Click here to switch to the map view.

The map label for this gene is fabG [H]

Identifier: 158336244

GI number: 158336244

Start: 3135919

End: 3136614

Strand: Reverse

Name: fabG [H]

Synonym: AM1_3106

Alternate gene names: 158336244

Gene position: 3136614-3135919 (Counterclockwise)

Preceding gene: 158336246

Following gene: 158336242

Centisome position: 48.23

GC content: 49.86

Gene sequence:

>696_bases
ATGCGAAATAGTCAAGTATTAATCACGGGTGGTACAGGCGGACTAGGACTAGGTGTGACACCAAAAGTCCTAGCCACCGG
GGCAGAAGTAACGCTGCCTTACATCGTTGAATCCGAAGTTGAGCGACTAAAGCATATCCTCTCTCCCGCAGAATTAGTCA
GAACCCATTTTGTCCCCACCGATCTGGGCAAAGAAGCCTCAGTCGCAGAACTCGTGGAAGGCATGGATCGAGTGGATGCT
TTGATTCATCTAGTCGGTGGGTTTTCCATGGGCAAAACCCATGAATATGCTTTTGAAGACTGGCAGCGAGATTTGAACCT
GAACCTAAACACTACCTTTTTGGTTTGCAAACATAGCCTTAAGCGGATGTTGCAGCATCACTATGGCCGGATTGTCACGG
TCGGATCTAGAGGAGCGGTTGATCCAGGAGGGCAGTTGGCCGCTTACTGTGCTGCCAAGGCAGGAGTGGTGGCATTAACG
AAAGCGATCGCAGATGAAACCAAAGGCACCAACATCACTGCTAATACCGTGTTGCCTAGCATTATTGATACCCCTACGAA
TCGAGAAGCCATGGGTGAAAACAACGCCGACCAATGGGTTAAACCCGAATCTTTAGCAGACGTGATCTGCTTTCTCGCCT
CCGATGCCGCCCAGGATGTTAGAGGTGCCGCTATTCCTGTATACGGGAATGCTTAA

Upstream 100 bases:

>100_bases
GATCAGAACTATCCTTTAGCTTGTGAAGCTTGTAACTTTGATATCAAATACTTTTTAACAAGATTGCTCATCCATCTCAA
AAGATAGAGGCTGCAACGAT

Downstream 100 bases:

>100_bases
TCTGTTTACCAGCCATCAAAAACGTTTTCACACCTATAAATTCTCTTTTCACACCTATTAAAGGTGAAGCGTATTGCTAA
TCGCACTATTGATATCTCGC

Product: 3-ketoacyl-(acyl-carrier-protein) reductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MRNSQVLITGGTGGLGLGVTPKVLATGAEVTLPYIVESEVERLKHILSPAELVRTHFVPTDLGKEASVAELVEGMDRVDA
LIHLVGGFSMGKTHEYAFEDWQRDLNLNLNTTFLVCKHSLKRMLQHHYGRIVTVGSRGAVDPGGQLAAYCAAKAGVVALT
KAIADETKGTNITANTVLPSIIDTPTNREAMGENNADQWVKPESLADVICFLASDAAQDVRGAAIPVYGNA

Sequences:

>Translated_231_residues
MRNSQVLITGGTGGLGLGVTPKVLATGAEVTLPYIVESEVERLKHILSPAELVRTHFVPTDLGKEASVAELVEGMDRVDA
LIHLVGGFSMGKTHEYAFEDWQRDLNLNLNTTFLVCKHSLKRMLQHHYGRIVTVGSRGAVDPGGQLAAYCAAKAGVVALT
KAIADETKGTNITANTVLPSIIDTPTNREAMGENNADQWVKPESLADVICFLASDAAQDVRGAAIPVYGNA
>Mature_231_residues
MRNSQVLITGGTGGLGLGVTPKVLATGAEVTLPYIVESEVERLKHILSPAELVRTHFVPTDLGKEASVAELVEGMDRVDA
LIHLVGGFSMGKTHEYAFEDWQRDLNLNLNTTFLVCKHSLKRMLQHHYGRIVTVGSRGAVDPGGQLAAYCAAKAGVVALT
KAIADETKGTNITANTVLPSIIDTPTNREAMGENNADQWVKPESLADVICFLASDAAQDVRGAAIPVYGNA

Specific function: Part of the bacABCDE operon responsible for the biosynthesis of bacilysin [H]

COG id: NA

COG function: NA

Gene ontology:
GO:0004316: 3-oxoacyl-(Acyl-carrier-protein) reductase
GO:0005488: 3-oxoacyl-(Acyl-carrier-protein) reductase
GO:0006633: 3-oxoacyl-(Acyl-carrier-protein) reductase
GO:0008152: 3-oxoacyl-(Acyl-carrier-protein) reductase
GO:0016491: 3-oxoacyl-(Acyl-carrier-protein) reductase
GO:0051287: 3-oxoacyl-(Acyl-carrier-protein) reductase
GO:0055114: 3-oxoacyl-(Acyl-carrier-protein) reductase

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI19923817, Length=250, Percent_Identity=28, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI66933014, Length=218, Percent_Identity=25.2293577981651, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI32483357, Length=245, Percent_Identity=25.7142857142857, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI1787335, Length=233, Percent_Identity=28.755364806867, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1786812, Length=182, Percent_Identity=27.4725274725275, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1789208, Length=241, Percent_Identity=26.5560165975104, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI87082160, Length=243, Percent_Identity=25.1028806584362, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788459, Length=196, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI87082100, Length=239, Percent_Identity=26.7782426778243, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=238, Percent_Identity=23.9495798319328, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17538182, Length=195, Percent_Identity=27.1794871794872, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17555706, Length=235, Percent_Identity=28.0851063829787, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17737361, Length=203, Percent_Identity=29.5566502463054, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24639444, Length=141, Percent_Identity=35.4609929078014, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 24605; Mature: 24605

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNSQVLITGGTGGLGLGVTPKVLATGAEVTLPYIVESEVERLKHILSPAELVRTHFVPT
CCCCCEEEECCCCCCCCCCCHHHHHCCCCEEEHHHHHHHHHHHHHHHCHHHHHHHHCCCC
DLGKEASVAELVEGMDRVDALIHLVGGFSMGKTHEYAFEDWQRDLNLNLNTTFLVCKHSL
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHH
KRMLQHHYGRIVTVGSRGAVDPGGQLAAYCAAKAGVVALTKAIADETKGTNITANTVLPS
HHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCEEHHHHHHH
IIDTPTNREAMGENNADQWVKPESLADVICFLASDAAQDVRGAAIPVYGNA
HHCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCC
>Mature Secondary Structure
MRNSQVLITGGTGGLGLGVTPKVLATGAEVTLPYIVESEVERLKHILSPAELVRTHFVPT
CCCCCEEEECCCCCCCCCCCHHHHHCCCCEEEHHHHHHHHHHHHHHHCHHHHHHHHCCCC
DLGKEASVAELVEGMDRVDALIHLVGGFSMGKTHEYAFEDWQRDLNLNLNTTFLVCKHSL
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHH
KRMLQHHYGRIVTVGSRGAVDPGGQLAAYCAAKAGVVALTKAIADETKGTNITANTVLPS
HHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCEEHHHHHHH
IIDTPTNREAMGENNADQWVKPESLADVICFLASDAAQDVRGAAIPVYGNA
HHCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA