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The map label for this gene is cobB [H]

Identifier: 158336863

GI number: 158336863

Start: 3785820

End: 3786548

Strand: Reverse

Name: cobB [H]

Synonym: AM1_3731

Alternate gene names: 158336863

Gene position: 3786548-3785820 (Counterclockwise)

Preceding gene: 158336864

Following gene: 158336862

Centisome position: 58.22

GC content: 51.3

Gene sequence:

>729_bases
ATGCCCTTGACGGAACTAAATTTAGCGGCCTACTCACGCATTGTTATTCTGACTGGTGCCGGGATTTCTGTTGCCTCAGG
GATTCGTCCTTTTCGGGGACCAAACGGGGTCTGGAACGAAATTTCGGCTGATCAGCTCAATGCCGAGGCTGGGCAAAATA
ATCCTGGTTTTATTTGGCAAACTTTGGGGGCTATGCGTAAAGTTGTGGCGTCAGCGGCTCCCAATGCGGCTCACCAAGCC
CTGGCGGATCTCGAACAAAATTTGACCCCATCTCAACAATTCACCCTGATCACGCAAAATATTGATGGACTACACCAACG
GGCAGGCAGCCAAAACGTTGTGGAACTGCATGGATCGCTCCTAGAGACCCGCTGTTCAAATTCTGCCTGCGATGCCCCTG
TCTTTGCAGATCAAGCCACCCATGCCGATCAGATGCCTCAATGCTCCGTCTGCCATGCCCATCAGTTACCCAATGTTGTC
TTATTCGAGGAACCCATTCCCCTAGATGCATCCTGGCAAAGCAAAAAGGCCCTTCGAGATTGTGATTTATTTCTAGCGAT
TGGCACCTCTGGCACGGTGCAGCCTGCCGCTAGTTTTGTTCGCTCAGCCGATTATGTTGGAGCCCACACGATCCTGATTA
ATCTGGAAGCCCCCTCTGAGCCCAATCCTTATTTTCACGAGGTCATTGTAGGGGCAGCAGAAGAGATCCTCCCCACACTA
CTCAAATGA

Upstream 100 bases:

>100_bases
CTAATCCTGAAAAAAGAGGTTTCCAATACTGCAAGCTAATCGTTATCCTCGCGATAACTGGGTTTTATGCTGCTGGGCAT
CCTAGAGATAAAGCAAGAGG

Downstream 100 bases:

>100_bases
GAATTCCAAAGCGGATACCGAAAAACCAGCTTTTAAGGGTGATGTGGGTGTGTAGCTGGGGGTTGATTGGCCTGATGGCT
TTCTGTATCGCCCAAGGGAT

Product: Sir2 family transcriptional regulator

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MPLTELNLAAYSRIVILTGAGISVASGIRPFRGPNGVWNEISADQLNAEAGQNNPGFIWQTLGAMRKVVASAAPNAAHQA
LADLEQNLTPSQQFTLITQNIDGLHQRAGSQNVVELHGSLLETRCSNSACDAPVFADQATHADQMPQCSVCHAHQLPNVV
LFEEPIPLDASWQSKKALRDCDLFLAIGTSGTVQPAASFVRSADYVGAHTILINLEAPSEPNPYFHEVIVGAAEEILPTL
LK

Sequences:

>Translated_242_residues
MPLTELNLAAYSRIVILTGAGISVASGIRPFRGPNGVWNEISADQLNAEAGQNNPGFIWQTLGAMRKVVASAAPNAAHQA
LADLEQNLTPSQQFTLITQNIDGLHQRAGSQNVVELHGSLLETRCSNSACDAPVFADQATHADQMPQCSVCHAHQLPNVV
LFEEPIPLDASWQSKKALRDCDLFLAIGTSGTVQPAASFVRSADYVGAHTILINLEAPSEPNPYFHEVIVGAAEEILPTL
LK
>Mature_241_residues
PLTELNLAAYSRIVILTGAGISVASGIRPFRGPNGVWNEISADQLNAEAGQNNPGFIWQTLGAMRKVVASAAPNAAHQAL
ADLEQNLTPSQQFTLITQNIDGLHQRAGSQNVVELHGSLLETRCSNSACDAPVFADQATHADQMPQCSVCHAHQLPNVVL
FEEPIPLDASWQSKKALRDCDLFLAIGTSGTVQPAASFVRSADYVGAHTILINLEAPSEPNPYFHEVIVGAAEEILPTLL
K

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI13787215, Length=241, Percent_Identity=33.6099585062241, Blast_Score=127, Evalue=9e-30,
Organism=Homo sapiens, GI6912664, Length=242, Percent_Identity=33.8842975206612, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI300795542, Length=224, Percent_Identity=35.2678571428571, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI6912660, Length=209, Percent_Identity=33.0143540669856, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI63054862, Length=202, Percent_Identity=32.6732673267327, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI7657575, Length=231, Percent_Identity=29.004329004329, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI308199517, Length=238, Percent_Identity=40.3361344537815, Blast_Score=147, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17541892, Length=217, Percent_Identity=26.7281105990783, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24648389, Length=202, Percent_Identity=28.2178217821782, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 25866; Mature: 25735

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLTELNLAAYSRIVILTGAGISVASGIRPFRGPNGVWNEISADQLNAEAGQNNPGFIWQ
CCCCCCCHHHHEEEEEEECCCHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHH
TLGAMRKVVASAAPNAAHQALADLEQNLTPSQQFTLITQNIDGLHQRAGSQNVVELHGSL
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHEEEEECCHHHHHHHCCCCCHHHHHHHH
LETRCSNSACDAPVFADQATHADQMPQCSVCHAHQLPNVVLFEEPIPLDASWQSKKALRD
HHHHCCCCCCCCCCCCCCCCCHHCCCCCCHHHHHCCCCEEEECCCCCCCCCCCHHHHHHC
CDLFLAIGTSGTVQPAASFVRSADYVGAHTILINLEAPSEPNPYFHEVIVGAAEEILPTL
CEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
LK
CC
>Mature Secondary Structure 
PLTELNLAAYSRIVILTGAGISVASGIRPFRGPNGVWNEISADQLNAEAGQNNPGFIWQ
CCCCCCHHHHEEEEEEECCCHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHH
TLGAMRKVVASAAPNAAHQALADLEQNLTPSQQFTLITQNIDGLHQRAGSQNVVELHGSL
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHEEEEECCHHHHHHHCCCCCHHHHHHHH
LETRCSNSACDAPVFADQATHADQMPQCSVCHAHQLPNVVLFEEPIPLDASWQSKKALRD
HHHHCCCCCCCCCCCCCCCCCHHCCCCCCHHHHHCCCCEEEECCCCCCCCCCCHHHHHHC
CDLFLAIGTSGTVQPAASFVRSADYVGAHTILINLEAPSEPNPYFHEVIVGAAEEILPTL
CEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
LK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]