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The map label for this gene is era [H]

Identifier: 158336712

GI number: 158336712

Start: 3628852

End: 3629799

Strand: Direct

Name: era [H]

Synonym: AM1_3580

Alternate gene names: 158336712

Gene position: 3628852-3629799 (Clockwise)

Preceding gene: 158336711

Following gene: 158336716

Centisome position: 55.8

GC content: 49.05

Gene sequence:

>948_bases
TTGTCTGATCTCTCGTCTTTAACTTCTATCCCCCAAGCCTCTCCTGAGTTTAAGTCAGGCTTTGTTGCCATTGTCGGTCG
GCCCAACGTGGGGAAGTCGACGTTGATGAATCAACTGATTGGGCAGAAAATCGCGATTACGTCTCCAGTTGCCCAAACCA
CCCGCAATCGCCTCCGGGGGATTTTAACTACCCCCACAGCCCAAATGATTTTTGTGGATACTCCTGGTATCCATAAGCCG
CATCATCAATTGGGGGAAATCTTAGTCAAGAATGCGCGCATGGCCATCCATGCAGTGGATGTGGTGTTATTTGTGGTGGA
TTGCTCAGAGCCGTTAGGGGGTGGAGACCGATTTATTGCTCAATTACTGGCCCAAACCAACACGCCCGTTATTTTGGGAC
TGAATAAGCTTGATATACAGCGGAAAACAGCCCAGCAGGCCTTGACCTTAGACCAAGCCTATAAAGCCCTGGCAAAAGAA
CACCATTGGCCCGTTTGTAAATTTTCGGCGTTGACGACGGCCAAATTAAAGTCGCTGCAGCGCCAACTGATTGAAAAGCT
GGTCCCTGGTCCCTACTATTACCCCCCTGACTTGGTAACCGATCAGCCGGAACGGTTCATTATGGGAGAGTTGATTCGAG
AACAGATTTTGCTGCTGACCCGGCAAGAAGTCCCCCATTCCGTGGCCATTGTGATTGAGCGCGTCGATGAATCGCCCAAA
ATCACCCGCATTTTAGCCACCATTCATGTGGAACGCCCCTCTCAAAAGCAGATTCTTATTGGCAAAAAGGGCAGTATGCT
CAAAGCCATTGGCACCGAAGCTCGCCAACAAATTCAAAAACTGATTGCAGGTAAAGTTTATTTGGAGCTGTTTGTTAAGG
TGCAACCCAAATGGCGACAGTCCAGAATGCAGTTGGCGGAACTGGGATATCAGGTGGAATCAAATTAG

Upstream 100 bases:

>100_bases
CCGTGATGGTGGTGATTGGGGAAACCAAAGCGATTGATGAGCTGCCTCTTTAACAGGTGATAATGTTAATAGCCTGCAGC
TTGAGGAATAAGTCCTAGCT

Downstream 100 bases:

>100_bases
GTCTGTCCGATCAATCTCGTGGATTCCTGTTGAGTGCTGCGCTAGGTGGGCACTAGTTCTCCCGGTCTGAGCCGTGCCCA
TTTACCTGCATCCTCGGAAA

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MSDLSSLTSIPQASPEFKSGFVAIVGRPNVGKSTLMNQLIGQKIAITSPVAQTTRNRLRGILTTPTAQMIFVDTPGIHKP
HHQLGEILVKNARMAIHAVDVVLFVVDCSEPLGGGDRFIAQLLAQTNTPVILGLNKLDIQRKTAQQALTLDQAYKALAKE
HHWPVCKFSALTTAKLKSLQRQLIEKLVPGPYYYPPDLVTDQPERFIMGELIREQILLLTRQEVPHSVAIVIERVDESPK
ITRILATIHVERPSQKQILIGKKGSMLKAIGTEARQQIQKLIAGKVYLELFVKVQPKWRQSRMQLAELGYQVESN

Sequences:

>Translated_315_residues
MSDLSSLTSIPQASPEFKSGFVAIVGRPNVGKSTLMNQLIGQKIAITSPVAQTTRNRLRGILTTPTAQMIFVDTPGIHKP
HHQLGEILVKNARMAIHAVDVVLFVVDCSEPLGGGDRFIAQLLAQTNTPVILGLNKLDIQRKTAQQALTLDQAYKALAKE
HHWPVCKFSALTTAKLKSLQRQLIEKLVPGPYYYPPDLVTDQPERFIMGELIREQILLLTRQEVPHSVAIVIERVDESPK
ITRILATIHVERPSQKQILIGKKGSMLKAIGTEARQQIQKLIAGKVYLELFVKVQPKWRQSRMQLAELGYQVESN
>Mature_314_residues
SDLSSLTSIPQASPEFKSGFVAIVGRPNVGKSTLMNQLIGQKIAITSPVAQTTRNRLRGILTTPTAQMIFVDTPGIHKPH
HQLGEILVKNARMAIHAVDVVLFVVDCSEPLGGGDRFIAQLLAQTNTPVILGLNKLDIQRKTAQQALTLDQAYKALAKEH
HWPVCKFSALTTAKLKSLQRQLIEKLVPGPYYYPPDLVTDQPERFIMGELIREQILLLTRQEVPHSVAIVIERVDESPKI
TRILATIHVERPSQKQILIGKKGSMLKAIGTEARQQIQKLIAGKVYLELFVKVQPKWRQSRMQLAELGYQVESN

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=320, Percent_Identity=27.1875, Blast_Score=92, Evalue=6e-19,
Organism=Escherichia coli, GI1788919, Length=294, Percent_Identity=38.7755102040816, Blast_Score=191, Evalue=6e-50,
Organism=Escherichia coli, GI87082120, Length=117, Percent_Identity=37.6068376068376, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI2367268, Length=149, Percent_Identity=32.2147651006711, Blast_Score=68, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24646434, Length=309, Percent_Identity=27.5080906148867, Blast_Score=104, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 35109; Mature: 34978

Theoretical pI: Translated: 10.37; Mature: 10.37

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLSSLTSIPQASPEFKSGFVAIVGRPNVGKSTLMNQLIGQKIAITSPVAQTTRNRLRG
CCCHHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCEEECCHHHHHHHHHHCE
ILTTPTAQMIFVDTPGIHKPHHQLGEILVKNARMAIHAVDVVLFVVDCSEPLGGGDRFIA
EEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHH
QLLAQTNTPVILGLNKLDIQRKTAQQALTLDQAYKALAKEHHWPVCKFSALTTAKLKSLQ
HHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHH
RQLIEKLVPGPYYYPPDLVTDQPERFIMGELIREQILLLTRQEVPHSVAIVIERVDESPK
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCH
ITRILATIHVERPSQKQILIGKKGSMLKAIGTEARQQIQKLIAGKVYLELFVKVQPKWRQ
HHEEEHEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
SRMQLAELGYQVESN
HHHHHHHCCCCCCCC
>Mature Secondary Structure 
SDLSSLTSIPQASPEFKSGFVAIVGRPNVGKSTLMNQLIGQKIAITSPVAQTTRNRLRG
CCHHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCEEECCHHHHHHHHHHCE
ILTTPTAQMIFVDTPGIHKPHHQLGEILVKNARMAIHAVDVVLFVVDCSEPLGGGDRFIA
EEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHH
QLLAQTNTPVILGLNKLDIQRKTAQQALTLDQAYKALAKEHHWPVCKFSALTTAKLKSLQ
HHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHH
RQLIEKLVPGPYYYPPDLVTDQPERFIMGELIREQILLLTRQEVPHSVAIVIERVDESPK
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCH
ITRILATIHVERPSQKQILIGKKGSMLKAIGTEARQQIQKLIAGKVYLELFVKVQPKWRQ
HHEEEHEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
SRMQLAELGYQVESN
HHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]