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The map label for this gene is mutSB [H]

Identifier: 158336591

GI number: 158336591

Start: 3489620

End: 3492004

Strand: Reverse

Name: mutSB [H]

Synonym: AM1_3455

Alternate gene names: 158336591

Gene position: 3492004-3489620 (Counterclockwise)

Preceding gene: 158336592

Following gene: 158336590

Centisome position: 53.69

GC content: 52.58

Gene sequence:

>2385_bases
GTGATTGTTGAAAAAACCTTAGAACTGCTGGAGTGGGAGCGATTATGCCAGCATCTGTCAACCTTTGCGGCAACTAAGTT
AGGGGTGGCCGCAGCAATTGAGCTGCCGATTCCTGATACGGTTGAAGCCAGTGAAACCCTATTGCAGCAAACCCAAGAGG
TTTATGACCTAGAAACTCAGCTTTTGACTGCACTGACCTTTGAGGGGATTCATGATATTCGAGCAGCATTGGTGCGATCG
CAACGTCAAGGCATTCTCAGAGGCGAAGAGCTACTGCAGGTTGCCACAACCCTGTTAGGCAGCCGCAACCTACGTCGCCT
CATCAATCGTTATCCCGAATTAACCAGTCTTAATCAGTTGGTGGCCGACCTGCGTACCTACCCTGAATTAGAGCAAGAAA
TCCGCCACTGTATTGATGAGCAAGGGGAAGTTGCCGACCGGGCCAGCGAAAAATTGATGGGGATTCGTGAACGTCAGCGG
CAGGTCCGCAATGACGTCCAAACCATCTTGCAGCGAATTTTGCAGAGAAAGGGAGCGGCATTACAAGAGCGACTGATTAC
CCAGCGCAGCAATCGGTTTGTGGTGCCCGTTAAAGCCCCCCAAAAAGATGCGGTTCCCGGCATTGTTCATGATGCTTCCA
CCAGTGGAGCCACCCTCTATATTGAACCAAAGGCCACGGTAGAGCTGAATAATCGGCTGCGGCAACTCACCCGCCAAGAA
CAAGCAGAAGCCGAAGCCATCCGCCAAGCCCTCACGGAAAAAGTGGCAGAGGTCCATGAAGACTTAGACGCCCTGCTACA
AATCGTGACGTTAGTGGACCTTGCCACCGCCCGCGCCCGATATAGCTATTGGTTAGAGGCCAATCGCCCCCGCTTTGTCA
ACCGCGCAGCAGACACCCTGACCCTGCGACGTTTGCGCCACCCTTTACTAGTCTGGCAACAGCAGCATGAGCAAGGCCCC
GAAGTGGTGGCCATTGACGTGACCATTCAACCTCAAATCCGCGTGGTGGCGATTACGGGTCCGAATACTGGCGGTAAAAC
CGTTACCCTAAAGACCTTAGGTTTAGCGACTCTGATGGCAAAGGTAGGACTATTTGTCCCTGCCCAAGAACCGGTGGAGC
TACCTTGGTTTGATCAGGTGCTGGCCGATATTGGCGATGAACAATCATTGCAGCAAAGTTTGTCCACCTTCTCCGGTCAT
ATTCGCCGAATTCAAGAGATTATTGCCGCACTAACTGACCAATCTTTAGTGCTGCTGGACGAAGTCGGTGCAGGTACTGA
CCCCTTAGAAGGAAGTGCTCTAGCCATTGCCTTATTGCGATACTTAGCCGATCAGGCTCAGCTCACCATTGCCACCACCC
ACTTTGGCGAACTCAAAGCTCTGAAATACACAGACAATCGATTTGAAAATGCCTCGGTGGAATTTGATGATGCCACCTTG
CAGCCCACCTATCGTTTGCTCTGGGGGATTCCGGGTCGCTCCAATGCCTTGATTATTGCCCAGCGATTGGGGCTAAATGA
GCAGGTAATCGCCCAAGCCCAGGCCCAGATGGATGGCGAAACCGATGATGTTAATCAGGTGATTGCCGGGTTAGAAACTG
AACGTCGTCAGCAGGAAACTAAGGCTCAAGCCGCCGCCCAACTGCTGCAAAGTACAGAACAGCTCCATGAGCAAGTGGCC
AAGAAAGCTTCGGATCTGAAAGTTCGAGAGCAAAAACTGCGGCAGCAGCAAGAGAAAGCCATTCAAGAAGAAATTCGCCG
AGCCAAACAAGCGATCGCACAAGTGATTCGCGACCTCCAACAACAGCCCAAGTCCGCCCCTGCCGCCCAGGTTGCCACCG
AACGTCTAGAAAAAATTGCCAACCAGCGACTTCCCTCGCGCACCAAGCCCAAAGCGCCGCCTCCCAAGGGGTTTCAACCT
CAAGTCGGAGATCGGGTTCGCATTCCCAGCATTGGCCAGAAGGCAGACGTGATTAAGATTACGCCCACCAACGAGCTGGT
GGTTAAGTTTGGGATGATGAAAATGACCGTCAAGCCCACGGAGATAGAGTCCTTAACGGGCGAGAAGGTCGCACCTCCCC
CCAAGAAAACGGATAGTGCACCTAAAAAAGGAGACAATACACCTAAAAATTCGGCTCCCATGGTTCGCACCTCCAAGAAC
ACCTTGGATATCCGGGGGTCTAGAGTCGCCGATGCCGAAGTGGTGATTGAAGATGCGATCGCAAAGGCCCAGGGGCCCCT
GTGGATTATTCACGGTCATGGTACCGGTAAACTTCGTCAAGGCGTCCAAGCCTATTTATCGCAACATCCCCTTGTCTCTC
GCTATGAATTTGCCGAACAGGCTGATGGTGGGAAAGGCGTAACCATTGCTTATTGTGGCGTTTGA

Upstream 100 bases:

>100_bases
GCTTACGTTTAACCTTAGCCATTTCATCTCCAGTGCCCCTCACCTCAGAGGTTGCTTGTTACGATGACAGAAGTGGAGAA
TCGGTTTGCATTAAGACATT

Downstream 100 bases:

>100_bases
GACTGTAGCCTTTTAACCACTCAAACAGAAAGCCTTTATGTTTTGTAATCGGATGTTAGGCCTCGCAAGGATTTAGGGCA
ATCTAAAAGGGCATTTTCTG

Product: recombination and DNA strand exchange inhibitor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 794; Mature: 794

Protein sequence:

>794_residues
MIVEKTLELLEWERLCQHLSTFAATKLGVAAAIELPIPDTVEASETLLQQTQEVYDLETQLLTALTFEGIHDIRAALVRS
QRQGILRGEELLQVATTLLGSRNLRRLINRYPELTSLNQLVADLRTYPELEQEIRHCIDEQGEVADRASEKLMGIRERQR
QVRNDVQTILQRILQRKGAALQERLITQRSNRFVVPVKAPQKDAVPGIVHDASTSGATLYIEPKATVELNNRLRQLTRQE
QAEAEAIRQALTEKVAEVHEDLDALLQIVTLVDLATARARYSYWLEANRPRFVNRAADTLTLRRLRHPLLVWQQQHEQGP
EVVAIDVTIQPQIRVVAITGPNTGGKTVTLKTLGLATLMAKVGLFVPAQEPVELPWFDQVLADIGDEQSLQQSLSTFSGH
IRRIQEIIAALTDQSLVLLDEVGAGTDPLEGSALAIALLRYLADQAQLTIATTHFGELKALKYTDNRFENASVEFDDATL
QPTYRLLWGIPGRSNALIIAQRLGLNEQVIAQAQAQMDGETDDVNQVIAGLETERRQQETKAQAAAQLLQSTEQLHEQVA
KKASDLKVREQKLRQQQEKAIQEEIRRAKQAIAQVIRDLQQQPKSAPAAQVATERLEKIANQRLPSRTKPKAPPPKGFQP
QVGDRVRIPSIGQKADVIKITPTNELVVKFGMMKMTVKPTEIESLTGEKVAPPPKKTDSAPKKGDNTPKNSAPMVRTSKN
TLDIRGSRVADAEVVIEDAIAKAQGPLWIIHGHGTGKLRQGVQAYLSQHPLVSRYEFAEQADGGKGVTIAYCGV

Sequences:

>Translated_794_residues
MIVEKTLELLEWERLCQHLSTFAATKLGVAAAIELPIPDTVEASETLLQQTQEVYDLETQLLTALTFEGIHDIRAALVRS
QRQGILRGEELLQVATTLLGSRNLRRLINRYPELTSLNQLVADLRTYPELEQEIRHCIDEQGEVADRASEKLMGIRERQR
QVRNDVQTILQRILQRKGAALQERLITQRSNRFVVPVKAPQKDAVPGIVHDASTSGATLYIEPKATVELNNRLRQLTRQE
QAEAEAIRQALTEKVAEVHEDLDALLQIVTLVDLATARARYSYWLEANRPRFVNRAADTLTLRRLRHPLLVWQQQHEQGP
EVVAIDVTIQPQIRVVAITGPNTGGKTVTLKTLGLATLMAKVGLFVPAQEPVELPWFDQVLADIGDEQSLQQSLSTFSGH
IRRIQEIIAALTDQSLVLLDEVGAGTDPLEGSALAIALLRYLADQAQLTIATTHFGELKALKYTDNRFENASVEFDDATL
QPTYRLLWGIPGRSNALIIAQRLGLNEQVIAQAQAQMDGETDDVNQVIAGLETERRQQETKAQAAAQLLQSTEQLHEQVA
KKASDLKVREQKLRQQQEKAIQEEIRRAKQAIAQVIRDLQQQPKSAPAAQVATERLEKIANQRLPSRTKPKAPPPKGFQP
QVGDRVRIPSIGQKADVIKITPTNELVVKFGMMKMTVKPTEIESLTGEKVAPPPKKTDSAPKKGDNTPKNSAPMVRTSKN
TLDIRGSRVADAEVVIEDAIAKAQGPLWIIHGHGTGKLRQGVQAYLSQHPLVSRYEFAEQADGGKGVTIAYCGV
>Mature_794_residues
MIVEKTLELLEWERLCQHLSTFAATKLGVAAAIELPIPDTVEASETLLQQTQEVYDLETQLLTALTFEGIHDIRAALVRS
QRQGILRGEELLQVATTLLGSRNLRRLINRYPELTSLNQLVADLRTYPELEQEIRHCIDEQGEVADRASEKLMGIRERQR
QVRNDVQTILQRILQRKGAALQERLITQRSNRFVVPVKAPQKDAVPGIVHDASTSGATLYIEPKATVELNNRLRQLTRQE
QAEAEAIRQALTEKVAEVHEDLDALLQIVTLVDLATARARYSYWLEANRPRFVNRAADTLTLRRLRHPLLVWQQQHEQGP
EVVAIDVTIQPQIRVVAITGPNTGGKTVTLKTLGLATLMAKVGLFVPAQEPVELPWFDQVLADIGDEQSLQQSLSTFSGH
IRRIQEIIAALTDQSLVLLDEVGAGTDPLEGSALAIALLRYLADQAQLTIATTHFGELKALKYTDNRFENASVEFDDATL
QPTYRLLWGIPGRSNALIIAQRLGLNEQVIAQAQAQMDGETDDVNQVIAGLETERRQQETKAQAAAQLLQSTEQLHEQVA
KKASDLKVREQKLRQQQEKAIQEEIRRAKQAIAQVIRDLQQQPKSAPAAQVATERLEKIANQRLPSRTKPKAPPPKGFQP
QVGDRVRIPSIGQKADVIKITPTNELVVKFGMMKMTVKPTEIESLTGEKVAPPPKKTDSAPKKGDNTPKNSAPMVRTSKN
TLDIRGSRVADAEVVIEDAIAKAQGPLWIIHGHGTGKLRQGVQAYLSQHPLVSRYEFAEQADGGKGVTIAYCGV

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=419, Percent_Identity=26.0143198090692, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI36949366, Length=251, Percent_Identity=27.4900398406374, Blast_Score=100, Evalue=7e-21,
Organism=Homo sapiens, GI4557761, Length=175, Percent_Identity=32.5714285714286, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI26638666, Length=212, Percent_Identity=34.4339622641509, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI4505253, Length=212, Percent_Identity=34.4339622641509, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI4504191, Length=372, Percent_Identity=24.7311827956989, Blast_Score=88, Evalue=4e-17,
Organism=Homo sapiens, GI26638664, Length=213, Percent_Identity=34.2723004694836, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI262231786, Length=213, Percent_Identity=34.2723004694836, Blast_Score=87, Evalue=7e-17,
Organism=Escherichia coli, GI1789089, Length=258, Percent_Identity=31.3953488372093, Blast_Score=101, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17508445, Length=311, Percent_Identity=23.4726688102894, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17534743, Length=343, Percent_Identity=25.0728862973761, Blast_Score=99, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17508447, Length=267, Percent_Identity=27.3408239700375, Blast_Score=89, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17539736, Length=283, Percent_Identity=24.0282685512367, Blast_Score=71, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319935, Length=287, Percent_Identity=28.9198606271777, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324482, Length=232, Percent_Identity=28.8793103448276, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320302, Length=315, Percent_Identity=26.984126984127, Blast_Score=95, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6321912, Length=190, Percent_Identity=29.4736842105263, Blast_Score=88, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6320047, Length=246, Percent_Identity=28.8617886178862, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321109, Length=325, Percent_Identity=24, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24584320, Length=232, Percent_Identity=31.8965517241379, Blast_Score=112, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24664545, Length=186, Percent_Identity=29.0322580645161, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 88175; Mature: 88175

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: PS50828 SMR ; PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVEKTLELLEWERLCQHLSTFAATKLGVAAAIELPIPDTVEASETLLQQTQEVYDLETQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
LLTALTFEGIHDIRAALVRSQRQGILRGEELLQVATTLLGSRNLRRLINRYPELTSLNQL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHH
VADLRTYPELEQEIRHCIDEQGEVADRASEKLMGIRERQRQVRNDVQTILQRILQRKGAA
HHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LQERLITQRSNRFVVPVKAPQKDAVPGIVHDASTSGATLYIEPKATVELNNRLRQLTRQE
HHHHHHHHCCCCEEEEECCCCCCCCCCEEECCCCCCCEEEECCCCHHHHHHHHHHHHHHH
QAEAEAIRQALTEKVAEVHEDLDALLQIVTLVDLATARARYSYWLEANRPRFVNRAADTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHH
TLRRLRHPLLVWQQQHEQGPEVVAIDVTIQPQIRVVAITGPNTGGKTVTLKTLGLATLMA
HHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEECCCCCCCEEEEHHHHHHHHHH
KVGLFVPAQEPVELPWFDQVLADIGDEQSLQQSLSTFSGHIRRIQEIIAALTDQSLVLLD
HHHCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
EVGAGTDPLEGSALAIALLRYLADQAQLTIATTHFGELKALKYTDNRFENASVEFDDATL
CCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCCCCCCCCEEECCCCC
QPTYRLLWGIPGRSNALIIAQRLGLNEQVIAQAQAQMDGETDDVNQVIAGLETERRQQET
CCHHHHHCCCCCCCCEEEEEHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
KAQAAAQLLQSTEQLHEQVAKKASDLKVREQKLRQQQEKAIQEEIRRAKQAIAQVIRDLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQPKSAPAAQVATERLEKIANQRLPSRTKPKAPPPKGFQPQVGDRVRIPSIGQKADVIKI
HCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCEEEE
TPTNELVVKFGMMKMTVKPTEIESLTGEKVAPPPKKTDSAPKKGDNTPKNSAPMVRTSKN
CCCHHHHHHHHHHEEEECCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCC
TLDIRGSRVADAEVVIEDAIAKAQGPLWIIHGHGTGKLRQGVQAYLSQHPLVSRYEFAEQ
CEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHH
ADGGKGVTIAYCGV
CCCCCCEEEEECCC
>Mature Secondary Structure
MIVEKTLELLEWERLCQHLSTFAATKLGVAAAIELPIPDTVEASETLLQQTQEVYDLETQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
LLTALTFEGIHDIRAALVRSQRQGILRGEELLQVATTLLGSRNLRRLINRYPELTSLNQL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHH
VADLRTYPELEQEIRHCIDEQGEVADRASEKLMGIRERQRQVRNDVQTILQRILQRKGAA
HHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LQERLITQRSNRFVVPVKAPQKDAVPGIVHDASTSGATLYIEPKATVELNNRLRQLTRQE
HHHHHHHHCCCCEEEEECCCCCCCCCCEEECCCCCCCEEEECCCCHHHHHHHHHHHHHHH
QAEAEAIRQALTEKVAEVHEDLDALLQIVTLVDLATARARYSYWLEANRPRFVNRAADTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHH
TLRRLRHPLLVWQQQHEQGPEVVAIDVTIQPQIRVVAITGPNTGGKTVTLKTLGLATLMA
HHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEECCCCCCCEEEEHHHHHHHHHH
KVGLFVPAQEPVELPWFDQVLADIGDEQSLQQSLSTFSGHIRRIQEIIAALTDQSLVLLD
HHHCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
EVGAGTDPLEGSALAIALLRYLADQAQLTIATTHFGELKALKYTDNRFENASVEFDDATL
CCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCCCCCCCCEEECCCCC
QPTYRLLWGIPGRSNALIIAQRLGLNEQVIAQAQAQMDGETDDVNQVIAGLETERRQQET
CCHHHHHCCCCCCCCEEEEEHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
KAQAAAQLLQSTEQLHEQVAKKASDLKVREQKLRQQQEKAIQEEIRRAKQAIAQVIRDLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQPKSAPAAQVATERLEKIANQRLPSRTKPKAPPPKGFQPQVGDRVRIPSIGQKADVIKI
HCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCEEEE
TPTNELVVKFGMMKMTVKPTEIESLTGEKVAPPPKKTDSAPKKGDNTPKNSAPMVRTSKN
CCCHHHHHHHHHHEEEECCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCC
TLDIRGSRVADAEVVIEDAIAKAQGPLWIIHGHGTGKLRQGVQAYLSQHPLVSRYEFAEQ
CEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHH
ADGGKGVTIAYCGV
CCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]