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The map label for this gene is csd [H]

Identifier: 158336427

GI number: 158336427

Start: 3321650

End: 3322831

Strand: Reverse

Name: csd [H]

Synonym: AM1_3291

Alternate gene names: 158336427

Gene position: 3322831-3321650 (Counterclockwise)

Preceding gene: 158336428

Following gene: 158336426

Centisome position: 51.09

GC content: 51.86

Gene sequence:

>1182_bases
ATGACCTCCGAACAGCAGCATTCTTTAGAAGTACATCGACAGCAATTTCCTGCTTTAGGGAATAAGCTGTACTTCAACTA
CGGTGGCCAAGGCCCCCTGCCACAGCCTGCTTTCACTGCCATTCAGTCTGCCTATATCCAAATGCAAGAGCTTGGCCCGT
TTACCGGGGGGGCATTGGCTTGGATGACGGAGAAAGTTGAAGGTACTAGACGTGCGATCGCATCCCAACTCAACGTCTCT
CCCAGCACCATCACCCTGACAGAATCCGTATCCAGCGGCTGCAATATCGCCATGTGGGGGTTTAACTGGCAACCGGGTGA
TCACATTCTTTTATCCGACTGTGAACATCCCGGAATTATTGCCACTGCCCAACAGCTTAGCCACCGCTATGGTGTCGAAG
TCTCGAACTTCCCCTTGATGGCAACCCTGAACGAGGGTGATCCAATTGCGGTCATGGTGGAGCATTTACGTCCCAACACA
CGATTGGCTATCGTGAGTCACATCCTGTGGAACACTGGCCAGGTCTTACCTCTCAAGGCTATGGCAGCCGCCTGTCGGCA
AGCCGTACCGACCGTGGCAATCTTAGTGGATGCCGCCCAATCCGTCGGGGTATTGCCCCTCAAGGTGGATGAATTGGATG
TCGATTTCTATGCTTTTACCGGTCATAAGTGGTTCTGCGGCCCTGATGGGTTAGGCGGGCTGTATGTTCGAGCAGCCTCT
TTAGATCGTTTGAAACCCACCTTTATCGGCTGGCGTGGGATTGATATGGATGTCCAGGGTAAACCAACGGGGTGGAAGCC
AGATGGTCGTCGGTATGAGGTCGCGACTTCTGCCTTTCCGCTGTTTCCGGGGTTAACCGCTGCCATTGAACTACAGGAGC
AGTGGGGAACGCCGACGGATCGCTATCAACGCATTGTCCATCTCAGTCGAATTTTGTGGGAGCTGCTCAGCACGATTCCA
AAAATCACTTGTTTACGCACTACCGCACCAGAGTCTGGTTTAGTCGCTTTCCAAATTGAAGACTTCAGCAATCATCGTCC
TTTTGTACAACAGCTCGAAAGCCAAAAGATGATGGTGCGTCTGATCGCAGATCCTAATTGCGTCAGAGCTTGTGTGCATT
ATCTGACTTTGGAATCTGAATTAGACCAGCTCGTCCAGGCCATTGAGCAAGCATTGGCATGA

Upstream 100 bases:

>100_bases
ACATCACACCCGGAACTTGCCGATCTAACAGGATGACAAAATCAGGCAGAATAGCAAAGGCTAGTATGCTGGCCTTGTGA
CCTGAACCCTAAGGATAGGT

Downstream 100 bases:

>100_bases
CGGACTGACGTGGGCTAACGCACCGGGTGGACATACTGTATGGAACATCAAACACTTCGTTTAGCCCGGCTAATTGCAGC
GATAGTGGTTATTGGCTTCG

Product: L-cysteine/cystine lyase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTSEQQHSLEVHRQQFPALGNKLYFNYGGQGPLPQPAFTAIQSAYIQMQELGPFTGGALAWMTEKVEGTRRAIASQLNVS
PSTITLTESVSSGCNIAMWGFNWQPGDHILLSDCEHPGIIATAQQLSHRYGVEVSNFPLMATLNEGDPIAVMVEHLRPNT
RLAIVSHILWNTGQVLPLKAMAAACRQAVPTVAILVDAAQSVGVLPLKVDELDVDFYAFTGHKWFCGPDGLGGLYVRAAS
LDRLKPTFIGWRGIDMDVQGKPTGWKPDGRRYEVATSAFPLFPGLTAAIELQEQWGTPTDRYQRIVHLSRILWELLSTIP
KITCLRTTAPESGLVAFQIEDFSNHRPFVQQLESQKMMVRLIADPNCVRACVHYLTLESELDQLVQAIEQALA

Sequences:

>Translated_393_residues
MTSEQQHSLEVHRQQFPALGNKLYFNYGGQGPLPQPAFTAIQSAYIQMQELGPFTGGALAWMTEKVEGTRRAIASQLNVS
PSTITLTESVSSGCNIAMWGFNWQPGDHILLSDCEHPGIIATAQQLSHRYGVEVSNFPLMATLNEGDPIAVMVEHLRPNT
RLAIVSHILWNTGQVLPLKAMAAACRQAVPTVAILVDAAQSVGVLPLKVDELDVDFYAFTGHKWFCGPDGLGGLYVRAAS
LDRLKPTFIGWRGIDMDVQGKPTGWKPDGRRYEVATSAFPLFPGLTAAIELQEQWGTPTDRYQRIVHLSRILWELLSTIP
KITCLRTTAPESGLVAFQIEDFSNHRPFVQQLESQKMMVRLIADPNCVRACVHYLTLESELDQLVQAIEQALA
>Mature_392_residues
TSEQQHSLEVHRQQFPALGNKLYFNYGGQGPLPQPAFTAIQSAYIQMQELGPFTGGALAWMTEKVEGTRRAIASQLNVSP
STITLTESVSSGCNIAMWGFNWQPGDHILLSDCEHPGIIATAQQLSHRYGVEVSNFPLMATLNEGDPIAVMVEHLRPNTR
LAIVSHILWNTGQVLPLKAMAAACRQAVPTVAILVDAAQSVGVLPLKVDELDVDFYAFTGHKWFCGPDGLGGLYVRAASL
DRLKPTFIGWRGIDMDVQGKPTGWKPDGRRYEVATSAFPLFPGLTAAIELQEQWGTPTDRYQRIVHLSRILWELLSTIPK
ITCLRTTAPESGLVAFQIEDFSNHRPFVQQLESQKMMVRLIADPNCVRACVHYLTLESELDQLVQAIEQALA

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=274, Percent_Identity=25.9124087591241, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1787970, Length=357, Percent_Identity=28.0112044817927, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI48994898, Length=238, Percent_Identity=30.672268907563, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1789175, Length=401, Percent_Identity=26.1845386533666, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI25143064, Length=244, Percent_Identity=25.4098360655738, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6319831, Length=201, Percent_Identity=27.8606965174129, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI20129463, Length=238, Percent_Identity=28.9915966386555, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 43433; Mature: 43302

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSEQQHSLEVHRQQFPALGNKLYFNYGGQGPLPQPAFTAIQSAYIQMQELGPFTGGALA
CCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHH
WMTEKVEGTRRAIASQLNVSPSTITLTESVSSGCNIAMWGFNWQPGDHILLSDCEHPGII
HHHHHHHHHHHHHHHHCCCCCCEEEEECHHCCCCCEEEECCCCCCCCEEEEECCCCCCEE
ATAQQLSHRYGVEVSNFPLMATLNEGDPIAVMVEHLRPNTRLAIVSHILWNTGQVLPLKA
HHHHHHHHHHCCEECCCEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEHHH
MAAACRQAVPTVAILVDAAQSVGVLPLKVDELDVDFYAFTGHKWFCGPDGLGGLYVRAAS
HHHHHHHHCCCCEEEEHHHHHCCEEEEEECCCCEEEEEEECCEEEECCCCCCCEEEEECC
LDRLKPTFIGWRGIDMDVQGKPTGWKPDGRRYEVATSAFPLFPGLTAAIELQEQWGTPTD
CCCCCCCEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEEHHHCCCCHH
RYQRIVHLSRILWELLSTIPKITCLRTTAPESGLVAFQIEDFSNHRPFVQQLESQKMMVR
HHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHEEEE
LIADPNCVRACVHYLTLESELDQLVQAIEQALA
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSEQQHSLEVHRQQFPALGNKLYFNYGGQGPLPQPAFTAIQSAYIQMQELGPFTGGALA
CCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHH
WMTEKVEGTRRAIASQLNVSPSTITLTESVSSGCNIAMWGFNWQPGDHILLSDCEHPGII
HHHHHHHHHHHHHHHHCCCCCCEEEEECHHCCCCCEEEECCCCCCCCEEEEECCCCCCEE
ATAQQLSHRYGVEVSNFPLMATLNEGDPIAVMVEHLRPNTRLAIVSHILWNTGQVLPLKA
HHHHHHHHHHCCEECCCEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEHHH
MAAACRQAVPTVAILVDAAQSVGVLPLKVDELDVDFYAFTGHKWFCGPDGLGGLYVRAAS
HHHHHHHHCCCCEEEEHHHHHCCEEEEEECCCCEEEEEEECCEEEECCCCCCCEEEEECC
LDRLKPTFIGWRGIDMDVQGKPTGWKPDGRRYEVATSAFPLFPGLTAAIELQEQWGTPTD
CCCCCCCEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEEHHHCCCCHH
RYQRIVHLSRILWELLSTIPKITCLRTTAPESGLVAFQIEDFSNHRPFVQQLESQKMMVR
HHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHEEEE
LIADPNCVRACVHYLTLESELDQLVQAIEQALA
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]