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The map label for this gene is thrS [H]

Identifier: 158336193

GI number: 158336193

Start: 3076797

End: 3078647

Strand: Reverse

Name: thrS [H]

Synonym: AM1_3055

Alternate gene names: 158336193

Gene position: 3078647-3076797 (Counterclockwise)

Preceding gene: 158336199

Following gene: 158336192

Centisome position: 47.34

GC content: 52.57

Gene sequence:

>1851_bases
ATGTCTACTGCTTCTTCGACCCTGTCAGCGCCCAATTCCACTGAACAATTGCAGCGACTCCGCCACACCTGCGCCCATGT
GATGGCCATGGCGGTGCAGAATCTGTTTCCGGAGACGAAGGTGACGATTGGTCCAACGACAGAGACCGGTTTCTACTATG
ACTTTGACCGGGACCAGGCATTTACGCCAGAAGATTTAGATGCCATATCAACTCAGATGCGGCGGATTATCAAAGCCAAT
TTGCCCATCATCCGCGAACAAGTGGATCGCGATCAGATGCAGGCCGAACTGGAACAGTTGCAAGAACCCTACAAATTAGA
AATATTGGCCCAGATTCCGGCGGGGGAAACCATTACCCGCTATTTTATTGGCAGTCCTGACACGGGACGGACCCAACATC
CCGAGGCGGAAGCCTCACTCATTGAGCCTCTACCAGTGGCCCCCAATGAATTTTGGTGGGATCTGTGCTCGGGTCCCCAT
CTCAACAGTACGGGGGAACTGCACTCTAAGGCCTTTATGCTCGAAAGCGTCGCCGGAGCCTACTGGCGTGGCGATGAAAC
CCAAGCGCAGCTACAGCGGATTTATGGAACCGCCTGGGAAACACCGAAGCAGTTAAAAGCTTACCTGCACCAAAAAGAAG
AAGCCCAGCGTCGAGACCATCGCCTGTTGGGCAAAAATCTGAAGCTTTTTAGTATTGAAGACAACGCTGGCGGAGGACTG
GTCTTTTGGCATCCCCGAGGGGCTCGAATTCGCCAGGTCATTGAAACCTACTGGCGACAAGCGCATACACAGGGGGGATA
TGAGTTGCTCTATACCCCTCATATGGCCAACCTGGATCTGTGGAAGACCTCGGGTCATTTCGACTTCTACCGGGACAGCA
TGTTTGATCAAATGGAAGTGGAGACCCAGGCCTATCAGATCAAACCCATGAACTGTCCCTTTCATGTGCTCACCTATCAG
CACGACCTCCACTCCTATCGAGAGTTTCCCCTGCGGTGGGCGGAGTTAGGGACGGTCTATCGGTACGAACGCTCCGGGAC
CTTACATGGACTGATGCGGGTCCGGGGCTTTACCCAAGACGATGCCCATATTTTCTGTCTACCGGATCAGGTGGCCGATG
AGATTTTGGCGGTTCTGGATCTAACCGAAACGGTGTTGTCGGACTTTGGCTTTCGGGATTATGAGGTTAATCTCTCAACC
CGGCCTGATAAATCAGTGGGTAGCGATGAGATTTGGGACTTGGCCACCCAGGACTTGCGCACGGCCCTAGACCGTAAAGG
CTGGGAGTACCTGACGGATGAAGGCGGGGGTGCCTTTTATGGACCGAAGATCGATCTCAAGATACGGGATGCGATCGGAC
GGCTGTGGCAATGCTCCACAATTCAGGTGGACTTTAACTTACCCGAGCGCTTCAAGATGGAATATGTCGCTGCAGATGGA
ACGCGGCAACGTCCCATTATGATTCATCGGGCCATTTTCGGGTCTTTAGAACGATTCTTCGGCATTTTAATCGAGAATTA
TGCAGGGGATTTCCCCCTATGGCTAGCCCCCGTACAAATTCGGCTACTCGTTGTCAGTGATGCCCAACGCCCCTATGCCC
TTGAAGTCTTAGAGCAGCTTCAGCAGAAGGGTTTTCGGGCTGAAATCGATCAGACGGGAGAGCGTTTAGGAAAACAAATT
CGCCAGTCCGCCCTGGAAAAAATTCCGGTGGTCGCCGTGGTGGGTCAAAAAGAAGTCGAAGCCCAGACCCTCAATATTCG
AACTCGGCATTCAGAAGAGCAGGAGCTATTGAAGCTCCCCGAACTGTGCGAAAAAATGCAGTCTGCCATTGATGCCAAAC
AACACATTTAG

Upstream 100 bases:

>100_bases
CCAGTCGGCTTTAATCCAAAAGCAAACTGACATTATACAGATATAATGATAATCATTATCATATGCTTAAGCAACCCTTC
ACCCTTCCCTTCAAGCCTCT

Downstream 100 bases:

>100_bases
AGTAGGAAAAATGATGAACGTTGCCTATCAGCCCTGCAGCTCAGATCAGCCCCAGCAGAGAACATTTCTCAGAATCAAGA
ATGCGATCGGAATGCTGCTG

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 616; Mature: 615

Protein sequence:

>616_residues
MSTASSTLSAPNSTEQLQRLRHTCAHVMAMAVQNLFPETKVTIGPTTETGFYYDFDRDQAFTPEDLDAISTQMRRIIKAN
LPIIREQVDRDQMQAELEQLQEPYKLEILAQIPAGETITRYFIGSPDTGRTQHPEAEASLIEPLPVAPNEFWWDLCSGPH
LNSTGELHSKAFMLESVAGAYWRGDETQAQLQRIYGTAWETPKQLKAYLHQKEEAQRRDHRLLGKNLKLFSIEDNAGGGL
VFWHPRGARIRQVIETYWRQAHTQGGYELLYTPHMANLDLWKTSGHFDFYRDSMFDQMEVETQAYQIKPMNCPFHVLTYQ
HDLHSYREFPLRWAELGTVYRYERSGTLHGLMRVRGFTQDDAHIFCLPDQVADEILAVLDLTETVLSDFGFRDYEVNLST
RPDKSVGSDEIWDLATQDLRTALDRKGWEYLTDEGGGAFYGPKIDLKIRDAIGRLWQCSTIQVDFNLPERFKMEYVAADG
TRQRPIMIHRAIFGSLERFFGILIENYAGDFPLWLAPVQIRLLVVSDAQRPYALEVLEQLQQKGFRAEIDQTGERLGKQI
RQSALEKIPVVAVVGQKEVEAQTLNIRTRHSEEQELLKLPELCEKMQSAIDAKQHI

Sequences:

>Translated_616_residues
MSTASSTLSAPNSTEQLQRLRHTCAHVMAMAVQNLFPETKVTIGPTTETGFYYDFDRDQAFTPEDLDAISTQMRRIIKAN
LPIIREQVDRDQMQAELEQLQEPYKLEILAQIPAGETITRYFIGSPDTGRTQHPEAEASLIEPLPVAPNEFWWDLCSGPH
LNSTGELHSKAFMLESVAGAYWRGDETQAQLQRIYGTAWETPKQLKAYLHQKEEAQRRDHRLLGKNLKLFSIEDNAGGGL
VFWHPRGARIRQVIETYWRQAHTQGGYELLYTPHMANLDLWKTSGHFDFYRDSMFDQMEVETQAYQIKPMNCPFHVLTYQ
HDLHSYREFPLRWAELGTVYRYERSGTLHGLMRVRGFTQDDAHIFCLPDQVADEILAVLDLTETVLSDFGFRDYEVNLST
RPDKSVGSDEIWDLATQDLRTALDRKGWEYLTDEGGGAFYGPKIDLKIRDAIGRLWQCSTIQVDFNLPERFKMEYVAADG
TRQRPIMIHRAIFGSLERFFGILIENYAGDFPLWLAPVQIRLLVVSDAQRPYALEVLEQLQQKGFRAEIDQTGERLGKQI
RQSALEKIPVVAVVGQKEVEAQTLNIRTRHSEEQELLKLPELCEKMQSAIDAKQHI
>Mature_615_residues
STASSTLSAPNSTEQLQRLRHTCAHVMAMAVQNLFPETKVTIGPTTETGFYYDFDRDQAFTPEDLDAISTQMRRIIKANL
PIIREQVDRDQMQAELEQLQEPYKLEILAQIPAGETITRYFIGSPDTGRTQHPEAEASLIEPLPVAPNEFWWDLCSGPHL
NSTGELHSKAFMLESVAGAYWRGDETQAQLQRIYGTAWETPKQLKAYLHQKEEAQRRDHRLLGKNLKLFSIEDNAGGGLV
FWHPRGARIRQVIETYWRQAHTQGGYELLYTPHMANLDLWKTSGHFDFYRDSMFDQMEVETQAYQIKPMNCPFHVLTYQH
DLHSYREFPLRWAELGTVYRYERSGTLHGLMRVRGFTQDDAHIFCLPDQVADEILAVLDLTETVLSDFGFRDYEVNLSTR
PDKSVGSDEIWDLATQDLRTALDRKGWEYLTDEGGGAFYGPKIDLKIRDAIGRLWQCSTIQVDFNLPERFKMEYVAADGT
RQRPIMIHRAIFGSLERFFGILIENYAGDFPLWLAPVQIRLLVVSDAQRPYALEVLEQLQQKGFRAEIDQTGERLGKQIR
QSALEKIPVVAVVGQKEVEAQTLNIRTRHSEEQELLKLPELCEKMQSAIDAKQHI

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38202255, Length=589, Percent_Identity=38.7096774193548, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI38570111, Length=575, Percent_Identity=38.6086956521739, Blast_Score=398, Evalue=1e-111,
Organism=Homo sapiens, GI20070344, Length=604, Percent_Identity=34.9337748344371, Blast_Score=357, Evalue=2e-98,
Organism=Escherichia coli, GI1788013, Length=613, Percent_Identity=41.1092985318108, Blast_Score=499, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI71984184, Length=603, Percent_Identity=37.1475953565506, Blast_Score=404, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI71984192, Length=603, Percent_Identity=37.1475953565506, Blast_Score=404, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6322112, Length=612, Percent_Identity=36.2745098039216, Blast_Score=382, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6322654, Length=406, Percent_Identity=36.2068965517241, Blast_Score=260, Evalue=4e-70,
Organism=Drosophila melanogaster, GI24583842, Length=592, Percent_Identity=37.3310810810811, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI28574141, Length=592, Percent_Identity=37.3310810810811, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24583839, Length=592, Percent_Identity=37.3310810810811, Blast_Score=400, Evalue=1e-111,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 70830; Mature: 70699

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTASSTLSAPNSTEQLQRLRHTCAHVMAMAVQNLFPETKVTIGPTTETGFYYDFDRDQA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEECCCCCC
FTPEDLDAISTQMRRIIKANLPIIREQVDRDQMQAELEQLQEPYKLEILAQIPAGETITR
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEE
YFIGSPDTGRTQHPEAEASLIEPLPVAPNEFWWDLCSGPHLNSTGELHSKAFMLESVAGA
EEECCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCH
YWRGDETQAQLQRIYGTAWETPKQLKAYLHQKEEAQRRDHRLLGKNLKLFSIEDNAGGGL
HCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCE
VFWHPRGARIRQVIETYWRQAHTQGGYELLYTPHMANLDLWKTSGHFDFYRDSMFDQMEV
EEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCCCHHHHHHHHHHHH
ETQAYQIKPMNCPFHVLTYQHDLHSYREFPLRWAELGTVYRYERSGTLHGLMRVRGFTQD
HHHEEEEEECCCCEEEEEEHHHHHHHHHCCCHHHHHCCEEEEECCCHHHHHHHHCCCCCC
DAHIFCLPDQVADEILAVLDLTETVLSDFGFRDYEVNLSTRPDKSVGSDEIWDLATQDLR
CCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHH
TALDRKGWEYLTDEGGGAFYGPKIDLKIRDAIGRLWQCSTIQVDFNLPERFKMEYVAADG
HHHHHCCCEEEECCCCCEEECCEEEEEEHHHHHHHEECEEEEEECCCCHHHCEEEEECCC
TRQRPIMIHRAIFGSLERFFGILIENYAGDFPLWLAPVQIRLLVVSDAQRPYALEVLEQL
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECEEEEEEEEECCCCCHHHHHHHHH
QQKGFRAEIDQTGERLGKQIRQSALEKIPVVAVVGQKEVEAQTLNIRTRHSEEQELLKLP
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHCCEEEEEEECCCHHHHHHHHH
ELCEKMQSAIDAKQHI
HHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STASSTLSAPNSTEQLQRLRHTCAHVMAMAVQNLFPETKVTIGPTTETGFYYDFDRDQA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEECCCCCC
FTPEDLDAISTQMRRIIKANLPIIREQVDRDQMQAELEQLQEPYKLEILAQIPAGETITR
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEE
YFIGSPDTGRTQHPEAEASLIEPLPVAPNEFWWDLCSGPHLNSTGELHSKAFMLESVAGA
EEECCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCH
YWRGDETQAQLQRIYGTAWETPKQLKAYLHQKEEAQRRDHRLLGKNLKLFSIEDNAGGGL
HCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCE
VFWHPRGARIRQVIETYWRQAHTQGGYELLYTPHMANLDLWKTSGHFDFYRDSMFDQMEV
EEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCCCHHHHHHHHHHHH
ETQAYQIKPMNCPFHVLTYQHDLHSYREFPLRWAELGTVYRYERSGTLHGLMRVRGFTQD
HHHEEEEEECCCCEEEEEEHHHHHHHHHCCCHHHHHCCEEEEECCCHHHHHHHHCCCCCC
DAHIFCLPDQVADEILAVLDLTETVLSDFGFRDYEVNLSTRPDKSVGSDEIWDLATQDLR
CCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHH
TALDRKGWEYLTDEGGGAFYGPKIDLKIRDAIGRLWQCSTIQVDFNLPERFKMEYVAADG
HHHHHCCCEEEECCCCCEEECCEEEEEEHHHHHHHEECEEEEEECCCCHHHCEEEEECCC
TRQRPIMIHRAIFGSLERFFGILIENYAGDFPLWLAPVQIRLLVVSDAQRPYALEVLEQL
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECEEEEEEEEECCCCCHHHHHHHHH
QQKGFRAEIDQTGERLGKQIRQSALEKIPVVAVVGQKEVEAQTLNIRTRHSEEQELLKLP
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHCCEEEEEEECCCHHHHHHHHH
ELCEKMQSAIDAKQHI
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA