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The map label for this gene is apt

Identifier: 158336084

GI number: 158336084

Start: 2977235

End: 2977747

Strand: Reverse

Name: apt

Synonym: AM1_2945

Alternate gene names: 158336084

Gene position: 2977747-2977235 (Counterclockwise)

Preceding gene: 158336094

Following gene: 158336083

Centisome position: 45.79

GC content: 53.02

Gene sequence:

>513_bases
ATGGATCTCAAATCACTGATTCGCGATATTCCCGATTTTCCCAAGCCTGGCATTTTGTTTCGGGACATTACGACCTTGTT
GCAAAATCCTGATGGTCTTCGCTACGTGATCGATCAGTTCACGGAGGATTATCGGGAGCAATCCATCGATTATGTGGTGG
GAATTGAGTCCCGAGGCTTTATCTTTGGAGCGCCGTTGGCCTATCAGTTGGGAGCTGGCTTTGTGCCTGTGCGCAAACCT
GGCAAACTGCCTGCGGCCATCCATGCCCAAGAATATGAGCTGGAGTACGGCACGGATCGCCTCGAAATTCACCAAGATGC
CTGTCCTGCAGGTAGTCGGGTGCTGGTTGTGGATGACCTTCTGGCAACGGGTGGCACAGCTGCAGCGACGGCCCAACTCC
TTGCTCCCCTAAACTGCACACTCGTCGGCTTTGGGTTTATCATCGAGCTGACAGGCTTAGCCGGGCGGCAAAAATTGCCC
GACTGTCACATTAATGCGTTGGTGGAGTATTAG

Upstream 100 bases:

>100_bases
CAACCACATTAGTGTACGATTTCTGACGTACCGTCCCCTGTCCTTTCATCAGGATAAAAGGTCATCCCATCTGTACACCT
TGCGCAAAATCACAACCCCT

Downstream 100 bases:

>100_bases
TTATCGGTAGCGAGCTTATCGGGTACACCATTAAGCGGGTGTTTCAAGGTCTGATCACCCTATTTTTGGCATCGCTATTG
ACCTTTTATATCGTCGATTT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MDLKSLIRDIPDFPKPGILFRDITTLLQNPDGLRYVIDQFTEDYREQSIDYVVGIESRGFIFGAPLAYQLGAGFVPVRKP
GKLPAAIHAQEYELEYGTDRLEIHQDACPAGSRVLVVDDLLATGGTAAATAQLLAPLNCTLVGFGFIIELTGLAGRQKLP
DCHINALVEY

Sequences:

>Translated_170_residues
MDLKSLIRDIPDFPKPGILFRDITTLLQNPDGLRYVIDQFTEDYREQSIDYVVGIESRGFIFGAPLAYQLGAGFVPVRKP
GKLPAAIHAQEYELEYGTDRLEIHQDACPAGSRVLVVDDLLATGGTAAATAQLLAPLNCTLVGFGFIIELTGLAGRQKLP
DCHINALVEY
>Mature_170_residues
MDLKSLIRDIPDFPKPGILFRDITTLLQNPDGLRYVIDQFTEDYREQSIDYVVGIESRGFIFGAPLAYQLGAGFVPVRKP
GKLPAAIHAQEYELEYGTDRLEIHQDACPAGSRVLVVDDLLATGGTAAATAQLLAPLNCTLVGFGFIIELTGLAGRQKLP
DCHINALVEY

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:
GO:0003999: Adenine phosphoribosyltransferase
GO:0005737: Adenine phosphoribosyltransferase
GO:0006166: Adenine phosphoribosyltransferase
GO:0006168: Adenine phosphoribosyltransferase
GO:0009116: Adenine phosphoribosyltransferase
GO:0016740: Adenine phosphoribosyltransferase
GO:0016757: Adenine phosphoribosyltransferase

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=167, Percent_Identity=45.5089820359281, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI71773201, Length=121, Percent_Identity=49.5867768595041, Blast_Score=115, Evalue=1e-26,
Organism=Escherichia coli, GI1786675, Length=164, Percent_Identity=54.2682926829268, Blast_Score=173, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI17509087, Length=167, Percent_Identity=45.5089820359281, Blast_Score=132, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6323619, Length=162, Percent_Identity=48.7654320987654, Blast_Score=141, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6320649, Length=162, Percent_Identity=35.8024691358025, Blast_Score=95, Evalue=6e-21,
Organism=Drosophila melanogaster, GI17136334, Length=170, Percent_Identity=41.7647058823529, Blast_Score=135, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_ACAM1 (B0CBF7)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001517258.1
- ProteinModelPortal:   B0CBF7
- SMR:   B0CBF7
- GeneID:   5681753
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_2945
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   AMAR329726:AM1_2945-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18591; Mature: 18591

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLKSLIRDIPDFPKPGILFRDITTLLQNPDGLRYVIDQFTEDYREQSIDYVVGIESRGF
CCHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCE
IFGAPLAYQLGAGFVPVRKPGKLPAAIHAQEYELEYGTDRLEIHQDACPAGSRVLVVDDL
EEECCHHHHHCCCCCCCCCCCCCCEEECCEEEEECCCCCEEEEECCCCCCCCEEEEEEHH
LATGGTAAATAQLLAPLNCTLVGFGFIIELTGLAGRQKLPDCHINALVEY
HHCCCCHHHHHHHHCCCCCEEEHHHHHEEECCCCCCCCCCCCCHHEEECC
>Mature Secondary Structure
MDLKSLIRDIPDFPKPGILFRDITTLLQNPDGLRYVIDQFTEDYREQSIDYVVGIESRGF
CCHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCE
IFGAPLAYQLGAGFVPVRKPGKLPAAIHAQEYELEYGTDRLEIHQDACPAGSRVLVVDDL
EEECCHHHHHCCCCCCCCCCCCCCEEECCEEEEECCCCCEEEEECCCCCCCCEEEEEEHH
LATGGTAAATAQLLAPLNCTLVGFGFIIELTGLAGRQKLPDCHINALVEY
HHCCCCHHHHHHHHCCCCCEEEHHHHHEEECCCCCCCCCCCCCHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA