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The map label for this gene is mprA [H]

Identifier: 158336238

GI number: 158336238

Start: 3130951

End: 3131613

Strand: Direct

Name: mprA [H]

Synonym: AM1_3101

Alternate gene names: 158336238

Gene position: 3130951-3131613 (Clockwise)

Preceding gene: 158336235

Following gene: 158336243

Centisome position: 48.14

GC content: 48.11

Gene sequence:

>663_bases
ATGCCTTTAACCGTGTTGATCGTGGATGATGAACCGGGCATTCGGTTAGCGGTCACCGACTATCTGGAAGCAGTGGGATA
TACAGTGATTTCAGCCGCAACGGGCAAACAAGCGTGGCAGCTGGTCCAACAGTATCGTCCTCATCTGCTCGTGACTGATA
TTAGAATGCCACAGATGGATGGCTATGAGTTAGTGAAGCTGGTGAGACAACAACCGGCTTTTCGATTGCTTCCCGTCATC
TATTTAACGGAATGCTCCCAAACCCAAGAGCGAATTCGAGGGTACAAATTAGGGTGTGATGCCTATTTGGCTAAGCCGTT
TAACTTAGAAGAATTGGCAGCCGTCATCCGTAACCTATTAGACCGAGTGCAAATTGTGCAAACGGAAATTCAGGCGGTTT
CTCAAGCGACTCCTAGCCGTGAACCGGTGGATACTGCATTAATCAACGCACTCGATCTGACCCAGCGAGAACAGCAAGTG
TTGCGATTGCTGATGGAAGGGCTATCCAATGCCCAAATTGGTGAACAACTCCATCTCAGCTCCCGGACGGTGGAAAAGTA
TGTGAGTAAGCTCTTGCAAAAAACAGAAACCAGCAATCGAGCCGAAATCGTCAGGTTTGCCATGGAACATAATTTATTAG
GGGCGATAGAGAACGATCCCTAA

Upstream 100 bases:

>100_bases
TCTGAATTGCTTGCAATTGATGAAGGGGAACTGAATGATGTCAAGGGATTGTTATAACTAAACAAAGGAGACGATACCTG
CAAAGCGCACGCGACATTTT

Downstream 100 bases:

>100_bases
GATTTGTGCAAATGATCCAATAAGCCACTGCAAGCATCCAGCAGAAGATCAATCACATAATCAAACCCTGAAGGCCCTCC
ATAATAAGGATCGGGCACCT

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MPLTVLIVDDEPGIRLAVTDYLEAVGYTVISAATGKQAWQLVQQYRPHLLVTDIRMPQMDGYELVKLVRQQPAFRLLPVI
YLTECSQTQERIRGYKLGCDAYLAKPFNLEELAAVIRNLLDRVQIVQTEIQAVSQATPSREPVDTALINALDLTQREQQV
LRLLMEGLSNAQIGEQLHLSSRTVEKYVSKLLQKTETSNRAEIVRFAMEHNLLGAIENDP

Sequences:

>Translated_220_residues
MPLTVLIVDDEPGIRLAVTDYLEAVGYTVISAATGKQAWQLVQQYRPHLLVTDIRMPQMDGYELVKLVRQQPAFRLLPVI
YLTECSQTQERIRGYKLGCDAYLAKPFNLEELAAVIRNLLDRVQIVQTEIQAVSQATPSREPVDTALINALDLTQREQQV
LRLLMEGLSNAQIGEQLHLSSRTVEKYVSKLLQKTETSNRAEIVRFAMEHNLLGAIENDP
>Mature_219_residues
PLTVLIVDDEPGIRLAVTDYLEAVGYTVISAATGKQAWQLVQQYRPHLLVTDIRMPQMDGYELVKLVRQQPAFRLLPVIY
LTECSQTQERIRGYKLGCDAYLAKPFNLEELAAVIRNLLDRVQIVQTEIQAVSQATPSREPVDTALINALDLTQREQQVL
RLLMEGLSNAQIGEQLHLSSRTVEKYVSKLLQKTETSNRAEIVRFAMEHNLLGAIENDP

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=216, Percent_Identity=25.462962962963, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788394, Length=208, Percent_Identity=28.8461538461538, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1786784, Length=129, Percent_Identity=33.3333333333333, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790863, Length=154, Percent_Identity=31.8181818181818, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1790299, Length=204, Percent_Identity=25.9803921568627, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1788550, Length=132, Percent_Identity=31.0606060606061, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1788713, Length=117, Percent_Identity=38.4615384615385, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1789809, Length=118, Percent_Identity=35.5932203389831, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1790860, Length=126, Percent_Identity=34.1269841269841, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI2367329, Length=210, Percent_Identity=31.9047619047619, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1787229, Length=127, Percent_Identity=31.496062992126, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1786911, Length=119, Percent_Identity=36.1344537815126, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1788222, Length=218, Percent_Identity=25.2293577981651, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI87082012, Length=169, Percent_Identity=28.4023668639053, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI145693157, Length=122, Percent_Identity=31.1475409836066, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790552, Length=120, Percent_Identity=35, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1786747, Length=216, Percent_Identity=23.6111111111111, Blast_Score=64, Evalue=5e-12,
Organism=Escherichia coli, GI1789402, Length=202, Percent_Identity=27.2277227722772, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788521, Length=201, Percent_Identity=29.3532338308458, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790437, Length=189, Percent_Identity=26.984126984127, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1788905, Length=122, Percent_Identity=28.6885245901639, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24870; Mature: 24739

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLTVLIVDDEPGIRLAVTDYLEAVGYTVISAATGKQAWQLVQQYRPHLLVTDIRMPQMD
CCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEECCCCCCC
GYELVKLVRQQPAFRLLPVIYLTECSQTQERIRGYKLGCDAYLAKPFNLEELAAVIRNLL
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHH
DRVQIVQTEIQAVSQATPSREPVDTALINALDLTQREQQVLRLLMEGLSNAQIGEQLHLS
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
SRTVEKYVSKLLQKTETSNRAEIVRFAMEHNLLGAIENDP
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PLTVLIVDDEPGIRLAVTDYLEAVGYTVISAATGKQAWQLVQQYRPHLLVTDIRMPQMD
CEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEECCCCCCC
GYELVKLVRQQPAFRLLPVIYLTECSQTQERIRGYKLGCDAYLAKPFNLEELAAVIRNLL
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHH
DRVQIVQTEIQAVSQATPSREPVDTALINALDLTQREQQVLRLLMEGLSNAQIGEQLHLS
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
SRTVEKYVSKLLQKTETSNRAEIVRFAMEHNLLGAIENDP
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA