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The map label for this gene is mpg1 [H]

Identifier: 158336307

GI number: 158336307

Start: 3198105

End: 3199235

Strand: Direct

Name: mpg1 [H]

Synonym: AM1_3169

Alternate gene names: 158336307

Gene position: 3198105-3199235 (Clockwise)

Preceding gene: 158336306

Following gene: 158336309

Centisome position: 49.17

GC content: 47.13

Gene sequence:

>1131_bases
ATGAAAGCGATGATTTTGGCGGCGGGTAAAGGTACCCGCGTTCGCCCAATAACATTCACTATCCCTAAGCCCATGATTCC
GATCATGCAAAAGCCTGTGATGGAATTCTTAGTGGAGCTACTTCGTCAGCATGGCTTTGATGAAATTATGGTGAATGTCA
GTCATTTAGCCGACGAGATCGAGAACTACTTTAGAGATGGGCAGCGGTTTGGCGTTGATATTGCTTATTCTTTTGAAGGT
CGAATTGAAGATGGCAATTTAATTGGGGATGCCGTTGGTTCTGCGGGTGGTATGCGTCGCATTCAAGATTTTTCGCCCTT
CTTTGACGATACGTTTATTGTTTTGTGTGGAGACGCTCTGATTGACCTCGACCTGACGGCAGCCGTGGAATGGCATCGGC
AAAAAGGCTCGATTGCCACTATCGTTATGAAGACTGTGGATCCCAACGATGTCTCTAGCTATGGTGTTGTCGTTACGGAT
GAGGAAGGGCAAGTCAAGTCTTTTCAGGAAAAACCCAGTGTAGATGAAGCCCTTAGCAACACGATTAATACGGGTATCTA
TATCTTTGAACCTGAAGTTCTCGACCTGATTCCTTCGGGCCAAGAGTTTGATATTGGGGGTGACCTCTTTCCCAAGCTGG
TGTCGATGAATATGCCTTTTTATGGCATTGCGATGGATTTCCAATGGGTAGACATCGGTAAAGTGCCGGATTATTGGCAT
GCCATTCGCAGTGTGTTGATGGGTGATGTCAAAAATGTGGCGATTCCAGGTCATGAAGTGAAGCCCGGCGTCTATACGGG
GCTAAACGTTGATATTGACTGGGATAAGGTTGATATTCAAGGCCCTGTTTATATTGGCGGCATGACGCGCATTGATGAAG
GGGTTAAGGTTATCGGCCCCACTATGATTGGTCCCAACTGCCATATTTGTACGGGGGCAACGGTGGATAACAGCGTTATT
TTTGAATATTCACGCTTAGGGTCAGAAGTGCGCCTTGTCGATAAGCTGGTGTTTGGACGCTATTGTGTAGATAAAACCGG
CGCTTCGTTGGATGTTCGAGCTGCATCTTTGGATTGGCTGATTACCGATGCCCGTCAAGATGCTCAGGTTCCGTCACCGA
TGGTAGGCTAA

Upstream 100 bases:

>100_bases
TGCCTAGACAGGTAGAGTGATATACAACTACATGAACTCTGAGAGTCAGAATATAAGTATTACGGTTGGTTGCTAATTCT
TTATAAGCAAGAAATTTGAT

Downstream 100 bases:

>100_bases
ATTGGCAGCGACAATGCTGATGGGATTGCCCCTATGCTTGGAACGTAGGTATGAGGGTAGTAGAGTCATTGTCCTCAAAA
AATTAATGATGTTGGTTTGA

Product: nucleotidyl transferase

Products: NA

Alternate protein names: ATP-mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; NDP-hexose pyrophosphorylase [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MKAMILAAGKGTRVRPITFTIPKPMIPIMQKPVMEFLVELLRQHGFDEIMVNVSHLADEIENYFRDGQRFGVDIAYSFEG
RIEDGNLIGDAVGSAGGMRRIQDFSPFFDDTFIVLCGDALIDLDLTAAVEWHRQKGSIATIVMKTVDPNDVSSYGVVVTD
EEGQVKSFQEKPSVDEALSNTINTGIYIFEPEVLDLIPSGQEFDIGGDLFPKLVSMNMPFYGIAMDFQWVDIGKVPDYWH
AIRSVLMGDVKNVAIPGHEVKPGVYTGLNVDIDWDKVDIQGPVYIGGMTRIDEGVKVIGPTMIGPNCHICTGATVDNSVI
FEYSRLGSEVRLVDKLVFGRYCVDKTGASLDVRAASLDWLITDARQDAQVPSPMVG

Sequences:

>Translated_376_residues
MKAMILAAGKGTRVRPITFTIPKPMIPIMQKPVMEFLVELLRQHGFDEIMVNVSHLADEIENYFRDGQRFGVDIAYSFEG
RIEDGNLIGDAVGSAGGMRRIQDFSPFFDDTFIVLCGDALIDLDLTAAVEWHRQKGSIATIVMKTVDPNDVSSYGVVVTD
EEGQVKSFQEKPSVDEALSNTINTGIYIFEPEVLDLIPSGQEFDIGGDLFPKLVSMNMPFYGIAMDFQWVDIGKVPDYWH
AIRSVLMGDVKNVAIPGHEVKPGVYTGLNVDIDWDKVDIQGPVYIGGMTRIDEGVKVIGPTMIGPNCHICTGATVDNSVI
FEYSRLGSEVRLVDKLVFGRYCVDKTGASLDVRAASLDWLITDARQDAQVPSPMVG
>Mature_376_residues
MKAMILAAGKGTRVRPITFTIPKPMIPIMQKPVMEFLVELLRQHGFDEIMVNVSHLADEIENYFRDGQRFGVDIAYSFEG
RIEDGNLIGDAVGSAGGMRRIQDFSPFFDDTFIVLCGDALIDLDLTAAVEWHRQKGSIATIVMKTVDPNDVSSYGVVVTD
EEGQVKSFQEKPSVDEALSNTINTGIYIFEPEVLDLIPSGQEFDIGGDLFPKLVSMNMPFYGIAMDFQWVDIGKVPDYWH
AIRSVLMGDVKNVAIPGHEVKPGVYTGLNVDIDWDKVDIQGPVYIGGMTRIDEGVKVIGPTMIGPNCHICTGATVDNSVI
FEYSRLGSEVRLVDKLVFGRYCVDKTGASLDVRAASLDWLITDARQDAQVPSPMVG

Specific function: Catalyzes The Formation Of Dtdp-Glucose, From Dttp And Glucose 1-Phosphate, As Well As Its Pyrophosphorolysis. [C]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=344, Percent_Identity=28.4883720930233, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI11761619, Length=240, Percent_Identity=33.75, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI31881779, Length=356, Percent_Identity=25.8426966292135, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI45447090, Length=356, Percent_Identity=25.8426966292135, Blast_Score=87, Evalue=4e-17,
Organism=Escherichia coli, GI1788351, Length=199, Percent_Identity=28.643216080402, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789837, Length=268, Percent_Identity=23.5074626865672, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI133931050, Length=350, Percent_Identity=30.8571428571429, Blast_Score=134, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6320148, Length=350, Percent_Identity=28, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI21355443, Length=323, Percent_Identity=30.9597523219814, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24644084, Length=323, Percent_Identity=30.9597523219814, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24653912, Length=220, Percent_Identity=27.7272727272727, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 41422; Mature: 41422

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAMILAAGKGTRVRPITFTIPKPMIPIMQKPVMEFLVELLRQHGFDEIMVNVSHLADEI
CCEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHEEHHHHHHHHHH
ENYFRDGQRFGVDIAYSFEGRIEDGNLIGDAVGSAGGMRRIQDFSPFFDDTFIVLCGDAL
HHHHHCCHHCCEEEEEEECCEECCCCEEHHHHCCCCCHHHHHHCCCCCCCEEEEEECCEE
IDLDLTAAVEWHRQKGSIATIVMKTVDPNDVSSYGVVVTDEEGQVKSFQEKPSVDEALSN
EEEEEHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEEECCCCCHHHHHCCCCHHHHHHH
TINTGIYIFEPEVLDLIPSGQEFDIGGDLFPKLVSMNMPFYGIAMDFQWVDIGKVPDYWH
HHHCCEEEECCHHHHHCCCCCCCCCCCHHHHHHHHCCCCEEEEEEEEEEEECCCCCHHHH
AIRSVLMGDVKNVAIPGHEVKPGVYTGLNVDIDWDKVDIQGPVYIGGMTRIDEGVKVIGP
HHHHHHHCCCCCEECCCCCCCCCEEECEEEEECCCEEEECCCEEECCHHHHCCCCEEECC
TMIGPNCHICTGATVDNSVIFEYSRLGSEVRLVDKLVFGRYCVDKTGASLDVRAASLDWL
EEECCCCEEEECCCCCCCEEEEHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEE
ITDARQDAQVPSPMVG
EECCCCCCCCCCCCCC
>Mature Secondary Structure
MKAMILAAGKGTRVRPITFTIPKPMIPIMQKPVMEFLVELLRQHGFDEIMVNVSHLADEI
CCEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHEEHHHHHHHHHH
ENYFRDGQRFGVDIAYSFEGRIEDGNLIGDAVGSAGGMRRIQDFSPFFDDTFIVLCGDAL
HHHHHCCHHCCEEEEEEECCEECCCCEEHHHHCCCCCHHHHHHCCCCCCCEEEEEECCEE
IDLDLTAAVEWHRQKGSIATIVMKTVDPNDVSSYGVVVTDEEGQVKSFQEKPSVDEALSN
EEEEEHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEEECCCCCHHHHHCCCCHHHHHHH
TINTGIYIFEPEVLDLIPSGQEFDIGGDLFPKLVSMNMPFYGIAMDFQWVDIGKVPDYWH
HHHCCEEEECCHHHHHCCCCCCCCCCCHHHHHHHHCCCCEEEEEEEEEEEECCCCCHHHH
AIRSVLMGDVKNVAIPGHEVKPGVYTGLNVDIDWDKVDIQGPVYIGGMTRIDEGVKVIGP
HHHHHHHCCCCCEECCCCCCCCCEEECEEEEECCCEEEECCCEEECCHHHHCCCCEEECC
TMIGPNCHICTGATVDNSVIFEYSRLGSEVRLVDKLVFGRYCVDKTGASLDVRAASLDWL
EEECCCCEEEECCCCCCCEEEEHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEE
ITDARQDAQVPSPMVG
EECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8334170 [H]