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The map label for this gene is zitB [H]

Identifier: 158336213

GI number: 158336213

Start: 3099219

End: 3100199

Strand: Reverse

Name: zitB [H]

Synonym: AM1_3075

Alternate gene names: 158336213

Gene position: 3100199-3099219 (Counterclockwise)

Preceding gene: 158336215

Following gene: 158336207

Centisome position: 47.67

GC content: 50.15

Gene sequence:

>981_bases
ATGCATATTCAAACCCTTGATCAGTGGCAACATTCTCACGACTTCTCGGTTAATCAGAATCAAGCGGAGAAAAATACCAA
GATCGTGATGCTGATCACCGCAGCCACGATGATTGCTGAGGTTGCAGCAGGTACTATTTTGGGTTCGATGGCCCTGTTGG
CGGATGGCTGGCATATGGCCACTCATGTAGCAGCGTTTGGTATCACAGTGTTTGCGTATCGCTATGCTCGCCAACATGCT
ACTGATGCTAGATATACCTTCGGTACGGGCAAAGTCAGTGTACTGGGTGGGTTTGCTAGTGCTGTTGCGCTTGCGGTCGT
CGCGTTTGTCATGGCATTTGAATCCGTCGGTCGATTTTTCCAGCCCCAGACGATTCAGTTTAACGAAGCGATTGGCGTGG
CCATTCTTGGATTAGTGGTTAATTTAGTGAGTGCCTGGTTACTCCATGATGATCACGGCCATAGCCACGATCATCATGGC
AGTCATGGTCACCACCATCATGCGGATCACAATCTGCGGGCTGCCTATGTCCACGTTTTAGCGGATGCCCTCACCTCTGT
TTTGGCCATCATTGCTTTATTTGCTGGGAAGTTTCTAGGTTGGATCTGGCTGGATGCCGCCATGGGAATCGTGGGGGCCG
GAGTTATCACTAAATGGGCCTCCGACTTGGTGAGTGAAACGGGTTCAATCTTGCTGGATGGCGGCATTGATAAGCACATC
AAGCAGGATATTTTAAACGCCATTGAAGACGATGCGGATAATCGTGTGGTCGATCTGCATGTTTGGCGTGTCAGCCAAAA
GCATCTGTCTGCAACGGTTTCGCTAGTCACCCACTATCCGCAAGCGCCAGAGTATTACAAGAGCCTCCTCAGTCAGATTC
CATCTCTCTCGCATGTGCTTATTGAGGTCAATCCCTGTCATGGTGAGCCTTGTTTGGATATCGACCACAGTCTAAACCCA
GCATCGGCGACACTAGGGTGA

Upstream 100 bases:

>100_bases
ACTCTCTCCTCTCACCCCATCTCGTAGGGGCATCCAGTGGGGTTGTAAAATTCAGGAATACTGATTGGTAAAGTCTTCAA
CTCAAGGATTTAGAGATTCA

Downstream 100 bases:

>100_bases
TAATGGGTAGCTGAAAATCAAATGAAATGAACATGACCTCGGTAGAATCGGCTGCGGGGTGGATAGCGCTGGTACGAGAA
TCACTTTTGATAAGAGTCAT

Product: Co/Zn/Cd efflux system component protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MHIQTLDQWQHSHDFSVNQNQAEKNTKIVMLITAATMIAEVAAGTILGSMALLADGWHMATHVAAFGITVFAYRYARQHA
TDARYTFGTGKVSVLGGFASAVALAVVAFVMAFESVGRFFQPQTIQFNEAIGVAILGLVVNLVSAWLLHDDHGHSHDHHG
SHGHHHHADHNLRAAYVHVLADALTSVLAIIALFAGKFLGWIWLDAAMGIVGAGVITKWASDLVSETGSILLDGGIDKHI
KQDILNAIEDDADNRVVDLHVWRVSQKHLSATVSLVTHYPQAPEYYKSLLSQIPSLSHVLIEVNPCHGEPCLDIDHSLNP
ASATLG

Sequences:

>Translated_326_residues
MHIQTLDQWQHSHDFSVNQNQAEKNTKIVMLITAATMIAEVAAGTILGSMALLADGWHMATHVAAFGITVFAYRYARQHA
TDARYTFGTGKVSVLGGFASAVALAVVAFVMAFESVGRFFQPQTIQFNEAIGVAILGLVVNLVSAWLLHDDHGHSHDHHG
SHGHHHHADHNLRAAYVHVLADALTSVLAIIALFAGKFLGWIWLDAAMGIVGAGVITKWASDLVSETGSILLDGGIDKHI
KQDILNAIEDDADNRVVDLHVWRVSQKHLSATVSLVTHYPQAPEYYKSLLSQIPSLSHVLIEVNPCHGEPCLDIDHSLNP
ASATLG
>Mature_326_residues
MHIQTLDQWQHSHDFSVNQNQAEKNTKIVMLITAATMIAEVAAGTILGSMALLADGWHMATHVAAFGITVFAYRYARQHA
TDARYTFGTGKVSVLGGFASAVALAVVAFVMAFESVGRFFQPQTIQFNEAIGVAILGLVVNLVSAWLLHDDHGHSHDHHG
SHGHHHHADHNLRAAYVHVLADALTSVLAIIALFAGKFLGWIWLDAAMGIVGAGVITKWASDLVSETGSILLDGGIDKHI
KQDILNAIEDDADNRVVDLHVWRVSQKHLSATVSLVTHYPQAPEYYKSLLSQIPSLSHVLIEVNPCHGEPCLDIDHSLNP
ASATLG

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI20070323, Length=309, Percent_Identity=25.2427184466019, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI52352803, Length=131, Percent_Identity=30.5343511450382, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI21359890, Length=290, Percent_Identity=26.2068965517241, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI52352805, Length=311, Percent_Identity=22.1864951768489, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1786966, Length=295, Percent_Identity=32.2033898305085, Blast_Score=107, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI32564488, Length=236, Percent_Identity=28.8135593220339, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI193210990, Length=279, Percent_Identity=24.7311827956989, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17555794, Length=308, Percent_Identity=24.025974025974, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323899, Length=152, Percent_Identity=31.5789473684211, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324892, Length=133, Percent_Identity=30.0751879699248, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24656728, Length=292, Percent_Identity=26.3698630136986, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24656724, Length=292, Percent_Identity=26.3698630136986, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24656720, Length=292, Percent_Identity=26.3698630136986, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24656715, Length=292, Percent_Identity=26.3698630136986, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21357035, Length=292, Percent_Identity=26.3698630136986, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 35305; Mature: 35305

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIQTLDQWQHSHDFSVNQNQAEKNTKIVMLITAATMIAEVAAGTILGSMALLADGWHMA
CCCCCHHHHHCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
THVAAFGITVFAYRYARQHATDARYTFGTGKVSVLGGFASAVALAVVAFVMAFESVGRFF
HHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
QPQTIQFNEAIGVAILGLVVNLVSAWLLHDDHGHSHDHHGSHGHHHHADHNLRAAYVHVL
CCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
ADALTSVLAIIALFAGKFLGWIWLDAAMGIVGAGVITKWASDLVSETGSILLDGGIDKHI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHH
KQDILNAIEDDADNRVVDLHVWRVSQKHLSATVSLVTHYPQAPEYYKSLLSQIPSLSHVL
HHHHHHHHHCCCCCCEEEEEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEE
IEVNPCHGEPCLDIDHSLNPASATLG
EEEECCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MHIQTLDQWQHSHDFSVNQNQAEKNTKIVMLITAATMIAEVAAGTILGSMALLADGWHMA
CCCCCHHHHHCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
THVAAFGITVFAYRYARQHATDARYTFGTGKVSVLGGFASAVALAVVAFVMAFESVGRFF
HHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
QPQTIQFNEAIGVAILGLVVNLVSAWLLHDDHGHSHDHHGSHGHHHHADHNLRAAYVHVL
CCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
ADALTSVLAIIALFAGKFLGWIWLDAAMGIVGAGVITKWASDLVSETGSILLDGGIDKHI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHH
KQDILNAIEDDADNRVVDLHVWRVSQKHLSATVSLVTHYPQAPEYYKSLLSQIPSLSHVL
HHHHHHHHHCCCCCCEEEEEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEE
IEVNPCHGEPCLDIDHSLNPASATLG
EEEECCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]