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The map label for this gene is mdmC [H]

Identifier: 158336527

GI number: 158336527

Start: 3419330

End: 3420004

Strand: Reverse

Name: mdmC [H]

Synonym: AM1_3391

Alternate gene names: 158336527

Gene position: 3420004-3419330 (Counterclockwise)

Preceding gene: 158336528

Following gene: 158336526

Centisome position: 52.59

GC content: 48.89

Gene sequence:

>675_bases
ATGTGGAAGCGCAGAAATCATAAAAACATTGGCCTCAGCGATACTCTTTACCACTATCTGCTATCCATCTCCTTACGAGA
ATCCCAGCTGCTTAACCAACTGCGACAGGAAACCGCCAAACGTCGTGACGGAATGATGCAAATTGCTCCCGACCAAGGGC
AGTTAATGGCGCTGCTAATCCAACTCATGGGGGCCAAGAACGGAATTGAGATTGGCACCTTTACCGGCTATAGCACCCTG
TGGTTGGCTCTAGCATTGCCAATCGATGGTCGGATCATTACCTGCGATGTGAACGAAAAGACAACAGCAGTTGCACGTCG
ATACTGGCAGCAGGCTGGTCTAGCCGACAAAATTGATCTGAGAATTGCTCCCGCGACCGAAACCCTTCAGCAGTTAATCG
CATCGGGCCAGAACGGCACCTTTGATTTTGCGTTTATTGATGCGGATAAGCCAAATTACCCAACTTATTATGAGCAATGT
TTACAACTTCTGAGATCTGGAGGGCTGATCATCATTGACAATGTGCTTTGGGGAGGCAAAGTCGCTCAACCCATGATGCA
AGACCACAATACTAGGGCCATTCGAGCGCTCAATGAGTGCCTGCATCAAGATAAGCGGGTCGATGTCAGCACCTTAGGTA
TTGCAGACGGTATAACTTTGGCTCGTAAGCGGTAG

Upstream 100 bases:

>100_bases
GTCCCTGCCTATCTGTGTTTAGGTTTACCCGGCCCCATCGGGACTGAGCTGTATCTAAACGAACTCAAGCAGCAGTTACT
CACACCCCAAACTAGAAAGC

Downstream 100 bases:

>100_bases
ATATAACTAACGCTGGTCTGAATTCCAGGCACTTCACTAAGGCAACTCCACACAAAATGCGTTTGGGGCGCAAAAAGACT
GTGTTTCCGGCTCAAAATCT

Product: O-methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MWKRRNHKNIGLSDTLYHYLLSISLRESQLLNQLRQETAKRRDGMMQIAPDQGQLMALLIQLMGAKNGIEIGTFTGYSTL
WLALALPIDGRIITCDVNEKTTAVARRYWQQAGLADKIDLRIAPATETLQQLIASGQNGTFDFAFIDADKPNYPTYYEQC
LQLLRSGGLIIIDNVLWGGKVAQPMMQDHNTRAIRALNECLHQDKRVDVSTLGIADGITLARKR

Sequences:

>Translated_224_residues
MWKRRNHKNIGLSDTLYHYLLSISLRESQLLNQLRQETAKRRDGMMQIAPDQGQLMALLIQLMGAKNGIEIGTFTGYSTL
WLALALPIDGRIITCDVNEKTTAVARRYWQQAGLADKIDLRIAPATETLQQLIASGQNGTFDFAFIDADKPNYPTYYEQC
LQLLRSGGLIIIDNVLWGGKVAQPMMQDHNTRAIRALNECLHQDKRVDVSTLGIADGITLARKR
>Mature_224_residues
MWKRRNHKNIGLSDTLYHYLLSISLRESQLLNQLRQETAKRRDGMMQIAPDQGQLMALLIQLMGAKNGIEIGTFTGYSTL
WLALALPIDGRIITCDVNEKTTAVARRYWQQAGLADKIDLRIAPATETLQQLIASGQNGTFDFAFIDADKPNYPTYYEQC
LQLLRSGGLIIIDNVLWGGKVAQPMMQDHNTRAIRALNECLHQDKRVDVSTLGIADGITLARKR

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=224, Percent_Identity=47.7678571428571, Blast_Score=189, Evalue=1e-48,
Organism=Homo sapiens, GI205830453, Length=180, Percent_Identity=26.1111111111111, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI205830451, Length=180, Percent_Identity=26.1111111111111, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI4502969, Length=180, Percent_Identity=26.1111111111111, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17565612, Length=220, Percent_Identity=39.0909090909091, Blast_Score=147, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI25148771, Length=232, Percent_Identity=36.6379310344828, Blast_Score=143, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI72001028, Length=210, Percent_Identity=38.5714285714286, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI72001127, Length=228, Percent_Identity=34.6491228070175, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71991493, Length=240, Percent_Identity=30.4166666666667, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 25215; Mature: 25215

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWKRRNHKNIGLSDTLYHYLLSISLRESQLLNQLRQETAKRRDGMMQIAPDQGQLMALLI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHH
QLMGAKNGIEIGTFTGYSTLWLALALPIDGRIITCDVNEKTTAVARRYWQQAGLADKIDL
HHHCCCCCCEEEECCCHHHHHHHHEECCCCEEEEEECCCHHHHHHHHHHHHCCCCCEEEE
RIAPATETLQQLIASGQNGTFDFAFIDADKPNYPTYYEQCLQLLRSGGLIIIDNVLWGGK
EEECHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCH
VAQPMMQDHNTRAIRALNECLHQDKRVDVSTLGIADGITLARKR
HHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHCCCC
>Mature Secondary Structure
MWKRRNHKNIGLSDTLYHYLLSISLRESQLLNQLRQETAKRRDGMMQIAPDQGQLMALLI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHH
QLMGAKNGIEIGTFTGYSTLWLALALPIDGRIITCDVNEKTTAVARRYWQQAGLADKIDL
HHHCCCCCCEEEECCCHHHHHHHHEECCCCEEEEEECCCHHHHHHHHHHHHCCCCCEEEE
RIAPATETLQQLIASGQNGTFDFAFIDADKPNYPTYYEQCLQLLRSGGLIIIDNVLWGGK
EEECHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCH
VAQPMMQDHNTRAIRALNECLHQDKRVDVSTLGIADGITLARKR
HHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]