure
MEIHPLSDQPSLSKDAVNIDPHHQQMMQRCLQLAQKAAGFTTPNPLVGCVIERDGEIVGE
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCEECC
GYHPKAGEPHAEVFALRAAGDKAKGATAYVSLEPCNHFGRTPPCSEALVKAGVATVVVGM
CCCCCCCCCHHHEEEEEECCCCCCCCEEEEEECCHHHCCCCCCHHHHHHHCCHHHEEEEE
VDPDPRVSGKGIERLRAAGIQVITGVEEADCQRVNEAFVHRILYQRPFGILKYAMTLDGK
CCCCCCCCCCHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCE
IATTAGHSAWITKEVARAHVHRLRATCDAVIVGGNTVRRDNPHLTTHHKADANQPPNNPL
EEECCCCHHHHHHHHHHHHHHHHHHHHCEEEECCCEEECCCCCEEECCCCCCCCCCCCHH
RVVLSRTLDLPPTAHLWETDIAPTIVLTQGHPNGEGQAYLEQQGVEVVNLDELTPATVMA
HHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHCCCEEEECCCCCHHHHHH
YLGKKELLSVLWECGGTLSARAIADGSVQKVLAFIAPKIVGGQNAPSPVGDLGFNKMTEA
HHCHHHHHHHHHHCCCCCEEHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
LQLERVRWHIVGEDCLVEGYLPKPASE
HHHHHHEEEEECCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]