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The map label for this gene is fabG [C]

Identifier: 158336688

GI number: 158336688

Start: 3599307

End: 3600251

Strand: Direct

Name: fabG [C]

Synonym: AM1_3557

Alternate gene names: 158336688

Gene position: 3599307-3600251 (Clockwise)

Preceding gene: 158336687

Following gene: 158336690

Centisome position: 55.34

GC content: 49.74

Gene sequence:

>945_bases
ATGGCGTTTGATATAGAAAATATCCCTTCTCAGCAAGGCAAGGTTGCCATTGTGACTGGGGCGAATACAGGCTTGGGCTA
TGAAACGGTGAGTTATCTAGCGCAAAAGCATTTCAAGGTGATCATGGCTTGCCGGAACTTGGAGAAAGCCGAGCAAGCTA
AAGCCAAAATCGAGGTGACAGTGCCGGTCGCGGATTTAGAGATTCTCCAGATTGATTTGTCTGATTTATCGTCTGTGAGA
CGGTTTGCCCAAACCTTTCGACAGCACTACAACAGCCTCGACCTTCTGATCAATAATGCTGGAATTATGTGGCCTCCCTA
TGCCCTGACTGTAGATGGGTTTGAGAGCCAAATAGGAGCCAATTACTTTGGCCATTTTCTCCTGACGGCATTGCTGTTGG
ATCTGATGCCGGATACCTCTGCATCTCGGGTGGTGTCTCTGAGTAGCAATGCTCATCGGTTGGGGTCTGGGAGAATTAAT
TTTGACGATCTGCAATCGGAACAGAACTATTCCAAAACGGGAGCTTACGCCCAGAGCAAACTGGCCTGTTTGATGTTTGG
GAATGAATTGCAGCGACGGTTAGCTCAAGCCGGTAAAAAAATTCTTTCCGTCACGGCTCACCCTGGCGTTTCCAACACAG
AACTCGCCAGACACATGCCTCAATACCAGGTTCAACTCATTCAAAATACGATTGGTCCGTTGCTCTGTCATGCCCCGGAT
CAGGCCGCGCTGCCCATTGTGATGGCAGCGCTAGACCCAGAGGCCCAAGGGGGAGAATATTTTGGCCCTCAAGGGTTTAT
GGAAATGAAAGGTCAGCCCGGACGGGCTACGCAGTCTGACTATGCCCAAAATCAAGCGGCTGCTGCCCAGCTCTGGGATG
TTTCAGAAGAATTAACAGGGTGCACCTTTGCCATACCTCAAGTTCAAGTCGTCACAACGTCATAG

Upstream 100 bases:

>100_bases
CTGGGCGTGGCAAAACGATGGAGCTGTATCTACGCACTCTGCATGTTGGGCTCAGTATCGAGTTGCAAACTATAATTCAC
AAACTTTAGGTGTCAACACA

Downstream 100 bases:

>100_bases
TCAATCAACTGCTGAAACATATCAGTGAGGGATGTGGCCAAGGGACGATAGGTGAGTCCTAGCTTCTGAATGCTCTTGCT
GTTATCGACACCAAAAGGAA

Product: short chain dehydrogenase/reductase family oxidoreductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MAFDIENIPSQQGKVAIVTGANTGLGYETVSYLAQKHFKVIMACRNLEKAEQAKAKIEVTVPVADLEILQIDLSDLSSVR
RFAQTFRQHYNSLDLLINNAGIMWPPYALTVDGFESQIGANYFGHFLLTALLLDLMPDTSASRVVSLSSNAHRLGSGRIN
FDDLQSEQNYSKTGAYAQSKLACLMFGNELQRRLAQAGKKILSVTAHPGVSNTELARHMPQYQVQLIQNTIGPLLCHAPD
QAALPIVMAALDPEAQGGEYFGPQGFMEMKGQPGRATQSDYAQNQAAAAQLWDVSEELTGCTFAIPQVQVVTTS

Sequences:

>Translated_314_residues
MAFDIENIPSQQGKVAIVTGANTGLGYETVSYLAQKHFKVIMACRNLEKAEQAKAKIEVTVPVADLEILQIDLSDLSSVR
RFAQTFRQHYNSLDLLINNAGIMWPPYALTVDGFESQIGANYFGHFLLTALLLDLMPDTSASRVVSLSSNAHRLGSGRIN
FDDLQSEQNYSKTGAYAQSKLACLMFGNELQRRLAQAGKKILSVTAHPGVSNTELARHMPQYQVQLIQNTIGPLLCHAPD
QAALPIVMAALDPEAQGGEYFGPQGFMEMKGQPGRATQSDYAQNQAAAAQLWDVSEELTGCTFAIPQVQVVTTS
>Mature_313_residues
AFDIENIPSQQGKVAIVTGANTGLGYETVSYLAQKHFKVIMACRNLEKAEQAKAKIEVTVPVADLEILQIDLSDLSSVRR
FAQTFRQHYNSLDLLINNAGIMWPPYALTVDGFESQIGANYFGHFLLTALLLDLMPDTSASRVVSLSSNAHRLGSGRINF
DDLQSEQNYSKTGAYAQSKLACLMFGNELQRRLAQAGKKILSVTAHPGVSNTELARHMPQYQVQLIQNTIGPLLCHAPDQ
AALPIVMAALDPEAQGGEYFGPQGFMEMKGQPGRATQSDYAQNQAAAAQLWDVSEELTGCTFAIPQVQVVTTS

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI186928839, Length=291, Percent_Identity=40.5498281786942, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI166795268, Length=290, Percent_Identity=41.3793103448276, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI193804850, Length=299, Percent_Identity=39.4648829431438, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI225579078, Length=294, Percent_Identity=39.7959183673469, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI10190746, Length=305, Percent_Identity=38.0327868852459, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI7706523, Length=294, Percent_Identity=34.3537414965986, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI19923931, Length=260, Percent_Identity=38.0769230769231, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI146231950, Length=294, Percent_Identity=33.6734693877551, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI7705421, Length=235, Percent_Identity=28.936170212766, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI72534732, Length=234, Percent_Identity=27.7777777777778, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI13375997, Length=204, Percent_Identity=28.921568627451, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17558006, Length=299, Percent_Identity=33.7792642140468, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI193207620, Length=300, Percent_Identity=30, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI72001364, Length=303, Percent_Identity=29.3729372937294, Blast_Score=104, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17532791, Length=205, Percent_Identity=32.1951219512195, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71992402, Length=278, Percent_Identity=31.294964028777, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17532805, Length=298, Percent_Identity=27.8523489932886, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17505416, Length=220, Percent_Identity=30.9090909090909, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17535059, Length=263, Percent_Identity=30.0380228136882, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI32565532, Length=133, Percent_Identity=36.0902255639098, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI115533172, Length=295, Percent_Identity=27.4576271186441, Blast_Score=64, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI115533174, Length=295, Percent_Identity=27.4576271186441, Blast_Score=64, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6324820, Length=328, Percent_Identity=29.2682926829268, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323882, Length=211, Percent_Identity=26.0663507109005, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI161076371, Length=257, Percent_Identity=43.9688715953307, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI28573296, Length=296, Percent_Identity=43.2432432432432, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24586328, Length=295, Percent_Identity=41.0169491525424, Blast_Score=184, Evalue=5e-47,
Organism=Drosophila melanogaster, GI22024069, Length=296, Percent_Identity=41.2162162162162, Blast_Score=184, Evalue=9e-47,
Organism=Drosophila melanogaster, GI19921754, Length=295, Percent_Identity=40.6779661016949, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI45554248, Length=291, Percent_Identity=41.9243986254296, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24640117, Length=291, Percent_Identity=41.9243986254296, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24656154, Length=263, Percent_Identity=36.5019011406844, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI19922628, Length=263, Percent_Identity=36.5019011406844, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI20129347, Length=298, Percent_Identity=33.5570469798658, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI45553409, Length=300, Percent_Identity=30.3333333333333, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24647948, Length=300, Percent_Identity=30.3333333333333, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24647946, Length=300, Percent_Identity=30.3333333333333, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24647931, Length=275, Percent_Identity=30.1818181818182, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21358495, Length=209, Percent_Identity=30.1435406698565, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 34224; Mature: 34093

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFDIENIPSQQGKVAIVTGANTGLGYETVSYLAQKHFKVIMACRNLEKAEQAKAKIEVT
CCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHCCCEEEEE
VPVADLEILQIDLSDLSSVRRFAQTFRQHYNSLDLLINNAGIMWPPYALTVDGFESQIGA
EEECCEEEEEECHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEECCHHHHHHH
NYFGHFLLTALLLDLMPDTSASRVVSLSSNAHRLGSGRINFDDLQSEQNYSKTGAYAQSK
HHHHHHHHHHHHHHHCCCCCHHHEEEECCCCCCCCCCCCCHHHHCCCCCCHHHCCHHHHH
LACLMFGNELQRRLAQAGKKILSVTAHPGVSNTELARHMPQYQVQLIQNTIGPLLCHAPD
HHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHCHHHHHHHHHHHHHHEEECCCC
QAALPIVMAALDPEAQGGEYFGPQGFMEMKGQPGRATQSDYAQNQAAAAQLWDVSEELTG
CCCCCEEEEECCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
CTFAIPQVQVVTTS
CEEECCEEEEEECC
>Mature Secondary Structure 
AFDIENIPSQQGKVAIVTGANTGLGYETVSYLAQKHFKVIMACRNLEKAEQAKAKIEVT
CCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHCCCEEEEE
VPVADLEILQIDLSDLSSVRRFAQTFRQHYNSLDLLINNAGIMWPPYALTVDGFESQIGA
EEECCEEEEEECHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEECCHHHHHHH
NYFGHFLLTALLLDLMPDTSASRVVSLSSNAHRLGSGRINFDDLQSEQNYSKTGAYAQSK
HHHHHHHHHHHHHHHCCCCCHHHEEEECCCCCCCCCCCCCHHHHCCCCCCHHHCCHHHHH
LACLMFGNELQRRLAQAGKKILSVTAHPGVSNTELARHMPQYQVQLIQNTIGPLLCHAPD
HHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHCHHHHHHHHHHHHHHEEECCCC
QAALPIVMAALDPEAQGGEYFGPQGFMEMKGQPGRATQSDYAQNQAAAAQLWDVSEELTG
CCCCCEEEEECCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
CTFAIPQVQVVTTS
CEEECCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8383668 [H]