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The map label for this gene is lspA

Identifier: 158336784

GI number: 158336784

Start: 3708559

End: 3709056

Strand: Reverse

Name: lspA

Synonym: AM1_3652

Alternate gene names: 158336784

Gene position: 3709056-3708559 (Counterclockwise)

Preceding gene: 158336785

Following gene: 158336780

Centisome position: 57.03

GC content: 46.79

Gene sequence:

>498_bases
ATGCGCTGGAAAAAATTGCTGTTTTGGGGATCTGCCCTGCTGAGTGTGGGGGCCGATCAGCTCACTAAGTTTTGGGTCAC
TCAGAACTTCGAACTACGAAGACCACCTGCACAACCTGACACTTGGCCTCTAATTCAGAACGTGTTTCATTTCACTTACG
TGACCAATGATGGAGCAGCCTTTAGCTTGTTCAAAGATAGTCCGCTTTTACCTTGGTTATCGTTTTTGGTTTGTCTGGGA
CTCATTGGGCTGGGCTTATTTGGACCTCGATTCCCCCAGTGGGAACAAGCAGGCTATGGGTTTTTGTTAGGTGGGGCAGC
AGGGAATGGGATTGATCGGATCTTTTTGGGTGAAGTGATTGACTTTTTAGATTTCCGCCTTATCCAATTTCCAGTGTTCA
ACATTGCAGATATCTCAATCAATGTGGGCCTAGCATGCCTGATATTTGCAACTTGGCAAAGTAGTCGTAAGGGCTCACGC
AAAACACCGACGCCATAA

Upstream 100 bases:

>100_bases
CTGGCAGTTCTCGATTTTGCCCTTTCCTGGACAGTTGATTGTCATGTGTGCCTCTGCTCTCATTGCATTTTTGCTTCGAC
GAATCTTGTTCTATTGACCT

Downstream 100 bases:

>100_bases
GGCCTAAACGTTATATCCTTATGCGGACTCAATTTTGACTAGCGTGGTGAGGCGGTCACCCGTCAGACGAACGACGACAA
TCGGGAGACCAATGATGCTT

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MRWKKLLFWGSALLSVGADQLTKFWVTQNFELRRPPAQPDTWPLIQNVFHFTYVTNDGAAFSLFKDSPLLPWLSFLVCLG
LIGLGLFGPRFPQWEQAGYGFLLGGAAGNGIDRIFLGEVIDFLDFRLIQFPVFNIADISINVGLACLIFATWQSSRKGSR
KTPTP

Sequences:

>Translated_165_residues
MRWKKLLFWGSALLSVGADQLTKFWVTQNFELRRPPAQPDTWPLIQNVFHFTYVTNDGAAFSLFKDSPLLPWLSFLVCLG
LIGLGLFGPRFPQWEQAGYGFLLGGAAGNGIDRIFLGEVIDFLDFRLIQFPVFNIADISINVGLACLIFATWQSSRKGSR
KTPTP
>Mature_165_residues
MRWKKLLFWGSALLSVGADQLTKFWVTQNFELRRPPAQPDTWPLIQNVFHFTYVTNDGAAFSLFKDSPLLPWLSFLVCLG
LIGLGLFGPRFPQWEQAGYGFLLGGAAGNGIDRIFLGEVIDFLDFRLIQFPVFNIADISINVGLACLIFATWQSSRKGSR
KTPTP

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:
GO:0004190: Lipoprotein signal peptidase
GO:0005886: Lipoprotein signal peptidase
GO:0006508: Lipoprotein signal peptidase
GO:0008233: Lipoprotein signal peptidase
GO:0016020: Lipoprotein signal peptidase
GO:0016021: Lipoprotein signal peptidase
GO:0016787: Lipoprotein signal peptidase

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_ACAM1 (B0C3E3)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001517958.1
- MEROPS:   A08.001
- GeneID:   5682458
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_3652
- HOGENOM:   HBG724422
- OMA:   IASEIHG
- ProtClustDB:   PRK00376
- BioCyc:   AMAR329726:AM1_3652-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 18544; Mature: 18544

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 112-112 ACT_SITE 137-137

Signals:

None

Transmembrane regions:

HASH(0x10ee872c)-; HASH(0x105e4cf4)-; HASH(0x123879cc)-;

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRWKKLLFWGSALLSVGADQLTKFWVTQNFELRRPPAQPDTWPLIQNVFHFTYVTNDGAA
CCCHHHHHHHHHHHHCCHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHHEEEECCCCE
FSLFKDSPLLPWLSFLVCLGLIGLGLFGPRFPQWEQAGYGFLLGGAAGNGIDRIFLGEVI
EEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCEEEECCCCCCHHHHHHHHHH
DFLDFRLIQFPVFNIADISINVGLACLIFATWQSSRKGSRKTPTP
HHHHHHHHHCCCCEEEEEEECCHHEEHHHHHHHCCCCCCCCCCCH
>Mature Secondary Structure
MRWKKLLFWGSALLSVGADQLTKFWVTQNFELRRPPAQPDTWPLIQNVFHFTYVTNDGAA
CCCHHHHHHHHHHHHCCHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHHEEEECCCCE
FSLFKDSPLLPWLSFLVCLGLIGLGLFGPRFPQWEQAGYGFLLGGAAGNGIDRIFLGEVI
EEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCEEEECCCCCCHHHHHHHHHH
DFLDFRLIQFPVFNIADISINVGLACLIFATWQSSRKGSRKTPTP
HHHHHHHHHCCCCEEEEEEECCHHEEHHHHHHHCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA