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The map label for this gene is clcB [H]

Identifier: 158336117

GI number: 158336117

Start: 3005695

End: 3007092

Strand: Direct

Name: clcB [H]

Synonym: AM1_2979

Alternate gene names: 158336117

Gene position: 3005695-3007092 (Clockwise)

Preceding gene: 158336115

Following gene: 158336118

Centisome position: 46.21

GC content: 50.14

Gene sequence:

>1398_bases
ATGACACAGACGCTAGCCAGTGGTCCAGAAGAACAGCATGCGCTGTCGGCACCATTCGAGATAGGAAAACGTGAGCTGAC
CTACTCACAATTAGTTATATGTGCCGCACTGATTGGCGTATTTGGGGGATTAGTGGCCACTGCATACTACTTTGTTCTCG
AAACCTTGATGCATGGTGTCTGGCACACCGTGCCCGATCGGGTTGTGCCCTATTTTCCCAGTTGGCTCCCTCAACAACAT
TACGTCTGGATCGCCTCGACCATTGGTGGTTTCTGTGTCGGGCTGGTCCTATTCTTTATGGGCCTACCAGGAGAGATGGC
CCAAGTCGTCGACAAAATCCACAGCCCCGGCAAAATTGATATTCGCAAAACCCCAGCCATGATTATTGCGTCCTTAGTAG
CGATTACCTCCGGGGGGAGTGCTGGCCCCGAAGCGCCTTTGGTGCAGGTCAATGGTAGCTTCGGCAGTTGGCTAGGAGAA
AAATTGCAGCTCACTACCACTTCGGTGCGGGTGCTGACCTTTTGTGGCATGAGTGCCGCCTTGGGTGCATTTTTTGGTGC
ACCGATTGGTGCTGCTCTATTCGCTTTAGAGATTCCCCATCGCAAAGGTTTGGAATATTACGAAGCCATTGCCCCCGCCG
TCGTTTCCGCAATTTTTTCCTTTGCAGTGTTTCGCATCAATACTGGCATGACCATTGGTGGTTTCTATCATTTCGAAACC
GTGCCACCTTTAACCCCAACTAACTTACTGGAAGGATTAGTACTGGGTGGGATTGGGGCAGGCGTTGCAGTGATGTTCAT
TGGCGTATTTCGATTGGTGGGCCATTTACTCGCTCCCCTAGAGCATCATCGAATTCTTTTAGCCACCCTAGGGGGACTCA
CCATTGGCTTGATCGCCTTAGCCTTTCCCCAAACGCTATTTTTTAGCGAAGAGCAAATTCATACGGTGATTGAAACGGGG
GCAACCCTGGGCATTACCTTTTTGCTGATGATTGCAGTGGCTAAAATGTTTGCCATTAGCGTGACGCTTCACTCTGGCTT
TTTAGGTGGCTTTATTTTTCCCCTCTTTTTTATTGGTGCGAATGTGGGTCTCGCCATTTCCTTGATGGTGCCGCAGGTGC
ATCCCACGTTAGGCATGGTCTGCTTAATGGCTGCCGTTAATGTGGCAGTGACTAAGACCCCTGTGAGCACCAGCATTATT
CTCAGCGTGTTGTCTGGGATGGCGATGCTGCCAGTGATTGTGATTTCAAGCTTTGTCAGCTTTCTACTCACCAGTCAAAT
TGCCATGATCAAAACTCAACGGTCCCGAGAGTTAGAAGGCTTTCCCACGTCTGCTCCTCAAACTTCTGAGGCTTCTCCTA
GATTGGTATCGAGCCCTGCCTCGTTGGCCATTGAATAA

Upstream 100 bases:

>100_bases
CAAGGAAAATTCTCCGTAATCTGCCTAAATACGCTTTCAAAGCAAAGCACTTGGATTGGCAGCTATCCACTGCCAATCGG
TAGATGGAGATTCAGCATTA

Downstream 100 bases:

>100_bases
GATCGCTGACCTCTCATATCCACCATGCTGGAATGCGACATTGCAAACTTTCTTGTTGATGAGCTGTCATTGCTGAACGA
CTCGATCTAGCTTGACGATA

Product: Cl- channel, voltage gated

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MTQTLASGPEEQHALSAPFEIGKRELTYSQLVICAALIGVFGGLVATAYYFVLETLMHGVWHTVPDRVVPYFPSWLPQQH
YVWIASTIGGFCVGLVLFFMGLPGEMAQVVDKIHSPGKIDIRKTPAMIIASLVAITSGGSAGPEAPLVQVNGSFGSWLGE
KLQLTTTSVRVLTFCGMSAALGAFFGAPIGAALFALEIPHRKGLEYYEAIAPAVVSAIFSFAVFRINTGMTIGGFYHFET
VPPLTPTNLLEGLVLGGIGAGVAVMFIGVFRLVGHLLAPLEHHRILLATLGGLTIGLIALAFPQTLFFSEEQIHTVIETG
ATLGITFLLMIAVAKMFAISVTLHSGFLGGFIFPLFFIGANVGLAISLMVPQVHPTLGMVCLMAAVNVAVTKTPVSTSII
LSVLSGMAMLPVIVISSFVSFLLTSQIAMIKTQRSRELEGFPTSAPQTSEASPRLVSSPASLAIE

Sequences:

>Translated_465_residues
MTQTLASGPEEQHALSAPFEIGKRELTYSQLVICAALIGVFGGLVATAYYFVLETLMHGVWHTVPDRVVPYFPSWLPQQH
YVWIASTIGGFCVGLVLFFMGLPGEMAQVVDKIHSPGKIDIRKTPAMIIASLVAITSGGSAGPEAPLVQVNGSFGSWLGE
KLQLTTTSVRVLTFCGMSAALGAFFGAPIGAALFALEIPHRKGLEYYEAIAPAVVSAIFSFAVFRINTGMTIGGFYHFET
VPPLTPTNLLEGLVLGGIGAGVAVMFIGVFRLVGHLLAPLEHHRILLATLGGLTIGLIALAFPQTLFFSEEQIHTVIETG
ATLGITFLLMIAVAKMFAISVTLHSGFLGGFIFPLFFIGANVGLAISLMVPQVHPTLGMVCLMAAVNVAVTKTPVSTSII
LSVLSGMAMLPVIVISSFVSFLLTSQIAMIKTQRSRELEGFPTSAPQTSEASPRLVSSPASLAIE
>Mature_464_residues
TQTLASGPEEQHALSAPFEIGKRELTYSQLVICAALIGVFGGLVATAYYFVLETLMHGVWHTVPDRVVPYFPSWLPQQHY
VWIASTIGGFCVGLVLFFMGLPGEMAQVVDKIHSPGKIDIRKTPAMIIASLVAITSGGSAGPEAPLVQVNGSFGSWLGEK
LQLTTTSVRVLTFCGMSAALGAFFGAPIGAALFALEIPHRKGLEYYEAIAPAVVSAIFSFAVFRINTGMTIGGFYHFETV
PPLTPTNLLEGLVLGGIGAGVAVMFIGVFRLVGHLLAPLEHHRILLATLGGLTIGLIALAFPQTLFFSEEQIHTVIETGA
TLGITFLLMIAVAKMFAISVTLHSGFLGGFIFPLFFIGANVGLAISLMVPQVHPTLGMVCLMAAVNVAVTKTPVSTSIIL
SVLSGMAMLPVIVISSFVSFLLTSQIAMIKTQRSRELEGFPTSAPQTSEASPRLVSSPASLAIE

Specific function: Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response [H]

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788733, Length=427, Percent_Identity=24.1217798594848, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 49235; Mature: 49104

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTLASGPEEQHALSAPFEIGKRELTYSQLVICAALIGVFGGLVATAYYFVLETLMHGV
CCCCCCCCCCHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WHTVPDRVVPYFPSWLPQQHYVWIASTIGGFCVGLVLFFMGLPGEMAQVVDKIHSPGKID
HHHCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEE
IRKTPAMIIASLVAITSGGSAGPEAPLVQVNGSFGSWLGEKLQLTTTSVRVLTFCGMSAA
ECCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHCCCCEEEEHHHHHHHHHHCHHHH
LGAFFGAPIGAALFALEIPHRKGLEYYEAIAPAVVSAIFSFAVFRINTGMTIGGFYHFET
HHHHHCCCHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECCEEEECC
VPPLTPTNLLEGLVLGGIGAGVAVMFIGVFRLVGHLLAPLEHHRILLATLGGLTIGLIAL
CCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCHHHHCEEHHHHHHHHHHHHHHH
AFPQTLFFSEEQIHTVIETGATLGITFLLMIAVAKMFAISVTLHSGFLGGFIFPLFFIGA
HHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NVGLAISLMVPQVHPTLGMVCLMAAVNVAVTKTPVSTSIILSVLSGMAMLPVIVISSFVS
CCCEEEEEECCCCCHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FLLTSQIAMIKTQRSRELEGFPTSAPQTSEASPRLVSSPASLAIE
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHCCCCHHCCC
>Mature Secondary Structure 
TQTLASGPEEQHALSAPFEIGKRELTYSQLVICAALIGVFGGLVATAYYFVLETLMHGV
CCCCCCCCCHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WHTVPDRVVPYFPSWLPQQHYVWIASTIGGFCVGLVLFFMGLPGEMAQVVDKIHSPGKID
HHHCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEE
IRKTPAMIIASLVAITSGGSAGPEAPLVQVNGSFGSWLGEKLQLTTTSVRVLTFCGMSAA
ECCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHCCCCEEEEHHHHHHHHHHCHHHH
LGAFFGAPIGAALFALEIPHRKGLEYYEAIAPAVVSAIFSFAVFRINTGMTIGGFYHFET
HHHHHCCCHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECCEEEECC
VPPLTPTNLLEGLVLGGIGAGVAVMFIGVFRLVGHLLAPLEHHRILLATLGGLTIGLIAL
CCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCHHHHCEEHHHHHHHHHHHHHHH
AFPQTLFFSEEQIHTVIETGATLGITFLLMIAVAKMFAISVTLHSGFLGGFIFPLFFIGA
HHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NVGLAISLMVPQVHPTLGMVCLMAAVNVAVTKTPVSTSIILSVLSGMAMLPVIVISSFVS
CCCEEEEEECCCCCHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FLLTSQIAMIKTQRSRELEGFPTSAPQTSEASPRLVSSPASLAIE
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA