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The map label for this gene is cyaA [H]

Identifier: 158336327

GI number: 158336327

Start: 3224597

End: 3226261

Strand: Reverse

Name: cyaA [H]

Synonym: AM1_3189

Alternate gene names: 158336327

Gene position: 3226261-3224597 (Counterclockwise)

Preceding gene: 158336329

Following gene: 158336326

Centisome position: 49.61

GC content: 50.45

Gene sequence:

>1665_bases
GTGCCGTACTTAGTGGCTCCCCCCAATGCACCAAATCCCAAATCCTACACCTTGGTTACAGGATCCAATTCGATTGGCCG
GGGGTTAGACAATCATATTGTGCTGATGCACCCAAGCTTATCGCGTCATCATGCGGAGCTGATGGTCCAAGAAAATGGTC
AGGCTGTCCTCAAGGATTTAGATAGCCTCAACCATACCTACGTTAACGATCAGCCGATTCAGCAATGCCATCTCAAGGAT
GGTGATCGGGTCCGGTTCGGGACCATTGATATGCAAATCACCTGGAATTTGACGGCCACCATCCCAGATCTGAGTCCCCC
CAGTCCACCCCCAGATCAATCCCTTTCCATCATTAGTCGTTTTGCCCCGGAAAATACTCGGATTGAACTCCAAGATTTAC
TAGAACCCGAAGCCCCCGGCGAATCCGGGGTGGGTTTGAAGCTCAAACAACAGGATGATCAAACCCGCTCGGTTGATAAG
CTCAAAATTCTGCTCGAAGTCAGTCAACAGCTGTCTTCTCCCAAAGAGTTAGAAGAGCTGCTCGATAAAATTCTCGATTT
GCTGTTTGAGATTATGACCGTTGACCGGGGTTTAATTCTCTTGGTCAATCCTCACACCCAGGAGCTAGAACAAAAAGCGA
TCAAATTCCGGAGTGGTATTCCCACGGGACTTCGCTTTTACAGCACCACCATCACGAATTTTGTTTATGGATCGGGCGAA
GGCATCCTCACGGATGATGCCGCCCGCGATCGCAGATTTCACGAATCGCGATCCATCGTCCAGCAGGCCATCCATGCCGC
CATGTGCGTCCCCCTGAAGCCTAGGGATGAGGTGATTGGGGTGTTGTACACAGACAACCTGTCTGTGCGGGCCATTTATT
CGGAAGAAGACCTGGAATTTTTAGGTGGATTAGCGAATCAGGCTGCGATCGCAATCGACAATGCCCATCTCTACAAAAAG
ATTCAAACTGAAGCCGTTCTGCGTACCAAATTAGAACGCTTTTTCCCACAAAACGTTTGGCGAAAATTAAGTGAGGAAAG
CCAATTAGAGGTCATTGACACCAAAGTCACCGTCGTCTTTGCTGACATCAGTCGGTTTACAGAGCTCTCTTCGCGCCTCG
AACCCCGCCAAGTCATCACCATGCTCAACGAATACTTTAGCGTCATGGTGGAGGGAATCGTCTTCCGATACGAAGGCACC
TTAGAACAATATATTGGCGATGCCCTATTGGCCGTCTGGGGAGCCCCCTATCAACATCCCAACGATGCAGAGCGGGCAGT
GAAAGCCGCCATCGCCATGCAAAAAGCCGTCTCCAAACTGAATCAACGCTGGGCCAAGCGGTGGAACTTTAACATTCAGA
TTCATATTGGGGTGAACACTGGCGTCGTTGCCGCTGGCAATATTGGGTCTGAACAACTGTTTCAATACGGCACCATTGGC
AATACCACTAACGTCAGTAGTCGTATATGTGACGTGGCCCGTGCTGGCGAAATCCTGATCTCCCAAAGCACCTTAAATGA
ACTGCATCAGTGTGACGTACCGCTCCAGCAGCTGACACCTGTGCAAGTCAAAGGCATTCAAGACCCCATTCAGCTATACC
GGCTGCTCTGGGACCAAAAGAACCCTCCTGCCCAAGGGCAAGCTGTGATGGCTAGGGAACCGTAG

Upstream 100 bases:

>100_bases
CATTAATATAGTGTTTAACTTTCCCTAATTTAGCGATTGGCAACCGTTAAACTATCTCTAAAGTTGTGATCAAGATGCGT
TATCCACGACAGGAGTGCAT

Downstream 100 bases:

>100_bases
ACTTGCTCGTGCTAGACCTACAATAGCAGCCTGCAGACGGACCTCCAGTAAGACTCTGTCCCATCTGCTGAGCATCCAAA
AACACCGTTTAGGATGTATA

Product: adenylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 2; Adenylyl cyclase 2; AC2 [H]

Number of amino acids: Translated: 554; Mature: 553

Protein sequence:

>554_residues
MPYLVAPPNAPNPKSYTLVTGSNSIGRGLDNHIVLMHPSLSRHHAELMVQENGQAVLKDLDSLNHTYVNDQPIQQCHLKD
GDRVRFGTIDMQITWNLTATIPDLSPPSPPPDQSLSIISRFAPENTRIELQDLLEPEAPGESGVGLKLKQQDDQTRSVDK
LKILLEVSQQLSSPKELEELLDKILDLLFEIMTVDRGLILLVNPHTQELEQKAIKFRSGIPTGLRFYSTTITNFVYGSGE
GILTDDAARDRRFHESRSIVQQAIHAAMCVPLKPRDEVIGVLYTDNLSVRAIYSEEDLEFLGGLANQAAIAIDNAHLYKK
IQTEAVLRTKLERFFPQNVWRKLSEESQLEVIDTKVTVVFADISRFTELSSRLEPRQVITMLNEYFSVMVEGIVFRYEGT
LEQYIGDALLAVWGAPYQHPNDAERAVKAAIAMQKAVSKLNQRWAKRWNFNIQIHIGVNTGVVAAGNIGSEQLFQYGTIG
NTTNVSSRICDVARAGEILISQSTLNELHQCDVPLQQLTPVQVKGIQDPIQLYRLLWDQKNPPAQGQAVMAREP

Sequences:

>Translated_554_residues
MPYLVAPPNAPNPKSYTLVTGSNSIGRGLDNHIVLMHPSLSRHHAELMVQENGQAVLKDLDSLNHTYVNDQPIQQCHLKD
GDRVRFGTIDMQITWNLTATIPDLSPPSPPPDQSLSIISRFAPENTRIELQDLLEPEAPGESGVGLKLKQQDDQTRSVDK
LKILLEVSQQLSSPKELEELLDKILDLLFEIMTVDRGLILLVNPHTQELEQKAIKFRSGIPTGLRFYSTTITNFVYGSGE
GILTDDAARDRRFHESRSIVQQAIHAAMCVPLKPRDEVIGVLYTDNLSVRAIYSEEDLEFLGGLANQAAIAIDNAHLYKK
IQTEAVLRTKLERFFPQNVWRKLSEESQLEVIDTKVTVVFADISRFTELSSRLEPRQVITMLNEYFSVMVEGIVFRYEGT
LEQYIGDALLAVWGAPYQHPNDAERAVKAAIAMQKAVSKLNQRWAKRWNFNIQIHIGVNTGVVAAGNIGSEQLFQYGTIG
NTTNVSSRICDVARAGEILISQSTLNELHQCDVPLQQLTPVQVKGIQDPIQLYRLLWDQKNPPAQGQAVMAREP
>Mature_553_residues
PYLVAPPNAPNPKSYTLVTGSNSIGRGLDNHIVLMHPSLSRHHAELMVQENGQAVLKDLDSLNHTYVNDQPIQQCHLKDG
DRVRFGTIDMQITWNLTATIPDLSPPSPPPDQSLSIISRFAPENTRIELQDLLEPEAPGESGVGLKLKQQDDQTRSVDKL
KILLEVSQQLSSPKELEELLDKILDLLFEIMTVDRGLILLVNPHTQELEQKAIKFRSGIPTGLRFYSTTITNFVYGSGEG
ILTDDAARDRRFHESRSIVQQAIHAAMCVPLKPRDEVIGVLYTDNLSVRAIYSEEDLEFLGGLANQAAIAIDNAHLYKKI
QTEAVLRTKLERFFPQNVWRKLSEESQLEVIDTKVTVVFADISRFTELSSRLEPRQVITMLNEYFSVMVEGIVFRYEGTL
EQYIGDALLAVWGAPYQHPNDAERAVKAAIAMQKAVSKLNQRWAKRWNFNIQIHIGVNTGVVAAGNIGSEQLFQYGTIGN
TTNVSSRICDVARAGEILISQSTLNELHQCDVPLQQLTPVQVKGIQDPIQLYRLLWDQKNPPAQGQAVMAREP

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Homo sapiens, GI4580422, Length=234, Percent_Identity=31.6239316239316, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI167830411, Length=228, Percent_Identity=30.2631578947368, Blast_Score=76, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71989805, Length=179, Percent_Identity=31.8435754189944, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71989822, Length=179, Percent_Identity=31.8435754189944, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17508769, Length=142, Percent_Identity=33.0985915492958, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17568383, Length=171, Percent_Identity=32.1637426900585, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17561804, Length=216, Percent_Identity=27.7777777777778, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71995305, Length=180, Percent_Identity=28.8888888888889, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17561800, Length=227, Percent_Identity=27.3127753303965, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17561802, Length=175, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI212645052, Length=173, Percent_Identity=28.3236994219653, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193206632, Length=194, Percent_Identity=29.3814432989691, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17534659, Length=174, Percent_Identity=31.0344827586207, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71983004, Length=187, Percent_Identity=24.5989304812834, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI62484477, Length=155, Percent_Identity=34.1935483870968, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI116008008, Length=155, Percent_Identity=34.1935483870968, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI62484298, Length=155, Percent_Identity=34.1935483870968, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI221330470, Length=197, Percent_Identity=31.9796954314721, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI221330468, Length=197, Percent_Identity=31.9796954314721, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI281366459, Length=201, Percent_Identity=30.8457711442786, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI281366457, Length=201, Percent_Identity=30.8457711442786, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI281366455, Length=201, Percent_Identity=30.8457711442786, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI56292422, Length=201, Percent_Identity=30.8457711442786, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI56292424, Length=201, Percent_Identity=30.8457711442786, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24666940, Length=201, Percent_Identity=30.8457711442786, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI161076872, Length=187, Percent_Identity=30.4812834224599, Blast_Score=76, Evalue=8e-14,
Organism=Drosophila melanogaster, GI28574512, Length=187, Percent_Identity=30.4812834224599, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI161078020, Length=179, Percent_Identity=27.9329608938547, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585694, Length=150, Percent_Identity=28, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24647268, Length=200, Percent_Identity=28.5, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI85725044, Length=181, Percent_Identity=28.7292817679558, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI116008022, Length=197, Percent_Identity=28.4263959390863, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI116008024, Length=197, Percent_Identity=28.4263959390863, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR011006
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00211 Guanylate_cyc; PF00072 Response_reg [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 62052; Mature: 61920

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS50006 FHA_DOMAIN ; PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYLVAPPNAPNPKSYTLVTGSNSIGRGLDNHIVLMHPSLSRHHAELMVQENGQAVLKDL
CCEEECCCCCCCCCEEEEEECCCHHCCCCCCCEEEECCCCCCCHHHEEEECCCHHHHHHH
DSLNHTYVNDQPIQQCHLKDGDRVRFGTIDMQITWNLTATIPDLSPPSPPPDQSLSIISR
HHCCCCCCCCCCHHHHCCCCCCEEEEEEEEEEEEEEEEEECCCCCCCCCCCCHHHHHHHH
FAPENTRIELQDLLEPEAPGESGVGLKLKQQDDQTRSVDKLKILLEVSQQLSSPKELEEL
HCCCCCCEEHHHHCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
LDKILDLLFEIMTVDRGLILLVNPHTQELEQKAIKFRSGIPTGLRFYSTTITNFVYGSGE
HHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEEECCC
GILTDDAARDRRFHESRSIVQQAIHAAMCVPLKPRDEVIGVLYTDNLSVRAIYSEEDLEF
EEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCEEEEEEECCHHHHH
LGGLANQAAIAIDNAHLYKKIQTEAVLRTKLERFFPQNVWRKLSEESQLEVIDTKVTVVF
HCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCEEEEEEEEEEEE
ADISRFTELSSRLEPRQVITMLNEYFSVMVEGIVFRYEGTLEQYIGDALLAVWGAPYQHP
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHCCCCCCC
NDAERAVKAAIAMQKAVSKLNQRWAKRWNFNIQIHIGVNTGVVAAGNIGSEQLFQYGTIG
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEECCCCHHHHHHHCCCC
NTTNVSSRICDVARAGEILISQSTLNELHQCDVPLQQLTPVQVKGIQDPIQLYRLLWDQK
CCCCHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCHHHCCCCEECCCCCHHHHHHHHHCCC
NPPAQGQAVMAREP
CCCCCCCEEECCCC
>Mature Secondary Structure 
PYLVAPPNAPNPKSYTLVTGSNSIGRGLDNHIVLMHPSLSRHHAELMVQENGQAVLKDL
CEEECCCCCCCCCEEEEEECCCHHCCCCCCCEEEECCCCCCCHHHEEEECCCHHHHHHH
DSLNHTYVNDQPIQQCHLKDGDRVRFGTIDMQITWNLTATIPDLSPPSPPPDQSLSIISR
HHCCCCCCCCCCHHHHCCCCCCEEEEEEEEEEEEEEEEEECCCCCCCCCCCCHHHHHHHH
FAPENTRIELQDLLEPEAPGESGVGLKLKQQDDQTRSVDKLKILLEVSQQLSSPKELEEL
HCCCCCCEEHHHHCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
LDKILDLLFEIMTVDRGLILLVNPHTQELEQKAIKFRSGIPTGLRFYSTTITNFVYGSGE
HHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEEECCC
GILTDDAARDRRFHESRSIVQQAIHAAMCVPLKPRDEVIGVLYTDNLSVRAIYSEEDLEF
EEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCEEEEEEECCHHHHH
LGGLANQAAIAIDNAHLYKKIQTEAVLRTKLERFFPQNVWRKLSEESQLEVIDTKVTVVF
HCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCEEEEEEEEEEEE
ADISRFTELSSRLEPRQVITMLNEYFSVMVEGIVFRYEGTLEQYIGDALLAVWGAPYQHP
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHCCCCCCC
NDAERAVKAAIAMQKAVSKLNQRWAKRWNFNIQIHIGVNTGVVAAGNIGSEQLFQYGTIG
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEECCCCHHHHHHHCCCC
NTTNVSSRICDVARAGEILISQSTLNELHQCDVPLQQLTPVQVKGIQDPIQLYRLLWDQK
CCCCHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCHHHCCCCEECCCCCHHHHHHHHHCCC
NPPAQGQAVMAREP
CCCCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]