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The map label for this gene is phoP [H]

Identifier: 158336368

GI number: 158336368

Start: 3269958

End: 3270671

Strand: Reverse

Name: phoP [H]

Synonym: AM1_3230

Alternate gene names: 158336368

Gene position: 3270671-3269958 (Counterclockwise)

Preceding gene: 158336369

Following gene: 158336366

Centisome position: 50.29

GC content: 47.34

Gene sequence:

>714_bases
TTGAAAGATCAGCAGCAAAAAATTCTAGTCGCTGATGATGAAGCTAGCATTCGTCGGATCCTAGAAACTCGTCTCTCCAT
GATGGGGTTCGTTGTCATCACTGCCGCTGATGGCGAGGAAGCCCTGCAAGTGTTTCAGCATCAAGAACCAGATTTGATTA
TTTTGGATGTCATGATGCCCAAGCTGAACGGGTATCAGGTCTGCCAATCCCTACGGCAAGAATCAGATGTCCCCATCATT
ATGTTGACGGCTCTTTCAGACGTCGCCGATCGGATTACGGGTCTGGAAATGGGCGCAGACGACTATATGGTCAAGCCGTT
TTCTCCCAAAGAACTAGAGTCACGCATTCGCTGTATTCTTCGACGGATTACAAAATCCCACTCTTCTCACCATAAATCAG
CCGGAGTGATTCAGGTCGGCCATCTAGAAATTGATACCAATAAACGCCAAGTCTATAAAGATAAAGAACGCATTCAGCTC
ACTCATCTCGAATTTAATCTACTAGAGCTGCTGGTTAGCCGCCCCGGAGAACCCATCTCTAGAGTTGAATTTTTACAAAA
GGTTTGGGGCTATAGCCCTGACGGCAAGATTGATACCCGTGTCGTCGATGTTCATATGTCGCGCCTCCGGAACAAGCTGA
AAGAAGATACGGAAGAACCCGACTTGATCTTGTCTGTACGAGGCGTAGGCTATGCCATCCAACGGGGTGATTAA

Upstream 100 bases:

>100_bases
TGTAAAAAAACTTCATATTCATACTTTATTGGGCTTTTTATTCATGGTTCAAAGAGTATTAGTCTCTTCAACGTTGTCTG
TCTTTGGATACTAAAGTAGT

Downstream 100 bases:

>100_bases
GGCTATCTCTGGTTCCTTGACGCTTTAAAAAGCAAAAAGCTGAGGCAGTACCTCAGCTTGGCATGGATGATGGTGTTCGC
AACTATGCGCCGGTCACAAT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MKDQQQKILVADDEASIRRILETRLSMMGFVVITAADGEEALQVFQHQEPDLIILDVMMPKLNGYQVCQSLRQESDVPII
MLTALSDVADRITGLEMGADDYMVKPFSPKELESRIRCILRRITKSHSSHHKSAGVIQVGHLEIDTNKRQVYKDKERIQL
THLEFNLLELLVSRPGEPISRVEFLQKVWGYSPDGKIDTRVVDVHMSRLRNKLKEDTEEPDLILSVRGVGYAIQRGD

Sequences:

>Translated_237_residues
MKDQQQKILVADDEASIRRILETRLSMMGFVVITAADGEEALQVFQHQEPDLIILDVMMPKLNGYQVCQSLRQESDVPII
MLTALSDVADRITGLEMGADDYMVKPFSPKELESRIRCILRRITKSHSSHHKSAGVIQVGHLEIDTNKRQVYKDKERIQL
THLEFNLLELLVSRPGEPISRVEFLQKVWGYSPDGKIDTRVVDVHMSRLRNKLKEDTEEPDLILSVRGVGYAIQRGD
>Mature_237_residues
MKDQQQKILVADDEASIRRILETRLSMMGFVVITAADGEEALQVFQHQEPDLIILDVMMPKLNGYQVCQSLRQESDVPII
MLTALSDVADRITGLEMGADDYMVKPFSPKELESRIRCILRRITKSHSSHHKSAGVIQVGHLEIDTNKRQVYKDKERIQL
THLEFNLLELLVSRPGEPISRVEFLQKVWGYSPDGKIDTRVVDVHMSRLRNKLKEDTEEPDLILSVRGVGYAIQRGD

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=232, Percent_Identity=37.9310344827586, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI87082012, Length=227, Percent_Identity=38.7665198237885, Blast_Score=154, Evalue=4e-39,
Organism=Escherichia coli, GI1786784, Length=234, Percent_Identity=39.7435897435897, Blast_Score=154, Evalue=6e-39,
Organism=Escherichia coli, GI1786599, Length=229, Percent_Identity=37.9912663755458, Blast_Score=151, Evalue=4e-38,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=34.6666666666667, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI1790860, Length=232, Percent_Identity=35.7758620689655, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=40.4347826086956, Blast_Score=137, Evalue=6e-34,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=34.9557522123894, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=32.9004329004329, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=34.2222222222222, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1789402, Length=228, Percent_Identity=31.5789473684211, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1790552, Length=228, Percent_Identity=31.5789473684211, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1787375, Length=230, Percent_Identity=29.1304347826087, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=30.2127659574468, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1788550, Length=166, Percent_Identity=30.1204819277108, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI1787487, Length=102, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788191, Length=127, Percent_Identity=33.0708661417323, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790299, Length=105, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI145693157, Length=123, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1788713, Length=154, Percent_Identity=32.4675324675325, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790437, Length=122, Percent_Identity=30.327868852459, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27062; Mature: 27062

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDQQQKILVADDEASIRRILETRLSMMGFVVITAADGEEALQVFQHQEPDLIILDVMMP
CCCCCCEEEEECCHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHCCCCCEEEEEEECC
KLNGYQVCQSLRQESDVPIIMLTALSDVADRITGLEMGADDYMVKPFSPKELESRIRCIL
CCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHH
RRITKSHSSHHKSAGVIQVGHLEIDTNKRQVYKDKERIQLTHLEFNLLELLVSRPGEPIS
HHHHHHHCCCCCCCCEEEEEEEEECCCHHHHHCCHHHEEEEHHHHHHHHHHHHCCCCHHH
RVEFLQKVWGYSPDGKIDTRVVDVHMSRLRNKLKEDTEEPDLILSVRGVGYAIQRGD
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEECCC
>Mature Secondary Structure
MKDQQQKILVADDEASIRRILETRLSMMGFVVITAADGEEALQVFQHQEPDLIILDVMMP
CCCCCCEEEEECCHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHCCCCCEEEEEEECC
KLNGYQVCQSLRQESDVPIIMLTALSDVADRITGLEMGADDYMVKPFSPKELESRIRCIL
CCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHH
RRITKSHSSHHKSAGVIQVGHLEIDTNKRQVYKDKERIQLTHLEFNLLELLVSRPGEPIS
HHHHHHHCCCCCCCCEEEEEEEEECCCHHHHHCCHHHEEEEHHHHHHHHHHHHCCCCHHH
RVEFLQKVWGYSPDGKIDTRVVDVHMSRLRNKLKEDTEEPDLILSVRGVGYAIQRGD
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]