Click here to switch to the map view.

The map label for this gene is mre11 [H]

Identifier: 158336361

GI number: 158336361

Start: 3263173

End: 3264456

Strand: Direct

Name: mre11 [H]

Synonym: AM1_3223

Alternate gene names: 158336361

Gene position: 3263173-3264456 (Clockwise)

Preceding gene: 158336359

Following gene: 158336365

Centisome position: 50.17

GC content: 45.87

Gene sequence:

>1284_bases
ATGCCTCGTTTCCTCCATGTTGCTGATGTACATTTGGGCTACACCAAATATGACTCACCAGAGCGTACCAAAGATTTTTT
TCACGCTTTTAGTGATGCGCTTGAACGCTATGCCATTGAACCCCAGGTCGACTTTGTCCTGATTGTTGGGGACTTGTTTG
AGCATCGCCAAGTGCTACCTGCGATCCTCAATCAAGCGCAGCTCTGCCTGAGACGATTACAAGAAGTCGGTATACCCGTC
TTAGCGATTGAAGGAAATCATGATTATTGCCTCTATGGAACGAATACCAGTTGGTTGCGATATCTAGCGAGTTGGGATCT
TCTAATGCTGTTGGAACCGGATGAGAATGAGCAGTTGATGCCTTGGGATCCGGATACTAAACGTGGAGGCTATATTGATC
TTGACTGTGGTGTGCGAGTGATTGGGTCTCGGTGGTATGGAGCGGCTGCGCCTCAGGCAATTCAATCCTTAGCCCCTTTG
ATAGAAAAACTCCCTTCTGGCCCTGATCATACGGTGATGATGTTCCATCATGGGTTAGAAGGACATGTCTCTCGCTACAG
TGGTGCATTGCGCTATCAAGACTTTGCTCCCTTGCTAACCGCAGGTGTAGATTATTTAGCCCTTGGCCATATCCACCGCA
GCTACTCTGCCGAAAGCTGGATTTTTAACCCTGGCTCCATCGAAGCGAATAGCGTGATTGAAAACCAAGACCAGAATCCT
CGGGGGGTGTTCTTGGTCAACCTAACCAAAAAAGGAATCAAAGCTGATCTCAAATCCGATTATTATCAACGCCATATTGA
GCGCTTAAACCTAAAAGCAGATCCGAAGCAAACGGCTGCAGAATTGGAAGCAGCGGCAATTACTACGATTGAAACGGCCT
ACAAAAACGGCAAAACAGAAGATGCCATCGTAGAACTAAAAATTCAGGGCACAATTGGATTTGAGCGTTCTGATTTGAAT
GTGAAAGAGCTGAGGACTCAACTCCATACCCTCAGTAAAGCTTTAATCATGCTGATTAAATATGAAGTCACTGGGGTTGA
ATATCACAGCTATATCAGCGATCAAGAAGAACTCCCCTCTCGCCACGATATTGAGCGATTGGTTTTTACCGATCTTTTAG
CTGCGAATGCTCATTACCGAGACCAGGCAGAATCCCTTTCTTCAGGCCTTATGGATCTAAAAGATCGCCTACTTAAACAG
CAAACTGAACCTGAACTCTATCAATATGCTCAGGAACTGCTGTCTGCAAAGTCTTCAGAAGCGGATAAGCCAGTGCAAGA
TTAG

Upstream 100 bases:

>100_bases
TTCTAGTTTTAAGTTTGATATCTCTATCATGATTGAATAAAAATAGTGCTAAATAGACTAGTACAATTATCCCTACTTAT
TTTGTATGGATTAGAGCATT

Downstream 100 bases:

>100_bases
ACCAAAAGTCTATTCCACAGGAATCTTGCACCGATCTGTAGAGCAATCAATTTGCCGTTGTCGTTCAGCTAGGATTGTTG
CTAAATCTGCTCTGCCTGTC

Product: Ser/Thr protein phosphatase family protein

Products: NA

Alternate protein names: pfMre11 [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MPRFLHVADVHLGYTKYDSPERTKDFFHAFSDALERYAIEPQVDFVLIVGDLFEHRQVLPAILNQAQLCLRRLQEVGIPV
LAIEGNHDYCLYGTNTSWLRYLASWDLLMLLEPDENEQLMPWDPDTKRGGYIDLDCGVRVIGSRWYGAAAPQAIQSLAPL
IEKLPSGPDHTVMMFHHGLEGHVSRYSGALRYQDFAPLLTAGVDYLALGHIHRSYSAESWIFNPGSIEANSVIENQDQNP
RGVFLVNLTKKGIKADLKSDYYQRHIERLNLKADPKQTAAELEAAAITTIETAYKNGKTEDAIVELKIQGTIGFERSDLN
VKELRTQLHTLSKALIMLIKYEVTGVEYHSYISDQEELPSRHDIERLVFTDLLAANAHYRDQAESLSSGLMDLKDRLLKQ
QTEPELYQYAQELLSAKSSEADKPVQD

Sequences:

>Translated_427_residues
MPRFLHVADVHLGYTKYDSPERTKDFFHAFSDALERYAIEPQVDFVLIVGDLFEHRQVLPAILNQAQLCLRRLQEVGIPV
LAIEGNHDYCLYGTNTSWLRYLASWDLLMLLEPDENEQLMPWDPDTKRGGYIDLDCGVRVIGSRWYGAAAPQAIQSLAPL
IEKLPSGPDHTVMMFHHGLEGHVSRYSGALRYQDFAPLLTAGVDYLALGHIHRSYSAESWIFNPGSIEANSVIENQDQNP
RGVFLVNLTKKGIKADLKSDYYQRHIERLNLKADPKQTAAELEAAAITTIETAYKNGKTEDAIVELKIQGTIGFERSDLN
VKELRTQLHTLSKALIMLIKYEVTGVEYHSYISDQEELPSRHDIERLVFTDLLAANAHYRDQAESLSSGLMDLKDRLLKQ
QTEPELYQYAQELLSAKSSEADKPVQD
>Mature_426_residues
PRFLHVADVHLGYTKYDSPERTKDFFHAFSDALERYAIEPQVDFVLIVGDLFEHRQVLPAILNQAQLCLRRLQEVGIPVL
AIEGNHDYCLYGTNTSWLRYLASWDLLMLLEPDENEQLMPWDPDTKRGGYIDLDCGVRVIGSRWYGAAAPQAIQSLAPLI
EKLPSGPDHTVMMFHHGLEGHVSRYSGALRYQDFAPLLTAGVDYLALGHIHRSYSAESWIFNPGSIEANSVIENQDQNPR
GVFLVNLTKKGIKADLKSDYYQRHIERLNLKADPKQTAAELEAAAITTIETAYKNGKTEDAIVELKIQGTIGFERSDLNV
KELRTQLHTLSKALIMLIKYEVTGVEYHSYISDQEELPSRHDIERLVFTDLLAANAHYRDQAESLSSGLMDLKDRLLKQQ
TEPELYQYAQELLSAKSSEADKPVQD

Specific function: Involved in DNA double-strand break repair (DSBR). The rad50/mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity [H]

COG id: COG0420

COG function: function code L; DNA repair exonuclease

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MRE11/RAD32 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003701
- InterPro:   IPR004843
- InterPro:   IPR004593 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: NA

Molecular weight: Translated: 48416; Mature: 48285

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRFLHVADVHLGYTKYDSPERTKDFFHAFSDALERYAIEPQVDFVLIVGDLFEHRQVLP
CCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHH
AILNQAQLCLRRLQEVGIPVLAIEGNHDYCLYGTNTSWLRYLASWDLLMLLEPDENEQLM
HHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCHHHHHHHHCCCEEEEECCCCCCCCC
PWDPDTKRGGYIDLDCGVRVIGSRWYGAAAPQAIQSLAPLIEKLPSGPDHTVMMFHHGLE
CCCCCCCCCCEEEECCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCH
GHVSRYSGALRYQDFAPLLTAGVDYLALGHIHRSYSAESWIFNPGSIEANSVIENQDQNP
HHHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHCCCCCCC
RGVFLVNLTKKGIKADLKSDYYQRHIERLNLKADPKQTAAELEAAAITTIETAYKNGKTE
CEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
DAIVELKIQGTIGFERSDLNVKELRTQLHTLSKALIMLIKYEVTGVEYHSYISDQEELPS
CEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHCCCHHHCCC
RHDIERLVFTDLLAANAHYRDQAESLSSGLMDLKDRLLKQQTEPELYQYAQELLSAKSSE
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
ADKPVQD
CCCCCCC
>Mature Secondary Structure 
PRFLHVADVHLGYTKYDSPERTKDFFHAFSDALERYAIEPQVDFVLIVGDLFEHRQVLP
CCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHH
AILNQAQLCLRRLQEVGIPVLAIEGNHDYCLYGTNTSWLRYLASWDLLMLLEPDENEQLM
HHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCHHHHHHHHCCCEEEEECCCCCCCCC
PWDPDTKRGGYIDLDCGVRVIGSRWYGAAAPQAIQSLAPLIEKLPSGPDHTVMMFHHGLE
CCCCCCCCCCEEEECCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCH
GHVSRYSGALRYQDFAPLLTAGVDYLALGHIHRSYSAESWIFNPGSIEANSVIENQDQNP
HHHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHCCCCCCC
RGVFLVNLTKKGIKADLKSDYYQRHIERLNLKADPKQTAAELEAAAITTIETAYKNGKTE
CEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
DAIVELKIQGTIGFERSDLNVKELRTQLHTLSKALIMLIKYEVTGVEYHSYISDQEELPS
CEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHCCCHHHCCC
RHDIERLVFTDLLAANAHYRDQAESLSSGLMDLKDRLLKQQTEPELYQYAQELLSAKSSE
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
ADKPVQD
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11029422 [H]